Abnormal visual activation in Parkinson's disease patients
Identifieur interne : 001C68 ( Istex/Corpus ); précédent : 001C67; suivant : 001C69Abnormal visual activation in Parkinson's disease patients
Auteurs : Ellison Fernando Cardoso ; Felipe Fregni ; Fernanda Martins Maia ; Luciano M. Melo ; João R. Sato ; Antonio Cesário Cruz Jr. ; Edno Tales Bianchi ; Danilo Botelho Fernandes ; Mário Luiz Ribeiro Monteiro ; Egberto Reis Barbosa ; Edson Amaro Jr.Source :
- Movement Disorders [ 0885-3185 ] ; 2010-08-15.
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Abstract
Among nonmotor symptoms observed in Parkinson's disease (PD) dysfunction in the visual system, including hallucinations, has a significant impact in their quality of life. To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyrus (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD. © 2010 Movement Disorders Society
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DOI: 10.1002/mds.23101
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ISTEX:F5F2D61684EF6FB4C9015D0D39B4EB4D3317DB17Le document en format XML
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To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyrus (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD. © 2010 Movement Disorders Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Ellison Fernando Cardoso MD, PhD</name><affiliations><json:string>NIF, LIM‐44, Department of Radiology, University of São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Felipe Fregni MD, PhD</name><affiliations><json:string>Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA</json:string></affiliations></json:item><json:item><name>Fernanda Martins Maia MD, PhD</name><affiliations><json:string>Department of Neurology, University of São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Luciano M. Melo MD</name><affiliations><json:string>Department of Neurology, University of São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>João R. Sato PhD</name><affiliations><json:string>NIF, LIM‐44, Department of Radiology, University of São Paulo, São Paulo, Brazil</json:string><json:string>Center of Mathematics, Computation and Cognition, Universidade Federal do ABC, Santo André, Brazil</json:string></affiliations></json:item><json:item><name>Antonio Cesário Cruz Jr.</name><affiliations><json:string>NIF, LIM‐44, Department of Radiology, University of São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Edno Tales Bianchi MD</name><affiliations><json:string>NIF, LIM‐44, Department of Radiology, University of São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Danilo Botelho Fernandes MD</name><affiliations><json:string>Department of Ophthalmology, University of São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Mário Luiz Ribeiro Monteiro MD, PhD</name><affiliations><json:string>Department of Ophthalmology, University of São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Egberto Reis Barbosa MD, PhD</name><affiliations><json:string>Department of Neurology, University of São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Edson Amaro Jr. MD, PhD</name><affiliations><json:string>NIF, LIM‐44, Department of Radiology, University of São Paulo, São Paulo, Brazil</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hallucinations</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>fMRI</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dopamine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>visual symptoms</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Among nonmotor symptoms observed in Parkinson's disease (PD) dysfunction in the visual system, including hallucinations, has a significant impact in their quality of life. To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyrus (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD. © 2010 Movement Disorders Society</abstract><qualityIndicators><score>5.591</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1017</abstractCharCount><pdfWordCount>3827</pdfWordCount><pdfCharCount>25084</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>147</abstractWordCount></qualityIndicators><title>Abnormal visual activation in Parkinson's disease patients</title><genre><json:string>Serial article</json:string></genre><host><volume>25</volume><pages><total>7</total><last>1596</last><first>1590</first></pages><issn><json:string>0885-3185</json:string></issn><issue>11</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement 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patients</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Nothing to report.</note><note>CAPES (a Brazilian Government Agency)</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Abnormal visual activation in Parkinson's disease patients</title><author><persName><forename type="first">Ellison Fernando</forename><surname>Cardoso</surname><roleName type="degree">MD, PhD</roleName></persName><note type="correspondence"><p>Correspondence: Department of Radiology Alameda Joaquim Eugênio de Lima, 711—Apto. 83, Jardim Paulista, São Paulo SP, Brazil</p></note><affiliation>NIF, LIM‐44, Department of Radiology, University of São Paulo, São Paulo, Brazil</affiliation></author><author><persName><forename type="first">Felipe</forename><surname>Fregni</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA</affiliation></author><author><persName><forename type="first">Fernanda Martins</forename><surname>Maia</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Neurology, University of São Paulo, São Paulo, Brazil</affiliation></author><author><persName><forename type="first">Luciano M.</forename><surname>Melo</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University of São Paulo, São Paulo, Brazil</affiliation></author><author><persName><forename type="first">João R.</forename><surname>Sato</surname><roleName type="degree">PhD</roleName></persName><affiliation>NIF, LIM‐44, Department of Radiology, University of São Paulo, São 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To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyrus (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. 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type="manuscriptAccepted" date="2010-02-22"></event><event type="firstOnline" date="2010-07-09"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2010-07-09"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.4.7 mode:FullText source:FullText result:FullText" date="2011-02-24"></event><event type="publishedOnlineFinalForm" date="2010-08-18"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1590</numbering><numbering type="pageLast">1596</numbering></numberingGroup><correspondenceTo>Department of Radiology Alameda Joaquim Eugênio de Lima, 711—Apto. 83, Jardim Paulista, São Paulo SP, Brazil</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23101.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="36"></count><count type="wordTotal" number="4445"></count></countGroup><titleGroup><title type="main" xml:lang="en">Abnormal visual activation in Parkinson's disease patients<link href="#fn1"></link></title><title type="short" xml:lang="en">Abnormal Visual Activation in PD Patients</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Ellison Fernando</givenNames><familyName>Cardoso</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>lim@usp.br</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Felipe</givenNames><familyName>Fregni</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Fernanda Martins</givenNames><familyName>Maia</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Luciano M.</givenNames><familyName>Melo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af4"><personName><givenNames>João R.</givenNames><familyName>Sato</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Antonio Cesário</givenNames><familyName>Cruz</familyName><nameSuffix>Jr.</nameSuffix></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Edno Tales</givenNames><familyName>Bianchi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Danilo Botelho</givenNames><familyName>Fernandes</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Mário Luiz Ribeiro</givenNames><familyName>Monteiro</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Egberto Reis</givenNames><familyName>Barbosa</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Edson</givenNames><familyName>Amaro</familyName><nameSuffix>Jr.</nameSuffix><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="BR" type="organization"><unparsedAffiliation>NIF, LIM‐44, Department of Radiology, University of São Paulo, São Paulo, Brazil</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="BR" type="organization"><unparsedAffiliation>Department of Neurology, University of São Paulo, São Paulo, Brazil</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="BR" type="organization"><unparsedAffiliation>Center of Mathematics, Computation and Cognition, Universidade Federal do ABC, Santo André, Brazil</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="BR" type="organization"><unparsedAffiliation>Department of Ophthalmology, University of São Paulo, São Paulo, Brazil</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">hallucinations</keyword><keyword xml:id="kwd3">fMRI</keyword><keyword xml:id="kwd4">dopamine</keyword><keyword xml:id="kwd5">visual symptoms</keyword></keywordGroup><fundingInfo><fundingAgency>CAPES (a Brazilian Government Agency)</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Among nonmotor symptoms observed in Parkinson's disease (PD) dysfunction in the visual system, including hallucinations, has a significant impact in their quality of life. To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyrus (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD. © 2010 Movement Disorders Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Abnormal visual activation in Parkinson's disease patients</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Abnormal Visual Activation in PD Patients</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Abnormal visual activation in Parkinson's disease patients</title></titleInfo><name type="personal"><namePart type="given">Ellison Fernando</namePart><namePart type="family">Cardoso</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>NIF, LIM‐44, Department of Radiology, University of São Paulo, São Paulo, Brazil</affiliation><description>Correspondence: Department of Radiology Alameda Joaquim Eugênio de Lima, 711—Apto. 83, Jardim Paulista, São Paulo SP, Brazil</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Felipe</namePart><namePart type="family">Fregni</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fernanda Martins</namePart><namePart type="family">Maia</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, University of São Paulo, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luciano M.</namePart><namePart type="family">Melo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of São Paulo, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">João R.</namePart><namePart type="family">Sato</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>NIF, LIM‐44, Department of Radiology, University of São Paulo, São Paulo, Brazil</affiliation><affiliation>Center of Mathematics, Computation and Cognition, Universidade Federal do ABC, Santo André, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonio Cesário</namePart><namePart type="family">Cruz Jr.</namePart><affiliation>NIF, LIM‐44, Department of Radiology, University of São Paulo, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Edno Tales</namePart><namePart type="family">Bianchi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>NIF, LIM‐44, Department of Radiology, University of São Paulo, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Danilo Botelho</namePart><namePart type="family">Fernandes</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Ophthalmology, University of São Paulo, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mário Luiz Ribeiro</namePart><namePart type="family">Monteiro</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Ophthalmology, University of São Paulo, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Egberto Reis</namePart><namePart type="family">Barbosa</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, University of São Paulo, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Edson</namePart><namePart type="family">Amaro Jr.</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>NIF, LIM‐44, Department of Radiology, University of São Paulo, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-08-15</dateIssued><dateCaptured encoding="w3cdtf">2008-12-04</dateCaptured><dateValid encoding="w3cdtf">2010-02-22</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">36</extent><extent unit="words">4445</extent></physicalDescription><abstract lang="en">Among nonmotor symptoms observed in Parkinson's disease (PD) dysfunction in the visual system, including hallucinations, has a significant impact in their quality of life. To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyrus (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD. © 2010 Movement Disorders Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><note type="funding">CAPES (a Brazilian Government Agency)</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>hallucinations</topic><topic>fMRI</topic><topic>dopamine</topic><topic>visual symptoms</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>1590</start><end>1596</end><total>7</total></extent></part></relatedItem><identifier type="istex">F5F2D61684EF6FB4C9015D0D39B4EB4D3317DB17</identifier><identifier type="DOI">10.1002/mds.23101</identifier><identifier type="ArticleID">MDS23101</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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