TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea
Identifieur interne : 001540 ( Istex/Corpus ); précédent : 001539; suivant : 001541TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea
Auteurs : Gabor G. Kovacs ; Jill R. Murrell ; Sandor Horvath ; Laszlo Haraszti ; Katalin Majtenyi ; Maria J. Molnar ; Herbert Budka ; Bernardino Ghetti ; Salvatore SpinaSource :
- Movement Disorders [ 0885-3185 ] ; 2009-09-15.
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Abstract
TDP‐43 has been identified as the pathological protein in the majority of cases of frontotemporal lobar degeneration and amyotrophic lateral sclerosis (ALS). TARDBP mutations have so far been uniquely associated with familial and sporadic ALS. We describe clinicopathological and genetic findings in a carrier of the novel K263E TARDBP variation, who developed frontotemporal dementia, supranuclear palsy, and chorea, but no signs of motor neuron disease. Neuropathologic examination revealed neuronal and glial TDP‐43‐immunoreactive deposits, predominantly in subcortical nuclei and brainstem. This is the first report of a TARDBP variation associated with a neurodegenerative syndrome other than ALS. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22697
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ISTEX:AB2FE497E09C8ADC123DB97AAB3BA90DC1E8CC8FLe document en format XML
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TARDBP mutations have so far been uniquely associated with familial and sporadic ALS. We describe clinicopathological and genetic findings in a carrier of the novel K263E TARDBP variation, who developed frontotemporal dementia, supranuclear palsy, and chorea, but no signs of motor neuron disease. Neuropathologic examination revealed neuronal and glial TDP‐43‐immunoreactive deposits, predominantly in subcortical nuclei and brainstem. This is the first report of a TARDBP variation associated with a neurodegenerative syndrome other than ALS. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Gabor G. 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Murrell PhD</name><affiliations><json:string>Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA</json:string></affiliations></json:item><json:item><name>Sandor Horvath MD, PhD</name><affiliations><json:string>Department of Neurology, Ferenc Flor Hospital, Kistarcsa, Hungary</json:string></affiliations></json:item><json:item><name>Laszlo Haraszti MD, PhD</name><affiliations><json:string>Department of Psychiatry, Ferenc Flor Hospital, Kistarcsa, Hungary</json:string></affiliations></json:item><json:item><name>Katalin Majtenyi MD, PhD</name><affiliations><json:string>National Institute of Psychiatry and Neurology, Budapest, Hungary</json:string></affiliations></json:item><json:item><name>Maria J. Molnar MD, PhD</name><affiliations><json:string>Clinical and Research Centre for Molecular Neurology, Semmelweis University, Budapest, Hungary</json:string></affiliations></json:item><json:item><name>Herbert Budka MD, MScDhc</name><affiliations><json:string>Institute of Neurology, Medical University of Vienna, Vienna, Austria</json:string></affiliations></json:item><json:item><name>Bernardino Ghetti MD</name><affiliations><json:string>Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA</json:string></affiliations></json:item><json:item><name>Salvatore Spina MD</name><affiliations><json:string>Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA</json:string><json:string>Department of Neurological, Neurosurgical and Behavioral Sciences, University of Siena, Siena, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>TDP‐43</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>atypical dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>amyotrophic lateral sclerosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>movement disorders</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>neuropathology</value></json:item></subject><language><json:string>eng</json:string></language><abstract>TDP‐43 has been identified as the pathological protein in the majority of cases of frontotemporal lobar degeneration and amyotrophic lateral sclerosis (ALS). TARDBP mutations have so far been uniquely associated with familial and sporadic ALS. We describe clinicopathological and genetic findings in a carrier of the novel K263E TARDBP variation, who developed frontotemporal dementia, supranuclear palsy, and chorea, but no signs of motor neuron disease. Neuropathologic examination revealed neuronal and glial TDP‐43‐immunoreactive deposits, predominantly in subcortical nuclei and brainstem. 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No. BNEII No LSHM‐CT‐2004‐503039;</note><note>Department of Neurological</note><note>Neurosurgical and Behavioral Sciences</note><note>University of Siena, Siena, Italy</note><note>National Cell Repository for Alzheimer's Disease (NCRAD) - No. U24 AG21886;</note><note>National Institute on Aging (NIA)</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea</title><author><persName><forename type="first">Gabor G.</forename><surname>Kovacs</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Institute of Neurology, Medical University of Vienna, Vienna, Austria</affiliation><affiliation>Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA</affiliation><affiliation>National Institute of Psychiatry and Neurology, Budapest, Hungary</affiliation></author><author><persName><forename type="first">Jill R.</forename><surname>Murrell</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA</affiliation></author><author><persName><forename type="first">Sandor</forename><surname>Horvath</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Neurology, Ferenc Flor Hospital, Kistarcsa, Hungary</affiliation></author><author><persName><forename type="first">Laszlo</forename><surname>Haraszti</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Psychiatry, Ferenc Flor Hospital, Kistarcsa, Hungary</affiliation></author><author><persName><forename type="first">Katalin</forename><surname>Majtenyi</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>National Institute of Psychiatry and Neurology, Budapest, Hungary</affiliation></author><author><persName><forename type="first">Maria J.</forename><surname>Molnar</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Clinical and Research Centre for Molecular Neurology, Semmelweis University, Budapest, Hungary</affiliation></author><author><persName><forename type="first">Herbert</forename><surname>Budka</surname><roleName type="degree">MD, MScDhc</roleName></persName><affiliation>Institute of Neurology, Medical University of Vienna, Vienna, Austria</affiliation></author><author><persName><forename type="first">Bernardino</forename><surname>Ghetti</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA</affiliation></author><author><persName><forename type="first">Salvatore</forename><surname>Spina</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Medical Science Building A134, 635 Barnhill Drive, Indianapolis, Indiana 46202</p></note><affiliation>Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA</affiliation><affiliation>Department of Neurological, Neurosurgical and Behavioral Sciences, University of Siena, Siena, Italy</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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TARDBP mutations have so far been uniquely associated with familial and sporadic ALS. We describe clinicopathological and genetic findings in a carrier of the novel K263E TARDBP variation, who developed frontotemporal dementia, supranuclear palsy, and chorea, but no signs of motor neuron disease. Neuropathologic examination revealed neuronal and glial TDP‐43‐immunoreactive deposits, predominantly in subcortical nuclei and brainstem. This is the first report of a TARDBP variation associated with a neurodegenerative syndrome other than ALS. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>TDP‐43</term></item><item><term>atypical dementia</term></item><item><term>amyotrophic lateral sclerosis</term></item><item><term>movement disorders</term></item><item><term>neuropathology</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-02-03">Received</change><change when="2009-06-12">Registration</change><change when="2009-09-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/AB2FE497E09C8ADC123DB97AAB3BA90DC1E8CC8F/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="120"><doi origin="wiley" registered="yes">10.1002/mds.v24:12</doi><numberingGroup><numbering type="journalVolume" number="24">24</numbering><numbering type="journalIssue">12</numbering></numberingGroup><coverDate startDate="2009-09-15">15 September 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="18" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22697</doi><idGroup><id type="unit" value="MDS22697"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">Copyright © 2009 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2009-02-03"></event><event type="manuscriptRevised" date="2009-05-07"></event><event type="manuscriptAccepted" date="2009-06-12"></event><event type="publishedOnlineEarlyUnpaginated" date="2009-07-16"></event><event type="firstOnline" date="2009-07-16"></event><event type="publishedOnlineFinalForm" date="2009-09-11"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.15 mode:FullText source:FullText result:FullText" date="2010-07-15"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1842</numbering><numbering type="pageLast">1847</numbering></numberingGroup><correspondenceTo>Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Medical Science Building A134, 635 Barnhill Drive, Indianapolis, Indiana 46202</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22697.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="20"></count><count type="wordTotal" number="3319"></count></countGroup><titleGroup><title type="main" xml:lang="en"><i>TARDBP</i> variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea<link href="#fn2"></link></title><title type="short" xml:lang="en"><fi>TARDBP</fi> Variation and Frontotemporal Dementia</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af3"><personName><givenNames>Gabor G.</givenNames><familyName>Kovacs</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Jill R.</givenNames><familyName>Murrell</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Sandor</givenNames><familyName>Horvath</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Laszlo</givenNames><familyName>Haraszti</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Katalin</givenNames><familyName>Majtenyi</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Maria J.</givenNames><familyName>Molnar</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Herbert</givenNames><familyName>Budka</familyName><degrees>MD, MScDhc</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Bernardino</givenNames><familyName>Ghetti</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af2 #af7" corresponding="yes"><personName><givenNames>Salvatore</givenNames><familyName>Spina</familyName><degrees>MD</degrees></personName><contactDetails><email>sspina@iupui.edu</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="AT" type="organization"><unparsedAffiliation>Institute of Neurology, Medical University of Vienna, Vienna, Austria</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="HU" type="organization"><unparsedAffiliation>National Institute of Psychiatry and Neurology, Budapest, Hungary</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="HU" type="organization"><unparsedAffiliation>Department of Neurology, Ferenc Flor Hospital, Kistarcsa, Hungary</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="HU" type="organization"><unparsedAffiliation>Department of Psychiatry, Ferenc Flor Hospital, Kistarcsa, Hungary</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="HU" type="organization"><unparsedAffiliation>Clinical and Research Centre for Molecular Neurology, Semmelweis University, Budapest, Hungary</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurological, Neurosurgical and Behavioral Sciences, University of Siena, Siena, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">TDP‐43</keyword><keyword xml:id="kwd2">atypical dementia</keyword><keyword xml:id="kwd3">amyotrophic lateral sclerosis</keyword><keyword xml:id="kwd4">movement disorders</keyword><keyword xml:id="kwd5">neuropathology</keyword></keywordGroup><fundingInfo><fundingAgency>NIH</fundingAgency><fundingNumber>AG010133</fundingNumber></fundingInfo><fundingInfo><fundingAgency>EU</fundingAgency><fundingNumber>FP6</fundingNumber><fundingNumber>BNEII No LSHM‐CT‐2004‐503039</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Department of Neurological</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Neurosurgical and Behavioral Sciences</fundingAgency></fundingInfo><fundingInfo><fundingAgency>University of Siena, Siena, Italy</fundingAgency></fundingInfo><fundingInfo><fundingAgency>National Cell Repository for Alzheimer's Disease (NCRAD)</fundingAgency><fundingNumber>U24 AG21886</fundingNumber></fundingInfo><fundingInfo><fundingAgency>National Institute on Aging (NIA)</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>TDP‐43 has been identified as the pathological protein in the majority of cases of frontotemporal lobar degeneration and amyotrophic lateral sclerosis (ALS). <i>TARDBP</i> mutations have so far been uniquely associated with familial and sporadic ALS. We describe clinicopathological and genetic findings in a carrier of the novel K263E <i>TARDBP</i> variation, who developed frontotemporal dementia, supranuclear palsy, and chorea, but no signs of motor neuron disease. Neuropathologic examination revealed neuronal and glial TDP‐43‐immunoreactive deposits, predominantly in subcortical nuclei and brainstem. This is the first report of a <i>TARDBP</i> variation associated with a neurodegenerative syndrome other than ALS. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn2"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>TARDBP Variation and Frontotemporal Dementia</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea</title></titleInfo><name type="personal"><namePart type="given">Gabor G.</namePart><namePart type="family">Kovacs</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Institute of Neurology, Medical University of Vienna, Vienna, Austria</affiliation><affiliation>Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA</affiliation><affiliation>National Institute of Psychiatry and Neurology, Budapest, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jill R.</namePart><namePart type="family">Murrell</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sandor</namePart><namePart type="family">Horvath</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Ferenc Flor Hospital, Kistarcsa, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laszlo</namePart><namePart type="family">Haraszti</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Psychiatry, Ferenc Flor Hospital, Kistarcsa, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Katalin</namePart><namePart type="family">Majtenyi</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>National Institute of Psychiatry and Neurology, Budapest, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maria J.</namePart><namePart type="family">Molnar</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Clinical and Research Centre for Molecular Neurology, Semmelweis University, Budapest, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Herbert</namePart><namePart type="family">Budka</namePart><namePart type="termsOfAddress">MD, MScDhc</namePart><affiliation>Institute of Neurology, Medical University of Vienna, Vienna, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bernardino</namePart><namePart type="family">Ghetti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Salvatore</namePart><namePart type="family">Spina</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA</affiliation><affiliation>Department of Neurological, Neurosurgical and Behavioral Sciences, University of Siena, Siena, Italy</affiliation><description>Correspondence: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Medical Science Building A134, 635 Barnhill Drive, Indianapolis, Indiana 46202</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-09-15</dateIssued><dateCaptured encoding="w3cdtf">2009-02-03</dateCaptured><dateValid encoding="w3cdtf">2009-06-12</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">20</extent><extent unit="words">3319</extent></physicalDescription><abstract lang="en">TDP‐43 has been identified as the pathological protein in the majority of cases of frontotemporal lobar degeneration and amyotrophic lateral sclerosis (ALS). TARDBP mutations have so far been uniquely associated with familial and sporadic ALS. We describe clinicopathological and genetic findings in a carrier of the novel K263E TARDBP variation, who developed frontotemporal dementia, supranuclear palsy, and chorea, but no signs of motor neuron disease. Neuropathologic examination revealed neuronal and glial TDP‐43‐immunoreactive deposits, predominantly in subcortical nuclei and brainstem. This is the first report of a TARDBP variation associated with a neurodegenerative syndrome other than ALS. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><note type="funding">NIH - No. AG010133; </note><note type="funding">EU - No. FP6; No. BNEII No LSHM‐CT‐2004‐503039; </note><note type="funding">Department of Neurological</note><note type="funding">Neurosurgical and Behavioral Sciences</note><note type="funding">University of Siena, Siena, Italy</note><note type="funding">National Cell Repository for Alzheimer's Disease (NCRAD) - No. U24 AG21886; </note><note type="funding">National Institute on Aging (NIA)</note><subject lang="en"><genre>Keywords</genre><topic>TDP‐43</topic><topic>atypical dementia</topic><topic>amyotrophic lateral sclerosis</topic><topic>movement disorders</topic><topic>neuropathology</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>1842</start><end>1847</end><total>6</total></extent></part></relatedItem><identifier type="istex">AB2FE497E09C8ADC123DB97AAB3BA90DC1E8CC8F</identifier><identifier type="DOI">10.1002/mds.22697</identifier><identifier type="ArticleID">MDS22697</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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