Decision making in de novo Parkinson's disease
Identifieur interne : 001D77 ( Istex/Corpus ); précédent : 001D76; suivant : 001D78Decision making in de novo Parkinson's disease
Auteurs : Michele Poletti ; Daniela Frosini ; Claudio Lucetti ; Paolo Del Dotto ; Roberto Ceravolo ; Ubaldo BonuccelliSource :
- Movement Disorders [ 0885-3185 ] ; 2010-07-30.
English descriptors
- KwdEn :
Abstract
The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age‐matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala‐damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age‐matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age‐matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23098
Links to Exploration step
ISTEX:FE0CEB919E772320EE7BBD5B1C45443C4F098AA7Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Decision making in de novo Parkinson's disease</title><author><name sortKey="Poletti, Michele" sort="Poletti, Michele" uniqKey="Poletti M" first="Michele" last="Poletti">Michele Poletti</name><affiliation><mods:affiliation>Neurology Unit, USL of Viareggio, Italy</mods:affiliation></affiliation></author><author><name sortKey="Frosini, Daniela" sort="Frosini, Daniela" uniqKey="Frosini D" first="Daniela" last="Frosini">Daniela Frosini</name><affiliation><mods:affiliation>Department of Neuroscience, University of Pisa, Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Lucetti, Claudio" sort="Lucetti, Claudio" uniqKey="Lucetti C" first="Claudio" last="Lucetti">Claudio Lucetti</name><affiliation><mods:affiliation>Neurology Unit, USL of Viareggio, Italy</mods:affiliation></affiliation></author><author><name sortKey="Dotto, Paolo Del" sort="Dotto, Paolo Del" uniqKey="Dotto P" first="Paolo Del" last="Dotto">Paolo Del Dotto</name><affiliation><mods:affiliation>Neurology Unit, USL of Viareggio, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ceravolo, Roberto" sort="Ceravolo, Roberto" uniqKey="Ceravolo R" first="Roberto" last="Ceravolo">Roberto Ceravolo</name><affiliation><mods:affiliation>Department of Neuroscience, University of Pisa, Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bonuccelli, Ubaldo" sort="Bonuccelli, Ubaldo" uniqKey="Bonuccelli U" first="Ubaldo" last="Bonuccelli">Ubaldo Bonuccelli</name><affiliation><mods:affiliation>Neurology Unit, USL of Viareggio, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroscience, University of Pisa, Pisa, Italy</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:FE0CEB919E772320EE7BBD5B1C45443C4F098AA7</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.23098</idno><idno type="url">https://api.istex.fr/document/FE0CEB919E772320EE7BBD5B1C45443C4F098AA7/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001D77</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Decision making in de novo Parkinson's disease</title><author><name sortKey="Poletti, Michele" sort="Poletti, Michele" uniqKey="Poletti M" first="Michele" last="Poletti">Michele Poletti</name><affiliation><mods:affiliation>Neurology Unit, USL of Viareggio, Italy</mods:affiliation></affiliation></author><author><name sortKey="Frosini, Daniela" sort="Frosini, Daniela" uniqKey="Frosini D" first="Daniela" last="Frosini">Daniela Frosini</name><affiliation><mods:affiliation>Department of Neuroscience, University of Pisa, Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Lucetti, Claudio" sort="Lucetti, Claudio" uniqKey="Lucetti C" first="Claudio" last="Lucetti">Claudio Lucetti</name><affiliation><mods:affiliation>Neurology Unit, USL of Viareggio, Italy</mods:affiliation></affiliation></author><author><name sortKey="Dotto, Paolo Del" sort="Dotto, Paolo Del" uniqKey="Dotto P" first="Paolo Del" last="Dotto">Paolo Del Dotto</name><affiliation><mods:affiliation>Neurology Unit, USL of Viareggio, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ceravolo, Roberto" sort="Ceravolo, Roberto" uniqKey="Ceravolo R" first="Roberto" last="Ceravolo">Roberto Ceravolo</name><affiliation><mods:affiliation>Department of Neuroscience, University of Pisa, Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bonuccelli, Ubaldo" sort="Bonuccelli, Ubaldo" uniqKey="Bonuccelli U" first="Ubaldo" last="Bonuccelli">Ubaldo Bonuccelli</name><affiliation><mods:affiliation>Neurology Unit, USL of Viareggio, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroscience, University of Pisa, Pisa, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-07-30">2010-07-30</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1432">1432</biblScope><biblScope unit="page" to="1436">1436</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">FE0CEB919E772320EE7BBD5B1C45443C4F098AA7</idno><idno type="DOI">10.1002/mds.23098</idno><idno type="ArticleID">MDS23098</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Iowa Gambling Task</term><term>amygdala</term><term>de novo Parkinson's disease</term><term>decision making</term><term>dopaminergic therapy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age‐matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala‐damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age‐matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age‐matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Michele Poletti PsyD</name><affiliations><json:string>Neurology Unit, USL of Viareggio, Italy</json:string></affiliations></json:item><json:item><name>Daniela Frosini MD</name><affiliations><json:string>Department of Neuroscience, University of Pisa, Pisa, Italy</json:string></affiliations></json:item><json:item><name>Claudio Lucetti MD</name><affiliations><json:string>Neurology Unit, USL of Viareggio, Italy</json:string></affiliations></json:item><json:item><name>Paolo Del Dotto MD</name><affiliations><json:string>Neurology Unit, USL of Viareggio, Italy</json:string></affiliations></json:item><json:item><name>Roberto Ceravolo MD</name><affiliations><json:string>Department of Neuroscience, University of Pisa, Pisa, Italy</json:string></affiliations></json:item><json:item><name>Ubaldo Bonuccelli MD</name><affiliations><json:string>Neurology Unit, USL of Viareggio, Italy</json:string><json:string>Department of Neuroscience, University of Pisa, Pisa, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>de novo Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>decision making</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Iowa Gambling Task</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dopaminergic therapy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>amygdala</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age‐matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala‐damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age‐matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age‐matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits. © 2010 Movement Disorder Society</abstract><qualityIndicators><score>5.549</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1245</abstractCharCount><pdfWordCount>3377</pdfWordCount><pdfCharCount>21747</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>181</abstractWordCount></qualityIndicators><title>Decision making in de novo Parkinson's disease</title><genre><json:string>Serial article</json:string></genre><host><volume>25</volume><pages><total>5</total><last>1436</last><first>1432</first></pages><issn><json:string>0885-3185</json:string></issn><issue>10</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1002/mds.23098</json:string></doi><id>FE0CEB919E772320EE7BBD5B1C45443C4F098AA7</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/FE0CEB919E772320EE7BBD5B1C45443C4F098AA7/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/FE0CEB919E772320EE7BBD5B1C45443C4F098AA7/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/FE0CEB919E772320EE7BBD5B1C45443C4F098AA7/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Decision making in de novo Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: All authors declare no potential conflicts of interest that relate to the research covered in this article.</note><note>Associazione Toscana Ricerca Neurologica (Ubaldo Bonuccelli)</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Decision making in de novo Parkinson's disease</title><author><persName><forename type="first">Michele</forename><surname>Poletti</surname><roleName type="degree">PsyD</roleName></persName><affiliation>Neurology Unit, USL of Viareggio, Italy</affiliation></author><author><persName><forename type="first">Daniela</forename><surname>Frosini</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neuroscience, University of Pisa, Pisa, Italy</affiliation></author><author><persName><forename type="first">Claudio</forename><surname>Lucetti</surname><roleName type="degree">MD</roleName></persName><affiliation>Neurology Unit, USL of Viareggio, Italy</affiliation></author><author><persName><forename type="first">Paolo Del</forename><surname>Dotto</surname><roleName type="degree">MD</roleName></persName><affiliation>Neurology Unit, USL of Viareggio, Italy</affiliation></author><author><persName><forename type="first">Roberto</forename><surname>Ceravolo</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neuroscience, University of Pisa, Pisa, Italy</affiliation></author><author><persName><forename type="first">Ubaldo</forename><surname>Bonuccelli</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: Department of Neuroscience, University of Pisa, Pisa, Italy</p></note><affiliation>Neurology Unit, USL of Viareggio, Italy</affiliation><affiliation>Department of Neuroscience, University of Pisa, Pisa, Italy</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-07-30"></date><biblScope unit="vol">25</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1432">1432</biblScope><biblScope unit="page" to="1436">1436</biblScope></imprint></monogr><idno type="istex">FE0CEB919E772320EE7BBD5B1C45443C4F098AA7</idno><idno type="DOI">10.1002/mds.23098</idno><idno type="ArticleID">MDS23098</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age‐matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala‐damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age‐matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age‐matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits. © 2010 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>de novo Parkinson's disease</term></item><item><term>decision making</term></item><item><term>Iowa Gambling Task</term></item><item><term>dopaminergic therapy</term></item><item><term>amygdala</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-09-10">Received</change><change when="2010-02-19">Registration</change><change when="2010-07-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/FE0CEB919E772320EE7BBD5B1C45443C4F098AA7/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="100"><doi origin="wiley" registered="yes">10.1002/mds.v25:10</doi><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">10</numbering></numberingGroup><coverDate startDate="2010-07-30">30 July 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="140" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.23098</doi><idGroup><id type="unit" value="MDS23098"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2010 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2009-09-10"></event><event type="manuscriptRevised" date="2009-12-04"></event><event type="manuscriptAccepted" date="2010-02-19"></event><event type="firstOnline" date="2010-03-29"></event><event type="publishedOnlineFinalForm" date="2010-07-23"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2010-03-29"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.5.2 mode:FullText source:FullText result:FullText" date="2011-06-21"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1432</numbering><numbering type="pageLast">1436</numbering></numberingGroup><correspondenceTo>Department of Neuroscience, University of Pisa, Pisa, Italy</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23098.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="40"></count><count type="wordTotal" number="3840"></count></countGroup><titleGroup><title type="main" xml:lang="en">Decision making in de novo Parkinson's disease<link href="#fn4"></link></title><title type="short" xml:lang="en">Decision Making in De Novo Parkinson's Disease</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Michele</givenNames><familyName>Poletti</familyName><degrees>PsyD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Daniela</givenNames><familyName>Frosini</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Claudio</givenNames><familyName>Lucetti</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Paolo Del</givenNames><familyName>Dotto</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Roberto</givenNames><familyName>Ceravolo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Ubaldo</givenNames><familyName>Bonuccelli</familyName><degrees>MD</degrees></personName><contactDetails><email>u.bonuccelli@med.unipi.it</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Neurology Unit, USL of Viareggio, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neuroscience, University of Pisa, Pisa, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">de novo Parkinson's disease</keyword><keyword xml:id="kwd2">decision making</keyword><keyword xml:id="kwd3">Iowa Gambling Task</keyword><keyword xml:id="kwd4">dopaminergic therapy</keyword><keyword xml:id="kwd5">amygdala</keyword></keywordGroup><fundingInfo><fundingAgency>Associazione Toscana Ricerca Neurologica (Ubaldo Bonuccelli)</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age‐matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala‐damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age‐matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age‐matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn4"><p>Potential conflict of interest: All authors declare no potential conflicts of interest that relate to the research covered in this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Decision making in de novo Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Decision Making in De Novo Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Decision making in de novo Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Michele</namePart><namePart type="family">Poletti</namePart><namePart type="termsOfAddress">PsyD</namePart><affiliation>Neurology Unit, USL of Viareggio, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Daniela</namePart><namePart type="family">Frosini</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neuroscience, University of Pisa, Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claudio</namePart><namePart type="family">Lucetti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurology Unit, USL of Viareggio, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paolo Del</namePart><namePart type="family">Dotto</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurology Unit, USL of Viareggio, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberto</namePart><namePart type="family">Ceravolo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neuroscience, University of Pisa, Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ubaldo</namePart><namePart type="family">Bonuccelli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurology Unit, USL of Viareggio, Italy</affiliation><affiliation>Department of Neuroscience, University of Pisa, Pisa, Italy</affiliation><description>Correspondence: Department of Neuroscience, University of Pisa, Pisa, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-07-30</dateIssued><dateCaptured encoding="w3cdtf">2009-09-10</dateCaptured><dateValid encoding="w3cdtf">2010-02-19</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">40</extent><extent unit="words">3840</extent></physicalDescription><abstract lang="en">The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age‐matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala‐damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age‐matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age‐matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: All authors declare no potential conflicts of interest that relate to the research covered in this article.</note><note type="funding">Associazione Toscana Ricerca Neurologica (Ubaldo Bonuccelli)</note><subject lang="en"><genre>Keywords</genre><topic>de novo Parkinson's disease</topic><topic>decision making</topic><topic>Iowa Gambling Task</topic><topic>dopaminergic therapy</topic><topic>amygdala</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1432</start><end>1436</end><total>5</total></extent></part></relatedItem><identifier type="istex">FE0CEB919E772320EE7BBD5B1C45443C4F098AA7</identifier><identifier type="DOI">10.1002/mds.23098</identifier><identifier type="ArticleID">MDS23098</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D77 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001D77 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:FE0CEB919E772320EE7BBD5B1C45443C4F098AA7
|texte= Decision making in de novo Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |