Fragile X syndrome associated with tic disorders
Identifieur interne : 001C62 ( Istex/Corpus ); précédent : 001C61; suivant : 001C63Fragile X syndrome associated with tic disorders
Auteurs : Susanne A. Schneider ; Mary M. Robertson ; Renata Rizzo ; Jeremy Turk ; Kailash P. Bhatia ; Michael OrthSource :
- Movement Disorders [ 0885-3185 ] ; 2008-06-15.
English descriptors
Abstract
Movement disorders other than late onset tremor‐ataxia in association with fragile X syndrome, the most common identifiable cause of inherited mental retardation, seem to be rare. Here we describe five male patients from three unrelated families with fragile X syndrome that presented with motor and phonic tics. Clinically, 4 patients fulfilled diagnostic criteria for Gilles de la Tourette syndrome (GTS) while 1 patient would have been diagnosed with an adult onset tic disorder. However, in all patients onset of tics was considerably later than in typical GTS. Three patients had atypical tics and two patients reported waxing and waning of tic intensity over time. Four of the 5 patients showed clinical signs typical of fragile X syndrome, in particular dysmorphic features, learning difficulties and speech and language problems that required special treatment. All patients had co‐morbidities common to both GTS and fragile X syndrome. We suggest considering fragile X syndrome in GTS complicated by co‐morbidity with late onset of atypical tics, in particular when learning disability and dysmorphic features are present. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.21995
Links to Exploration step
ISTEX:BF6C49D4801426854F5E62D762EDD7B1E12CB757Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fragile X syndrome associated with tic disorders</title><author><name sortKey="Schneider, Susanne A" sort="Schneider, Susanne A" uniqKey="Schneider S" first="Susanne A." last="Schneider">Susanne A. Schneider</name><affiliation><mods:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Robertson, Mary M" sort="Robertson, Mary M" uniqKey="Robertson M" first="Mary M." last="Robertson">Mary M. Robertson</name><affiliation><mods:affiliation>Department of Mental Health Sciences, University College London, London, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Current Address: Department of Neurology, St.George's Hospital and Medical School, Blackshaw Road, Tooting London, SW17 0QT, UK</mods:affiliation></affiliation></author><author><name sortKey="Rizzo, Renata" sort="Rizzo, Renata" uniqKey="Rizzo R" first="Renata" last="Rizzo">Renata Rizzo</name><affiliation><mods:affiliation>Department of Paediatrics, University of Catania, Italy</mods:affiliation></affiliation></author><author><name sortKey="Turk, Jeremy" sort="Turk, Jeremy" uniqKey="Turk J" first="Jeremy" last="Turk">Jeremy Turk</name><affiliation><mods:affiliation>Academic Child and Adolescent Mental Health, Division of Clinical Developmental Sciences, St. George's, University of London, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name><affiliation><mods:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name><affiliation><mods:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Universitätsklinikum Eppendorf, Hamburg, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:BF6C49D4801426854F5E62D762EDD7B1E12CB757</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/mds.21995</idno><idno type="url">https://api.istex.fr/document/BF6C49D4801426854F5E62D762EDD7B1E12CB757/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001C62</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Fragile X syndrome associated with tic disorders</title><author><name sortKey="Schneider, Susanne A" sort="Schneider, Susanne A" uniqKey="Schneider S" first="Susanne A." last="Schneider">Susanne A. Schneider</name><affiliation><mods:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Robertson, Mary M" sort="Robertson, Mary M" uniqKey="Robertson M" first="Mary M." last="Robertson">Mary M. Robertson</name><affiliation><mods:affiliation>Department of Mental Health Sciences, University College London, London, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Current Address: Department of Neurology, St.George's Hospital and Medical School, Blackshaw Road, Tooting London, SW17 0QT, UK</mods:affiliation></affiliation></author><author><name sortKey="Rizzo, Renata" sort="Rizzo, Renata" uniqKey="Rizzo R" first="Renata" last="Rizzo">Renata Rizzo</name><affiliation><mods:affiliation>Department of Paediatrics, University of Catania, Italy</mods:affiliation></affiliation></author><author><name sortKey="Turk, Jeremy" sort="Turk, Jeremy" uniqKey="Turk J" first="Jeremy" last="Turk">Jeremy Turk</name><affiliation><mods:affiliation>Academic Child and Adolescent Mental Health, Division of Clinical Developmental Sciences, St. George's, University of London, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name><affiliation><mods:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name><affiliation><mods:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Universitätsklinikum Eppendorf, Hamburg, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-06-15">2008-06-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1108">1108</biblScope><biblScope unit="page" to="1112">1112</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">BF6C49D4801426854F5E62D762EDD7B1E12CB757</idno><idno type="DOI">10.1002/mds.21995</idno><idno type="ArticleID">MDS21995</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gilles de la Tourette syndrome</term><term>fragile X syndrome</term><term>tics</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Movement disorders other than late onset tremor‐ataxia in association with fragile X syndrome, the most common identifiable cause of inherited mental retardation, seem to be rare. Here we describe five male patients from three unrelated families with fragile X syndrome that presented with motor and phonic tics. Clinically, 4 patients fulfilled diagnostic criteria for Gilles de la Tourette syndrome (GTS) while 1 patient would have been diagnosed with an adult onset tic disorder. However, in all patients onset of tics was considerably later than in typical GTS. Three patients had atypical tics and two patients reported waxing and waning of tic intensity over time. Four of the 5 patients showed clinical signs typical of fragile X syndrome, in particular dysmorphic features, learning difficulties and speech and language problems that required special treatment. All patients had co‐morbidities common to both GTS and fragile X syndrome. We suggest considering fragile X syndrome in GTS complicated by co‐morbidity with late onset of atypical tics, in particular when learning disability and dysmorphic features are present. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Susanne A. Schneider MD</name><affiliations><json:string>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Mary M. Robertson MD, DSc (Med) FRCPsych, FRCP FRCPCH</name><affiliations><json:string>Department of Mental Health Sciences, University College London, London, United Kingdom</json:string><json:string>Current Address: Department of Neurology, St.George's Hospital and Medical School, Blackshaw Road, Tooting London, SW17 0QT, UK</json:string></affiliations></json:item><json:item><name>Renata Rizzo MD</name><affiliations><json:string>Department of Paediatrics, University of Catania, Italy</json:string></affiliations></json:item><json:item><name>Jeremy Turk MD, FRCPsych, FRCPCH</name><affiliations><json:string>Academic Child and Adolescent Mental Health, Division of Clinical Developmental Sciences, St. George's, University of London, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Kailash P. Bhatia FRCP</name><affiliations><json:string>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Michael Orth MD, PhD</name><affiliations><json:string>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</json:string><json:string>Department of Neurology, Universitätsklinikum Eppendorf, Hamburg, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Gilles de la Tourette syndrome</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>fragile X syndrome</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>tics</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Movement disorders other than late onset tremor‐ataxia in association with fragile X syndrome, the most common identifiable cause of inherited mental retardation, seem to be rare. Here we describe five male patients from three unrelated families with fragile X syndrome that presented with motor and phonic tics. Clinically, 4 patients fulfilled diagnostic criteria for Gilles de la Tourette syndrome (GTS) while 1 patient would have been diagnosed with an adult onset tic disorder. However, in all patients onset of tics was considerably later than in typical GTS. Three patients had atypical tics and two patients reported waxing and waning of tic intensity over time. Four of the 5 patients showed clinical signs typical of fragile X syndrome, in particular dysmorphic features, learning difficulties and speech and language problems that required special treatment. All patients had co‐morbidities common to both GTS and fragile X syndrome. We suggest considering fragile X syndrome in GTS complicated by co‐morbidity with late onset of atypical tics, in particular when learning disability and dysmorphic features are present. © 2008 Movement Disorder Society</abstract><qualityIndicators><score>5.593</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1164</abstractCharCount><pdfWordCount>3481</pdfWordCount><pdfCharCount>21432</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>176</abstractWordCount></qualityIndicators><title>Fragile X syndrome associated with tic disorders</title><genre><json:string>Serial article</json:string></genre><host><volume>23</volume><pages><total>5</total><last>1112</last><first>1108</first></pages><issn><json:string>0885-3185</json:string></issn><issue>8</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1002/mds.21995</json:string></doi><id>BF6C49D4801426854F5E62D762EDD7B1E12CB757</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/BF6C49D4801426854F5E62D762EDD7B1E12CB757/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/BF6C49D4801426854F5E62D762EDD7B1E12CB757/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/BF6C49D4801426854F5E62D762EDD7B1E12CB757/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Fragile X syndrome associated with tic disorders</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2008</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Fragile X syndrome associated with tic disorders</title><author><persName><forename type="first">Susanne A.</forename><surname>Schneider</surname><roleName type="degree">MD</roleName></persName><affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</affiliation></author><author><persName><forename type="first">Mary M.</forename><surname>Robertson</surname><roleName type="degree">MD, DSc (Med) FRCPsych, FRCP FRCPCH</roleName></persName><affiliation>Department of Mental Health Sciences, University College London, London, United Kingdom</affiliation><affiliation>Current Address: Department of Neurology, St.George's Hospital and Medical School, Blackshaw Road, Tooting London, SW17 0QT, UK</affiliation></author><author><persName><forename type="first">Renata</forename><surname>Rizzo</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Paediatrics, University of Catania, Italy</affiliation></author><author><persName><forename type="first">Jeremy</forename><surname>Turk</surname><roleName type="degree">MD, FRCPsych, FRCPCH</roleName></persName><affiliation>Academic Child and Adolescent Mental Health, Division of Clinical Developmental Sciences, St. George's, University of London, London, United Kingdom</affiliation></author><author><persName><forename type="first">Kailash P.</forename><surname>Bhatia</surname><roleName type="degree">FRCP</roleName></persName><affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</affiliation></author><author><persName><forename type="first">Michael</forename><surname>Orth</surname><roleName type="degree">MD, PhD</roleName></persName><note type="correspondence"><p>Correspondence: Department of Neurology, Universitätsklinikum Eppendorf, Martinistr.20, 20246 Hamburg, Germany</p></note><affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</affiliation><affiliation>Department of Neurology, Universitätsklinikum Eppendorf, Hamburg, Germany</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-06-15"></date><biblScope unit="vol">23</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1108">1108</biblScope><biblScope unit="page" to="1112">1112</biblScope></imprint></monogr><idno type="istex">BF6C49D4801426854F5E62D762EDD7B1E12CB757</idno><idno type="DOI">10.1002/mds.21995</idno><idno type="ArticleID">MDS21995</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Movement disorders other than late onset tremor‐ataxia in association with fragile X syndrome, the most common identifiable cause of inherited mental retardation, seem to be rare. Here we describe five male patients from three unrelated families with fragile X syndrome that presented with motor and phonic tics. Clinically, 4 patients fulfilled diagnostic criteria for Gilles de la Tourette syndrome (GTS) while 1 patient would have been diagnosed with an adult onset tic disorder. However, in all patients onset of tics was considerably later than in typical GTS. Three patients had atypical tics and two patients reported waxing and waning of tic intensity over time. Four of the 5 patients showed clinical signs typical of fragile X syndrome, in particular dysmorphic features, learning difficulties and speech and language problems that required special treatment. All patients had co‐morbidities common to both GTS and fragile X syndrome. We suggest considering fragile X syndrome in GTS complicated by co‐morbidity with late onset of atypical tics, in particular when learning disability and dysmorphic features are present. © 2008 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Gilles de la Tourette syndrome</term></item><item><term>fragile X syndrome</term></item><item><term>tics</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-10-25">Received</change><change when="2008-02-02">Registration</change><change when="2008-06-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/BF6C49D4801426854F5E62D762EDD7B1E12CB757/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="80"><doi origin="wiley" registered="yes">10.1002/mds.v23:8</doi><numberingGroup><numbering type="journalVolume" number="23">23</numbering><numbering type="journalIssue">8</numbering></numberingGroup><coverDate startDate="2008-06-15">15 June 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="60" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.21995</doi><idGroup><id type="unit" value="MDS21995"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2008 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2007-10-25"></event><event type="manuscriptRevised" date="2008-01-23"></event><event type="manuscriptAccepted" date="2008-02-02"></event><event type="publishedOnlineEarlyUnpaginated" date="2008-03-26"></event><event type="firstOnline" date="2008-03-26"></event><event type="publishedOnlineFinalForm" date="2008-06-24"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1108</numbering><numbering type="pageLast">1112</numbering></numberingGroup><correspondenceTo>Department of Neurology, Universitätsklinikum Eppendorf, Martinistr.20, 20246 Hamburg, Germany</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS21995.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="0"></count><count type="referenceTotal" number="25"></count><count type="wordTotal" number="3719"></count></countGroup><titleGroup><title type="main" xml:lang="en">Fragile X syndrome associated with tic disorders</title><title type="short" xml:lang="en">Fragile X Syndrome Associated with Tic Disorders</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Susanne A.</givenNames><familyName>Schneider</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af3" currentRef="#curr1"><personName><givenNames>Mary M.</givenNames><familyName>Robertson</familyName><degrees>MD, DSc (Med) FRCPsych, FRCP FRCPCH</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Renata</givenNames><familyName>Rizzo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Jeremy</givenNames><familyName>Turk</familyName><degrees>MD, FRCPsych, FRCPCH</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Kailash P.</givenNames><familyName>Bhatia</familyName><degrees>FRCP</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1 #af5" corresponding="yes"><personName><givenNames>Michael</givenNames><familyName>Orth</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email normalForm="m.orth@uke.uni-hamburg.de">m.orth@uke.uni‐hamburg.de</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="GB" type="organization"><unparsedAffiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Department of Paediatrics, University of Catania, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="GB" type="organization"><unparsedAffiliation>Department of Mental Health Sciences, University College London, London, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="GB" type="organization"><unparsedAffiliation>Academic Child and Adolescent Mental Health, Division of Clinical Developmental Sciences, St. George's, University of London, London, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, Universitätsklinikum Eppendorf, Hamburg, Germany</unparsedAffiliation></affiliation><affiliation xml:id="curr1"><unparsedAffiliation>Department of Neurology, St.George's Hospital and Medical School, Blackshaw Road, Tooting London, SW17 0QT, UK</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Gilles de la Tourette syndrome</keyword><keyword xml:id="kwd2">fragile X syndrome</keyword><keyword xml:id="kwd3">tics</keyword></keywordGroup><supportingInformation><p> This article includes supplementary video clips, available online at <url href="http://www.interscience.wiley.com/jpages/0885-3185/suppmat"> http://www.interscience.wiley.com/jpages/0885‐3185/suppmat </url> . </p></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Movement disorders other than late onset tremor‐ataxia in association with fragile X syndrome, the most common identifiable cause of inherited mental retardation, seem to be rare. Here we describe five male patients from three unrelated families with fragile X syndrome that presented with motor and phonic tics. Clinically, 4 patients fulfilled diagnostic criteria for Gilles de la Tourette syndrome (GTS) while 1 patient would have been diagnosed with an adult onset tic disorder. However, in all patients onset of tics was considerably later than in typical GTS. Three patients had atypical tics and two patients reported waxing and waning of tic intensity over time. Four of the 5 patients showed clinical signs typical of fragile X syndrome, in particular dysmorphic features, learning difficulties and speech and language problems that required special treatment. All patients had co‐morbidities common to both GTS and fragile X syndrome. We suggest considering fragile X syndrome in GTS complicated by co‐morbidity with late onset of atypical tics, in particular when learning disability and dysmorphic features are present. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Fragile X syndrome associated with tic disorders</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Fragile X Syndrome Associated with Tic Disorders</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Fragile X syndrome associated with tic disorders</title></titleInfo><name type="personal"><namePart type="given">Susanne A.</namePart><namePart type="family">Schneider</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mary M.</namePart><namePart type="family">Robertson</namePart><namePart type="termsOfAddress">MD, DSc (Med) FRCPsych, FRCP FRCPCH</namePart><affiliation>Department of Mental Health Sciences, University College London, London, United Kingdom</affiliation><affiliation>Current Address: Department of Neurology, St.George's Hospital and Medical School, Blackshaw Road, Tooting London, SW17 0QT, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Renata</namePart><namePart type="family">Rizzo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Paediatrics, University of Catania, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jeremy</namePart><namePart type="family">Turk</namePart><namePart type="termsOfAddress">MD, FRCPsych, FRCPCH</namePart><affiliation>Academic Child and Adolescent Mental Health, Division of Clinical Developmental Sciences, St. George's, University of London, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kailash P.</namePart><namePart type="family">Bhatia</namePart><namePart type="termsOfAddress">FRCP</namePart><affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Orth</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom</affiliation><affiliation>Department of Neurology, Universitätsklinikum Eppendorf, Hamburg, Germany</affiliation><description>Correspondence: Department of Neurology, Universitätsklinikum Eppendorf, Martinistr.20, 20246 Hamburg, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-06-15</dateIssued><dateCaptured encoding="w3cdtf">2007-10-25</dateCaptured><dateValid encoding="w3cdtf">2008-02-02</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">25</extent><extent unit="words">3719</extent></physicalDescription><abstract lang="en">Movement disorders other than late onset tremor‐ataxia in association with fragile X syndrome, the most common identifiable cause of inherited mental retardation, seem to be rare. Here we describe five male patients from three unrelated families with fragile X syndrome that presented with motor and phonic tics. Clinically, 4 patients fulfilled diagnostic criteria for Gilles de la Tourette syndrome (GTS) while 1 patient would have been diagnosed with an adult onset tic disorder. However, in all patients onset of tics was considerably later than in typical GTS. Three patients had atypical tics and two patients reported waxing and waning of tic intensity over time. Four of the 5 patients showed clinical signs typical of fragile X syndrome, in particular dysmorphic features, learning difficulties and speech and language problems that required special treatment. All patients had co‐morbidities common to both GTS and fragile X syndrome. We suggest considering fragile X syndrome in GTS complicated by co‐morbidity with late onset of atypical tics, in particular when learning disability and dysmorphic features are present. © 2008 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>Gilles de la Tourette syndrome</topic><topic>fragile X syndrome</topic><topic>tics</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><note type="content"> This article includes supplementary video clips, available online at http://www.interscience.wiley.com/jpages/0885‐3185/suppmat .</note><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>1108</start><end>1112</end><total>5</total></extent></part></relatedItem><identifier type="istex">BF6C49D4801426854F5E62D762EDD7B1E12CB757</identifier><identifier type="DOI">10.1002/mds.21995</identifier><identifier type="ArticleID">MDS21995</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C62 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001C62 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:BF6C49D4801426854F5E62D762EDD7B1E12CB757
|texte= Fragile X syndrome associated with tic disorders
}}
| This area was generated with Dilib version V0.6.23. |  |