The effect of drug treatment on neurogenesis in Parkinson's disease
Identifieur interne : 001C23 ( Istex/Corpus ); précédent : 001C22; suivant : 001C24The effect of drug treatment on neurogenesis in Parkinson's disease
Auteurs : Sean S. O'Sullivan ; Mary Johnson ; David R. Williams ; Tamas Revesz ; Janice L. Holton ; Andrew J. Lees ; Elaine K. PerrySource :
- Movement Disorders [ 0885-3185 ] ; 2011-01.
English descriptors
- KwdEn :
Abstract
There has been recent interest in the possibility that impaired neurogenesis may contribute to the decline in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease (PD). We have investigated the effects of commonly used treatments for PD on neural stem cell (NSC) activity in nondemented patients. Postmortem of brain tissue containing the subventricular zone (SVZ) and ependymal layer cells was obtained from 32 nondemented patients with PD. NSC activity was assessed by immunohistochemical staining for RNA‐binding protein Musashi1. Regression analyses were then used to identify which clinical factors independently influenced NSC activity. Disease duration was negatively associated with SVZ Musashi1 staining, whereas lifetime levodopa was positively associated in this region. Our findings suggest a positive impact of chronic L‐dopa use on the number of NSC in the SVZ of PD patients, which may have relevance for future studies on neuroprotection in neurodegenerative diseases. © 2010 Movement Disorder Society.
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DOI: 10.1002/mds.23340
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<keyword xml:id="kwd4">stem cells</keyword>
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<p>There has been recent interest in the possibility that impaired neurogenesis may contribute to the decline in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease (PD). We have investigated the effects of commonly used treatments for PD on neural stem cell (NSC) activity in nondemented patients. Postmortem of brain tissue containing the subventricular zone (SVZ) and ependymal layer cells was obtained from 32 nondemented patients with PD. NSC activity was assessed by immunohistochemical staining for RNA‐binding protein Musashi1. Regression analyses were then used to identify which clinical factors independently influenced NSC activity. Disease duration was negatively associated with SVZ Musashi1 staining, whereas lifetime levodopa was positively associated in this region. Our findings suggest a positive impact of chronic <sc>L</sc>
‐dopa use on the number of NSC in the SVZ of PD patients, which may have relevance for future studies on neuroprotection in neurodegenerative diseases. © 2010 Movement Disorder Society.</p>
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<!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>The effect of drug treatment on neurogenesis in Parkinson's disease</title>
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<titleInfo type="abbreviated" lang="en"><title>PD Treatments and Neurogenesis</title>
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<titleInfo type="alternative" contentType="CDATA" lang="en"><title>The effect of drug treatment on neurogenesis in Parkinson's disease</title>
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<name type="personal"><namePart type="given">Sean S.</namePart>
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<affiliation>Reta Lila Weston Institute of Neurological Studies, University College London, London, United Kingdom</affiliation>
<affiliation>Queen Square Brain Bank for Neurological Disorders and Institute of Neurology, University College London, London, United Kingdom</affiliation>
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<name type="personal"><namePart type="given">David R.</namePart>
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<abstract lang="en">There has been recent interest in the possibility that impaired neurogenesis may contribute to the decline in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease (PD). We have investigated the effects of commonly used treatments for PD on neural stem cell (NSC) activity in nondemented patients. Postmortem of brain tissue containing the subventricular zone (SVZ) and ependymal layer cells was obtained from 32 nondemented patients with PD. NSC activity was assessed by immunohistochemical staining for RNA‐binding protein Musashi1. Regression analyses were then used to identify which clinical factors independently influenced NSC activity. Disease duration was negatively associated with SVZ Musashi1 staining, whereas lifetime levodopa was positively associated in this region. Our findings suggest a positive impact of chronic L‐dopa use on the number of NSC in the SVZ of PD patients, which may have relevance for future studies on neuroprotection in neurodegenerative diseases. © 2010 Movement Disorder Society.</abstract>
<note type="content">*Potential conflict of interest: The authors have no conflicts of interest and no financial disclosures to make.</note>
<subject lang="en"><genre>Keywords</genre>
<topic>Parkinson's disease</topic>
<topic>neurogenesis</topic>
<topic>neuroprotection</topic>
<topic>stem cells</topic>
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<identifier type="ISSN">0885-3185</identifier>
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<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
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<part><date>2011</date>
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