Movement Disorders (revue)

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Susceptibility genes in movement disorders

Identifieur interne : 001215 ( Istex/Corpus ); précédent : 001214; suivant : 001216

Susceptibility genes in movement disorders

Auteurs : Sonja Scholz ; Andrew Singleton

Source :

RBID : ISTEX:410C307BA276A22DA15FD14937016AEFE50009F9

English descriptors

Abstract

During the last years, remarkable progress in our understanding of molecular genetic mechanisms underlying movement disorders has been achieved. The successes of linkage studies, followed by positional cloning, have dominated the last decade and several genes underlying monogenic disorders have been discovered. The pathobiological understanding garnered from these mutations has laid the foundation for much of the search for genetic loci that confer risk for, rather than cause, disease. With the introduction of whole genome association studies as a novel tool to investigate genetic variation underlying common, complex diseases, a new era in neurogenomics has just begun. As the field rapidly moves forward several new challenges and critical questions in clinical care have to be addressed. In this review, we summarize recent advances in the discovery of susceptibility loci underlying major movement disorders, explain the newest methodologies and tools employed for finding and characterizing genes and discuss how insights into the molecular genetic basis of neurological disorders will impact therapeutic concepts in patient care. © 2008 Movement Disorder Society

Url:
DOI: 10.1002/mds.21983

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ISTEX:410C307BA276A22DA15FD14937016AEFE50009F9

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<topic>whole genome association study</topic>
</subject>
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<titleInfo>
<title>Movement Disorders</title>
<subTitle>Official Journal of the Movement Disorder Society</subTitle>
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<title>Mov. Disord.</title>
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<note type="content"> This article is part of the journal's CME program. The CME form can be found on page 1064 and is available online at http://www.movementdisorders.org/education/activities.html</note>
<subject>
<genre>article category</genre>
<topic>Review</topic>
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<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part>
<date>2008</date>
<detail type="volume">
<caption>vol.</caption>
<number>23</number>
</detail>
<detail type="issue">
<caption>no.</caption>
<number>7</number>
</detail>
<extent unit="pages">
<start>927</start>
<end>934</end>
<total>8</total>
</extent>
</part>
</relatedItem>
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<identifier type="DOI">10.1002/mds.21983</identifier>
<identifier type="ArticleID">MDS21983</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition>
<recordInfo>
<recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin>
<recordContentSource>WILEY</recordContentSource>
</recordInfo>
</mods>
</metadata>
<serie></serie>
</istex>
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   |texte=   Susceptibility genes in movement disorders
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