Set‐shifting and behavioral dysfunction in primary focal dystonia
Identifieur interne : 001910 ( Istex/Corpus ); précédent : 001909; suivant : 001911Set‐shifting and behavioral dysfunction in primary focal dystonia
Auteurs : Paulo Bugalho ; Bernardo Corrêa ; João Guimarães ; Miguel XavierSource :
- Movement Disorders [ 0885-3185 ] ; 2008-01-30.
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Abstract
The occurrence of cognitive and behavioral symptoms in patients with primary dystonia remains a matter of debate. We compared 45 patients with primary dystonia with 27 control subjects for performance on neuropsychological tasks with a load on executive‐Wisconsin Card Sorting Test (WCST) and Stroop test, and visuospatial‐Benton's visual retention test (BVRT) and Block assembly test from Wechsler Adult Intelligence Scale BAT‐functions, as well as for intensity of obsessive‐compulsive symptoms (Yale Brown Obsessive Compulsive Scale, Y‐BOCS). Correlation analysis was performed between neuropsychological performance, dystonia characteristics (duration, age of onset) and severity (Unified Dystonia Rating Scale, UDRS), and Y‐BOCS. Patients made more perseverative errors on the WCST (P = 0.042) and had a higher mean Y‐BOCS (P = 0.003) score than controls. Timed tests (BVRT, BAT, Stroop test) correlated with UDRS. Y‐BOCS, WCST, and UDRS scores were not significantly correlated with one another.These results suggest that patients with primary dystonia may have set‐shifting deficits and a higher intensity of obsessive compulsive symptoms when compared to healthy subjects. This may reflect a pattern of complex neurophysiological dysfunction involving dorsolateral, orbitofrontal, and motor frontostriatal circuits. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21784
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ISTEX:0D92C89C99720074C60D8B7075AB71C3EA5F1DECLe document en format XML
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We compared 45 patients with primary dystonia with 27 control subjects for performance on neuropsychological tasks with a load on executive‐Wisconsin Card Sorting Test (WCST) and Stroop test, and visuospatial‐Benton's visual retention test (BVRT) and Block assembly test from Wechsler Adult Intelligence Scale BAT‐functions, as well as for intensity of obsessive‐compulsive symptoms (Yale Brown Obsessive Compulsive Scale, Y‐BOCS). Correlation analysis was performed between neuropsychological performance, dystonia characteristics (duration, age of onset) and severity (Unified Dystonia Rating Scale, UDRS), and Y‐BOCS. Patients made more perseverative errors on the WCST (P = 0.042) and had a higher mean Y‐BOCS (P = 0.003) score than controls. Timed tests (BVRT, BAT, Stroop test) correlated with UDRS. Y‐BOCS, WCST, and UDRS scores were not significantly correlated with one another.These results suggest that patients with primary dystonia may have set‐shifting deficits and a higher intensity of obsessive compulsive symptoms when compared to healthy subjects. This may reflect a pattern of complex neurophysiological dysfunction involving dorsolateral, orbitofrontal, and motor frontostriatal circuits. © 2007 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Paulo Bugalho MD</name><affiliations><json:string>Department of Neurology, Hospital Egas Moniz, Rua da Junqueira, Lisboa, Portugal</json:string></affiliations></json:item><json:item><name>Bernardo Corrêa MD</name><affiliations><json:string>Department of Psychiatry and Mental Health, Hospital São Francisco Xavier, Lisboa, Portugal</json:string><json:string>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal</json:string></affiliations></json:item><json:item><name>João Guimarães MD</name><affiliations><json:string>Department of Neurology, Hospital Egas Moniz, Rua da Junqueira, Lisboa, Portugal</json:string><json:string>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal</json:string></affiliations></json:item><json:item><name>Miguel Xavier PhD</name><affiliations><json:string>Department of Psychiatry and Mental Health, Hospital São Francisco Xavier, Lisboa, Portugal</json:string><json:string>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>primary dystonia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>executive dysfunction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>obsessive compulsive symptoms</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>frontostriatal circuits.</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The occurrence of cognitive and behavioral symptoms in patients with primary dystonia remains a matter of debate. 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Y‐BOCS, WCST, and UDRS scores were not significantly correlated with one another.These results suggest that patients with primary dystonia may have set‐shifting deficits and a higher intensity of obsessive compulsive symptoms when compared to healthy subjects. 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We compared 45 patients with primary dystonia with 27 control subjects for performance on neuropsychological tasks with a load on executive‐Wisconsin Card Sorting Test (WCST) and Stroop test, and visuospatial‐Benton's visual retention test (BVRT) and Block assembly test from Wechsler Adult Intelligence Scale BAT‐functions, as well as for intensity of obsessive‐compulsive symptoms (Yale Brown Obsessive Compulsive Scale, Y‐BOCS). Correlation analysis was performed between neuropsychological performance, dystonia characteristics (duration, age of onset) and severity (Unified Dystonia Rating Scale, UDRS), and Y‐BOCS. Patients made more perseverative errors on the WCST (P = 0.042) and had a higher mean Y‐BOCS (P = 0.003) score than controls. Timed tests (BVRT, BAT, Stroop test) correlated with UDRS. Y‐BOCS, WCST, and UDRS scores were not significantly correlated with one another.These results suggest that patients with primary dystonia may have set‐shifting deficits and a higher intensity of obsessive compulsive symptoms when compared to healthy subjects. This may reflect a pattern of complex neurophysiological dysfunction involving dorsolateral, orbitofrontal, and motor frontostriatal circuits. © 2007 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>primary dystonia</term></item><item><term>executive dysfunction</term></item><item><term>obsessive compulsive symptoms</term></item><item><term>frontostriatal circuits.</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-04-18">Received</change><change when="2007-09-23">Registration</change><change when="2008-01-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/0D92C89C99720074C60D8B7075AB71C3EA5F1DEC/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body" wicri:toSee="Element #text; element #text"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"> <header> <publicationMeta level="product"> <publisherInfo> <publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName> <publisherLoc>Hoboken</publisherLoc> </publisherInfo> <doi registered="yes">10.1002/(ISSN)1531-8257</doi> <issn type="print">0885-3185</issn> <issn type="electronic">1531-8257</issn> <idGroup> <id type="product" value="MDS"></id> </idGroup> <titleGroup> <title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title> <title type="short">Mov. 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We compared 45 patients with primary dystonia with 27 control subjects for performance on neuropsychological tasks with a load on executive‐Wisconsin Card Sorting Test (WCST) and Stroop test, and visuospatial‐Benton's visual retention test (BVRT) and Block assembly test from Wechsler Adult Intelligence Scale BAT‐functions, as well as for intensity of obsessive‐compulsive symptoms (Yale Brown Obsessive Compulsive Scale, Y‐BOCS). Correlation analysis was performed between neuropsychological performance, dystonia characteristics (duration, age of onset) and severity (Unified Dystonia Rating Scale, UDRS), and Y‐BOCS. Patients made more perseverative errors on the WCST (<i>P</i> = 0.042) and had a higher mean Y‐BOCS (<i>P</i> = 0.003) score than controls. Timed tests (BVRT, BAT, Stroop test) correlated with UDRS. Y‐BOCS, WCST, and UDRS scores were not significantly correlated with one another.These results suggest that patients with primary dystonia may have set‐shifting deficits and a higher intensity of obsessive compulsive symptoms when compared to healthy subjects. This may reflect a pattern of complex neurophysiological dysfunction involving dorsolateral, orbitofrontal, and motor frontostriatal circuits. © 2007 Movement Disorder Society</p> </abstract> </abstractGroup> </contentMeta> </header> </component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Set‐shifting and behavioral dysfunction in primary focal dystonia</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Cognitive Dysfunction in Primary Dystonia</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Set‐shifting and behavioral dysfunction in primary focal dystonia</title></titleInfo><name type="personal"><namePart type="given">Paulo</namePart><namePart type="family">Bugalho</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Hospital Egas Moniz, Rua da Junqueira, Lisboa, Portugal</affiliation><description>Correspondence: Department of Neurology, Hospital de Egas Moniz, Rua da Junqueira, 126, 1349‐019 Lisboa, Portugal</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bernardo</namePart><namePart type="family">Corrêa</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Psychiatry and Mental Health, Hospital São Francisco Xavier, Lisboa, Portugal</affiliation><affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">João</namePart><namePart type="family">Guimarães</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Hospital Egas Moniz, Rua da Junqueira, Lisboa, Portugal</affiliation><affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Miguel</namePart><namePart type="family">Xavier</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Psychiatry and Mental Health, Hospital São Francisco Xavier, Lisboa, Portugal</affiliation><affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-01-30</dateIssued><dateCaptured encoding="w3cdtf">2007-04-18</dateCaptured><dateValid encoding="w3cdtf">2007-09-23</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">42</extent><extent unit="words">4304</extent></physicalDescription><abstract lang="en">The occurrence of cognitive and behavioral symptoms in patients with primary dystonia remains a matter of debate. We compared 45 patients with primary dystonia with 27 control subjects for performance on neuropsychological tasks with a load on executive‐Wisconsin Card Sorting Test (WCST) and Stroop test, and visuospatial‐Benton's visual retention test (BVRT) and Block assembly test from Wechsler Adult Intelligence Scale BAT‐functions, as well as for intensity of obsessive‐compulsive symptoms (Yale Brown Obsessive Compulsive Scale, Y‐BOCS). Correlation analysis was performed between neuropsychological performance, dystonia characteristics (duration, age of onset) and severity (Unified Dystonia Rating Scale, UDRS), and Y‐BOCS. Patients made more perseverative errors on the WCST (P = 0.042) and had a higher mean Y‐BOCS (P = 0.003) score than controls. Timed tests (BVRT, BAT, Stroop test) correlated with UDRS. Y‐BOCS, WCST, and UDRS scores were not significantly correlated with one another.These results suggest that patients with primary dystonia may have set‐shifting deficits and a higher intensity of obsessive compulsive symptoms when compared to healthy subjects. This may reflect a pattern of complex neurophysiological dysfunction involving dorsolateral, orbitofrontal, and motor frontostriatal circuits. © 2007 Movement Disorder Society</abstract><note type="funding">Movement Disorders department of the Portuguese Neurological Society</note><subject lang="en"><genre>Keywords</genre><topic>primary dystonia</topic><topic>executive dysfunction</topic><topic>obsessive compulsive symptoms</topic><topic>frontostriatal circuits.</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>200</start><end>206</end><total>7</total></extent></part></relatedItem><identifier type="istex">0D92C89C99720074C60D8B7075AB71C3EA5F1DEC</identifier><identifier type="DOI">10.1002/mds.21784</identifier><identifier type="ArticleID">MDS21784</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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