Cognitive dysfunction in Nigerians with Parkinson's disease
Identifieur interne : 001550 ( Istex/Corpus ); précédent : 001549; suivant : 001551Cognitive dysfunction in Nigerians with Parkinson's disease
Auteurs : Rufus O. Akinyemi ; Njideka N. Okubadejo ; Joshua O. Akinyemi ; Mayowa O. Owolabi ; Lukman F. Owolabi ; Adesola OgunniyiSource :
- Movement Disorders [ 0885-3185 ] ; 2008-07-30.
English descriptors
Abstract
Despite the original description of Parkinson's disease (PD) as a disorder in which “the senses and intellect remain uninjured,” there is now sufficient evidence that cognitive dysfunction does occur. This research determined the frequency, pattern, and predictors of cognitive dysfunction among 51 Nigerian patients with PD compared with 50 demographically matched controls using the modified Community Screening Instrument for Dementia (CSI‘D’) and selected items from the Ibadan Neuropsychological Battery (I‐NB). In all, 21.6% patients with PD (4% of controls) exhibited cognitive impairment (P = 0.008) defined, for the purposes of this study, as total modified CSI‘D’ score below 2 SD of the mean score of the control group. Cognitive dysfunction in patients with PD encompassed memory, language, and executive dysfunction. Correlates of cognitive dysfunction included older age at PD onset (P = 0.001), older current age (P < 0.001), and higher UPDRS motor score (P = 0.005). After logistic regression, older age at onset of PD was the only independent predictor of cognitive dysfunction. (O.R = 1.29; 95% CI = 1.08–1.57, P = 0.006). Cognitive dysfunction occurs more frequently in Nigerians with PD compared to controls. Older age at disease onset is an important determinant of cognitive dysfunction in PD. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22087
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ISTEX:FF0A2A7AC43B3905CC63708C27059C11F9D0DA05Le document en format XML
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Akinyemi</name><affiliation><mods:affiliation>Division of Neurology, Department of Medicine, Federal Medical Centre, Abeokuta, Nigeria</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Neurology, Department of Medicine, University College Hospital, Ibadan, Nigeria</mods:affiliation></affiliation></author><author><name sortKey="Okubadejo, Njideka N" sort="Okubadejo, Njideka N" uniqKey="Okubadejo N" first="Njideka N." last="Okubadejo">Njideka N. Okubadejo</name><affiliation><mods:affiliation>Division of Neurology, Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria</mods:affiliation></affiliation></author><author><name sortKey="Akinyemi, Joshua O" sort="Akinyemi, Joshua O" uniqKey="Akinyemi J" first="Joshua O." last="Akinyemi">Joshua O. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-07-30">2008-07-30</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1378">1378</biblScope><biblScope unit="page" to="1383">1383</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">FF0A2A7AC43B3905CC63708C27059C11F9D0DA05</idno><idno type="DOI">10.1002/mds.22087</idno><idno type="ArticleID">MDS22087</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africans</term><term>Nigerians</term><term>Parkinson's disease</term><term>cognitive dysfunction</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite the original description of Parkinson's disease (PD) as a disorder in which “the senses and intellect remain uninjured,” there is now sufficient evidence that cognitive dysfunction does occur. This research determined the frequency, pattern, and predictors of cognitive dysfunction among 51 Nigerian patients with PD compared with 50 demographically matched controls using the modified Community Screening Instrument for Dementia (CSI‘D’) and selected items from the Ibadan Neuropsychological Battery (I‐NB). In all, 21.6% patients with PD (4% of controls) exhibited cognitive impairment (P = 0.008) defined, for the purposes of this study, as total modified CSI‘D’ score below 2 SD of the mean score of the control group. Cognitive dysfunction in patients with PD encompassed memory, language, and executive dysfunction. Correlates of cognitive dysfunction included older age at PD onset (P = 0.001), older current age (P < 0.001), and higher UPDRS motor score (P = 0.005). After logistic regression, older age at onset of PD was the only independent predictor of cognitive dysfunction. (O.R = 1.29; 95% CI = 1.08–1.57, P = 0.006). Cognitive dysfunction occurs more frequently in Nigerians with PD compared to controls. Older age at disease onset is an important determinant of cognitive dysfunction in PD. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Rufus O. Akinyemi MSc, FMCP</name><affiliations><json:string>Division of Neurology, Department of Medicine, Federal Medical Centre, Abeokuta, Nigeria</json:string><json:string>Division of Neurology, Department of Medicine, University College Hospital, Ibadan, Nigeria</json:string></affiliations></json:item><json:item><name>Njideka N. Okubadejo FMCP</name><affiliations><json:string>Division of Neurology, Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria</json:string></affiliations></json:item><json:item><name>Joshua O. Akinyemi MSc</name><affiliations><json:string>Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Ibadan, Nigeria</json:string></affiliations></json:item><json:item><name>Mayowa O. Owolabi FMCP</name><affiliations><json:string>Division of Neurology, Department of Medicine, University College Hospital, Ibadan, Nigeria</json:string></affiliations></json:item><json:item><name>Lukman F. Owolabi FMCP</name><affiliations><json:string>Division of Neurology, Department of Medicine, University College Hospital, Ibadan, Nigeria</json:string></affiliations></json:item><json:item><name>Adesola Ogunniyi FRCP</name><affiliations><json:string>Division of Neurology, Department of Medicine, University College Hospital, Ibadan, Nigeria</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cognitive dysfunction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Nigerians</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Africans</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Despite the original description of Parkinson's disease (PD) as a disorder in which “the senses and intellect remain uninjured,” there is now sufficient evidence that cognitive dysfunction does occur. This research determined the frequency, pattern, and predictors of cognitive dysfunction among 51 Nigerian patients with PD compared with 50 demographically matched controls using the modified Community Screening Instrument for Dementia (CSI‘D’) and selected items from the Ibadan Neuropsychological Battery (I‐NB). In all, 21.6% patients with PD (4% of controls) exhibited cognitive impairment (P = 0.008) defined, for the purposes of this study, as total modified CSI‘D’ score below 2 SD of the mean score of the control group. Cognitive dysfunction in patients with PD encompassed memory, language, and executive dysfunction. Correlates of cognitive dysfunction included older age at PD onset (P = 0.001), older current age (P > 0.001), and higher UPDRS motor score (P = 0.005). After logistic regression, older age at onset of PD was the only independent predictor of cognitive dysfunction. (O.R = 1.29; 95% CI = 1.08–1.57, P = 0.006). Cognitive dysfunction occurs more frequently in Nigerians with PD compared to controls. 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Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-07-30"></date><biblScope unit="vol">23</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1378">1378</biblScope><biblScope unit="page" to="1383">1383</biblScope></imprint></monogr><idno type="istex">FF0A2A7AC43B3905CC63708C27059C11F9D0DA05</idno><idno type="DOI">10.1002/mds.22087</idno><idno type="ArticleID">MDS22087</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Despite the original description of Parkinson's disease (PD) as a disorder in which “the senses and intellect remain uninjured,” there is now sufficient evidence that cognitive dysfunction does occur. This research determined the frequency, pattern, and predictors of cognitive dysfunction among 51 Nigerian patients with PD compared with 50 demographically matched controls using the modified Community Screening Instrument for Dementia (CSI‘D’) and selected items from the Ibadan Neuropsychological Battery (I‐NB). In all, 21.6% patients with PD (4% of controls) exhibited cognitive impairment (P = 0.008) defined, for the purposes of this study, as total modified CSI‘D’ score below 2 SD of the mean score of the control group. Cognitive dysfunction in patients with PD encompassed memory, language, and executive dysfunction. Correlates of cognitive dysfunction included older age at PD onset (P = 0.001), older current age (P < 0.001), and higher UPDRS motor score (P = 0.005). After logistic regression, older age at onset of PD was the only independent predictor of cognitive dysfunction. (O.R = 1.29; 95% CI = 1.08–1.57, P = 0.006). Cognitive dysfunction occurs more frequently in Nigerians with PD compared to controls. Older age at disease onset is an important determinant of cognitive dysfunction in PD. © 2008 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>cognitive dysfunction</term></item><item><term>Nigerians</term></item><item><term>Africans</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-10-26">Received</change><change when="2008-03-23">Registration</change><change when="2008-07-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/FF0A2A7AC43B3905CC63708C27059C11F9D0DA05/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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xml:id="au3" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Joshua O.</givenNames><familyName>Akinyemi</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Mayowa O.</givenNames><familyName>Owolabi</familyName><degrees>FMCP</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Lukman F.</givenNames><familyName>Owolabi</familyName><degrees>FMCP</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Adesola</givenNames><familyName>Ogunniyi</familyName><degrees>FRCP</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="NG" type="organization"><unparsedAffiliation>Division of Neurology, Department of Medicine, Federal Medical Centre, Abeokuta, Nigeria</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="NG" type="organization"><unparsedAffiliation>Division of Neurology, Department of Medicine, University College Hospital, Ibadan, Nigeria</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="NG" type="organization"><unparsedAffiliation>Division of Neurology, Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="NG" type="organization"><unparsedAffiliation>Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Ibadan, Nigeria</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">cognitive dysfunction</keyword><keyword xml:id="kwd3">Nigerians</keyword><keyword xml:id="kwd4">Africans</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Despite the original description of Parkinson's disease (PD) as a disorder in which “<i>the senses and intellect remain uninjured</i>,” there is now sufficient evidence that cognitive dysfunction does occur. This research determined the frequency, pattern, and predictors of cognitive dysfunction among 51 Nigerian patients with PD compared with 50 demographically matched controls using the modified Community Screening Instrument for Dementia (CSI‘D’) and selected items from the Ibadan Neuropsychological Battery (I‐NB). In all, 21.6% patients with PD (4% of controls) exhibited cognitive impairment (<i>P</i> = 0.008) defined, for the purposes of this study, as total modified CSI‘D’ score below 2 SD of the mean score of the control group. Cognitive dysfunction in patients with PD encompassed memory, language, and executive dysfunction. Correlates of cognitive dysfunction included older age at PD onset (<i>P</i> = 0.001), older current age (<i>P</i> < 0.001), and higher UPDRS motor score (<i>P</i> = 0.005). After logistic regression, older age at onset of PD was the only independent predictor of cognitive dysfunction. (O.R = 1.29; 95% CI = 1.08–1.57, <i>P</i> = 0.006). Cognitive dysfunction occurs more frequently in Nigerians with PD compared to controls. Older age at disease onset is an important determinant of cognitive dysfunction in PD. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Cognitive dysfunction in Nigerians with Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Cognitive Dysfunction in Nigerians with PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Cognitive dysfunction in Nigerians with Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Rufus O.</namePart><namePart type="family">Akinyemi</namePart><namePart type="termsOfAddress">MSc, FMCP</namePart><affiliation>Division of Neurology, Department of Medicine, Federal Medical Centre, Abeokuta, Nigeria</affiliation><affiliation>Division of Neurology, Department of Medicine, University College Hospital, Ibadan, Nigeria</affiliation><description>Correspondence: Division of Neurology, Department of Medicine, Federal Medical Centre, PMB 3031 Sapon, Abeokuta, Nigeria</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Njideka N.</namePart><namePart type="family">Okubadejo</namePart><namePart type="termsOfAddress">FMCP</namePart><affiliation>Division of Neurology, Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joshua O.</namePart><namePart type="family">Akinyemi</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Ibadan, Nigeria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mayowa O.</namePart><namePart type="family">Owolabi</namePart><namePart type="termsOfAddress">FMCP</namePart><affiliation>Division of Neurology, Department of Medicine, University College Hospital, Ibadan, Nigeria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lukman F.</namePart><namePart type="family">Owolabi</namePart><namePart type="termsOfAddress">FMCP</namePart><affiliation>Division of Neurology, Department of Medicine, University College Hospital, Ibadan, Nigeria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Adesola</namePart><namePart type="family">Ogunniyi</namePart><namePart type="termsOfAddress">FRCP</namePart><affiliation>Division of Neurology, Department of Medicine, University College Hospital, Ibadan, Nigeria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-07-30</dateIssued><dateCaptured encoding="w3cdtf">2007-10-26</dateCaptured><dateValid encoding="w3cdtf">2008-03-23</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">43</extent><extent unit="words">4767</extent></physicalDescription><abstract lang="en">Despite the original description of Parkinson's disease (PD) as a disorder in which “the senses and intellect remain uninjured,” there is now sufficient evidence that cognitive dysfunction does occur. This research determined the frequency, pattern, and predictors of cognitive dysfunction among 51 Nigerian patients with PD compared with 50 demographically matched controls using the modified Community Screening Instrument for Dementia (CSI‘D’) and selected items from the Ibadan Neuropsychological Battery (I‐NB). In all, 21.6% patients with PD (4% of controls) exhibited cognitive impairment (P = 0.008) defined, for the purposes of this study, as total modified CSI‘D’ score below 2 SD of the mean score of the control group. Cognitive dysfunction in patients with PD encompassed memory, language, and executive dysfunction. Correlates of cognitive dysfunction included older age at PD onset (P = 0.001), older current age (P < 0.001), and higher UPDRS motor score (P = 0.005). After logistic regression, older age at onset of PD was the only independent predictor of cognitive dysfunction. (O.R = 1.29; 95% CI = 1.08–1.57, P = 0.006). Cognitive dysfunction occurs more frequently in Nigerians with PD compared to controls. Older age at disease onset is an important determinant of cognitive dysfunction in PD. © 2008 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>cognitive dysfunction</topic><topic>Nigerians</topic><topic>Africans</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1378</start><end>1383</end><total>6</total></extent></part></relatedItem><identifier type="istex">FF0A2A7AC43B3905CC63708C27059C11F9D0DA05</identifier><identifier type="DOI">10.1002/mds.22087</identifier><identifier type="ArticleID">MDS22087</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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