Impaired modulation of motor cortex excitability by homonymous and heteronymous muscle afferents in focal hand dystonia
Identifieur interne : 001E59 ( Istex/Corpus ); précédent : 001E58; suivant : 001E60Impaired modulation of motor cortex excitability by homonymous and heteronymous muscle afferents in focal hand dystonia
Auteurs : George Lourenço ; Sabine Meunier ; Marie Vidailhet ; Marion Simonetta-MoreauSource :
- Movement Disorders [ 0885-3185 ] ; 2007-03-15.
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Abstract
A decrease of heteronymous median nerve‐evoked inhibition of corticospinal projections to forearm extensor muscles was reported in a group of 10 dystonic patients by Bertolasi and colleagues in 2003. Here we tested the excitability of corticomotoneuronal connections to both wrist extensor (ECR) and flexor (FCR) muscles after conditioning stimulation of median and also radial nerve at rest in a group of 25 patients with focal hand dystonia compared to 20 healthy subjects. We also investigated the effect of the wrist dystonic posture, either in flexion or in extension, on the afferent modulation of ECR and FCR motor evolved potentials (MEPs). The heteronymous (median‐induced) but also homonymous (radial‐induced) inhibitions (interstimuli intervals 13–21 ms) of ECR MEP size observed in healthy subjects were decreased in patients. In addition, homonymous (median‐induced) facilitation of FCR MEP size was also decreased in patients while heteronymous inhibition (radial‐induced) was not. Neither the involvement of the target muscle in the dystonic posture nor the origin of the afferent volley (from a dystonic muscle) influenced the degree of impairment of afferent modulation of the MEP. These findings support the view that a global abnormal somatosensory coupling in focal hand dystonia may contribute to an inadequate motor command to wrist muscles. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.21312
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ISTEX:0CD8D21BC243328F534E5D5A1943CA0E8633FF70Le document en format XML
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Here we tested the excitability of corticomotoneuronal connections to both wrist extensor (ECR) and flexor (FCR) muscles after conditioning stimulation of median and also radial nerve at rest in a group of 25 patients with focal hand dystonia compared to 20 healthy subjects. We also investigated the effect of the wrist dystonic posture, either in flexion or in extension, on the afferent modulation of ECR and FCR motor evolved potentials (MEPs). The heteronymous (median‐induced) but also homonymous (radial‐induced) inhibitions (interstimuli intervals 13–21 ms) of ECR MEP size observed in healthy subjects were decreased in patients. In addition, homonymous (median‐induced) facilitation of FCR MEP size was also decreased in patients while heteronymous inhibition (radial‐induced) was not. Neither the involvement of the target muscle in the dystonic posture nor the origin of the afferent volley (from a dystonic muscle) influenced the degree of impairment of afferent modulation of the MEP. These findings support the view that a global abnormal somatosensory coupling in focal hand dystonia may contribute to an inadequate motor command to wrist muscles. © 2006 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>George Lourenço PhD</name><affiliations><json:string>INSERM U731, Paris, France</json:string><json:string>Université Pierre et Marie Curie, Paris VI, UMR S731, Paris, France</json:string></affiliations></json:item><json:item><name>Sabine Meunier MD, PhD</name><affiliations><json:string>INSERM U731, Paris, France</json:string><json:string>Université Pierre et Marie Curie, Paris VI, UMR S731, Paris, France</json:string></affiliations></json:item><json:item><name>Marie Vidailhet MD, PhD</name><affiliations><json:string>Service de Neurologie, Assistance Publique–Hôpitaux de Paris, Hôpital Saint‐Antoine, Paris, France</json:string><json:string>INSERM U679, France</json:string></affiliations></json:item><json:item><name>Marion Simonetta‐Moreau MD, PhD</name><affiliations><json:string>INSERM U455, Toulouse, France</json:string><json:string>Fédération de Neurologie, Hôpital Purpan, Toulouse, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>focal hand dystonia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>transcranial magnetic stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>muscle afferent input</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>sensorimotor system</value></json:item></subject><language><json:string>eng</json:string></language><abstract>A decrease of heteronymous median nerve‐evoked inhibition of corticospinal projections to forearm extensor muscles was reported in a group of 10 dystonic patients by Bertolasi and colleagues in 2003. 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Network</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Institut National pour la Santé et la Recherche Médicale</fundingAgency><fundingNumber>INSERM RBM 0113</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Association des Malades Atteints de Dystonie (AMADYS)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Clinical Investigation Center of Toulouse (CHU Purpan)</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>A decrease of heteronymous median nerve‐evoked inhibition of corticospinal projections to forearm extensor muscles was reported in a group of 10 dystonic patients by Bertolasi and colleagues in 2003. Here we tested the excitability of corticomotoneuronal connections to both wrist extensor (ECR) and flexor (FCR) muscles after conditioning stimulation of median and also radial nerve at rest in a group of 25 patients with focal hand dystonia compared to 20 healthy subjects. We also investigated the effect of the wrist dystonic posture, either in flexion or in extension, on the afferent modulation of ECR and FCR motor evolved potentials (MEPs). The heteronymous (median‐induced) but also homonymous (radial‐induced) inhibitions (interstimuli intervals 13–21 ms) of ECR MEP size observed in healthy subjects were decreased in patients. In addition, homonymous (median‐induced) facilitation of FCR MEP size was also decreased in patients while heteronymous inhibition (radial‐induced) was not. Neither the involvement of the target muscle in the dystonic posture nor the origin of the afferent volley (from a dystonic muscle) influenced the degree of impairment of afferent modulation of the MEP. These findings support the view that a global abnormal somatosensory coupling in focal hand dystonia may contribute to an inadequate motor command to wrist muscles. © 2006 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Impaired modulation of motor cortex excitability by homonymous and heteronymous muscle afferents in focal hand dystonia</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Sensorimotor Impairment in FHD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Impaired modulation of motor cortex excitability by homonymous and heteronymous muscle afferents in focal hand dystonia</title></titleInfo><name type="personal"><namePart type="given">George</namePart><namePart type="family">Lourenço</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>INSERM U731, Paris, France</affiliation><affiliation>Université Pierre et Marie Curie, Paris VI, UMR S731, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sabine</namePart><namePart type="family">Meunier</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>INSERM U731, Paris, France</affiliation><affiliation>Université Pierre et Marie Curie, Paris VI, UMR S731, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marie</namePart><namePart type="family">Vidailhet</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Service de Neurologie, Assistance Publique–Hôpitaux de Paris, Hôpital Saint‐Antoine, Paris, France</affiliation><affiliation>INSERM U679, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marion</namePart><namePart type="family">Simonetta‐Moreau</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>INSERM U455, Toulouse, France</affiliation><affiliation>Fédération de Neurologie, Hôpital Purpan, Toulouse, France</affiliation><description>Correspondence: Service de Neurologie, Hôpital Purpan, Place du Dr Baylac, 31059 TSA 40031, Toulouse Cedex 9, France</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-03-15</dateIssued><dateCaptured encoding="w3cdtf">2006-06-22</dateCaptured><dateValid encoding="w3cdtf">2006-09-26</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="references">13</extent><extent unit="words">3211</extent></physicalDescription><abstract lang="en">A decrease of heteronymous median nerve‐evoked inhibition of corticospinal projections to forearm extensor muscles was reported in a group of 10 dystonic patients by Bertolasi and colleagues in 2003. Here we tested the excitability of corticomotoneuronal connections to both wrist extensor (ECR) and flexor (FCR) muscles after conditioning stimulation of median and also radial nerve at rest in a group of 25 patients with focal hand dystonia compared to 20 healthy subjects. We also investigated the effect of the wrist dystonic posture, either in flexion or in extension, on the afferent modulation of ECR and FCR motor evolved potentials (MEPs). The heteronymous (median‐induced) but also homonymous (radial‐induced) inhibitions (interstimuli intervals 13–21 ms) of ECR MEP size observed in healthy subjects were decreased in patients. In addition, homonymous (median‐induced) facilitation of FCR MEP size was also decreased in patients while heteronymous inhibition (radial‐induced) was not. Neither the involvement of the target muscle in the dystonic posture nor the origin of the afferent volley (from a dystonic muscle) influenced the degree of impairment of afferent modulation of the MEP. These findings support the view that a global abnormal somatosensory coupling in focal hand dystonia may contribute to an inadequate motor command to wrist muscles. © 2006 Movement Disorder Society</abstract><note type="funding">GIS Maladies Rares Dystonie</note><note type="funding">INSERM Dystonia French Network</note><note type="funding">Institut National pour la Santé et la Recherche Médicale - No. INSERM RBM 0113; </note><note type="funding">Association des Malades Atteints de Dystonie (AMADYS)</note><note type="funding">Clinical Investigation Center of Toulouse (CHU Purpan)</note><subject lang="en"><genre>Keywords</genre><topic>focal hand dystonia</topic><topic>transcranial magnetic stimulation</topic><topic>muscle afferent input</topic><topic>sensorimotor system</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>523</start><end>527</end><total>5</total></extent></part></relatedItem><identifier type="istex">0CD8D21BC243328F534E5D5A1943CA0E8633FF70</identifier><identifier type="DOI">10.1002/mds.21312</identifier><identifier type="ArticleID">MDS21312</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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