Pyramidal tract degeneration in multiple system atrophy: The relevance of magnetization transfer imaging
Identifieur interne : 001280 ( Istex/Corpus ); précédent : 001279; suivant : 001281Pyramidal tract degeneration in multiple system atrophy: The relevance of magnetization transfer imaging
Auteurs : Antonio José Da Rocha ; Antonio Carlos Martins Maia Jr. ; Carlos Jorge Da Silva ; Flávio Túlio Braga ; Nelson Paes Diniz Fortes Ferreira ; Orlando Graziani Povoas Barsottini ; Henrique Ballalai FerrazSource :
- Movement Disorders [ 0885-3185 ] ; 2007-01-15.
English descriptors
Abstract
The clinical features of multiple system atrophy (MSA) include four domains: autonomic failure/urinary dysfunction, Parkinsonism, cerebellar ataxia, and corticospinal tract dysfunction. Although the diagnosis of definite MSA requires pathological confirmation, magnetic resonance imaging (MRI) studies have been shown to contribute to the diagnosis of MSA. Although pyramidal tract dysfunction is frequent in MSA patients, signs of pyramidal tract involvement are controversially demonstrated by MRI. We evaluated the pyramidal involvement in 10 patients (7 women) with clinically probable MSA, detecting the presence of spasticity, hyperreflexia, and Babinski sign, as well as demonstrating degeneration of the pyramidal tract and primary motor cortex by MRI in all of them. Our article also discusses key radiological features of this syndrome. In MSA, pyramidal tract involvement seems to be more frequent than previously thought, and the clinicoradiological correlation between pyramidal tract dysfunction and degeneration may contribute to the understanding of the clinical hallmarks of MSA. MRI may also add information regarding the differential diagnosis of this syndrome. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.21229
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ISTEX:6AA341CCACA3BFEB3D2A74707A82E009ED0221F6Le document en format XML
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Orlando Graziani Povoas" uniqKey="Barsottini O" first="Orlando Graziani Povoas" last="Barsottini">Orlando Graziani Povoas Barsottini</name><affiliation><mods:affiliation>Department of Neurology, Universidade Federal de São Paulo, São Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Ferraz, Henrique Ballalai" sort="Ferraz, Henrique Ballalai" uniqKey="Ferraz H" first="Henrique Ballalai" last="Ferraz">Henrique Ballalai Ferraz</name><affiliation><mods:affiliation>Department of Neurology, Universidade Federal de São Paulo, São Paulo, Brazil</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-01-15">2007-01-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="238">238</biblScope><biblScope unit="page" to="243">243</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">6AA341CCACA3BFEB3D2A74707A82E009ED0221F6</idno><idno type="DOI">10.1002/mds.21229</idno><idno type="ArticleID">MDS21229</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MRI</term><term>MSA</term><term>Parkinsonism</term><term>cortico‐spinal tract</term><term>magnetization transfer imaging</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The clinical features of multiple system atrophy (MSA) include four domains: autonomic failure/urinary dysfunction, Parkinsonism, cerebellar ataxia, and corticospinal tract dysfunction. Although the diagnosis of definite MSA requires pathological confirmation, magnetic resonance imaging (MRI) studies have been shown to contribute to the diagnosis of MSA. Although pyramidal tract dysfunction is frequent in MSA patients, signs of pyramidal tract involvement are controversially demonstrated by MRI. We evaluated the pyramidal involvement in 10 patients (7 women) with clinically probable MSA, detecting the presence of spasticity, hyperreflexia, and Babinski sign, as well as demonstrating degeneration of the pyramidal tract and primary motor cortex by MRI in all of them. Our article also discusses key radiological features of this syndrome. In MSA, pyramidal tract involvement seems to be more frequent than previously thought, and the clinicoradiological correlation between pyramidal tract dysfunction and degeneration may contribute to the understanding of the clinical hallmarks of MSA. MRI may also add information regarding the differential diagnosis of this syndrome. © 2006 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Antonio José da Rocha MD, PhD</name><affiliations><json:string>Centro de Medicina Diagnóstica Fleury, Setor de Neuroradiologia, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Antonio Carlos Martins Maia Jr. MD</name><affiliations><json:string>Centro de Medicina Diagnóstica Fleury, Setor de Neuroradiologia, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Carlos Jorge da Silva MD</name><affiliations><json:string>Centro de Medicina Diagnóstica Fleury, Setor de Neuroradiologia, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Flávio Túlio Braga MD</name><affiliations><json:string>Centro de Medicina Diagnóstica Fleury, Setor de Neuroradiologia, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Nelson Paes Diniz Fortes Ferreira MD</name><affiliations><json:string>Medimagem Hospital Beneficiência Portuguesa, Setor de Neuroradiologia, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Orlando Graziani Povoas Barsottini MD</name><affiliations><json:string>Department of Neurology, Universidade Federal de São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Henrique Ballalai Ferraz MD</name><affiliations><json:string>Department of Neurology, Universidade Federal de São Paulo, São Paulo, Brazil</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinsonism</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MRI</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MSA</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>magnetization transfer imaging</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cortico‐spinal tract</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The clinical features of multiple system atrophy (MSA) include four domains: autonomic failure/urinary dysfunction, Parkinsonism, cerebellar ataxia, and corticospinal tract dysfunction. Although the diagnosis of definite MSA requires pathological confirmation, magnetic resonance imaging (MRI) studies have been shown to contribute to the diagnosis of MSA. Although pyramidal tract dysfunction is frequent in MSA patients, signs of pyramidal tract involvement are controversially demonstrated by MRI. We evaluated the pyramidal involvement in 10 patients (7 women) with clinically probable MSA, detecting the presence of spasticity, hyperreflexia, and Babinski sign, as well as demonstrating degeneration of the pyramidal tract and primary motor cortex by MRI in all of them. Our article also discusses key radiological features of this syndrome. In MSA, pyramidal tract involvement seems to be more frequent than previously thought, and the clinicoradiological correlation between pyramidal tract dysfunction and degeneration may contribute to the understanding of the clinical hallmarks of MSA. 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Although the diagnosis of definite MSA requires pathological confirmation, magnetic resonance imaging (MRI) studies have been shown to contribute to the diagnosis of MSA. Although pyramidal tract dysfunction is frequent in MSA patients, signs of pyramidal tract involvement are controversially demonstrated by MRI. We evaluated the pyramidal involvement in 10 patients (7 women) with clinically probable MSA, detecting the presence of spasticity, hyperreflexia, and Babinski sign, as well as demonstrating degeneration of the pyramidal tract and primary motor cortex by MRI in all of them. Our article also discusses key radiological features of this syndrome. In MSA, pyramidal tract involvement seems to be more frequent than previously thought, and the clinicoradiological correlation between pyramidal tract dysfunction and degeneration may contribute to the understanding of the clinical hallmarks of MSA. 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affiliationRef="#af3"><personName><givenNames>Henrique Ballalai</givenNames><familyName>Ferraz</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="BR" type="organization"><unparsedAffiliation>Centro de Medicina Diagnóstica Fleury, Setor de Neuroradiologia, São Paulo, Brazil</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="BR" type="organization"><unparsedAffiliation>Medimagem Hospital Beneficiência Portuguesa, Setor de Neuroradiologia, São Paulo, Brazil</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="BR" type="organization"><unparsedAffiliation>Department of Neurology, Universidade Federal de São Paulo, São Paulo, Brazil</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinsonism</keyword><keyword xml:id="kwd2">MRI</keyword><keyword xml:id="kwd3">MSA</keyword><keyword xml:id="kwd4">magnetization transfer imaging</keyword><keyword xml:id="kwd5">cortico‐spinal tract</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The clinical features of multiple system atrophy (MSA) include four domains: autonomic failure/urinary dysfunction, Parkinsonism, cerebellar ataxia, and corticospinal tract dysfunction. Although the diagnosis of definite MSA requires pathological confirmation, magnetic resonance imaging (MRI) studies have been shown to contribute to the diagnosis of MSA. Although pyramidal tract dysfunction is frequent in MSA patients, signs of pyramidal tract involvement are controversially demonstrated by MRI. We evaluated the pyramidal involvement in 10 patients (7 women) with clinically probable MSA, detecting the presence of spasticity, hyperreflexia, and Babinski sign, as well as demonstrating degeneration of the pyramidal tract and primary motor cortex by MRI in all of them. Our article also discusses key radiological features of this syndrome. In MSA, pyramidal tract involvement seems to be more frequent than previously thought, and the clinicoradiological correlation between pyramidal tract dysfunction and degeneration may contribute to the understanding of the clinical hallmarks of MSA. MRI may also add information regarding the differential diagnosis of this syndrome. © 2006 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Pyramidal tract degeneration in multiple system atrophy: The relevance of magnetization transfer imaging</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Pyramidal Tract Degeneration in MSA</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Pyramidal tract degeneration in multiple system atrophy: The relevance of magnetization transfer imaging</title></titleInfo><name type="personal"><namePart type="given">Antonio José</namePart><namePart type="family">da Rocha</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Centro de Medicina Diagnóstica Fleury, Setor de Neuroradiologia, São Paulo, Brazil</affiliation><description>Correspondence: Centro de Medicina Diagnóstica Fleury, Setor de Neuroradiologia, Rua Cincinato Braga 282, Paraíso, São Paulo, SP Brazil 01333‐910</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonio Carlos Martins</namePart><namePart type="family">Maia Jr.</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Centro de Medicina Diagnóstica Fleury, Setor de Neuroradiologia, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carlos Jorge</namePart><namePart type="family">da Silva</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Centro de Medicina Diagnóstica Fleury, Setor de Neuroradiologia, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Flávio Túlio</namePart><namePart type="family">Braga</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Centro de Medicina Diagnóstica Fleury, Setor de Neuroradiologia, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nelson Paes Diniz Fortes</namePart><namePart type="family">Ferreira</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Medimagem Hospital Beneficiência Portuguesa, Setor de Neuroradiologia, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Orlando Graziani Povoas</namePart><namePart type="family">Barsottini</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Henrique Ballalai</namePart><namePart type="family">Ferraz</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-01-15</dateIssued><dateCaptured encoding="w3cdtf">2006-05-15</dateCaptured><dateValid encoding="w3cdtf">2006-08-03</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">2</extent><extent unit="references">41</extent><extent unit="words">3956</extent></physicalDescription><abstract lang="en">The clinical features of multiple system atrophy (MSA) include four domains: autonomic failure/urinary dysfunction, Parkinsonism, cerebellar ataxia, and corticospinal tract dysfunction. Although the diagnosis of definite MSA requires pathological confirmation, magnetic resonance imaging (MRI) studies have been shown to contribute to the diagnosis of MSA. Although pyramidal tract dysfunction is frequent in MSA patients, signs of pyramidal tract involvement are controversially demonstrated by MRI. We evaluated the pyramidal involvement in 10 patients (7 women) with clinically probable MSA, detecting the presence of spasticity, hyperreflexia, and Babinski sign, as well as demonstrating degeneration of the pyramidal tract and primary motor cortex by MRI in all of them. Our article also discusses key radiological features of this syndrome. In MSA, pyramidal tract involvement seems to be more frequent than previously thought, and the clinicoradiological correlation between pyramidal tract dysfunction and degeneration may contribute to the understanding of the clinical hallmarks of MSA. MRI may also add information regarding the differential diagnosis of this syndrome. © 2006 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinsonism</topic><topic>MRI</topic><topic>MSA</topic><topic>magnetization transfer imaging</topic><topic>cortico‐spinal tract</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>238</start><end>243</end><total>6</total></extent></part></relatedItem><identifier type="istex">6AA341CCACA3BFEB3D2A74707A82E009ED0221F6</identifier><identifier type="DOI">10.1002/mds.21229</identifier><identifier type="ArticleID">MDS21229</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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