Environmental and genetic risk factors in Parkinson's disease: A case–control study in southern italy
Identifieur interne : 001356 ( Istex/Corpus ); précédent : 001355; suivant : 001357Environmental and genetic risk factors in Parkinson's disease: A case–control study in southern italy
Auteurs : G. De Michele ; A. Filla ; G. Volpe ; V. De Marco ; A. Gogliettino ; G. Ambrosio ; R. Marconi ; A. E. Castellano ; CampanellaSource :
- Movement Disorders [ 0885-3185 ] ; 1996-01.
English descriptors
Abstract
To clarify the role of heredity and of some environmental risk factors in the etiology of idopathic Parkinson's disease, we performed a case‐control study in two regions of southern Italy, Campania and Molise. We selected two controls for each parkinsonian patient, the patient's spouse and a sex‐ and age‐matched neurological control. One hundred sixteen consecutive outpatients with Parkinson's disease (77 men, 39 women; mean age ± SD = 62.5 ± 9.9) and the same number of spouses and neurological controls were interviewed about five environmental risk factors (cigarette smoking, well‐water drinking, head trauma with loss of consciousness, strict diets, general anesthesia) and two genetic risk factors (family history of Parkinson's disease or of essential tremor). Well‐water drinking and family history of Parkinson's disease or essential tremor showed a positive association with Parkinson's disease; smoking showed a negative association. The most relevant risk factor was history of familial Parkinson's disease (odds ratio = 14.6; 95% confidence interval = 7.2 − 29.6); 33% of our patients had at least one affected relative. We also showed a unilateral distribution of ancestral secondary cases on the paternal or on the maternal side, which suggests a dominant inheritance. Clinical and epidemiologic features of cases with familial Parkinson's disease showed no peculiarity. The study suggests a strong role of the genetic factors in the etiology of Parkinson's disease.
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DOI: 10.1002/mds.870110105
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ISTEX:F7568060A721FF11CB5A29DD33B94F440BE1CB16Le document en format XML
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We also showed a unilateral distribution of ancestral secondary cases on the paternal or on the maternal side, which suggests a dominant inheritance. Clinical and epidemiologic features of cases with familial Parkinson's disease showed no peculiarity. The study suggests a strong role of the genetic factors in the etiology of Parkinson's disease.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>G. De Michele</name><affiliations><json:string>Department of Neurology, Federico II University, Naples</json:string></affiliations></json:item><json:item><name>A. Filla</name><affiliations><json:string>Department of Neurology, Federico II University, Naples</json:string></affiliations></json:item><json:item><name>G. Volpe</name><affiliations><json:string>Department of Neurology, Federico II University, Naples</json:string></affiliations></json:item><json:item><name>V. De Marco</name><affiliations><json:string>Department of Neurology, Federico II University, Naples</json:string></affiliations></json:item><json:item><name>A. Gogliettino</name><affiliations><json:string>Department of Neurology, Federico II University, Naples</json:string></affiliations></json:item><json:item><name>G. Ambrosio</name><affiliations><json:string>Department of Neurology, Federico II University, Naples</json:string></affiliations></json:item><json:item><name>R. Marconi</name><affiliations><json:string>Sanatrix Neurological Institute, Pozzilli (IS), Italy</json:string></affiliations></json:item><json:item><name>A. E. Castellano</name><affiliations><json:string>Sanatrix Neurological Institute, Pozzilli (IS), Italy</json:string></affiliations></json:item><json:item><name>Prof. Campanella</name><affiliations><json:string>Department of Neurology, Federico II University, Naples</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Essential tremor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Genetic risk factors</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Environmental risk factors</value></json:item></subject><language><json:string>eng</json:string></language><abstract>To clarify the role of heredity and of some environmental risk factors in the etiology of idopathic Parkinson's disease, we performed a case‐control study in two regions of southern Italy, Campania and Molise. We selected two controls for each parkinsonian patient, the patient's spouse and a sex‐ and age‐matched neurological control. One hundred sixteen consecutive outpatients with Parkinson's disease (77 men, 39 women; mean age ± SD = 62.5 ± 9.9) and the same number of spouses and neurological controls were interviewed about five environmental risk factors (cigarette smoking, well‐water drinking, head trauma with loss of consciousness, strict diets, general anesthesia) and two genetic risk factors (family history of Parkinson's disease or of essential tremor). Well‐water drinking and family history of Parkinson's disease or essential tremor showed a positive association with Parkinson's disease; smoking showed a negative association. The most relevant risk factor was history of familial Parkinson's disease (odds ratio = 14.6; 95% confidence interval = 7.2 − 29.6); 33% of our patients had at least one affected relative. We also showed a unilateral distribution of ancestral secondary cases on the paternal or on the maternal side, which suggests a dominant inheritance. Clinical and epidemiologic features of cases with familial Parkinson's disease showed no peculiarity. 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We also showed a unilateral distribution of ancestral secondary cases on the paternal or on the maternal side, which suggests a dominant inheritance. Clinical and epidemiologic features of cases with familial Parkinson's disease showed no peculiarity. 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E.</givenNames><familyName>Castellano</familyName></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><honorifics>Prof.</honorifics><givenNames>G.</givenNames><familyName>Campanella</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurology, Federico II University, Naples</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Sanatrix Neurological Institute, Pozzilli (IS), Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">Essential tremor</keyword><keyword xml:id="kwd3">Genetic risk factors</keyword><keyword xml:id="kwd4">Environmental risk factors</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>To clarify the role of heredity and of some environmental risk factors in the etiology of idopathic Parkinson's disease, we performed a case‐control study in two regions of southern Italy, Campania and Molise. We selected two controls for each parkinsonian patient, the patient's spouse and a sex‐ and age‐matched neurological control. One hundred sixteen consecutive outpatients with Parkinson's disease (77 men, 39 women; mean age ± <i>SD</i> = 62.5 ± 9.9) and the same number of spouses and neurological controls were interviewed about five environmental risk factors (cigarette smoking, well‐water drinking, head trauma with loss of consciousness, strict diets, general anesthesia) and two genetic risk factors (family history of Parkinson's disease or of essential tremor). Well‐water drinking and family history of Parkinson's disease or essential tremor showed a positive association with Parkinson's disease; smoking showed a negative association. The most relevant risk factor was history of familial Parkinson's disease (odds ratio = 14.6; 95% confidence interval = 7.2 − 29.6); 33% of our patients had at least one affected relative. We also showed a unilateral distribution of ancestral secondary cases on the paternal or on the maternal side, which suggests a dominant inheritance. Clinical and epidemiologic features of cases with familial Parkinson's disease showed no peculiarity. The study suggests a strong role of the genetic factors in the etiology of Parkinson's disease.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Environmental and genetic risk factors in Parkinson's disease: A case–control study in southern italy</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>PARKINSON'S DISEASE: ENVIRONMENT AND HEREDITY</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Environmental and genetic risk factors in Parkinson's disease: A case–control study in southern italy</title></titleInfo><name type="personal"><namePart type="given">G.</namePart><namePart type="family">De Michele</namePart><affiliation>Department of Neurology, Federico II University, Naples</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Filla</namePart><affiliation>Department of Neurology, Federico II University, Naples</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Volpe</namePart><affiliation>Department of Neurology, Federico II University, Naples</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">De Marco</namePart><affiliation>Department of Neurology, Federico II University, Naples</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Gogliettino</namePart><affiliation>Department of Neurology, Federico II University, Naples</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Ambrosio</namePart><affiliation>Department of Neurology, Federico II University, Naples</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Marconi</namePart><affiliation>Sanatrix Neurological Institute, Pozzilli (IS), Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. E.</namePart><namePart type="family">Castellano</namePart><affiliation>Sanatrix Neurological Institute, Pozzilli (IS), Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Prof.</namePart><namePart type="family">Campanella</namePart><affiliation>Department of Neurology, Federico II University, Naples</affiliation><description>Correspondence: Clinica Neurologica II, Università Federico II, via S. Pansini 5, 80131, Napoli, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1996-01</dateIssued><dateValid encoding="w3cdtf">1995-05-17</dateValid><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">5</extent><extent unit="references">34</extent></physicalDescription><abstract lang="en">To clarify the role of heredity and of some environmental risk factors in the etiology of idopathic Parkinson's disease, we performed a case‐control study in two regions of southern Italy, Campania and Molise. We selected two controls for each parkinsonian patient, the patient's spouse and a sex‐ and age‐matched neurological control. One hundred sixteen consecutive outpatients with Parkinson's disease (77 men, 39 women; mean age ± SD = 62.5 ± 9.9) and the same number of spouses and neurological controls were interviewed about five environmental risk factors (cigarette smoking, well‐water drinking, head trauma with loss of consciousness, strict diets, general anesthesia) and two genetic risk factors (family history of Parkinson's disease or of essential tremor). Well‐water drinking and family history of Parkinson's disease or essential tremor showed a positive association with Parkinson's disease; smoking showed a negative association. The most relevant risk factor was history of familial Parkinson's disease (odds ratio = 14.6; 95% confidence interval = 7.2 − 29.6); 33% of our patients had at least one affected relative. We also showed a unilateral distribution of ancestral secondary cases on the paternal or on the maternal side, which suggests a dominant inheritance. Clinical and epidemiologic features of cases with familial Parkinson's disease showed no peculiarity. The study suggests a strong role of the genetic factors in the etiology of Parkinson's disease.</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>Essential tremor</topic><topic>Genetic risk factors</topic><topic>Environmental risk factors</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>17</start><end>23</end><total>7</total></extent></part></relatedItem><identifier type="istex">F7568060A721FF11CB5A29DD33B94F440BE1CB16</identifier><identifier type="DOI">10.1002/mds.870110105</identifier><identifier type="ArticleID">MDS870110105</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1996 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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