Movement Disorders (revue)

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A case‐control study of Parkinson's disease in a horticultural region of British Columbia

Identifieur interne : 001E57 ( Istex/Corpus ); précédent : 001E56; suivant : 001E58

A case‐control study of Parkinson's disease in a horticultural region of British Columbia

Auteurs : Clyde Hertzman ; Michele Wiens ; Barry Snow ; Shona Kelly ; Donald Calne

Source :

RBID : ISTEX:9390274BEFED7A2C1B5EABCBA05F1D129D06BBA4

English descriptors

Abstract

We compared personal histories of 127 cases and 245 controls to identify possible environmental risk factors for idiopathic parkinsonism (IP). Of our controls, 121 had cardiac disease (CD) and 124 were randomly selected from electoral lists (voters). Using logistic regression and adjusting for sex and age, we ran separate analyses: IP versus CD and IP versus voters. A full occupational history was collected, as was known contact with all pesticides associated with the tree fruit sector of the agricultural industry. We found a significant association between IP and having had an occupation in which exposure through handling or directly contacting pesticides was probable, but no specific chemicals were associated with IP. We conclude that although occupations involving the use of agricultural chemicals may predispose to the development of IP, it seems likely that the pathogenesis is multifactorial rather than related to a specific agent.

Url:
DOI: 10.1002/mds.870090111

Links to Exploration step

ISTEX:9390274BEFED7A2C1B5EABCBA05F1D129D06BBA4

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<description>Correspondence: Division of Occupational and Environmental Health, Department of Health Care and Epidemiology, Mather Building, 5804 Fairview Avenue, Vancouver, B.C., Canada V6T 1W5</description>
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<name type="personal">
<namePart type="given">Barry</namePart>
<namePart type="family">Snow</namePart>
<affiliation>Division of Occupational and Environmental Health, Department of Health Care and Epidemiology, Vancouver, B.C.</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Shona</namePart>
<namePart type="family">Kelly</namePart>
<affiliation>Division of Neurology, University of British Columbia, Vancouver, B.C.</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Donald</namePart>
<namePart type="family">Calne</namePart>
<affiliation>Division of Neurology, University of British Columbia, Vancouver, B.C.</affiliation>
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<roleTerm type="text">author</roleTerm>
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<typeOfResource>text</typeOfResource>
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<publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<place>
<placeTerm type="text">Hoboken</placeTerm>
</place>
<dateIssued encoding="w3cdtf">1994</dateIssued>
<copyrightDate encoding="w3cdtf">1994</copyrightDate>
</originInfo>
<language>
<languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
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<internetMediaType>text/html</internetMediaType>
<extent unit="tables">5</extent>
<extent unit="references">27</extent>
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<abstract lang="en">We compared personal histories of 127 cases and 245 controls to identify possible environmental risk factors for idiopathic parkinsonism (IP). Of our controls, 121 had cardiac disease (CD) and 124 were randomly selected from electoral lists (voters). Using logistic regression and adjusting for sex and age, we ran separate analyses: IP versus CD and IP versus voters. A full occupational history was collected, as was known contact with all pesticides associated with the tree fruit sector of the agricultural industry. We found a significant association between IP and having had an occupation in which exposure through handling or directly contacting pesticides was probable, but no specific chemicals were associated with IP. We conclude that although occupations involving the use of agricultural chemicals may predispose to the development of IP, it seems likely that the pathogenesis is multifactorial rather than related to a specific agent.</abstract>
<subject lang="en">
<genre>Keywords</genre>
<topic>Parkinson's disease</topic>
<topic>Environmental exposure</topic>
<topic>Occupational exposure</topic>
<topic>Pesticides</topic>
<topic>Toxins</topic>
<topic>Agricultural workers</topic>
</subject>
<relatedItem type="host">
<titleInfo>
<title>Movement Disorders</title>
</titleInfo>
<titleInfo type="abbreviated">
<title>Mov. Disord.</title>
</titleInfo>
<subject>
<genre>article category</genre>
<topic>Article</topic>
</subject>
<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part>
<date>1994</date>
<detail type="volume">
<caption>vol.</caption>
<number>9</number>
</detail>
<detail type="issue">
<caption>no.</caption>
<number>1</number>
</detail>
<extent unit="pages">
<start>69</start>
<end>75</end>
<total>7</total>
</extent>
</part>
</relatedItem>
<identifier type="istex">9390274BEFED7A2C1B5EABCBA05F1D129D06BBA4</identifier>
<identifier type="DOI">10.1002/mds.870090111</identifier>
<identifier type="ArticleID">MDS870090111</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 1994 Movement Disorder Society</accessCondition>
<recordInfo>
<recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin>
<recordContentSource>WILEY</recordContentSource>
</recordInfo>
</mods>
</metadata>
<serie></serie>
</istex>
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