Community‐based data on associations of disease duration and age with severity of essential tremor: Implications for disease pathophysiology
Identifieur interne : 001C34 ( Istex/Corpus ); précédent : 001C33; suivant : 001C35Community‐based data on associations of disease duration and age with severity of essential tremor: Implications for disease pathophysiology
Auteurs : Elan D. Louis ; Eva C. Jurewicz ; Dryden WatnerSource :
- Movement Disorders [ 0885-3185 ] ; 2003-01.
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- KwdEn :
Abstract
The pathophysiology of essential tremor (ET) is not well understood, although the tremor often worsens over time. Several processes could contribute, including the inherent worsening of the underlying disease with increasing disease duration and the effects of aging on the nervous system. Our objective was to examine the associations of disease duration and age with tremor severity in ET. Cases were ascertained from a community‐based study of ET in northern Manhattan, New York. A neurologist rated tremor severity using a clinical rating scale and assigned a total tremor score (0–36 [maximum]). Analyses were repeated in a sample of cases from a tertiary referral center, the Neurological Institute of New York. There were 55 cases from the community‐based study (mean age, 72.1 years, mean disease duration, 13.2 years). Disease duration was associated with the total tremor score (r = 0.30; P = 0.02). Age was associated with the total tremor score (r = 0.30; P = 0.025). In a linear regression analysis the dependent variable was the total tremor score and independent variables were disease duration, age gender. Duration (β = 0.11; P = 0.02) and age (β = 0.10; P = 0.02) were independently associated with the total tremor score. Results were similar in 79 ET cases from the Neurological Institute. Disease duration and age were independently associated with tremor severity in ET. This suggests that the reported increase in tremor severity may be related to the inherent worsening of the disease with increasing duration that this is independent of age and age‐related processes like neuronal attrition and change in tremor frequency. © 2002 Movement Disorder Society
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DOI: 10.1002/mds.10302
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Several processes could contribute, including the inherent worsening of the underlying disease with increasing disease duration and the effects of aging on the nervous system. Our objective was to examine the associations of disease duration and age with tremor severity in ET. Cases were ascertained from a community‐based study of ET in northern Manhattan, New York. A neurologist rated tremor severity using a clinical rating scale and assigned a total tremor score (0–36 [maximum]). Analyses were repeated in a sample of cases from a tertiary referral center, the Neurological Institute of New York. There were 55 cases from the community‐based study (mean age, 72.1 years, mean disease duration, 13.2 years). Disease duration was associated with the total tremor score (r = 0.30; P = 0.02). Age was associated with the total tremor score (r = 0.30; P = 0.025). In a linear regression analysis the dependent variable was the total tremor score and independent variables were disease duration, age gender. Duration (β = 0.11; P = 0.02) and age (β = 0.10; P = 0.02) were independently associated with the total tremor score. Results were similar in 79 ET cases from the Neurological Institute. Disease duration and age were independently associated with tremor severity in ET. This suggests that the reported increase in tremor severity may be related to the inherent worsening of the disease with increasing duration that this is independent of age and age‐related processes like neuronal attrition and change in tremor frequency. © 2002 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Elan D. Louis MD, MS</name><affiliations><json:string>Gertrude H. 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In a linear regression analysis the dependent variable was the total tremor score and independent variables were disease duration, age gender. Duration (β = 0.11; P = 0.02) and age (β = 0.10; P = 0.02) were independently associated with the total tremor score. Results were similar in 79 ET cases from the Neurological Institute. Disease duration and age were independently associated with tremor severity in ET. 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Several processes could contribute, including the inherent worsening of the underlying disease with increasing disease duration and the effects of aging on the nervous system. Our objective was to examine the associations of disease duration and age with tremor severity in ET. Cases were ascertained from a community‐based study of ET in northern Manhattan, New York. A neurologist rated tremor severity using a clinical rating scale and assigned a total tremor score (0–36 [maximum]). Analyses were repeated in a sample of cases from a tertiary referral center, the Neurological Institute of New York. There were 55 cases from the community‐based study (mean age, 72.1 years, mean disease duration, 13.2 years). Disease duration was associated with the total tremor score (r = 0.30; <i>P</i> = 0.02). Age was associated with the total tremor score (r = 0.30; <i>P</i> = 0.025). In a linear regression analysis the dependent variable was the total tremor score and independent variables were disease duration, age gender. Duration (β = 0.11; <i>P</i> = 0.02) and age (β = 0.10; <i>P</i> = 0.02) were independently associated with the total tremor score. Results were similar in 79 ET cases from the Neurological Institute. Disease duration and age were independently associated with tremor severity in ET. This suggests that the reported increase in tremor severity may be related to the inherent worsening of the disease with increasing duration that this is independent of age and age‐related processes like neuronal attrition and change in tremor frequency. © 2002 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Community‐based data on associations of disease duration and age with severity of essential tremor: Implications for disease pathophysiology</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Duration and Age in Essential Tremor</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Community‐based data on associations of disease duration and age with severity of essential tremor: Implications for disease pathophysiology</title></titleInfo><name type="personal"><namePart type="given">Elan D.</namePart><namePart type="family">Louis</namePart><namePart type="termsOfAddress">MD, MS</namePart><affiliation>Gertrude H. 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Several processes could contribute, including the inherent worsening of the underlying disease with increasing disease duration and the effects of aging on the nervous system. Our objective was to examine the associations of disease duration and age with tremor severity in ET. Cases were ascertained from a community‐based study of ET in northern Manhattan, New York. A neurologist rated tremor severity using a clinical rating scale and assigned a total tremor score (0–36 [maximum]). Analyses were repeated in a sample of cases from a tertiary referral center, the Neurological Institute of New York. There were 55 cases from the community‐based study (mean age, 72.1 years, mean disease duration, 13.2 years). Disease duration was associated with the total tremor score (r = 0.30; P = 0.02). Age was associated with the total tremor score (r = 0.30; P = 0.025). In a linear regression analysis the dependent variable was the total tremor score and independent variables were disease duration, age gender. Duration (β = 0.11; P = 0.02) and age (β = 0.10; P = 0.02) were independently associated with the total tremor score. Results were similar in 79 ET cases from the Neurological Institute. Disease duration and age were independently associated with tremor severity in ET. This suggests that the reported increase in tremor severity may be related to the inherent worsening of the disease with increasing duration that this is independent of age and age‐related processes like neuronal attrition and change in tremor frequency. © 2002 Movement Disorder Society</abstract><note type="funding">National Institutes of Health - No. R01 NS39422; No. RR00645; </note><subject lang="en"><genre>Keywords</genre><topic>essential tremor</topic><topic>duration</topic><topic>age</topic><topic>pathophysiology</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>90</start><end>93</end><total>4</total></extent></part></relatedItem><identifier type="istex">4CAC674E5C9441688CE467BBB4CB8393E8C17B3F</identifier><identifier type="DOI">10.1002/mds.10302</identifier><identifier type="ArticleID">MDS10302</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2002 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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