Factors predicting improvement in primary generalized dystonia treated by pallidal deep brain stimulation
Identifieur interne : 001434 ( Istex/Corpus ); précédent : 001433; suivant : 001435Factors predicting improvement in primary generalized dystonia treated by pallidal deep brain stimulation
Auteurs : Xavier Vasques ; Laura Cif ; Victoria Gonzalez ; Claire Nicholson ; Philippe CoubesSource :
- Movement Disorders [ 0885-3185 ] ; 2009-04-30.
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Abstract
Despite the beneficial effects of Globus Pallidus internus (GPi) deep brain stimulation (DBS) in patients with primary generalized dystonia (PGD), the degree of improvement varies from one patient to another. The objective of this study was to examine the effects of clinical, anatomical (volume of the GPi), and electrical variables on the postoperative Burke‐Fahn‐Marsden Dystonia rating scale (BFMDRS) motor score to identify which factors may be predictive of the degree of improvement. We reviewed retrospectively the clinical records of 40 steady‐state patients with PGD who had been treated by bilateral GPi lead implantation. The follow‐up period was 2 to 8 years. The correlation between the electrical parameters (voltage, impedance, and current) and the clinical outcome was studied. An analysis of covariance was performed to identify factors predictive of the magnitude of improvement. The most influential factors according to the model are as follows: the preoperative BFMDRS score (P < 0.0001); age at surgery (P < 0.0001); the right GPi volume (P = 0.002); the left stimulated GPi volume (P = 0.005). No significant correlation was found between the electrical parameters used and the mean motor scores in steady state. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22433
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The objective of this study was to examine the effects of clinical, anatomical (volume of the GPi), and electrical variables on the postoperative Burke‐Fahn‐Marsden Dystonia rating scale (BFMDRS) motor score to identify which factors may be predictive of the degree of improvement. We reviewed retrospectively the clinical records of 40 steady‐state patients with PGD who had been treated by bilateral GPi lead implantation. The follow‐up period was 2 to 8 years. The correlation between the electrical parameters (voltage, impedance, and current) and the clinical outcome was studied. An analysis of covariance was performed to identify factors predictive of the magnitude of improvement. The most influential factors according to the model are as follows: the preoperative BFMDRS score (P < 0.0001); age at surgery (P < 0.0001); the right GPi volume (P = 0.002); the left stimulated GPi volume (P = 0.005). No significant correlation was found between the electrical parameters used and the mean motor scores in steady state. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Xavier Vasques PhD</name><affiliations><json:string>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</json:string><json:string>IGF, Montpellier, France</json:string><json:string>CNRS, UMRS203, Montpellier, France</json:string><json:string>INSERM, U06‐1, Montpellier, France</json:string><json:string>Univ Montpellier I, Montpellier, France</json:string></affiliations></json:item><json:item><name>Laura Cif MD</name><affiliations><json:string>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</json:string><json:string>IGF, Montpellier, France</json:string><json:string>CNRS, UMRS203, Montpellier, France</json:string><json:string>INSERM, U06‐1, Montpellier, France</json:string><json:string>Univ Montpellier I, Montpellier, France</json:string></affiliations></json:item><json:item><name>Victoria Gonzalez MD</name><affiliations><json:string>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</json:string><json:string>IGF, Montpellier, France</json:string><json:string>CNRS, UMRS203, Montpellier, France</json:string><json:string>INSERM, U06‐1, Montpellier, France</json:string><json:string>Univ Montpellier I, Montpellier, France</json:string></affiliations></json:item><json:item><name>Claire Nicholson MD</name><affiliations><json:string>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</json:string><json:string>IGF, Montpellier, France</json:string><json:string>CNRS, UMRS203, Montpellier, France</json:string><json:string>INSERM, U06‐1, Montpellier, France</json:string><json:string>Univ Montpellier I, Montpellier, France</json:string></affiliations></json:item><json:item><name>Philippe Coubes MD, PhD</name><affiliations><json:string>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</json:string><json:string>IGF, Montpellier, France</json:string><json:string>CNRS, UMRS203, Montpellier, France</json:string><json:string>INSERM, U06‐1, Montpellier, France</json:string><json:string>Univ Montpellier I, Montpellier, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>primary generalized dystonia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>deep brain stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>clinical outcome predictors</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>globus pallidus internus</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Despite the beneficial effects of Globus Pallidus internus (GPi) deep brain stimulation (DBS) in patients with primary generalized dystonia (PGD), the degree of improvement varies from one patient to another. The objective of this study was to examine the effects of clinical, anatomical (volume of the GPi), and electrical variables on the postoperative Burke‐Fahn‐Marsden Dystonia rating scale (BFMDRS) motor score to identify which factors may be predictive of the degree of improvement. We reviewed retrospectively the clinical records of 40 steady‐state patients with PGD who had been treated by bilateral GPi lead implantation. The follow‐up period was 2 to 8 years. The correlation between the electrical parameters (voltage, impedance, and current) and the clinical outcome was studied. An analysis of covariance was performed to identify factors predictive of the magnitude of improvement. The most influential factors according to the model are as follows: the preoperative BFMDRS score (P > 0.0001); age at surgery (P > 0.0001); the right GPi volume (P = 0.002); the left stimulated GPi volume (P = 0.005). 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The objective of this study was to examine the effects of clinical, anatomical (volume of the GPi), and electrical variables on the postoperative Burke‐Fahn‐Marsden Dystonia rating scale (BFMDRS) motor score to identify which factors may be predictive of the degree of improvement. We reviewed retrospectively the clinical records of 40 steady‐state patients with PGD who had been treated by bilateral GPi lead implantation. The follow‐up period was 2 to 8 years. The correlation between the electrical parameters (voltage, impedance, and current) and the clinical outcome was studied. An analysis of covariance was performed to identify factors predictive of the magnitude of improvement. The most influential factors according to the model are as follows: the preoperative BFMDRS score (P < 0.0001); age at surgery (P < 0.0001); the right GPi volume (P = 0.002); the left stimulated GPi volume (P = 0.005). 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Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="60"><doi origin="wiley" registered="yes">10.1002/mds.v24:6</doi><numberingGroup><numbering type="journalVolume" number="24">24</numbering><numbering type="journalIssue">6</numbering></numberingGroup><coverDate startDate="2009-04-30">30 April 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="80" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22433</doi><idGroup><id type="unit" value="MDS22433"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2009 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2008-07-15"></event><event type="manuscriptRevised" date="2008-10-09"></event><event 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href="file:MDS.MDS22433.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="47"></count><count type="wordTotal" number="6365"></count></countGroup><titleGroup><title type="main" xml:lang="en">Factors predicting improvement in primary generalized dystonia treated by pallidal deep brain stimulation<link href="#fn1"></link></title><title type="short" xml:lang="en">Factors Predicting Outcome in Dystonia</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af3 #af4 #af5"><personName><givenNames>Xavier</givenNames><familyName>Vasques</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af2 #af3 #af4 #af5"><personName><givenNames>Laura</givenNames><familyName>Cif</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af2 #af3 #af4 #af5"><personName><givenNames>Victoria</givenNames><familyName>Gonzalez</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af2 #af3 #af4 #af5"><personName><givenNames>Claire</givenNames><familyName>Nicholson</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af2 #af3 #af4 #af5" corresponding="yes"><personName><givenNames>Philippe</givenNames><familyName>Coubes</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email normalForm="p-coubes@chu-montpellier.fr">p‐coubes@chu‐montpellier.fr</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="FR" type="organization"><unparsedAffiliation>IGF, Montpellier, France</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="FR" type="organization"><unparsedAffiliation>CNRS, UMRS203, Montpellier, France</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="FR" type="organization"><unparsedAffiliation>INSERM, U06‐1, Montpellier, France</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="FR" type="organization"><unparsedAffiliation>Univ Montpellier I, Montpellier, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">primary generalized dystonia</keyword><keyword xml:id="kwd2">deep brain stimulation</keyword><keyword xml:id="kwd3">clinical outcome predictors</keyword><keyword xml:id="kwd4">globus pallidus internus</keyword></keywordGroup><fundingInfo><fundingAgency>IBM Montpellier</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Products and Solutions Support Center department (PSSC)</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Despite the beneficial effects of Globus Pallidus internus (GPi) deep brain stimulation (DBS) in patients with primary generalized dystonia (PGD), the degree of improvement varies from one patient to another. The objective of this study was to examine the effects of clinical, anatomical (volume of the GPi), and electrical variables on the postoperative Burke‐Fahn‐Marsden Dystonia rating scale (BFMDRS) motor score to identify which factors may be predictive of the degree of improvement. We reviewed retrospectively the clinical records of 40 steady‐state patients with PGD who had been treated by bilateral GPi lead implantation. The follow‐up period was 2 to 8 years. The correlation between the electrical parameters (voltage, impedance, and current) and the clinical outcome was studied. An analysis of covariance was performed to identify factors predictive of the magnitude of improvement. The most influential factors according to the model are as follows: the preoperative BFMDRS score (<i>P</i> < 0.0001); age at surgery (<i>P</i> < 0.0001); the right GPi volume (<i>P</i> = 0.002); the left stimulated GPi volume (<i>P</i> = 0.005). No significant correlation was found between the electrical parameters used and the mean motor scores in steady state. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Factors predicting improvement in primary generalized dystonia treated by pallidal deep brain stimulation</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Factors Predicting Outcome in Dystonia</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Factors predicting improvement in primary generalized dystonia treated by pallidal deep brain stimulation</title></titleInfo><name type="personal"><namePart type="given">Xavier</namePart><namePart type="family">Vasques</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</affiliation><affiliation>IGF, Montpellier, France</affiliation><affiliation>CNRS, UMRS203, Montpellier, France</affiliation><affiliation>INSERM, U06‐1, Montpellier, France</affiliation><affiliation>Univ Montpellier I, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laura</namePart><namePart type="family">Cif</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</affiliation><affiliation>IGF, Montpellier, France</affiliation><affiliation>CNRS, UMRS203, Montpellier, France</affiliation><affiliation>INSERM, U06‐1, Montpellier, France</affiliation><affiliation>Univ Montpellier I, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Victoria</namePart><namePart type="family">Gonzalez</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</affiliation><affiliation>IGF, Montpellier, France</affiliation><affiliation>CNRS, UMRS203, Montpellier, France</affiliation><affiliation>INSERM, U06‐1, Montpellier, France</affiliation><affiliation>Univ Montpellier I, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claire</namePart><namePart type="family">Nicholson</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</affiliation><affiliation>IGF, Montpellier, France</affiliation><affiliation>CNRS, UMRS203, Montpellier, France</affiliation><affiliation>INSERM, U06‐1, Montpellier, France</affiliation><affiliation>Univ Montpellier I, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Philippe</namePart><namePart type="family">Coubes</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>CHRU Montpellier, Service de Neurochirurgie, Montpellier, France</affiliation><affiliation>IGF, Montpellier, France</affiliation><affiliation>CNRS, UMRS203, Montpellier, France</affiliation><affiliation>INSERM, U06‐1, Montpellier, France</affiliation><affiliation>Univ Montpellier I, Montpellier, France</affiliation><description>Correspondence: Unité de Recherche sur les Mouvements Anormaux, Hôpital Gui de Chauliac, 80 Avenue Augustin Fliche, 34295 Montpellier cedex 05, France</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-04-30</dateIssued><dateCaptured encoding="w3cdtf">2008-07-15</dateCaptured><dateValid encoding="w3cdtf">2008-11-27</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">2</extent><extent unit="references">47</extent><extent unit="words">6365</extent></physicalDescription><abstract lang="en">Despite the beneficial effects of Globus Pallidus internus (GPi) deep brain stimulation (DBS) in patients with primary generalized dystonia (PGD), the degree of improvement varies from one patient to another. The objective of this study was to examine the effects of clinical, anatomical (volume of the GPi), and electrical variables on the postoperative Burke‐Fahn‐Marsden Dystonia rating scale (BFMDRS) motor score to identify which factors may be predictive of the degree of improvement. We reviewed retrospectively the clinical records of 40 steady‐state patients with PGD who had been treated by bilateral GPi lead implantation. The follow‐up period was 2 to 8 years. The correlation between the electrical parameters (voltage, impedance, and current) and the clinical outcome was studied. An analysis of covariance was performed to identify factors predictive of the magnitude of improvement. The most influential factors according to the model are as follows: the preoperative BFMDRS score (P < 0.0001); age at surgery (P < 0.0001); the right GPi volume (P = 0.002); the left stimulated GPi volume (P = 0.005). No significant correlation was found between the electrical parameters used and the mean motor scores in steady state. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><note type="funding">IBM Montpellier</note><note type="funding">Products and Solutions Support Center department (PSSC)</note><subject lang="en"><genre>Keywords</genre><topic>primary generalized dystonia</topic><topic>deep brain stimulation</topic><topic>clinical outcome predictors</topic><topic>globus pallidus internus</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>846</start><end>853</end><total>8</total></extent></part></relatedItem><identifier type="istex">C1DC2DE49D6E5A339215E4674BA810BC2B2D5E85</identifier><identifier type="DOI">10.1002/mds.22433</identifier><identifier type="ArticleID">MDS22433</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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