Mirthful laughter induced by subthalamic nucleus stimulation
Identifieur interne : 001298 ( Istex/Corpus ); précédent : 001297; suivant : 001299Mirthful laughter induced by subthalamic nucleus stimulation
Auteurs : Paul Krack ; Rajeev Kumar ; Claire Ardouin ; Patricia Limousin Dowsey ; John M. Mcvicker ; Alim-Louis Benabid ; Pierre PollakSource :
- Movement Disorders [ 0885-3185 ] ; 2001-09.
English descriptors
Abstract
High‐frequency stimulation of the subthalamic nucleus (STN) improves the motor signs of Parkinson's disease (PD). The three main components (motor, associative, and limbic) of the cortical‐basal ganglia‐cortical circuits pass through the STN. It is not known whether STN stimulation can influence the limbic loop. We present two PD patients in whom acute stimulation of an electrode located in the STN using high stimulation parameters (50% higher than therapeutic) induced funny associations, leading to infectious laughter and hilarity, whereas the therapeutic parameters induced a hypomanic behavior and marked improvement of akinesia. Our report suggests that the STN, with its sensorimotor, cognitive, and limbic parts is not only involved in motor, but also in psychomotor regulation. © 2001 Movement Disorder Society.
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DOI: 10.1002/mds.1174
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ISTEX:E97908DA8F01334E1A161E24237DB3E3D27C2A62Le document en format XML
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Mcvicker</name><affiliation><mods:affiliation>Colorado Neurological Institute, Englewood, Colorado, USA</mods:affiliation></affiliation></author><author><name sortKey="Benabid, Alim Ouis" sort="Benabid, Alim Ouis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation><mods:affiliation>Neuroscience Department, University of Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation><mods:affiliation>Neuroscience Department, University of Grenoble, Grenoble, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2001-09">2001-09</date><biblScope unit="vol">16</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="867">867</biblScope><biblScope unit="page" to="875">875</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">E97908DA8F01334E1A161E24237DB3E3D27C2A62</idno><idno type="DOI">10.1002/mds.1174</idno><idno type="ArticleID">MDS1174</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>deep brain stimulation</term><term>laughter</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High‐frequency stimulation of the subthalamic nucleus (STN) improves the motor signs of Parkinson's disease (PD). The three main components (motor, associative, and limbic) of the cortical‐basal ganglia‐cortical circuits pass through the STN. It is not known whether STN stimulation can influence the limbic loop. We present two PD patients in whom acute stimulation of an electrode located in the STN using high stimulation parameters (50% higher than therapeutic) induced funny associations, leading to infectious laughter and hilarity, whereas the therapeutic parameters induced a hypomanic behavior and marked improvement of akinesia. Our report suggests that the STN, with its sensorimotor, cognitive, and limbic parts is not only involved in motor, but also in psychomotor regulation. © 2001 Movement Disorder Society.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Paul Krack MD</name><affiliations><json:string>Neuroscience Department, University of Grenoble, Grenoble, France</json:string><json:string>Department of Neurology, University of Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Rajeev Kumar MD</name><affiliations><json:string>Colorado Neurological Institute, Englewood, Colorado, USA</json:string></affiliations></json:item><json:item><name>Claire Ardouin PhD</name><affiliations><json:string>Neuroscience Department, University of Grenoble, Grenoble, France</json:string></affiliations></json:item><json:item><name>Patricia Limousin Dowsey MD, PhD</name><affiliations><json:string>Neuroscience Department, University of Grenoble, Grenoble, France</json:string><json:string>Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom</json:string></affiliations></json:item><json:item><name>John M. McVicker MD</name><affiliations><json:string>Colorado Neurological Institute, Englewood, Colorado, USA</json:string></affiliations></json:item><json:item><name>Alim‐Louis Benabid MD, PhD</name><affiliations><json:string>Neuroscience Department, University of Grenoble, Grenoble, France</json:string></affiliations></json:item><json:item><name>Pierre Pollak MD</name><affiliations><json:string>Neuroscience Department, University of Grenoble, Grenoble, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>subthalamic nucleus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>deep brain stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>laughter</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item></subject><language><json:string>eng</json:string></language><abstract>High‐frequency stimulation of the subthalamic nucleus (STN) improves the motor signs of Parkinson's disease (PD). 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type="author"><keyword xml:id="kwd1">subthalamic nucleus</keyword><keyword xml:id="kwd2">deep brain stimulation</keyword><keyword xml:id="kwd3">laughter</keyword><keyword xml:id="kwd4">Parkinson's disease</keyword></keywordGroup><supportingInformation><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds1174:MDS_1174_SI"></mediaResource><caption>Supplemental_Video</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>High‐frequency stimulation of the subthalamic nucleus (STN) improves the motor signs of Parkinson's disease (PD). The three main components (motor, associative, and limbic) of the cortical‐basal ganglia‐cortical circuits pass through the STN. It is not known whether STN stimulation can influence the limbic loop. We present two PD patients in whom acute stimulation of an electrode located in the STN using high stimulation parameters (50% higher than therapeutic) induced funny associations, leading to infectious laughter and hilarity, whereas the therapeutic parameters induced a hypomanic behavior and marked improvement of akinesia. Our report suggests that the STN, with its sensorimotor, cognitive, and limbic parts is not only involved in motor, but also in psychomotor regulation. © 2001 Movement Disorder Society.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>A videotape accompanies this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Mirthful laughter induced by subthalamic nucleus stimulation</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Mirthful Laughter Induced by STN Stimulation</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Mirthful laughter induced by subthalamic nucleus stimulation</title></titleInfo><name type="personal"><namePart type="given">Paul</namePart><namePart type="family">Krack</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neuroscience Department, University of Grenoble, Grenoble, France</affiliation><affiliation>Department of Neurology, University of Kiel, Kiel, Germany</affiliation><description>Correspondence: Neurology Department, University of Kiel, Niemannsweg 147, 24105 Kiel, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rajeev</namePart><namePart type="family">Kumar</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Colorado Neurological Institute, Englewood, Colorado, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claire</namePart><namePart type="family">Ardouin</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Neuroscience Department, University of Grenoble, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Patricia Limousin</namePart><namePart type="family">Dowsey</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Neuroscience Department, University of Grenoble, Grenoble, France</affiliation><affiliation>Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John M.</namePart><namePart type="family">McVicker</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Colorado Neurological Institute, Englewood, Colorado, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alim‐Louis</namePart><namePart type="family">Benabid</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Neuroscience Department, University of Grenoble, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pierre</namePart><namePart type="family">Pollak</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neuroscience Department, University of Grenoble, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2001-09</dateIssued><dateCaptured encoding="w3cdtf">2000-05-18</dateCaptured><dateValid encoding="w3cdtf">2000-12-01</dateValid><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="references">79</extent><extent unit="words">5779</extent></physicalDescription><abstract lang="en">High‐frequency stimulation of the subthalamic nucleus (STN) improves the motor signs of Parkinson's disease (PD). The three main components (motor, associative, and limbic) of the cortical‐basal ganglia‐cortical circuits pass through the STN. It is not known whether STN stimulation can influence the limbic loop. We present two PD patients in whom acute stimulation of an electrode located in the STN using high stimulation parameters (50% higher than therapeutic) induced funny associations, leading to infectious laughter and hilarity, whereas the therapeutic parameters induced a hypomanic behavior and marked improvement of akinesia. Our report suggests that the STN, with its sensorimotor, cognitive, and limbic parts is not only involved in motor, but also in psychomotor regulation. © 2001 Movement Disorder Society.</abstract><note type="additional physical form">Supplemental_Video</note><note type="content">*A videotape accompanies this article.</note><subject lang="en"><genre>Keywords</genre><topic>subthalamic nucleus</topic><topic>deep brain stimulation</topic><topic>laughter</topic><topic>Parkinson's disease</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>867</start><end>875</end><total>9</total></extent></part></relatedItem><identifier type="istex">E97908DA8F01334E1A161E24237DB3E3D27C2A62</identifier><identifier type="DOI">10.1002/mds.1174</identifier><identifier type="ArticleID">MDS1174</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2001 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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