No brain structure abnormalities in boys with Tourette's syndrome: A voxel‐based morphometry study
Identifieur interne : 001F03 ( Istex/Corpus ); précédent : 001F02; suivant : 001F04No brain structure abnormalities in boys with Tourette's syndrome: A voxel‐based morphometry study
Auteurs : Veit Roessner ; Sebastian Overlack ; Juergen Baudewig ; Peter Dechent ; Aribert Rothenberger ; Gunther HelmsSource :
- Movement Disorders [ 0885-3185 ] ; 2009-12-15.
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Abstract
Morphometric findings in Tourette's syndrome (TS) are still inconsistent probably due to differences in analysis approaches as well as several confounders (coexisting psychiatric conditions, medication status, etc.). Our aim was to identify possible morphometric changes in a well‐defined sample of drug‐naïve boys with “pure” TS. High‐resolution structural magnetic resonance images of 38 boys with TS were compared with those of 38 healthy boys matched for age and IQ using voxel‐based morphometry (VBM). Coexisting psychiatric conditions and previous medication were excluded. The inclusion of 10‐ to 15‐year‐old boys minimized the well known compensatory changes due to tic suppression over many years. VBM analyses revealed no differences between the treatment naïve boys with “pure” TS and healthy controls. Brain morphology is not altered in boys with “pure” TS. Further studies should reveal whether previous findings might be ascribed to confounding factors like coexisting psychiatric conditions or long‐term compensatory mechanisms due to voluntary tic suppression. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22847
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Our aim was to identify possible morphometric changes in a well‐defined sample of drug‐naïve boys with “pure” TS. High‐resolution structural magnetic resonance images of 38 boys with TS were compared with those of 38 healthy boys matched for age and IQ using voxel‐based morphometry (VBM). Coexisting psychiatric conditions and previous medication were excluded. The inclusion of 10‐ to 15‐year‐old boys minimized the well known compensatory changes due to tic suppression over many years. VBM analyses revealed no differences between the treatment naïve boys with “pure” TS and healthy controls. Brain morphology is not altered in boys with “pure” TS. Further studies should reveal whether previous findings might be ascribed to confounding factors like coexisting psychiatric conditions or long‐term compensatory mechanisms due to voluntary tic suppression. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Veit Roessner MD</name><affiliations><json:string>Department of Child and Adolescent Psychiatry, University Medical Center, Dresden, Germany</json:string><json:string>Department of Child and Adolescent Psychiatry, University Medical Center, Goettingen, Germany</json:string></affiliations></json:item><json:item><name>Sebastian Overlack MB</name><affiliations><json:string>Department of Child and Adolescent Psychiatry, University Medical Center, Goettingen, Germany</json:string></affiliations></json:item><json:item><name>Juergen Baudewig PhD</name><affiliations><json:string>MR‐Research in Neurology and Psychiatry, University Medical Center, Goettingen, Germany</json:string></affiliations></json:item><json:item><name>Peter Dechent PhD</name><affiliations><json:string>MR‐Research in Neurology and Psychiatry, University Medical Center, Goettingen, Germany</json:string></affiliations></json:item><json:item><name>Aribert Rothenberger MD</name><affiliations><json:string>Department of Child and Adolescent Psychiatry, University Medical Center, Goettingen, Germany</json:string></affiliations></json:item><json:item><name>Gunther Helms PhD</name><affiliations><json:string>MR‐Research in Neurology and Psychiatry, University Medical Center, Goettingen, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>tics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>child psychiatry</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>child neurology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MRI</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Morphometric findings in Tourette's syndrome (TS) are still inconsistent probably due to differences in analysis approaches as well as several confounders (coexisting psychiatric conditions, medication status, etc.). 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Our aim was to identify possible morphometric changes in a well‐defined sample of drug‐naïve boys with “pure” TS. High‐resolution structural magnetic resonance images of 38 boys with TS were compared with those of 38 healthy boys matched for age and IQ using voxel‐based morphometry (VBM). Coexisting psychiatric conditions and previous medication were excluded. The inclusion of 10‐ to 15‐year‐old boys minimized the well known compensatory changes due to tic suppression over many years. VBM analyses revealed no differences between the treatment naïve boys with “pure” TS and healthy controls. Brain morphology is not altered in boys with “pure” TS. Further studies should reveal whether previous findings might be ascribed to confounding factors like coexisting psychiatric conditions or long‐term compensatory mechanisms due to voluntary tic suppression. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>tics</term></item><item><term>child psychiatry</term></item><item><term>child neurology</term></item><item><term>MRI</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-06-04">Received</change><change when="2009-09-20">Registration</change><change when="2009-12-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/F888CE5F133A7BB5E6F0E631D30E504D82A80BC2/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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type="main">Abstract</title><p>Morphometric findings in Tourette's syndrome (TS) are still inconsistent probably due to differences in analysis approaches as well as several confounders (coexisting psychiatric conditions, medication status, etc.). Our aim was to identify possible morphometric changes in a well‐defined sample of drug‐naïve boys with “pure” TS. High‐resolution structural magnetic resonance images of 38 boys with TS were compared with those of 38 healthy boys matched for age and IQ using voxel‐based morphometry (VBM). Coexisting psychiatric conditions and previous medication were excluded. The inclusion of 10‐ to 15‐year‐old boys minimized the well known compensatory changes due to tic suppression over many years. VBM analyses revealed no differences between the treatment naïve boys with “pure” TS and healthy controls. Brain morphology is not altered in boys with “pure” TS. Further studies should reveal whether previous findings might be ascribed to confounding factors like coexisting psychiatric conditions or long‐term compensatory mechanisms due to voluntary tic suppression. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn8"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>No brain structure abnormalities in boys with Tourette's syndrome: A voxel‐based morphometry study</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Voxel‐Based Morphometry in Tourette's Syndrome</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>No brain structure abnormalities in boys with Tourette's syndrome: A voxel‐based morphometry study</title></titleInfo><name type="personal"><namePart type="given">Veit</namePart><namePart type="family">Roessner</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Child and Adolescent Psychiatry, University Medical Center, Dresden, Germany</affiliation><affiliation>Department of Child and Adolescent Psychiatry, University Medical Center, Goettingen, Germany</affiliation><description>Correspondence: Department of Child and Adolescent Psychiatry, University of Dresden, Goetheallee 12, 01309 Dresden, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sebastian</namePart><namePart type="family">Overlack</namePart><namePart type="termsOfAddress">MB</namePart><affiliation>Department of Child and Adolescent Psychiatry, University Medical Center, Goettingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Juergen</namePart><namePart type="family">Baudewig</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>MR‐Research in Neurology and Psychiatry, University Medical Center, Goettingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter</namePart><namePart type="family">Dechent</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>MR‐Research in Neurology and Psychiatry, University Medical Center, Goettingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Aribert</namePart><namePart type="family">Rothenberger</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Child and Adolescent Psychiatry, University Medical Center, Goettingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gunther</namePart><namePart type="family">Helms</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>MR‐Research in Neurology and Psychiatry, University Medical Center, Goettingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-12-15</dateIssued><dateCaptured encoding="w3cdtf">2009-06-04</dateCaptured><dateValid encoding="w3cdtf">2009-09-20</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">50</extent><extent unit="words">4102</extent></physicalDescription><abstract lang="en">Morphometric findings in Tourette's syndrome (TS) are still inconsistent probably due to differences in analysis approaches as well as several confounders (coexisting psychiatric conditions, medication status, etc.). Our aim was to identify possible morphometric changes in a well‐defined sample of drug‐naïve boys with “pure” TS. High‐resolution structural magnetic resonance images of 38 boys with TS were compared with those of 38 healthy boys matched for age and IQ using voxel‐based morphometry (VBM). Coexisting psychiatric conditions and previous medication were excluded. The inclusion of 10‐ to 15‐year‐old boys minimized the well known compensatory changes due to tic suppression over many years. VBM analyses revealed no differences between the treatment naïve boys with “pure” TS and healthy controls. Brain morphology is not altered in boys with “pure” TS. Further studies should reveal whether previous findings might be ascribed to confounding factors like coexisting psychiatric conditions or long‐term compensatory mechanisms due to voluntary tic suppression. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><note type="funding">Volkswagen‐Stiftung</note><subject lang="en"><genre>Keywords</genre><topic>tics</topic><topic>child psychiatry</topic><topic>child neurology</topic><topic>MRI</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>16</number></detail><extent unit="pages"><start>2398</start><end>2403</end><total>6</total></extent></part></relatedItem><identifier type="istex">F888CE5F133A7BB5E6F0E631D30E504D82A80BC2</identifier><identifier type="DOI">10.1002/mds.22847</identifier><identifier type="ArticleID">MDS22847</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorders Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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