Burden of illness in Parkinson's disease
Identifieur interne : 001857 ( Istex/Corpus ); précédent : 001856; suivant : 001858Burden of illness in Parkinson's disease
Auteurs : Daniel M. Huse ; Kathy Schulman ; Lucinda Orsini ; Jane Castelli-Haley ; Sean Kennedy ; Gregory LenhartSource :
- Movement Disorders [ 0885-3185 ] ; 2005-11.
English descriptors
Abstract
This study quantifies direct medical care costs for individual patients with Parkinson's disease (PD) and projects total national costs of PD. Anonymous, patient‐level data on health care utilization and cost were obtained from Medstat's MarketScan Research Databases. Patients were selected for study if they had either two instances of a diagnosis of PD or one diagnosis and two or more prescriptions for PD‐related medication. A control group of persons without PD was selected for comparison. Total annual health care utilization and costs were calculated for both PD patients and controls. A total of 20,016 patients with PD were identified and followed up for an average of 853 days. The mean age of the patients was 73.6 years, and 51.2% were women. Total annual direct costs were $23,101 (SD 27,529) per patient with PD versus $11,247 (SD 16,486) for controls. The regression‐adjusted incremental direct cost of PD versus control was $10,349 (95% confidence interval, 9,053, 11,645). Adding $25,326 in indirect costs, and multiplying by 645,000 cases of PD in the United States, the total cost to the nation is projected to be $23 billion annually. This estimate is higher than most previous studies, with important implications for health care delivery systems worldwide. © 2005 Movement Disorder Society
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DOI: 10.1002/mds.20609
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ISTEX:D5F4BC3C405F04FCE02FD174DC18799BEDFB75EDLe document en format XML
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Huse</name><affiliation><mods:affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</mods:affiliation></affiliation></author><author><name sortKey="Schulman, Kathy" sort="Schulman, Kathy" uniqKey="Schulman K" first="Kathy" last="Schulman">Kathy Schulman</name><affiliation><mods:affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</mods:affiliation></affiliation></author><author><name sortKey="Orsini, Lucinda" sort="Orsini, Lucinda" uniqKey="Orsini L" first="Lucinda" last="Orsini">Lucinda Orsini</name><affiliation><mods:affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</mods:affiliation></affiliation></author><author><name sortKey="Castelli Aley, Jane" sort="Castelli Aley, Jane" uniqKey="Castelli Aley J" first="Jane" last="Castelli-Haley">Jane Castelli-Haley</name><affiliation><mods:affiliation>Teva Neuroscience, Kansas City, Missouri, USA</mods:affiliation></affiliation></author><author><name sortKey="Kennedy, Sean" sort="Kennedy, Sean" uniqKey="Kennedy S" first="Sean" last="Kennedy">Sean Kennedy</name><affiliation><mods:affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</mods:affiliation></affiliation></author><author><name sortKey="Lenhart, Gregory" sort="Lenhart, Gregory" uniqKey="Lenhart G" first="Gregory" last="Lenhart">Gregory Lenhart</name><affiliation><mods:affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D5F4BC3C405F04FCE02FD174DC18799BEDFB75ED</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1002/mds.20609</idno><idno type="url">https://api.istex.fr/document/D5F4BC3C405F04FCE02FD174DC18799BEDFB75ED/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001857</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Burden of illness in Parkinson's disease</title><author><name sortKey="Huse, Daniel M" sort="Huse, Daniel M" uniqKey="Huse D" first="Daniel M." last="Huse">Daniel M. Huse</name><affiliation><mods:affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</mods:affiliation></affiliation></author><author><name sortKey="Schulman, Kathy" sort="Schulman, Kathy" uniqKey="Schulman K" first="Kathy" last="Schulman">Kathy Schulman</name><affiliation><mods:affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</mods:affiliation></affiliation></author><author><name sortKey="Orsini, Lucinda" sort="Orsini, Lucinda" uniqKey="Orsini L" first="Lucinda" last="Orsini">Lucinda Orsini</name><affiliation><mods:affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</mods:affiliation></affiliation></author><author><name sortKey="Castelli Aley, Jane" sort="Castelli Aley, Jane" uniqKey="Castelli Aley J" first="Jane" last="Castelli-Haley">Jane Castelli-Haley</name><affiliation><mods:affiliation>Teva Neuroscience, Kansas City, Missouri, USA</mods:affiliation></affiliation></author><author><name sortKey="Kennedy, Sean" sort="Kennedy, Sean" uniqKey="Kennedy S" first="Sean" last="Kennedy">Sean Kennedy</name><affiliation><mods:affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</mods:affiliation></affiliation></author><author><name sortKey="Lenhart, Gregory" sort="Lenhart, Gregory" uniqKey="Lenhart G" first="Gregory" last="Lenhart">Gregory Lenhart</name><affiliation><mods:affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-11">2005-11</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1449">1449</biblScope><biblScope unit="page" to="1454">1454</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D5F4BC3C405F04FCE02FD174DC18799BEDFB75ED</idno><idno type="DOI">10.1002/mds.20609</idno><idno type="ArticleID">MDS20609</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cost of illness</term><term>health economics</term><term>resource use</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study quantifies direct medical care costs for individual patients with Parkinson's disease (PD) and projects total national costs of PD. Anonymous, patient‐level data on health care utilization and cost were obtained from Medstat's MarketScan Research Databases. Patients were selected for study if they had either two instances of a diagnosis of PD or one diagnosis and two or more prescriptions for PD‐related medication. A control group of persons without PD was selected for comparison. Total annual health care utilization and costs were calculated for both PD patients and controls. A total of 20,016 patients with PD were identified and followed up for an average of 853 days. The mean age of the patients was 73.6 years, and 51.2% were women. Total annual direct costs were $23,101 (SD 27,529) per patient with PD versus $11,247 (SD 16,486) for controls. The regression‐adjusted incremental direct cost of PD versus control was $10,349 (95% confidence interval, 9,053, 11,645). Adding $25,326 in indirect costs, and multiplying by 645,000 cases of PD in the United States, the total cost to the nation is projected to be $23 billion annually. This estimate is higher than most previous studies, with important implications for health care delivery systems worldwide. © 2005 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Daniel M. Huse MA</name><affiliations><json:string>Thomson Medstat, Cambridge, Massachusetts, USA</json:string></affiliations></json:item><json:item><name>Kathy Schulman MA</name><affiliations><json:string>Thomson Medstat, Cambridge, Massachusetts, USA</json:string></affiliations></json:item><json:item><name>Lucinda Orsini DPM, MPH</name><affiliations><json:string>Thomson Medstat, Cambridge, Massachusetts, USA</json:string></affiliations></json:item><json:item><name>Jane Castelli‐Haley MBA</name><affiliations><json:string>Teva Neuroscience, Kansas City, Missouri, USA</json:string></affiliations></json:item><json:item><name>Sean Kennedy BA</name><affiliations><json:string>Thomson Medstat, Cambridge, Massachusetts, USA</json:string></affiliations></json:item><json:item><name>Gregory Lenhart MS</name><affiliations><json:string>Thomson Medstat, Cambridge, Massachusetts, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>health economics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cost of illness</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>resource use</value></json:item></subject><language><json:string>eng</json:string></language><abstract>This study quantifies direct medical care costs for individual patients with Parkinson's disease (PD) and projects total national costs of PD. Anonymous, patient‐level data on health care utilization and cost were obtained from Medstat's MarketScan Research Databases. Patients were selected for study if they had either two instances of a diagnosis of PD or one diagnosis and two or more prescriptions for PD‐related medication. A control group of persons without PD was selected for comparison. Total annual health care utilization and costs were calculated for both PD patients and controls. A total of 20,016 patients with PD were identified and followed up for an average of 853 days. The mean age of the patients was 73.6 years, and 51.2% were women. Total annual direct costs were $23,101 (SD 27,529) per patient with PD versus $11,247 (SD 16,486) for controls. The regression‐adjusted incremental direct cost of PD versus control was $10,349 (95% confidence interval, 9,053, 11,645). Adding $25,326 in indirect costs, and multiplying by 645,000 cases of PD in the United States, the total cost to the nation is projected to be $23 billion annually. 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(Teaneck, NJ)</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Burden of illness in Parkinson's disease</title><author><persName><forename type="first">Daniel M.</forename><surname>Huse</surname><roleName type="degree">MA</roleName></persName><note type="correspondence"><p>Correspondence: Thomson Medstat, 125 Cambridgepark Drive, Cambridge, MA 02140</p></note><affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</affiliation></author><author><persName><forename type="first">Kathy</forename><surname>Schulman</surname><roleName type="degree">MA</roleName></persName><affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</affiliation></author><author><persName><forename type="first">Lucinda</forename><surname>Orsini</surname><roleName type="degree">DPM, MPH</roleName></persName><affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</affiliation></author><author><persName><forename type="first">Jane</forename><surname>Castelli‐Haley</surname><roleName type="degree">MBA</roleName></persName><affiliation>Teva Neuroscience, Kansas City, Missouri, USA</affiliation></author><author><persName><forename type="first">Sean</forename><surname>Kennedy</surname><roleName type="degree">BA</roleName></persName><affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</affiliation></author><author><persName><forename type="first">Gregory</forename><surname>Lenhart</surname><roleName type="degree">MS</roleName></persName><affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-11"></date><biblScope unit="vol">20</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1449">1449</biblScope><biblScope unit="page" to="1454">1454</biblScope></imprint></monogr><idno type="istex">D5F4BC3C405F04FCE02FD174DC18799BEDFB75ED</idno><idno type="DOI">10.1002/mds.20609</idno><idno type="ArticleID">MDS20609</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2005</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>This study quantifies direct medical care costs for individual patients with Parkinson's disease (PD) and projects total national costs of PD. Anonymous, patient‐level data on health care utilization and cost were obtained from Medstat's MarketScan Research Databases. Patients were selected for study if they had either two instances of a diagnosis of PD or one diagnosis and two or more prescriptions for PD‐related medication. A control group of persons without PD was selected for comparison. Total annual health care utilization and costs were calculated for both PD patients and controls. A total of 20,016 patients with PD were identified and followed up for an average of 853 days. The mean age of the patients was 73.6 years, and 51.2% were women. Total annual direct costs were $23,101 (SD 27,529) per patient with PD versus $11,247 (SD 16,486) for controls. The regression‐adjusted incremental direct cost of PD versus control was $10,349 (95% confidence interval, 9,053, 11,645). Adding $25,326 in indirect costs, and multiplying by 645,000 cases of PD in the United States, the total cost to the nation is projected to be $23 billion annually. This estimate is higher than most previous studies, with important implications for health care delivery systems worldwide. © 2005 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>health economics</term></item><item><term>cost of illness</term></item><item><term>resource use</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2004-12-03">Received</change><change when="2005-02-08">Registration</change><change when="2005-11">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/D5F4BC3C405F04FCE02FD174DC18799BEDFB75ED/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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(Teaneck, NJ)</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>This study quantifies direct medical care costs for individual patients with Parkinson's disease (PD) and projects total national costs of PD. Anonymous, patient‐level data on health care utilization and cost were obtained from Medstat's MarketScan Research Databases. Patients were selected for study if they had either two instances of a diagnosis of PD or one diagnosis and two or more prescriptions for PD‐related medication. A control group of persons without PD was selected for comparison. Total annual health care utilization and costs were calculated for both PD patients and controls. A total of 20,016 patients with PD were identified and followed up for an average of 853 days. The mean age of the patients was 73.6 years, and 51.2% were women. Total annual direct costs were $23,101 (SD 27,529) per patient with PD versus $11,247 (SD 16,486) for controls. The regression‐adjusted incremental direct cost of PD versus control was $10,349 (95% confidence interval, 9,053, 11,645). Adding $25,326 in indirect costs, and multiplying by 645,000 cases of PD in the United States, the total cost to the nation is projected to be $23 billion annually. This estimate is higher than most previous studies, with important implications for health care delivery systems worldwide. © 2005 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Burden of illness in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Burden of Illness in Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Burden of illness in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Daniel M.</namePart><namePart type="family">Huse</namePart><namePart type="termsOfAddress">MA</namePart><affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</affiliation><description>Correspondence: Thomson Medstat, 125 Cambridgepark Drive, Cambridge, MA 02140</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kathy</namePart><namePart type="family">Schulman</namePart><namePart type="termsOfAddress">MA</namePart><affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lucinda</namePart><namePart type="family">Orsini</namePart><namePart type="termsOfAddress">DPM, MPH</namePart><affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jane</namePart><namePart type="family">Castelli‐Haley</namePart><namePart type="termsOfAddress">MBA</namePart><affiliation>Teva Neuroscience, Kansas City, Missouri, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sean</namePart><namePart type="family">Kennedy</namePart><namePart type="termsOfAddress">BA</namePart><affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gregory</namePart><namePart type="family">Lenhart</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>Thomson Medstat, Cambridge, Massachusetts, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2005-11</dateIssued><dateCaptured encoding="w3cdtf">2004-12-03</dateCaptured><dateValid encoding="w3cdtf">2005-02-08</dateValid><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">4</extent><extent unit="references">21</extent><extent unit="words">4185</extent></physicalDescription><abstract lang="en">This study quantifies direct medical care costs for individual patients with Parkinson's disease (PD) and projects total national costs of PD. Anonymous, patient‐level data on health care utilization and cost were obtained from Medstat's MarketScan Research Databases. Patients were selected for study if they had either two instances of a diagnosis of PD or one diagnosis and two or more prescriptions for PD‐related medication. A control group of persons without PD was selected for comparison. Total annual health care utilization and costs were calculated for both PD patients and controls. A total of 20,016 patients with PD were identified and followed up for an average of 853 days. The mean age of the patients was 73.6 years, and 51.2% were women. Total annual direct costs were $23,101 (SD 27,529) per patient with PD versus $11,247 (SD 16,486) for controls. The regression‐adjusted incremental direct cost of PD versus control was $10,349 (95% confidence interval, 9,053, 11,645). Adding $25,326 in indirect costs, and multiplying by 645,000 cases of PD in the United States, the total cost to the nation is projected to be $23 billion annually. This estimate is higher than most previous studies, with important implications for health care delivery systems worldwide. © 2005 Movement Disorder Society</abstract><note type="funding">Teva Neuroscience (Kansas City, MO)</note><note type="funding">Eisai, Inc. (Teaneck, NJ)</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>health economics</topic><topic>cost of illness</topic><topic>resource use</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>1449</start><end>1454</end><total>6</total></extent></part></relatedItem><identifier type="istex">D5F4BC3C405F04FCE02FD174DC18799BEDFB75ED</identifier><identifier type="DOI">10.1002/mds.20609</identifier><identifier type="ArticleID">MDS20609</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2005 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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