Predictive value of nigrostriatal dysfunction in isolated tremor: A clinical and SPECT study
Identifieur interne : 001E06 ( Istex/Corpus ); précédent : 001E05; suivant : 001E07Predictive value of nigrostriatal dysfunction in isolated tremor: A clinical and SPECT study
Auteurs : Roberto Ceravolo ; Angelo Antonini ; Duccio Volterrani ; Carlo Rossi ; Lorenzo Kiferle ; Daniela Frosini ; Claudio Lucetti ; Ioannis U. Isaias ; Riccardo Benti ; Luigi Murri ; Ubaldo BonuccelliSource :
- Movement Disorders [ 0885-3185 ] ; 2008-10-30.
English descriptors
Abstract
The overlap among tremor disorders is wide and complex because essential tremor patients may present resting tremor coexisting with postural tremor, while postural may coexist with resting tremor in Parkinson's disease. We investigated dopamine transporter binding in 61 subjects presenting with isolated atypical tremors defined as unilateral either postural, resting, or mixed (i.e. resting and postural) tremor, without rigidity or bradykinesia, by means of 123I‐FPCIT SPECT imaging at baseline. Patients were followed‐up clinically for 28.4 ± 7.2 months. Twenty‐five patients with baseline normal SPECT continued to present only tremor at follow‐up. Among 36 patients with abnormal SPECT, 23 (64%) developed PD, while the remaining 13 continued to present only tremor at follow‐up. The value of 123I‐FPCIT SPECT in predicting the evolution to PD was very high in a way independent from the first clinical presentation of tremor (Rest tremor, P = 0.015; Mixed tremor, P = 0.015; Postural tremor, P = 0.039; chi‐square test). Our data suggest that the clinical presentation of isolated tremors is insufficient to allow a precise early‐stage diagnosis, whereas the detection of presynaptic nigrostriatal dopaminergic dysfunction could lead to diagnosis of atypical tremor disorders at a very early stage. We suggest this disorder to be labeled as “isolated tremor with dopaminergic presynaptic dysfunction.” © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22259
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Isaias</name><affiliation><mods:affiliation>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Benti, Riccardo" sort="Benti, Riccardo" uniqKey="Benti R" first="Riccardo" last="Benti">Riccardo Benti</name><affiliation><mods:affiliation>Nuclear Medicine, IRCCS‐Ospedale Maggiore, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Murri, Luigi" sort="Murri, Luigi" uniqKey="Murri L" first="Luigi" last="Murri">Luigi Murri</name><affiliation><mods:affiliation>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bonuccelli, Ubaldo" sort="Bonuccelli, Ubaldo" uniqKey="Bonuccelli U" first="Ubaldo" last="Bonuccelli">Ubaldo Bonuccelli</name><affiliation><mods:affiliation>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-10-30">2008-10-30</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2049">2049</biblScope><biblScope unit="page" to="2054">2054</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">8F0057EF5881D49283FA88A7172428481992F9A4</idno><idno type="DOI">10.1002/mds.22259</idno><idno type="ArticleID">MDS22259</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>SPECT</term><term>dopamine transporter</term><term>isolated tremors</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The overlap among tremor disorders is wide and complex because essential tremor patients may present resting tremor coexisting with postural tremor, while postural may coexist with resting tremor in Parkinson's disease. We investigated dopamine transporter binding in 61 subjects presenting with isolated atypical tremors defined as unilateral either postural, resting, or mixed (i.e. resting and postural) tremor, without rigidity or bradykinesia, by means of 123I‐FPCIT SPECT imaging at baseline. Patients were followed‐up clinically for 28.4 ± 7.2 months. Twenty‐five patients with baseline normal SPECT continued to present only tremor at follow‐up. Among 36 patients with abnormal SPECT, 23 (64%) developed PD, while the remaining 13 continued to present only tremor at follow‐up. The value of 123I‐FPCIT SPECT in predicting the evolution to PD was very high in a way independent from the first clinical presentation of tremor (Rest tremor, P = 0.015; Mixed tremor, P = 0.015; Postural tremor, P = 0.039; chi‐square test). Our data suggest that the clinical presentation of isolated tremors is insufficient to allow a precise early‐stage diagnosis, whereas the detection of presynaptic nigrostriatal dopaminergic dysfunction could lead to diagnosis of atypical tremor disorders at a very early stage. We suggest this disorder to be labeled as “isolated tremor with dopaminergic presynaptic dysfunction.” © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Roberto Ceravolo MD</name><affiliations><json:string>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</json:string></affiliations></json:item><json:item><name>Angelo Antonini MD</name><affiliations><json:string>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</json:string></affiliations></json:item><json:item><name>Duccio Volterrani MD</name><affiliations><json:string>Nuclear Medicine, University of Pisa, Pisa, Italy</json:string></affiliations></json:item><json:item><name>Carlo Rossi MD</name><affiliations><json:string>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</json:string></affiliations></json:item><json:item><name>Lorenzo Kiferle MD</name><affiliations><json:string>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</json:string></affiliations></json:item><json:item><name>Daniela Frosini MD</name><affiliations><json:string>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</json:string></affiliations></json:item><json:item><name>Claudio Lucetti MD</name><affiliations><json:string>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</json:string></affiliations></json:item><json:item><name>Ioannis U. Isaias MD</name><affiliations><json:string>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</json:string></affiliations></json:item><json:item><name>Riccardo Benti MD</name><affiliations><json:string>Nuclear Medicine, IRCCS‐Ospedale Maggiore, Milan, Italy</json:string></affiliations></json:item><json:item><name>Luigi Murri MD</name><affiliations><json:string>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</json:string></affiliations></json:item><json:item><name>Ubaldo Bonuccelli MD</name><affiliations><json:string>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>isolated tremors</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dopamine transporter</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SPECT</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The overlap among tremor disorders is wide and complex because essential tremor patients may present resting tremor coexisting with postural tremor, while postural may coexist with resting tremor in Parkinson's disease. We investigated dopamine transporter binding in 61 subjects presenting with isolated atypical tremors defined as unilateral either postural, resting, or mixed (i.e. resting and postural) tremor, without rigidity or bradykinesia, by means of 123I‐FPCIT SPECT imaging at baseline. Patients were followed‐up clinically for 28.4 ± 7.2 months. Twenty‐five patients with baseline normal SPECT continued to present only tremor at follow‐up. Among 36 patients with abnormal SPECT, 23 (64%) developed PD, while the remaining 13 continued to present only tremor at follow‐up. The value of 123I‐FPCIT SPECT in predicting the evolution to PD was very high in a way independent from the first clinical presentation of tremor (Rest tremor, P = 0.015; Mixed tremor, P = 0.015; Postural tremor, P = 0.039; chi‐square test). Our data suggest that the clinical presentation of isolated tremors is insufficient to allow a precise early‐stage diagnosis, whereas the detection of presynaptic nigrostriatal dopaminergic dysfunction could lead to diagnosis of atypical tremor disorders at a very early stage. We suggest this disorder to be labeled as “isolated tremor with dopaminergic presynaptic dysfunction.” © 2008 Movement Disorder Society</abstract><qualityIndicators><score>5.473</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1441</abstractCharCount><pdfWordCount>2929</pdfWordCount><pdfCharCount>18451</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>212</abstractWordCount></qualityIndicators><title>Predictive value of nigrostriatal dysfunction in isolated tremor: A clinical and SPECT study</title><genre><json:string>Serial article</json:string></genre><host><volume>23</volume><pages><total>6</total><last>2054</last><first>2049</first></pages><issn><json:string>0885-3185</json:string></issn><issue>14</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement 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study</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2008</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: None reported.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Predictive value of nigrostriatal dysfunction in isolated tremor: A clinical and SPECT study</title><author><persName><forename type="first">Roberto</forename><surname>Ceravolo</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</affiliation></author><author><persName><forename type="first">Angelo</forename><surname>Antonini</surname><roleName type="degree">MD</roleName></persName><affiliation>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation></author><author><persName><forename type="first">Duccio</forename><surname>Volterrani</surname><roleName type="degree">MD</roleName></persName><affiliation>Nuclear Medicine, University of Pisa, Pisa, Italy</affiliation></author><author><persName><forename type="first">Carlo</forename><surname>Rossi</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</affiliation></author><author><persName><forename type="first">Lorenzo</forename><surname>Kiferle</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</affiliation></author><author><persName><forename type="first">Daniela</forename><surname>Frosini</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</affiliation></author><author><persName><forename type="first">Claudio</forename><surname>Lucetti</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</affiliation></author><author><persName><forename type="first">Ioannis U.</forename><surname>Isaias</surname><roleName type="degree">MD</roleName></persName><affiliation>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation></author><author><persName><forename type="first">Riccardo</forename><surname>Benti</surname><roleName type="degree">MD</roleName></persName><affiliation>Nuclear Medicine, IRCCS‐Ospedale Maggiore, Milan, Italy</affiliation></author><author><persName><forename type="first">Luigi</forename><surname>Murri</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</affiliation></author><author><persName><forename type="first">Ubaldo</forename><surname>Bonuccelli</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: via Roma 67, Pisa 56100, Italy</p></note><affiliation>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. 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We investigated dopamine transporter binding in 61 subjects presenting with isolated atypical tremors defined as unilateral either postural, resting, or mixed (i.e. resting and postural) tremor, without rigidity or bradykinesia, by means of 123I‐FPCIT SPECT imaging at baseline. Patients were followed‐up clinically for 28.4 ± 7.2 months. Twenty‐five patients with baseline normal SPECT continued to present only tremor at follow‐up. Among 36 patients with abnormal SPECT, 23 (64%) developed PD, while the remaining 13 continued to present only tremor at follow‐up. The value of 123I‐FPCIT SPECT in predicting the evolution to PD was very high in a way independent from the first clinical presentation of tremor (Rest tremor, P = 0.015; Mixed tremor, P = 0.015; Postural tremor, P = 0.039; chi‐square test). Our data suggest that the clinical presentation of isolated tremors is insufficient to allow a precise early‐stage diagnosis, whereas the detection of presynaptic nigrostriatal dopaminergic dysfunction could lead to diagnosis of atypical tremor disorders at a very early stage. We suggest this disorder to be labeled as “isolated tremor with dopaminergic presynaptic dysfunction.” © 2008 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>isolated tremors</term></item><item><term>Parkinson's disease</term></item><item><term>dopamine transporter</term></item><item><term>SPECT</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-02-12">Received</change><change when="2008-07-08">Registration</change><change when="2008-10-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/8F0057EF5881D49283FA88A7172428481992F9A4/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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number="1"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="20"></count><count type="wordTotal" number="3445"></count></countGroup><titleGroup><title type="main" xml:lang="en">Predictive value of nigrostriatal dysfunction in isolated tremor: A clinical and SPECT study<link href="#fn1"></link></title><title type="short" xml:lang="en">Datscan in Isolated Atypical Tremors</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Roberto</givenNames><familyName>Ceravolo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Angelo</givenNames><familyName>Antonini</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Duccio</givenNames><familyName>Volterrani</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Carlo</givenNames><familyName>Rossi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Lorenzo</givenNames><familyName>Kiferle</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Daniela</givenNames><familyName>Frosini</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Claudio</givenNames><familyName>Lucetti</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Ioannis U.</givenNames><familyName>Isaias</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Riccardo</givenNames><familyName>Benti</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Luigi</givenNames><familyName>Murri</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Ubaldo</givenNames><familyName>Bonuccelli</familyName><degrees>MD</degrees></personName><contactDetails><email>u.bonuccelli@med.unii.it</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="IT" type="organization"><unparsedAffiliation>Nuclear Medicine, University of Pisa, Pisa, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="IT" type="organization"><unparsedAffiliation>Nuclear Medicine, IRCCS‐Ospedale Maggiore, Milan, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">isolated tremors</keyword><keyword xml:id="kwd2">Parkinson's disease</keyword><keyword xml:id="kwd3">dopamine transporter</keyword><keyword xml:id="kwd4">SPECT</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The overlap among tremor disorders is wide and complex because essential tremor patients may present resting tremor coexisting with postural tremor, while postural may coexist with resting tremor in Parkinson's disease. We investigated dopamine transporter binding in 61 subjects presenting with isolated atypical tremors defined as unilateral either postural, resting, or mixed (i.e. resting and postural) tremor, without rigidity or bradykinesia, by means of 123I‐FPCIT SPECT imaging at baseline. Patients were followed‐up clinically for 28.4 ± 7.2 months. Twenty‐five patients with baseline normal SPECT continued to present only tremor at follow‐up. Among 36 patients with abnormal SPECT, 23 (64%) developed PD, while the remaining 13 continued to present only tremor at follow‐up. The value of 123I‐FPCIT SPECT in predicting the evolution to PD was very high in a way independent from the first clinical presentation of tremor (Rest tremor, <i>P</i> = 0.015; Mixed tremor, <i>P</i> = 0.015; Postural tremor, <i>P</i> = 0.039; chi‐square test). Our data suggest that the clinical presentation of isolated tremors is insufficient to allow a precise early‐stage diagnosis, whereas the detection of presynaptic nigrostriatal dopaminergic dysfunction could lead to diagnosis of atypical tremor disorders at a very early stage. We suggest this disorder to be labeled as “isolated tremor with dopaminergic presynaptic dysfunction.” © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Predictive value of nigrostriatal dysfunction in isolated tremor: A clinical and SPECT study</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Datscan in Isolated Atypical Tremors</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Predictive value of nigrostriatal dysfunction in isolated tremor: A clinical and SPECT study</title></titleInfo><name type="personal"><namePart type="given">Roberto</namePart><namePart type="family">Ceravolo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Angelo</namePart><namePart type="family">Antonini</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Duccio</namePart><namePart type="family">Volterrani</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Nuclear Medicine, University of Pisa, Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carlo</namePart><namePart type="family">Rossi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lorenzo</namePart><namePart type="family">Kiferle</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Daniela</namePart><namePart type="family">Frosini</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claudio</namePart><namePart type="family">Lucetti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ioannis U.</namePart><namePart type="family">Isaias</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Riccardo</namePart><namePart type="family">Benti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Nuclear Medicine, IRCCS‐Ospedale Maggiore, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luigi</namePart><namePart type="family">Murri</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ubaldo</namePart><namePart type="family">Bonuccelli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosciences, Neurologic Clinic, University of Pisa, Pisa, Italy</affiliation><description>Correspondence: via Roma 67, Pisa 56100, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-10-30</dateIssued><dateCaptured encoding="w3cdtf">2008-02-12</dateCaptured><dateValid encoding="w3cdtf">2008-07-08</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">3</extent><extent unit="references">20</extent><extent unit="words">3445</extent></physicalDescription><abstract lang="en">The overlap among tremor disorders is wide and complex because essential tremor patients may present resting tremor coexisting with postural tremor, while postural may coexist with resting tremor in Parkinson's disease. We investigated dopamine transporter binding in 61 subjects presenting with isolated atypical tremors defined as unilateral either postural, resting, or mixed (i.e. resting and postural) tremor, without rigidity or bradykinesia, by means of 123I‐FPCIT SPECT imaging at baseline. Patients were followed‐up clinically for 28.4 ± 7.2 months. Twenty‐five patients with baseline normal SPECT continued to present only tremor at follow‐up. Among 36 patients with abnormal SPECT, 23 (64%) developed PD, while the remaining 13 continued to present only tremor at follow‐up. The value of 123I‐FPCIT SPECT in predicting the evolution to PD was very high in a way independent from the first clinical presentation of tremor (Rest tremor, P = 0.015; Mixed tremor, P = 0.015; Postural tremor, P = 0.039; chi‐square test). Our data suggest that the clinical presentation of isolated tremors is insufficient to allow a precise early‐stage diagnosis, whereas the detection of presynaptic nigrostriatal dopaminergic dysfunction could lead to diagnosis of atypical tremor disorders at a very early stage. We suggest this disorder to be labeled as “isolated tremor with dopaminergic presynaptic dysfunction.” © 2008 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><subject lang="en"><genre>Keywords</genre><topic>isolated tremors</topic><topic>Parkinson's disease</topic><topic>dopamine transporter</topic><topic>SPECT</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>14</number></detail><extent unit="pages"><start>2049</start><end>2054</end><total>6</total></extent></part></relatedItem><identifier type="istex">8F0057EF5881D49283FA88A7172428481992F9A4</identifier><identifier type="DOI">10.1002/mds.22259</identifier><identifier type="ArticleID">MDS22259</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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