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A comparison of two brief screening measures of cognitive impairment in Huntington's disease

Identifieur interne : 001249 ( Istex/Corpus ); précédent : 001248; suivant : 001250

A comparison of two brief screening measures of cognitive impairment in Huntington's disease

Auteurs : Laura Mickes ; Mark Jacobson ; Guerry Peavy ; John T. Wixted ; Stephanie Lessig ; Jody L. Goldstein ; Jody Corey-Bloom

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RBID : ISTEX:6ACBF159DF0D12ADC7F702DA568A1C604D250AD3

English descriptors

Abstract

The goal of this study was to explore whether the Montreal Cognitive Assessment (MoCA), a new screening instrument, would be more sensitive to mild to moderate cognitive impairment in Huntington's disease (HD) than an established screening measure, the Mini Mental State Exam (MMSE). Our reasoning for this query is that the MoCA includes a broader range of test items and an additional assessment of executive functioning and attention compared with the MMSE. Using the receiver operating characteristic (ROC) analysis to examine performance of HD and control groups on both tests on overall scores and scores from various subdomains (i.e., visuospatial abilities) revealed that the MoCA achieved higher sensitivity without sacrificing specificity in many domains relative to the MMSE. © 2010 Movement Disorder Society

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DOI: 10.1002/mds.23181

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ISTEX:6ACBF159DF0D12ADC7F702DA568A1C604D250AD3

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