Perverted head‐shaking and positional downbeat nystagmus in patients with multiple system atrophy
Identifieur interne : 001731 ( Istex/Corpus ); précédent : 001730; suivant : 001732Perverted head‐shaking and positional downbeat nystagmus in patients with multiple system atrophy
Auteurs : Jee-Young Lee ; Woong-Woo Lee ; Ji Soo Kim ; Hee Jin Kim ; Jin-Kyung Kim ; Beom S. JeonSource :
- Movement Disorders [ 0885-3185 ] ; 2009-07-15.
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- KwdEn :
Abstract
The diagnosis of multiple system atrophy (MSA) is mainly based on the clinical criteria, which are often of little assistance in the early stages of the disease. Positional downbeat nystagmus (pDBN) and perverted head‐shaking nystagmus (pHSN), possible signs of cerebellar dysfunction, may be useful in differentiating MSA from other parkinsonian disorders. To investigate the occurrences of pDBN and pHSN in patients with MSA compared with those in patients with Parkinson's disease (PD). A total of 127 consecutive patients with MSA and 274 patients with PD underwent a video‐oculographic recording of head‐shaking and positional nystagmus over a year. The occurrences of pDBN and pHSN were higher in MSA than in PD. pDBN was more frequently observed in MSA with overt cerebellar signs than in those without, but the occurrence of pHSN did not differ between the MSA groups. pHSN was more frequently observed in MSA‐p without overt cerebellar signs than in PD, but there was no difference in the occurrence of pDBN between them. The presence of pHSN and pDBN may be a clue for the diagnosis of MSA, and pHSN may be helpful in differentiating MSA‐p from PD when the patients do not have overt cerebellar features. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22559
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<front><div type="abstract" xml:lang="en">The diagnosis of multiple system atrophy (MSA) is mainly based on the clinical criteria, which are often of little assistance in the early stages of the disease. Positional downbeat nystagmus (pDBN) and perverted head‐shaking nystagmus (pHSN), possible signs of cerebellar dysfunction, may be useful in differentiating MSA from other parkinsonian disorders. To investigate the occurrences of pDBN and pHSN in patients with MSA compared with those in patients with Parkinson's disease (PD). A total of 127 consecutive patients with MSA and 274 patients with PD underwent a video‐oculographic recording of head‐shaking and positional nystagmus over a year. The occurrences of pDBN and pHSN were higher in MSA than in PD. pDBN was more frequently observed in MSA with overt cerebellar signs than in those without, but the occurrence of pHSN did not differ between the MSA groups. pHSN was more frequently observed in MSA‐p without overt cerebellar signs than in PD, but there was no difference in the occurrence of pDBN between them. The presence of pHSN and pDBN may be a clue for the diagnosis of MSA, and pHSN may be helpful in differentiating MSA‐p from PD when the patients do not have overt cerebellar features. © 2009 Movement Disorder Society</div>
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<titleGroup><title type="main" xml:lang="en">Perverted head‐shaking and positional downbeat nystagmus in patients with multiple system atrophy<link href="#fn1"></link>
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<title type="short" xml:lang="en">Induced Downbeat Nystagmus in MSA</title>
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<creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af4"><personName><givenNames>Hee Jin</givenNames>
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<keyword xml:id="kwd4">positional downbeat nystagmus</keyword>
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<fundingInfo><fundingAgency>Seoul National University Hospital Research</fundingAgency>
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<fundingInfo><fundingAgency>Chung Suk‐Gyoo and Shinyang Cultural Foundation</fundingAgency>
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<supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p>
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<caption>Clinical profiles of the patients clinically diagnosed with PD, but showing pDBN or pHSN</caption>
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<p>The diagnosis of multiple system atrophy (MSA) is mainly based on the clinical criteria, which are often of little assistance in the early stages of the disease. Positional downbeat nystagmus (pDBN) and perverted head‐shaking nystagmus (pHSN), possible signs of cerebellar dysfunction, may be useful in differentiating MSA from other parkinsonian disorders. To investigate the occurrences of pDBN and pHSN in patients with MSA compared with those in patients with Parkinson's disease (PD). A total of 127 consecutive patients with MSA and 274 patients with PD underwent a video‐oculographic recording of head‐shaking and positional nystagmus over a year. The occurrences of pDBN and pHSN were higher in MSA than in PD. pDBN was more frequently observed in MSA with overt cerebellar signs than in those without, but the occurrence of pHSN did not differ between the MSA groups. pHSN was more frequently observed in MSA‐p without overt cerebellar signs than in PD, but there was no difference in the occurrence of pDBN between them. The presence of pHSN and pDBN may be a clue for the diagnosis of MSA, and pHSN may be helpful in differentiating MSA‐p from PD when the patients do not have overt cerebellar features. © 2009 Movement Disorder Society</p>
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<noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Nothing to reported.</p>
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<titleInfo type="abbreviated" lang="en"><title>Induced Downbeat Nystagmus in MSA</title>
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<affiliation>Clinical Research Institute and Movement Disorder Center, Seoul National University Hospital, Seoul, South Korea</affiliation>
<affiliation>Current Address: Inje University Ilsan Paik Hospital, Goyang, Gyeonggi‐Do, South Korea</affiliation>
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<name type="personal"><namePart type="given">Beom S.</namePart>
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<affiliation>Clinical Research Institute and Movement Disorder Center, Seoul National University Hospital, Seoul, South Korea</affiliation>
<description>Correspondence: Department of Neurology, Seoul National University Hospital, College of Medicine, Seoul National University, 28, Yongon‐Dong, Chongno‐Gu, Seoul 110‐744, Korea</description>
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<abstract lang="en">The diagnosis of multiple system atrophy (MSA) is mainly based on the clinical criteria, which are often of little assistance in the early stages of the disease. Positional downbeat nystagmus (pDBN) and perverted head‐shaking nystagmus (pHSN), possible signs of cerebellar dysfunction, may be useful in differentiating MSA from other parkinsonian disorders. To investigate the occurrences of pDBN and pHSN in patients with MSA compared with those in patients with Parkinson's disease (PD). A total of 127 consecutive patients with MSA and 274 patients with PD underwent a video‐oculographic recording of head‐shaking and positional nystagmus over a year. The occurrences of pDBN and pHSN were higher in MSA than in PD. pDBN was more frequently observed in MSA with overt cerebellar signs than in those without, but the occurrence of pHSN did not differ between the MSA groups. pHSN was more frequently observed in MSA‐p without overt cerebellar signs than in PD, but there was no difference in the occurrence of pDBN between them. The presence of pHSN and pDBN may be a clue for the diagnosis of MSA, and pHSN may be helpful in differentiating MSA‐p from PD when the patients do not have overt cerebellar features. © 2009 Movement Disorder Society</abstract>
<note type="content">*Potential conflict of interest: Nothing to reported.</note>
<note type="funding">Seoul National University Hospital Research</note>
<note type="funding">Chung Suk‐Gyoo and Shinyang Cultural Foundation</note>
<subject lang="en"><genre>Keywords</genre>
<topic>multiple system atrophy</topic>
<topic>Parkinson's disease</topic>
<topic>perverted head‐shaking nystagmus</topic>
<topic>positional downbeat nystagmus</topic>
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<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
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<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>24</number>
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