Auditory startle reaction in primary blepharospasm
Identifieur interne : 001C21 ( Istex/Corpus ); précédent : 001C20; suivant : 001C22Auditory startle reaction in primary blepharospasm
Auteurs : Jörg Müller ; Martina Rinnerthaler ; Werner Poewe ; Markus KoflerSource :
- Movement Disorders [ 0885-3185 ] ; 2007-01-15.
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- KwdEn :
Abstract
Primary dystonia is associated with abnormal brainstem function, as shown by abnormalities of the blink reflex in blepharospasm (BSP) and of the auditory startle reaction in cervical dystonia. We examined the auditory startle reaction—a brainstem reflex elicited by an unexpected loud stimulus—in patients with primary BSP to expand knowledge on brainstem pathophysiology in primary focal dystonia. Thirteen patients with primary BSP were included and 13 age‐ and sex‐matched healthy volunteers served as controls. Auditory startle responses (ASRs) were elicited by binaural high‐intensity auditory stimuli, and reflex electromyographic activity was recorded simultaneously with surface electrodes bilaterally from masseter, orbicularis oculi, sternocleidomastoid, and biceps brachii muscles. Patients with BSP showed higher ASR probabilities (masseter, sternocleidomastoid, biceps brachii), shorter ASR onset latencies (masseter, orbicularis oculi, sternocleidomastoid), and larger ASR area‐under‐the‐curve (masseter, sternocleidomastoid) as compared with normal controls. Habituation of ASRs did not differ significantly between patients and controls. These results corroborate previous findings of increased brainstem excitability in primary BSP but point to a different pattern of brainstem dysfunction compared to cervical dystonia, indicating that different pathophysiological mechanisms are involved in the two types of focal dystonia. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.21270
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ISTEX:7599D0584CA5EA696E3FE606DF81AFBFF678BCA5Le document en format XML
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We examined the auditory startle reaction—a brainstem reflex elicited by an unexpected loud stimulus—in patients with primary BSP to expand knowledge on brainstem pathophysiology in primary focal dystonia. Thirteen patients with primary BSP were included and 13 age‐ and sex‐matched healthy volunteers served as controls. Auditory startle responses (ASRs) were elicited by binaural high‐intensity auditory stimuli, and reflex electromyographic activity was recorded simultaneously with surface electrodes bilaterally from masseter, orbicularis oculi, sternocleidomastoid, and biceps brachii muscles. Patients with BSP showed higher ASR probabilities (masseter, sternocleidomastoid, biceps brachii), shorter ASR onset latencies (masseter, orbicularis oculi, sternocleidomastoid), and larger ASR area‐under‐the‐curve (masseter, sternocleidomastoid) as compared with normal controls. Habituation of ASRs did not differ significantly between patients and controls. 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We examined the auditory startle reaction—a brainstem reflex elicited by an unexpected loud stimulus—in patients with primary BSP to expand knowledge on brainstem pathophysiology in primary focal dystonia. Thirteen patients with primary BSP were included and 13 age‐ and sex‐matched healthy volunteers served as controls. Auditory startle responses (ASRs) were elicited by binaural high‐intensity auditory stimuli, and reflex electromyographic activity was recorded simultaneously with surface electrodes bilaterally from masseter, orbicularis oculi, sternocleidomastoid, and biceps brachii muscles. Patients with BSP showed higher ASR probabilities (masseter, sternocleidomastoid, biceps brachii), shorter ASR onset latencies (masseter, orbicularis oculi, sternocleidomastoid), and larger ASR area‐under‐the‐curve (masseter, sternocleidomastoid) as compared with normal controls. Habituation of ASRs did not differ significantly between patients and controls. These results corroborate previous findings of increased brainstem excitability in primary BSP but point to a different pattern of brainstem dysfunction compared to cervical dystonia, indicating that different pathophysiological mechanisms are involved in the two types of focal dystonia. © 2006 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Auditory startle reaction in primary blepharospasm</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Auditory Startle Reaction in Blepharospasm</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Auditory startle reaction in primary blepharospasm</title></titleInfo><name type="personal"><namePart type="given">Jörg</namePart><namePart type="family">Müller</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Medical University Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Martina</namePart><namePart type="family">Rinnerthaler</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Medical University Innsbruck, Austria</affiliation><affiliation>Department of Neurology, Hospital Hochzirl, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Werner</namePart><namePart type="family">Poewe</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Medical University Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Markus</namePart><namePart type="family">Kofler</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Medical University Innsbruck, Austria</affiliation><affiliation>Department of Neurology, Hospital Hochzirl, Austria</affiliation><description>Correspondence: Department of Neurology, Medical University Innsbruck, A‐6020 Innsbruck, Austria</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-01-15</dateIssued><dateCaptured encoding="w3cdtf">2006-07-13</dateCaptured><dateValid encoding="w3cdtf">2006-09-06</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">33</extent><extent unit="words">3220</extent></physicalDescription><abstract lang="en">Primary dystonia is associated with abnormal brainstem function, as shown by abnormalities of the blink reflex in blepharospasm (BSP) and of the auditory startle reaction in cervical dystonia. We examined the auditory startle reaction—a brainstem reflex elicited by an unexpected loud stimulus—in patients with primary BSP to expand knowledge on brainstem pathophysiology in primary focal dystonia. Thirteen patients with primary BSP were included and 13 age‐ and sex‐matched healthy volunteers served as controls. Auditory startle responses (ASRs) were elicited by binaural high‐intensity auditory stimuli, and reflex electromyographic activity was recorded simultaneously with surface electrodes bilaterally from masseter, orbicularis oculi, sternocleidomastoid, and biceps brachii muscles. Patients with BSP showed higher ASR probabilities (masseter, sternocleidomastoid, biceps brachii), shorter ASR onset latencies (masseter, orbicularis oculi, sternocleidomastoid), and larger ASR area‐under‐the‐curve (masseter, sternocleidomastoid) as compared with normal controls. Habituation of ASRs did not differ significantly between patients and controls. These results corroborate previous findings of increased brainstem excitability in primary BSP but point to a different pattern of brainstem dysfunction compared to cervical dystonia, indicating that different pathophysiological mechanisms are involved in the two types of focal dystonia. © 2006 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>auditory startle reaction</topic><topic>auditory startle response</topic><topic>botulinum toxin</topic><topic>brainstem reflex</topic><topic>essential blepharospasm</topic><topic>pedunculopontine nucleus (PPN)</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>268</start><end>271</end><total>5</total></extent></part></relatedItem><identifier type="istex">7599D0584CA5EA696E3FE606DF81AFBFF678BCA5</identifier><identifier type="DOI">10.1002/mds.21270</identifier><identifier type="ArticleID">MDS21270</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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