Clinically deployable Kinesia™ technology for automated tremor assessment
Identifieur interne : 001A11 ( Istex/Corpus ); précédent : 001A10; suivant : 001A12Clinically deployable Kinesia™ technology for automated tremor assessment
Auteurs : Joseph P. Giuffrida ; David E. Riley ; Brian N. Maddux ; Dustin A. HeldmanSource :
- Movement Disorders [ 0885-3185 ] ; 2009-04-15.
English descriptors
- KwdEn :
Abstract
The objective was to design, build, and assess Kinesia™, a wireless system for automated assessment of Parkinson's disease (PD) tremor. The current standard in evaluating PD is the Unified Parkinson's Disease Rating Scale (UPDRS), a qualitative ranking system typically completed during an office visit. Kinesia integrates accelerometers and gyroscopes in a compact patient‐worn unit to capture kinematic movement disorder features. Objectively quantifying PD manifestations with increased time resolution should aid in evaluating efficacy of treatment protocols and improve patient management. In this study, PD subjects performed the tremor subset of the UPDRS motor section while wearing Kinesia. Quantitative kinematic features were processed and highly correlated to clinician scores for rest tremor (r2 = 0.89), postural tremor (r2 = 0.90), and kinetic tremor (r2 = 0.69). The quantitative features were used to develop a mathematical model that predicted tremor severity scores for new data with low errors. Finally, PD subjects indicated high clinical acceptance. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22445
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<front><div type="abstract" xml:lang="en">The objective was to design, build, and assess Kinesia™, a wireless system for automated assessment of Parkinson's disease (PD) tremor. The current standard in evaluating PD is the Unified Parkinson's Disease Rating Scale (UPDRS), a qualitative ranking system typically completed during an office visit. Kinesia integrates accelerometers and gyroscopes in a compact patient‐worn unit to capture kinematic movement disorder features. Objectively quantifying PD manifestations with increased time resolution should aid in evaluating efficacy of treatment protocols and improve patient management. In this study, PD subjects performed the tremor subset of the UPDRS motor section while wearing Kinesia. Quantitative kinematic features were processed and highly correlated to clinician scores for rest tremor (r2 = 0.89), postural tremor (r2 = 0.90), and kinetic tremor (r2 = 0.69). The quantitative features were used to develop a mathematical model that predicted tremor severity scores for new data with low errors. Finally, PD subjects indicated high clinical acceptance. © 2009 Movement Disorder Society</div>
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<p>The objective was to design, build, and assess Kinesia™, a wireless system for automated assessment of Parkinson's disease (PD) tremor. The current standard in evaluating PD is the Unified Parkinson's Disease Rating Scale (UPDRS), a qualitative ranking system typically completed during an office visit. Kinesia integrates accelerometers and gyroscopes in a compact patient‐worn unit to capture kinematic movement disorder features. Objectively quantifying PD manifestations with increased time resolution should aid in evaluating efficacy of treatment protocols and improve patient management. In this study, PD subjects performed the tremor subset of the UPDRS motor section while wearing Kinesia. Quantitative kinematic features were processed and highly correlated to clinician scores for rest tremor (r<sup>2</sup>
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<place><placeTerm type="text">Hoboken</placeTerm>
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<dateIssued encoding="w3cdtf">2009-04-15</dateIssued>
<dateCaptured encoding="w3cdtf">2008-05-16</dateCaptured>
<dateValid encoding="w3cdtf">2008-12-02</dateValid>
<copyrightDate encoding="w3cdtf">2009</copyrightDate>
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<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
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<extent unit="figures">6</extent>
<extent unit="tables">4</extent>
<extent unit="references">25</extent>
<extent unit="words">4822</extent>
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<abstract lang="en">The objective was to design, build, and assess Kinesia™, a wireless system for automated assessment of Parkinson's disease (PD) tremor. The current standard in evaluating PD is the Unified Parkinson's Disease Rating Scale (UPDRS), a qualitative ranking system typically completed during an office visit. Kinesia integrates accelerometers and gyroscopes in a compact patient‐worn unit to capture kinematic movement disorder features. Objectively quantifying PD manifestations with increased time resolution should aid in evaluating efficacy of treatment protocols and improve patient management. In this study, PD subjects performed the tremor subset of the UPDRS motor section while wearing Kinesia. Quantitative kinematic features were processed and highly correlated to clinician scores for rest tremor (r2 = 0.89), postural tremor (r2 = 0.90), and kinetic tremor (r2 = 0.69). The quantitative features were used to develop a mathematical model that predicted tremor severity scores for new data with low errors. Finally, PD subjects indicated high clinical acceptance. © 2009 Movement Disorder Society</abstract>
<note type="content">*Potential conflict of interest: Dr. Giuffrida and Dr. Heldman are employess of CleveMed.</note>
<note type="funding">National Institutes of Health</note>
<note type="funding">National Institute of Neurological Disorders and Stroke</note>
<note type="funding">Phase II SBIR - No. 5R44NS043816‐03; </note>
<subject lang="en"><genre>Keywords</genre>
<topic>Parkinson's disease</topic>
<topic>UPDRS</topic>
<topic>Kinesia</topic>
<topic>tremor</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Movement Disorders</title>
<subTitle>Official Journal of the Movement Disorder Society</subTitle>
</titleInfo>
<titleInfo type="abbreviated"><title>Mov. Disord.</title>
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<subject><genre>article category</genre>
<topic>Research Article</topic>
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<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>24</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>5</number>
</detail>
<extent unit="pages"><start>723</start>
<end>730</end>
<total>8</total>
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</part>
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<identifier type="istex">5E3ECD49515AA95782467635A7EEFFE83BEF1245</identifier>
<identifier type="DOI">10.1002/mds.22445</identifier>
<identifier type="ArticleID">MDS22445</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition>
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