The p.Asp216His TOR1A allele effect is not found in the French population
Identifieur interne : 001412 ( Istex/Corpus ); précédent : 001411; suivant : 001413The p.Asp216His TOR1A allele effect is not found in the French population
Auteurs : Mélissa Yana Frédéric ; Fabienne Clot ; Arnaud Blanchard ; Claire-Marie Dhaenens ; Gaëtan Lesca ; Laura Cif ; Alexandra Dürr ; Marie Vidailhet ; Bernard Sablonniere ; Alain Calender ; Maria Martinez ; Nicolas Molinari ; Alexis Brice ; Mireille Claustres ; Sylvie Tuffery-Giraud ; Gwenaëlle Collod-BeroudSource :
- Movement Disorders [ 0885-3185 ] ; 2009-04-30.
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Abstract
DYT1 dystonia are one of the exceptions in human genetics with its unique and recurrent mutation (c.907delGAG). In this rare movement disorder, the mutation is associated with incomplete penetrance as well as great clinical variability, making this disease a benchmark to search for genetic modifiers. Recently, Risch et al. have demonstrated the implication of the rs1801968 SNP in disease penetrance. We attempted to replicate this result in an exhaustive DYT1 French population with no success. Our results argue that the rs1801968 H allele effect is not part of the modifiers in the French population of DYT1 patients and that others have to be identified in our population. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22407
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ISTEX:DB787F55A9A4FE6C41D77828B89D3783BA73103FLe document en format XML
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Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name><affiliation><mods:affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</mods:affiliation></affiliation><affiliation><mods:affiliation>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</mods:affiliation></affiliation><affiliation><mods:affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Département de Génétique et Cytogénétique, Paris, F‐75013, France</mods:affiliation></affiliation></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name><affiliation><mods:affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</mods:affiliation></affiliation><affiliation><mods:affiliation>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</mods:affiliation></affiliation><affiliation><mods:affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Fédération des Maladies du Système Nerveux, Paris, F‐75013, France</mods:affiliation></affiliation></author><author><name sortKey="Sablonniere, Bernard" sort="Sablonniere, Bernard" uniqKey="Sablonniere B" first="Bernard" last="Sablonniere">Bernard Sablonniere</name><affiliation><mods:affiliation>CHRU de Lille, UF de Neurobiologie, Centre de Biologie‐Pathologie, Lille, F‐59037, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM, U837, Institut de Médecine Prédictive et de Recherche Thérapeutique, Lille, F‐59045, France</mods:affiliation></affiliation></author><author><name sortKey="Calender, Alain" sort="Calender, Alain" uniqKey="Calender A" first="Alain" last="Calender">Alain Calender</name><affiliation><mods:affiliation>Hôpital Edouard Herriot, Service de Génétique Moléculaire et Clinique, Lyon, F‐69437, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université Claude Bernard Lyon 1, Villeurbanne, F‐69622, France</mods:affiliation></affiliation></author><author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name><affiliation><mods:affiliation>INSERM, U563, Toulouse, F‐31024, France</mods:affiliation></affiliation></author><author><name sortKey="Molinari, Nicolas" sort="Molinari, Nicolas" uniqKey="Molinari N" first="Nicolas" last="Molinari">Nicolas Molinari</name><affiliation><mods:affiliation>CHU Nîmes, Département d'Information Médicale, Nîmes, F‐30025, France</mods:affiliation></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation><mods:affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</mods:affiliation></affiliation><affiliation><mods:affiliation>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</mods:affiliation></affiliation><affiliation><mods:affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Département de Génétique et Cytogénétique, Paris, F‐75013, France</mods:affiliation></affiliation><affiliation><mods:affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Fédération des Maladies du Système Nerveux, Paris, F‐75013, France</mods:affiliation></affiliation></author><author><name sortKey="Claustres, Mireille" sort="Claustres, Mireille" uniqKey="Claustres M" first="Mireille" last="Claustres">Mireille Claustres</name><affiliation><mods:affiliation>INSERM, U827, Montpellier, F‐34000, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</mods:affiliation></affiliation><affiliation><mods:affiliation>CHU Montpellier, Hôpital Arnaud de Villeneuve, Laboratoire de Génétique Moléculaire, Montpellier, F‐34000, France</mods:affiliation></affiliation></author><author><name sortKey="Tuffery Iraud, Sylvie" sort="Tuffery Iraud, Sylvie" uniqKey="Tuffery Iraud S" first="Sylvie" last="Tuffery-Giraud">Sylvie Tuffery-Giraud</name><affiliation><mods:affiliation>INSERM, U827, Montpellier, F‐34000, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</mods:affiliation></affiliation></author><author><name sortKey="Collod Eroud, Gwenaelle" sort="Collod Eroud, Gwenaelle" uniqKey="Collod Eroud G" first="Gwenaëlle" last="Collod-Beroud">Gwenaëlle Collod-Beroud</name><affiliation><mods:affiliation>INSERM, U827, Montpellier, F‐34000, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DB787F55A9A4FE6C41D77828B89D3783BA73103F</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22407</idno><idno type="url">https://api.istex.fr/document/DB787F55A9A4FE6C41D77828B89D3783BA73103F/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001412</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The p.Asp216His TOR1A allele effect is not found in the French population</title><author><name sortKey="Frederic, Melissa Yana" sort="Frederic, Melissa Yana" uniqKey="Frederic M" first="Mélissa Yana" last="Frédéric">Mélissa Yana Frédéric</name><affiliation><mods:affiliation>INSERM, U827, Montpellier, F‐34000, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</mods:affiliation></affiliation></author><author><name sortKey="Clot, Fabienne" sort="Clot, Fabienne" uniqKey="Clot F" first="Fabienne" last="Clot">Fabienne Clot</name><affiliation><mods:affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</mods:affiliation></affiliation><affiliation><mods:affiliation>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</mods:affiliation></affiliation><affiliation><mods:affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Département de Génétique et Cytogénétique, Paris, F‐75013, France</mods:affiliation></affiliation></author><author><name sortKey="Blanchard, Arnaud" sort="Blanchard, Arnaud" uniqKey="Blanchard A" first="Arnaud" last="Blanchard">Arnaud Blanchard</name><affiliation><mods:affiliation>INSERM, U827, Montpellier, F‐34000, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</mods:affiliation></affiliation></author><author><name sortKey="Dhaenens, Claire Arie" sort="Dhaenens, Claire Arie" uniqKey="Dhaenens C" first="Claire-Marie" last="Dhaenens">Claire-Marie Dhaenens</name><affiliation><mods:affiliation>CHRU de Lille, UF de Neurobiologie, Centre de Biologie‐Pathologie, Lille, F‐59037, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM, U837, Institut de Médecine Prédictive et de Recherche Thérapeutique, Lille, F‐59045, France</mods:affiliation></affiliation></author><author><name sortKey="Lesca, Gaetan" sort="Lesca, Gaetan" uniqKey="Lesca G" first="Gaëtan" last="Lesca">Gaëtan Lesca</name><affiliation><mods:affiliation>Hôpital Edouard Herriot, Service de Génétique Moléculaire et Clinique, Lyon, F‐69437, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université Claude Bernard Lyon 1, Villeurbanne, F‐69622, France</mods:affiliation></affiliation></author><author><name sortKey="Cif, Laura" sort="Cif, Laura" uniqKey="Cif L" first="Laura" last="Cif">Laura Cif</name><affiliation><mods:affiliation>CHU Montpellier, Hôpital Guy de Chauliac, Service de Neurochirurgie, Montpellier, F‐34000, France</mods:affiliation></affiliation></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name><affiliation><mods:affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</mods:affiliation></affiliation><affiliation><mods:affiliation>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</mods:affiliation></affiliation><affiliation><mods:affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Département de Génétique et Cytogénétique, Paris, F‐75013, France</mods:affiliation></affiliation></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name><affiliation><mods:affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</mods:affiliation></affiliation><affiliation><mods:affiliation>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</mods:affiliation></affiliation><affiliation><mods:affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Fédération des Maladies du Système Nerveux, Paris, F‐75013, France</mods:affiliation></affiliation></author><author><name sortKey="Sablonniere, Bernard" sort="Sablonniere, Bernard" uniqKey="Sablonniere B" first="Bernard" last="Sablonniere">Bernard Sablonniere</name><affiliation><mods:affiliation>CHRU de Lille, UF de Neurobiologie, Centre de Biologie‐Pathologie, Lille, F‐59037, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM, U837, Institut de Médecine Prédictive et de Recherche Thérapeutique, Lille, F‐59045, France</mods:affiliation></affiliation></author><author><name sortKey="Calender, Alain" sort="Calender, Alain" uniqKey="Calender A" first="Alain" last="Calender">Alain Calender</name><affiliation><mods:affiliation>Hôpital Edouard Herriot, Service de Génétique Moléculaire et Clinique, Lyon, F‐69437, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université Claude Bernard Lyon 1, Villeurbanne, F‐69622, France</mods:affiliation></affiliation></author><author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name><affiliation><mods:affiliation>INSERM, U563, Toulouse, F‐31024, France</mods:affiliation></affiliation></author><author><name sortKey="Molinari, Nicolas" sort="Molinari, Nicolas" uniqKey="Molinari N" first="Nicolas" last="Molinari">Nicolas Molinari</name><affiliation><mods:affiliation>CHU Nîmes, Département d'Information Médicale, Nîmes, F‐30025, France</mods:affiliation></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation><mods:affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</mods:affiliation></affiliation><affiliation><mods:affiliation>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</mods:affiliation></affiliation><affiliation><mods:affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Département de Génétique et Cytogénétique, Paris, F‐75013, France</mods:affiliation></affiliation><affiliation><mods:affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Fédération des Maladies du Système Nerveux, Paris, F‐75013, France</mods:affiliation></affiliation></author><author><name sortKey="Claustres, Mireille" sort="Claustres, Mireille" uniqKey="Claustres M" first="Mireille" last="Claustres">Mireille Claustres</name><affiliation><mods:affiliation>INSERM, U827, Montpellier, F‐34000, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</mods:affiliation></affiliation><affiliation><mods:affiliation>CHU Montpellier, Hôpital Arnaud de Villeneuve, Laboratoire de Génétique Moléculaire, Montpellier, F‐34000, France</mods:affiliation></affiliation></author><author><name sortKey="Tuffery Iraud, Sylvie" sort="Tuffery Iraud, Sylvie" uniqKey="Tuffery Iraud S" first="Sylvie" last="Tuffery-Giraud">Sylvie Tuffery-Giraud</name><affiliation><mods:affiliation>INSERM, U827, Montpellier, F‐34000, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</mods:affiliation></affiliation></author><author><name sortKey="Collod Eroud, Gwenaelle" sort="Collod Eroud, Gwenaelle" uniqKey="Collod Eroud G" first="Gwenaëlle" last="Collod-Beroud">Gwenaëlle Collod-Beroud</name><affiliation><mods:affiliation>INSERM, U827, Montpellier, F‐34000, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-04-30">2009-04-30</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="919">919</biblScope><biblScope unit="page" to="921">921</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">DB787F55A9A4FE6C41D77828B89D3783BA73103F</idno><idno type="DOI">10.1002/mds.22407</idno><idno type="ArticleID">MDS22407</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DYT1</term><term>TOR1A</term><term>dystonia</term><term>genetic modifiers</term><term>movement disorders</term><term>population studies</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">DYT1 dystonia are one of the exceptions in human genetics with its unique and recurrent mutation (c.907delGAG). In this rare movement disorder, the mutation is associated with incomplete penetrance as well as great clinical variability, making this disease a benchmark to search for genetic modifiers. Recently, Risch et al. have demonstrated the implication of the rs1801968 SNP in disease penetrance. We attempted to replicate this result in an exhaustive DYT1 French population with no success. Our results argue that the rs1801968 H allele effect is not part of the modifiers in the French population of DYT1 patients and that others have to be identified in our population. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Mélissa Yana Frédéric PhD</name><affiliations><json:string>INSERM, U827, Montpellier, F‐34000, France</json:string><json:string>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</json:string></affiliations></json:item><json:item><name>Fabienne Clot PhD</name><affiliations><json:string>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</json:string><json:string>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</json:string><json:string>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</json:string><json:string>AP‐HP, Hôpital Pitié‐Salpêtrière, Département de Génétique et Cytogénétique, Paris, F‐75013, France</json:string></affiliations></json:item><json:item><name>Arnaud Blanchard MS</name><affiliations><json:string>INSERM, U827, Montpellier, F‐34000, France</json:string><json:string>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</json:string></affiliations></json:item><json:item><name>Claire‐Marie Dhaenens PharmD, PhD</name><affiliations><json:string>CHRU de Lille, UF de Neurobiologie, Centre de Biologie‐Pathologie, Lille, F‐59037, France</json:string><json:string>INSERM, U837, Institut de Médecine Prédictive et de Recherche Thérapeutique, Lille, F‐59045, France</json:string></affiliations></json:item><json:item><name>Gaëtan Lesca MD, PhD</name><affiliations><json:string>Hôpital Edouard Herriot, Service de Génétique Moléculaire et Clinique, Lyon, F‐69437, France</json:string><json:string>Université Claude Bernard Lyon 1, Villeurbanne, F‐69622, France</json:string></affiliations></json:item><json:item><name>Laura Cif MD</name><affiliations><json:string>CHU Montpellier, Hôpital Guy de Chauliac, Service de Neurochirurgie, Montpellier, F‐34000, France</json:string></affiliations></json:item><json:item><name>Alexandra Dürr MD, PhD</name><affiliations><json:string>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</json:string><json:string>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</json:string><json:string>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</json:string><json:string>AP‐HP, Hôpital Pitié‐Salpêtrière, Département de Génétique et Cytogénétique, Paris, F‐75013, France</json:string></affiliations></json:item><json:item><name>Marie Vidailhet MD, PhD</name><affiliations><json:string>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</json:string><json:string>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</json:string><json:string>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</json:string><json:string>AP‐HP, Hôpital Pitié‐Salpêtrière, Fédération des Maladies du Système Nerveux, Paris, F‐75013, France</json:string></affiliations></json:item><json:item><name>Bernard Sablonniere MD, PhD</name><affiliations><json:string>CHRU de Lille, UF de Neurobiologie, Centre de Biologie‐Pathologie, Lille, F‐59037, France</json:string><json:string>INSERM, U837, Institut de Médecine Prédictive et de Recherche Thérapeutique, Lille, F‐59045, France</json:string></affiliations></json:item><json:item><name>Alain Calender MD, PhD</name><affiliations><json:string>Hôpital Edouard Herriot, Service de Génétique Moléculaire et Clinique, Lyon, F‐69437, France</json:string><json:string>Université Claude Bernard Lyon 1, Villeurbanne, F‐69622, France</json:string></affiliations></json:item><json:item><name>Maria Martinez PhD</name><affiliations><json:string>INSERM, U563, Toulouse, F‐31024, France</json:string></affiliations></json:item><json:item><name>Nicolas Molinari PhD</name><affiliations><json:string>CHU Nîmes, Département d'Information Médicale, Nîmes, F‐30025, France</json:string></affiliations></json:item><json:item><name>Alexis Brice MD</name><affiliations><json:string>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</json:string><json:string>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</json:string><json:string>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</json:string><json:string>AP‐HP, Hôpital Pitié‐Salpêtrière, Département de Génétique et Cytogénétique, Paris, F‐75013, France</json:string><json:string>AP‐HP, Hôpital Pitié‐Salpêtrière, Fédération des Maladies du Système Nerveux, Paris, F‐75013, France</json:string></affiliations></json:item><json:item><name>Mireille Claustres MD, PhD</name><affiliations><json:string>INSERM, U827, Montpellier, F‐34000, France</json:string><json:string>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</json:string><json:string>CHU Montpellier, Hôpital Arnaud de Villeneuve, Laboratoire de Génétique Moléculaire, Montpellier, F‐34000, France</json:string></affiliations></json:item><json:item><name>Sylvie Tuffery‐Giraud PhD</name><affiliations><json:string>INSERM, U827, Montpellier, F‐34000, France</json:string><json:string>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</json:string></affiliations></json:item><json:item><name>Gwenaëlle Collod‐Beroud PhD</name><affiliations><json:string>INSERM, U827, Montpellier, F‐34000, France</json:string><json:string>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>TOR1A</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>DYT1</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>population studies</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genetic modifiers</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>movement disorders</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dystonia</value></json:item></subject><language><json:string>eng</json:string></language><abstract>DYT1 dystonia are one of the exceptions in human genetics with its unique and recurrent mutation (c.907delGAG). In this rare movement disorder, the mutation is associated with incomplete penetrance as well as great clinical variability, making this disease a benchmark to search for genetic modifiers. Recently, Risch et al. have demonstrated the implication of the rs1801968 SNP in disease penetrance. We attempted to replicate this result in an exhaustive DYT1 French population with no success. Our results argue that the rs1801968 H allele effect is not part of the modifiers in the French population of DYT1 patients and that others have to be identified in our population. © 2008 Movement Disorder Society</abstract><qualityIndicators><score>6.344</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>711</abstractCharCount><pdfWordCount>12343</pdfWordCount><pdfCharCount>81578</pdfCharCount><pdfPageCount>22</pdfPageCount><abstractWordCount>112</abstractWordCount></qualityIndicators><title>The p.Asp216His TOR1A allele effect is not found in the French population</title><genre><json:string>Serial article</json:string></genre><host><volume>24</volume><pages><total>3</total><last>921</last><first>919</first></pages><issn><json:string>0885-3185</json:string></issn><issue>6</issue><subject><json:item><value>Brief 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xml:lang="en">The p.Asp216His TOR1A allele effect is not found in the French population</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: None reported.</note><note>AFM (Association Française contre les Myopathies)</note><note>LFCD‐AMADYS and INSERM Dystonia National Network</note><note>Gis Maladies Rares</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">The p.Asp216His TOR1A allele effect is not found in the French population</title><author><persName><forename type="first">Mélissa Yana</forename><surname>Frédéric</surname><roleName type="degree">PhD</roleName></persName><affiliation>INSERM, U827, Montpellier, F‐34000, France</affiliation><affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</affiliation></author><author><persName><forename type="first">Fabienne</forename><surname>Clot</surname><roleName type="degree">PhD</roleName></persName><affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</affiliation><affiliation>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</affiliation><affiliation>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</affiliation><affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Département de Génétique et Cytogénétique, Paris, F‐75013, France</affiliation></author><author><persName><forename type="first">Arnaud</forename><surname>Blanchard</surname><roleName type="degree">MS</roleName></persName><affiliation>INSERM, U827, Montpellier, F‐34000, France</affiliation><affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</affiliation></author><author><persName><forename type="first">Claire‐Marie</forename><surname>Dhaenens</surname><roleName type="degree">PharmD, PhD</roleName></persName><affiliation>CHRU de Lille, UF de Neurobiologie, Centre de Biologie‐Pathologie, Lille, F‐59037, France</affiliation><affiliation>INSERM, U837, Institut de Médecine Prédictive et de Recherche Thérapeutique, Lille, F‐59045, France</affiliation></author><author><persName><forename type="first">Gaëtan</forename><surname>Lesca</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Hôpital Edouard Herriot, Service de Génétique Moléculaire et Clinique, Lyon, F‐69437, France</affiliation><affiliation>Université Claude Bernard Lyon 1, Villeurbanne, F‐69622, France</affiliation></author><author><persName><forename type="first">Laura</forename><surname>Cif</surname><roleName type="degree">MD</roleName></persName><affiliation>CHU Montpellier, Hôpital Guy de Chauliac, Service de Neurochirurgie, Montpellier, F‐34000, France</affiliation></author><author><persName><forename type="first">Alexandra</forename><surname>Dürr</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</affiliation><affiliation>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</affiliation><affiliation>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</affiliation><affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Département de Génétique et Cytogénétique, Paris, F‐75013, France</affiliation></author><author><persName><forename type="first">Marie</forename><surname>Vidailhet</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</affiliation><affiliation>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</affiliation><affiliation>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</affiliation><affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Fédération des Maladies du Système Nerveux, Paris, F‐75013, France</affiliation></author><author><persName><forename type="first">Bernard</forename><surname>Sablonniere</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>CHRU de Lille, UF de Neurobiologie, Centre de Biologie‐Pathologie, Lille, F‐59037, France</affiliation><affiliation>INSERM, U837, Institut de Médecine Prédictive et de Recherche Thérapeutique, Lille, F‐59045, France</affiliation></author><author><persName><forename type="first">Alain</forename><surname>Calender</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Hôpital Edouard Herriot, Service de Génétique Moléculaire et Clinique, Lyon, F‐69437, France</affiliation><affiliation>Université Claude Bernard Lyon 1, Villeurbanne, F‐69622, France</affiliation></author><author><persName><forename type="first">Maria</forename><surname>Martinez</surname><roleName type="degree">PhD</roleName></persName><affiliation>INSERM, U563, Toulouse, F‐31024, France</affiliation></author><author><persName><forename type="first">Nicolas</forename><surname>Molinari</surname><roleName type="degree">PhD</roleName></persName><affiliation>CHU Nîmes, Département d'Information Médicale, Nîmes, F‐30025, France</affiliation></author><author><persName><forename type="first">Alexis</forename><surname>Brice</surname><roleName type="degree">MD</roleName></persName><affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</affiliation><affiliation>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</affiliation><affiliation>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</affiliation><affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Département de Génétique et Cytogénétique, Paris, F‐75013, France</affiliation><affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Fédération des Maladies du Système Nerveux, Paris, F‐75013, France</affiliation></author><author><persName><forename type="first">Mireille</forename><surname>Claustres</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>INSERM, U827, Montpellier, F‐34000, France</affiliation><affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</affiliation><affiliation>CHU Montpellier, Hôpital Arnaud de Villeneuve, Laboratoire de Génétique Moléculaire, Montpellier, F‐34000, France</affiliation></author><author><persName><forename type="first">Sylvie</forename><surname>Tuffery‐Giraud</surname><roleName type="degree">PhD</roleName></persName><affiliation>INSERM, U827, Montpellier, F‐34000, France</affiliation><affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</affiliation></author><author><persName><forename type="first">Gwenaëlle</forename><surname>Collod‐Beroud</surname><roleName type="degree">PhD</roleName></persName><note type="correspondence"><p>Correspondence: INSERM U827, Institut Universitaire de Recherche Clinique, 641 av du doyen Gaston Giraud, 34093 Montpellier Cedex 05, France</p></note><affiliation>INSERM, U827, Montpellier, F‐34000, France</affiliation><affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. 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Pitié‐Salpêtrière, Département de Génétique et Cytogénétique, Paris, F‐75013, France</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="FR" type="organization"><unparsedAffiliation>CHRU de Lille, UF de Neurobiologie, Centre de Biologie‐Pathologie, Lille, F‐59037, France</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="FR" type="organization"><unparsedAffiliation>INSERM, U837, Institut de Médecine Prédictive et de Recherche Thérapeutique, Lille, F‐59045, France</unparsedAffiliation></affiliation><affiliation xml:id="af9" countryCode="FR" type="organization"><unparsedAffiliation>Hôpital Edouard Herriot, Service de Génétique Moléculaire et Clinique, Lyon, F‐69437, France</unparsedAffiliation></affiliation><affiliation xml:id="af10" countryCode="FR" type="organization"><unparsedAffiliation>Université Claude Bernard Lyon 1, Villeurbanne, F‐69622, France</unparsedAffiliation></affiliation><affiliation xml:id="af11" countryCode="FR" type="organization"><unparsedAffiliation>CHU Montpellier, Hôpital Guy de Chauliac, Service de Neurochirurgie, Montpellier, F‐34000, France</unparsedAffiliation></affiliation><affiliation xml:id="af12" countryCode="FR" type="organization"><unparsedAffiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Fédération des Maladies du Système Nerveux, Paris, F‐75013, France</unparsedAffiliation></affiliation><affiliation xml:id="af13" countryCode="FR" type="organization"><unparsedAffiliation>INSERM, U563, Toulouse, F‐31024, France</unparsedAffiliation></affiliation><affiliation xml:id="af14" countryCode="FR" type="organization"><unparsedAffiliation>CHU Nîmes, Département d'Information Médicale, Nîmes, F‐30025, France</unparsedAffiliation></affiliation><affiliation xml:id="af15" countryCode="FR" type="organization"><unparsedAffiliation>CHU Montpellier, Hôpital Arnaud de Villeneuve, Laboratoire de Génétique Moléculaire, Montpellier, F‐34000, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">TOR1A</keyword><keyword xml:id="kwd2">DYT1</keyword><keyword xml:id="kwd3">population studies</keyword><keyword xml:id="kwd4">genetic modifiers</keyword><keyword xml:id="kwd5">movement disorders</keyword><keyword xml:id="kwd6">dystonia</keyword></keywordGroup><fundingInfo><fundingAgency>AFM (Association Française contre les Myopathies)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>LFCD‐AMADYS and INSERM Dystonia National Network</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Gis Maladies Rares</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="fr"><title type="main">Abstract</title><p>DYT1 dystonia are one of the exceptions in human genetics with its unique and recurrent mutation (c.907delGAG). In this rare movement disorder, the mutation is associated with incomplete penetrance as well as great clinical variability, making this disease a benchmark to search for genetic modifiers. Recently, Risch et al. have demonstrated the implication of the rs1801968 SNP in disease penetrance. We attempted to replicate this result in an exhaustive DYT1 French population with no success. Our results argue that the rs1801968 H allele effect is not part of the modifiers in the French population of DYT1 patients and that others have to be identified in our population. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>The p.Asp216His TOR1A allele effect is not found in the French population</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>p.Asp216His TOR1A Allele Effect in the French Population</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The p.Asp216His</title></titleInfo><name type="personal"><namePart type="given">Mélissa Yana</namePart><namePart type="family">Frédéric</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>INSERM, U827, Montpellier, F‐34000, France</affiliation><affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fabienne</namePart><namePart type="family">Clot</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</affiliation><affiliation>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</affiliation><affiliation>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</affiliation><affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Département de Génétique et Cytogénétique, Paris, F‐75013, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Arnaud</namePart><namePart type="family">Blanchard</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>INSERM, U827, Montpellier, F‐34000, France</affiliation><affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claire‐Marie</namePart><namePart type="family">Dhaenens</namePart><namePart type="termsOfAddress">PharmD, PhD</namePart><affiliation>CHRU de Lille, UF de Neurobiologie, Centre de Biologie‐Pathologie, Lille, F‐59037, France</affiliation><affiliation>INSERM, U837, Institut de Médecine Prédictive et de Recherche Thérapeutique, Lille, F‐59045, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gaëtan</namePart><namePart type="family">Lesca</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Hôpital Edouard Herriot, Service de Génétique Moléculaire et Clinique, Lyon, F‐69437, France</affiliation><affiliation>Université Claude Bernard Lyon 1, Villeurbanne, F‐69622, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laura</namePart><namePart type="family">Cif</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>CHU Montpellier, Hôpital Guy de Chauliac, Service de Neurochirurgie, Montpellier, F‐34000, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexandra</namePart><namePart type="family">Dürr</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</affiliation><affiliation>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</affiliation><affiliation>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</affiliation><affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Département de Génétique et Cytogénétique, Paris, F‐75013, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marie</namePart><namePart type="family">Vidailhet</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</affiliation><affiliation>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</affiliation><affiliation>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</affiliation><affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Fédération des Maladies du Système Nerveux, Paris, F‐75013, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bernard</namePart><namePart type="family">Sablonniere</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>CHRU de Lille, UF de Neurobiologie, Centre de Biologie‐Pathologie, Lille, F‐59037, France</affiliation><affiliation>INSERM, U837, Institut de Médecine Prédictive et de Recherche Thérapeutique, Lille, F‐59045, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alain</namePart><namePart type="family">Calender</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Hôpital Edouard Herriot, Service de Génétique Moléculaire et Clinique, Lyon, F‐69437, France</affiliation><affiliation>Université Claude Bernard Lyon 1, Villeurbanne, F‐69622, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maria</namePart><namePart type="family">Martinez</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>INSERM, U563, Toulouse, F‐31024, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nicolas</namePart><namePart type="family">Molinari</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>CHU Nîmes, Département d'Information Médicale, Nîmes, F‐30025, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexis</namePart><namePart type="family">Brice</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, F‐75013, France</affiliation><affiliation>UPMC Univ Paris 06, UMR_S679, Paris, F‐75005, France</affiliation><affiliation>Institut Fédératif des Neurosciences (IFR70), Hôpital Pitié‐Salpêtrière, Paris, F‐75013, France</affiliation><affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Département de Génétique et Cytogénétique, Paris, F‐75013, France</affiliation><affiliation>AP‐HP, Hôpital Pitié‐Salpêtrière, Fédération des Maladies du Système Nerveux, Paris, F‐75013, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mireille</namePart><namePart type="family">Claustres</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>INSERM, U827, Montpellier, F‐34000, France</affiliation><affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</affiliation><affiliation>CHU Montpellier, Hôpital Arnaud de Villeneuve, Laboratoire de Génétique Moléculaire, Montpellier, F‐34000, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sylvie</namePart><namePart type="family">Tuffery‐Giraud</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>INSERM, U827, Montpellier, F‐34000, France</affiliation><affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gwenaëlle</namePart><namePart type="family">Collod‐Beroud</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>INSERM, U827, Montpellier, F‐34000, France</affiliation><affiliation>Université MONTPELLIER1, UFR Médecine, Montpellier, F‐34000 France</affiliation><description>Correspondence: INSERM U827, Institut Universitaire de Recherche Clinique, 641 av du doyen Gaston Giraud, 34093 Montpellier Cedex 05, France</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-04-30</dateIssued><dateCaptured encoding="w3cdtf">2008-04-03</dateCaptured><dateValid encoding="w3cdtf">2008-11-05</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">2</extent><extent unit="references">6</extent><extent unit="words">2186</extent></physicalDescription><abstract lang="fr">DYT1 dystonia are one of the exceptions in human genetics with its unique and recurrent mutation (c.907delGAG). In this rare movement disorder, the mutation is associated with incomplete penetrance as well as great clinical variability, making this disease a benchmark to search for genetic modifiers. Recently, Risch et al. have demonstrated the implication of the rs1801968 SNP in disease penetrance. We attempted to replicate this result in an exhaustive DYT1 French population with no success. Our results argue that the rs1801968 H allele effect is not part of the modifiers in the French population of DYT1 patients and that others have to be identified in our population. © 2008 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><note type="funding">AFM (Association Française contre les Myopathies)</note><note type="funding">LFCD‐AMADYS and INSERM Dystonia National Network</note><note type="funding">Gis Maladies Rares</note><subject lang="en"><genre>Keywords</genre><topic>TOR1A</topic><topic>DYT1</topic><topic>population studies</topic><topic>genetic modifiers</topic><topic>movement disorders</topic><topic>dystonia</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>919</start><end>921</end><total>3</total></extent></part></relatedItem><identifier type="istex">DB787F55A9A4FE6C41D77828B89D3783BA73103F</identifier><identifier type="DOI">10.1002/mds.22407</identifier><identifier type="ArticleID">MDS22407</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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