Swallowing abnormalities and dyskinesia in Parkinson's disease
Identifieur interne : 001642 ( Istex/Corpus ); précédent : 001641; suivant : 001643Swallowing abnormalities and dyskinesia in Parkinson's disease
Auteurs : Francisca Sueli Monte ; Francisco Pereira Da Silva-Júnior ; Pedro Braga-Neto ; Miguel Ngelo Nobre E Souza ; Veralice Meireles Sales De BruinSource :
- Movement Disorders [ 0885-3185 ] ; 2005-04.
English descriptors
- KwdEn :
Abstract
Gastrointestinal abnormalities in Parkinson's disease (PD) have been known for almost two centuries, but many aspects concerning their pathophysiology have not been completely clarified. The aim of this study was to characterize the oropharyngeal dynamics in PD patients with and without levodopa‐induced dyskinesia. Fifteen dyskinetic, 12 nondyskinetic patients, and a control group were included. Patients were asked about dysphagia and evaluated with the Unified Parkinson's Disease Rating Scale Parts II and III and the Hoehn and Yahr scale. Deglutition was assessed using modified barium swallow with videofluoroscopy. Nondyskinetic patients, but not the dyskinetic ones, showed less oropharyngeal swallowing efficiency (OPSE) for liquid food than controls (Dunnett, P = 0.02). Dyskinetic patients tended to have a greater OPSE than nondyskinetic (Dunnett, P = 0.06). Patients who were using a higher dose of levodopa had a greater OPSE and a trend toward a smaller oral transit time (Pearson's correlation, P = 0.01 and 0.08, respectively). Neither the report of dysphagia nor any of the PD severity parameters correlated to the videofluoroscopic variables. In the current study, dyskinetic patients performed better in swallowing function, which could be explained on the basis of a greater levodopa dose. Our results suggest a role for levodopa in the oral phase of deglutition and confirm that dysphagia is not a good predictor of deglutition alterations in PD. © 2004 Movement Disorder Society
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DOI: 10.1002/mds.20342
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ISTEX:76FF6C13A93651EE1F84F9950D7215213E7BE99DLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Swallowing abnormalities and dyskinesia in Parkinson's disease</title><author><name sortKey="Monte, Francisca Sueli" sort="Monte, Francisca Sueli" uniqKey="Monte F" first="Francisca Sueli" last="Monte">Francisca Sueli Monte</name><affiliation><mods:affiliation>Department of Pharmacy, Federal University of Ceará, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Da Silva Nior, Francisco Pereira" sort="Da Silva Nior, Francisco Pereira" uniqKey="Da Silva Nior F" first="Francisco Pereira" last="Da Silva-Júnior">Francisco Pereira Da Silva-Júnior</name><affiliation><mods:affiliation>Department of Clinical Medicine, Federal University of Ceará, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Braga Eto, Pedro" sort="Braga Eto, Pedro" uniqKey="Braga Eto P" first="Pedro" last="Braga-Neto">Pedro Braga-Neto</name><affiliation><mods:affiliation>Department of Clinical Medicine, Federal University of Ceará, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Nobre E Souza, Miguel Ngelo" sort="Nobre E Souza, Miguel Ngelo" uniqKey="Nobre E Souza M" first="Miguel Ngelo" last="Nobre E Souza">Miguel Ngelo Nobre E Souza</name><affiliation><mods:affiliation>Department of Clinical Medicine, Federal University of Ceará, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Sales De Bruin, Veralice Meireles" sort="Sales De Bruin, Veralice Meireles" uniqKey="Sales De Bruin V" first="Veralice Meireles" last="Sales De Bruin">Veralice Meireles Sales De Bruin</name><affiliation><mods:affiliation>Department of Clinical Medicine, Federal University of Ceará, Brazil</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:76FF6C13A93651EE1F84F9950D7215213E7BE99D</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1002/mds.20342</idno><idno type="url">https://api.istex.fr/document/76FF6C13A93651EE1F84F9950D7215213E7BE99D/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001642</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Swallowing abnormalities and dyskinesia in Parkinson's disease</title><author><name sortKey="Monte, Francisca Sueli" sort="Monte, Francisca Sueli" uniqKey="Monte F" first="Francisca Sueli" last="Monte">Francisca Sueli Monte</name><affiliation><mods:affiliation>Department of Pharmacy, Federal University of Ceará, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Da Silva Nior, Francisco Pereira" sort="Da Silva Nior, Francisco Pereira" uniqKey="Da Silva Nior F" first="Francisco Pereira" last="Da Silva-Júnior">Francisco Pereira Da Silva-Júnior</name><affiliation><mods:affiliation>Department of Clinical Medicine, Federal University of Ceará, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Braga Eto, Pedro" sort="Braga Eto, Pedro" uniqKey="Braga Eto P" first="Pedro" last="Braga-Neto">Pedro Braga-Neto</name><affiliation><mods:affiliation>Department of Clinical Medicine, Federal University of Ceará, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Nobre E Souza, Miguel Ngelo" sort="Nobre E Souza, Miguel Ngelo" uniqKey="Nobre E Souza M" first="Miguel Ngelo" last="Nobre E Souza">Miguel Ngelo Nobre E Souza</name><affiliation><mods:affiliation>Department of Clinical Medicine, Federal University of Ceará, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Sales De Bruin, Veralice Meireles" sort="Sales De Bruin, Veralice Meireles" uniqKey="Sales De Bruin V" first="Veralice Meireles" last="Sales De Bruin">Veralice Meireles Sales De Bruin</name><affiliation><mods:affiliation>Department of Clinical Medicine, Federal University of Ceará, Brazil</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-04">2005-04</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="457">457</biblScope><biblScope unit="page" to="462">462</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">76FF6C13A93651EE1F84F9950D7215213E7BE99D</idno><idno type="DOI">10.1002/mds.20342</idno><idno type="ArticleID">MDS20342</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>dyskinesia</term><term>dysphagia</term><term>levodopa</term><term>swallowing</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gastrointestinal abnormalities in Parkinson's disease (PD) have been known for almost two centuries, but many aspects concerning their pathophysiology have not been completely clarified. The aim of this study was to characterize the oropharyngeal dynamics in PD patients with and without levodopa‐induced dyskinesia. Fifteen dyskinetic, 12 nondyskinetic patients, and a control group were included. Patients were asked about dysphagia and evaluated with the Unified Parkinson's Disease Rating Scale Parts II and III and the Hoehn and Yahr scale. Deglutition was assessed using modified barium swallow with videofluoroscopy. Nondyskinetic patients, but not the dyskinetic ones, showed less oropharyngeal swallowing efficiency (OPSE) for liquid food than controls (Dunnett, P = 0.02). Dyskinetic patients tended to have a greater OPSE than nondyskinetic (Dunnett, P = 0.06). Patients who were using a higher dose of levodopa had a greater OPSE and a trend toward a smaller oral transit time (Pearson's correlation, P = 0.01 and 0.08, respectively). Neither the report of dysphagia nor any of the PD severity parameters correlated to the videofluoroscopic variables. In the current study, dyskinetic patients performed better in swallowing function, which could be explained on the basis of a greater levodopa dose. Our results suggest a role for levodopa in the oral phase of deglutition and confirm that dysphagia is not a good predictor of deglutition alterations in PD. © 2004 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Francisca Sueli Monte MPharm</name><affiliations><json:string>Department of Pharmacy, Federal University of Ceará, Brazil</json:string></affiliations></json:item><json:item><name>Francisco Pereira da Silva‐Júnior MD</name><affiliations><json:string>Department of Clinical Medicine, Federal University of Ceará, Brazil</json:string></affiliations></json:item><json:item><name>Pedro Braga‐Neto MD</name><affiliations><json:string>Department of Clinical Medicine, Federal University of Ceará, Brazil</json:string></affiliations></json:item><json:item><name>Miguel Ângelo Nobre e Souza PhD</name><affiliations><json:string>Department of Clinical Medicine, Federal University of Ceará, Brazil</json:string></affiliations></json:item><json:item><name>Veralice Meireles Sales de Bruin PhD</name><affiliations><json:string>Department of Clinical Medicine, Federal University of Ceará, Brazil</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dyskinesia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>swallowing</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dysphagia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>levodopa</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Gastrointestinal abnormalities in Parkinson's disease (PD) have been known for almost two centuries, but many aspects concerning their pathophysiology have not been completely clarified. The aim of this study was to characterize the oropharyngeal dynamics in PD patients with and without levodopa‐induced dyskinesia. Fifteen dyskinetic, 12 nondyskinetic patients, and a control group were included. Patients were asked about dysphagia and evaluated with the Unified Parkinson's Disease Rating Scale Parts II and III and the Hoehn and Yahr scale. Deglutition was assessed using modified barium swallow with videofluoroscopy. Nondyskinetic patients, but not the dyskinetic ones, showed less oropharyngeal swallowing efficiency (OPSE) for liquid food than controls (Dunnett, P = 0.02). Dyskinetic patients tended to have a greater OPSE than nondyskinetic (Dunnett, P = 0.06). Patients who were using a higher dose of levodopa had a greater OPSE and a trend toward a smaller oral transit time (Pearson's correlation, P = 0.01 and 0.08, respectively). Neither the report of dysphagia nor any of the PD severity parameters correlated to the videofluoroscopic variables. In the current study, dyskinetic patients performed better in swallowing function, which could be explained on the basis of a greater levodopa dose. 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Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-04"></date><biblScope unit="vol">20</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="457">457</biblScope><biblScope unit="page" to="462">462</biblScope></imprint></monogr><idno type="istex">76FF6C13A93651EE1F84F9950D7215213E7BE99D</idno><idno type="DOI">10.1002/mds.20342</idno><idno type="ArticleID">MDS20342</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2005</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Gastrointestinal abnormalities in Parkinson's disease (PD) have been known for almost two centuries, but many aspects concerning their pathophysiology have not been completely clarified. The aim of this study was to characterize the oropharyngeal dynamics in PD patients with and without levodopa‐induced dyskinesia. Fifteen dyskinetic, 12 nondyskinetic patients, and a control group were included. Patients were asked about dysphagia and evaluated with the Unified Parkinson's Disease Rating Scale Parts II and III and the Hoehn and Yahr scale. Deglutition was assessed using modified barium swallow with videofluoroscopy. Nondyskinetic patients, but not the dyskinetic ones, showed less oropharyngeal swallowing efficiency (OPSE) for liquid food than controls (Dunnett, P = 0.02). Dyskinetic patients tended to have a greater OPSE than nondyskinetic (Dunnett, P = 0.06). Patients who were using a higher dose of levodopa had a greater OPSE and a trend toward a smaller oral transit time (Pearson's correlation, P = 0.01 and 0.08, respectively). Neither the report of dysphagia nor any of the PD severity parameters correlated to the videofluoroscopic variables. In the current study, dyskinetic patients performed better in swallowing function, which could be explained on the basis of a greater levodopa dose. Our results suggest a role for levodopa in the oral phase of deglutition and confirm that dysphagia is not a good predictor of deglutition alterations in PD. © 2004 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>dyskinesia</term></item><item><term>swallowing</term></item><item><term>dysphagia</term></item><item><term>levodopa</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2004-05-02">Received</change><change when="2004-07-20">Registration</change><change when="2005-04">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/76FF6C13A93651EE1F84F9950D7215213E7BE99D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="40"><doi origin="wiley" registered="yes">10.1002/mds.v20:4</doi><numberingGroup><numbering type="journalVolume" number="20">20</numbering><numbering type="journalIssue">4</numbering></numberingGroup><coverDate startDate="2005-04">April 2005</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="90" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.20342</doi><idGroup><id type="unit" value="MDS20342"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2004 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2004-05-02"></event><event type="manuscriptRevised" date="2004-05-02"></event><event type="manuscriptAccepted" date="2004-07-20"></event><event type="firstOnline" date="2004-12-29"></event><event type="publishedOnlineFinalForm" date="2005-04-05"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2004-12-29"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.4.7 mode:FullText source:FullText result:FullText" date="2011-02-24"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">457</numbering><numbering type="pageLast">462</numbering></numberingGroup><correspondenceTo>Department of Clinical Medicine, Rua Prof. Costa Mendes 1608, 4° Andar, CEP: 60430 040, Fortaleza, Ceará, Brazil</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS20342.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="31"></count><count type="wordTotal" number="3954"></count></countGroup><titleGroup><title type="main" xml:lang="en">Swallowing abnormalities and dyskinesia in Parkinson's disease</title><title type="short" xml:lang="en">Swallowing Abnormalities and Dyskinesia in PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Francisca Sueli</givenNames><familyName>Monte</familyName><degrees>MPharm</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Francisco Pereira</givenNames><familyName>da Silva‐Júnior</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Pedro</givenNames><familyName>Braga‐Neto</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Miguel Ângelo</givenNames><familyName>Nobre e Souza</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2" corresponding="yes"><personName><givenNames>Veralice Meireles</givenNames><familyName>Sales de Bruin</familyName><degrees>PhD</degrees></personName><contactDetails><email>veralice@superig.com.br</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="BR" type="organization"><unparsedAffiliation>Department of Pharmacy, Federal University of Ceará, Brazil</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="BR" type="organization"><unparsedAffiliation>Department of Clinical Medicine, Federal University of Ceará, Brazil</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">dyskinesia</keyword><keyword xml:id="kwd3">swallowing</keyword><keyword xml:id="kwd4">dysphagia</keyword><keyword xml:id="kwd5">levodopa</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Gastrointestinal abnormalities in Parkinson's disease (PD) have been known for almost two centuries, but many aspects concerning their pathophysiology have not been completely clarified. The aim of this study was to characterize the oropharyngeal dynamics in PD patients with and without levodopa‐induced dyskinesia. Fifteen dyskinetic, 12 nondyskinetic patients, and a control group were included. Patients were asked about dysphagia and evaluated with the Unified Parkinson's Disease Rating Scale Parts II and III and the Hoehn and Yahr scale. Deglutition was assessed using modified barium swallow with videofluoroscopy. Nondyskinetic patients, but not the dyskinetic ones, showed less oropharyngeal swallowing efficiency (OPSE) for liquid food than controls (Dunnett, <i>P</i> = 0.02). Dyskinetic patients tended to have a greater OPSE than nondyskinetic (Dunnett, <i>P</i> = 0.06). Patients who were using a higher dose of levodopa had a greater OPSE and a trend toward a smaller oral transit time (Pearson's correlation, <i>P</i> = 0.01 and 0.08, respectively). Neither the report of dysphagia nor any of the PD severity parameters correlated to the videofluoroscopic variables. In the current study, dyskinetic patients performed better in swallowing function, which could be explained on the basis of a greater levodopa dose. Our results suggest a role for levodopa in the oral phase of deglutition and confirm that dysphagia is not a good predictor of deglutition alterations in PD. © 2004 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Swallowing abnormalities and dyskinesia in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Swallowing Abnormalities and Dyskinesia in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Swallowing abnormalities and dyskinesia in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Francisca Sueli</namePart><namePart type="family">Monte</namePart><namePart type="termsOfAddress">MPharm</namePart><affiliation>Department of Pharmacy, Federal University of Ceará, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francisco Pereira</namePart><namePart type="family">da Silva‐Júnior</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Clinical Medicine, Federal University of Ceará, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pedro</namePart><namePart type="family">Braga‐Neto</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Clinical Medicine, Federal University of Ceará, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Miguel Ângelo</namePart><namePart type="family">Nobre e Souza</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Clinical Medicine, Federal University of Ceará, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Veralice Meireles</namePart><namePart type="family">Sales de Bruin</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Clinical Medicine, Federal University of Ceará, Brazil</affiliation><description>Correspondence: Department of Clinical Medicine, Rua Prof. Costa Mendes 1608, 4° Andar, CEP: 60430 040, Fortaleza, Ceará, Brazil</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2005-04</dateIssued><dateCaptured encoding="w3cdtf">2004-05-02</dateCaptured><dateValid encoding="w3cdtf">2004-07-20</dateValid><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">2</extent><extent unit="references">31</extent><extent unit="words">3954</extent></physicalDescription><abstract lang="en">Gastrointestinal abnormalities in Parkinson's disease (PD) have been known for almost two centuries, but many aspects concerning their pathophysiology have not been completely clarified. The aim of this study was to characterize the oropharyngeal dynamics in PD patients with and without levodopa‐induced dyskinesia. Fifteen dyskinetic, 12 nondyskinetic patients, and a control group were included. Patients were asked about dysphagia and evaluated with the Unified Parkinson's Disease Rating Scale Parts II and III and the Hoehn and Yahr scale. Deglutition was assessed using modified barium swallow with videofluoroscopy. Nondyskinetic patients, but not the dyskinetic ones, showed less oropharyngeal swallowing efficiency (OPSE) for liquid food than controls (Dunnett, P = 0.02). Dyskinetic patients tended to have a greater OPSE than nondyskinetic (Dunnett, P = 0.06). Patients who were using a higher dose of levodopa had a greater OPSE and a trend toward a smaller oral transit time (Pearson's correlation, P = 0.01 and 0.08, respectively). Neither the report of dysphagia nor any of the PD severity parameters correlated to the videofluoroscopic variables. In the current study, dyskinetic patients performed better in swallowing function, which could be explained on the basis of a greater levodopa dose. Our results suggest a role for levodopa in the oral phase of deglutition and confirm that dysphagia is not a good predictor of deglutition alterations in PD. © 2004 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>dyskinesia</topic><topic>swallowing</topic><topic>dysphagia</topic><topic>levodopa</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>457</start><end>462</end><total>6</total></extent></part></relatedItem><identifier type="istex">76FF6C13A93651EE1F84F9950D7215213E7BE99D</identifier><identifier type="DOI">10.1002/mds.20342</identifier><identifier type="ArticleID">MDS20342</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2004 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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