Parkinson's disease mortality and the industrial use of heavy metals in Michigan
Identifieur interne : 001193 ( Istex/Corpus ); précédent : 001192; suivant : 001194Parkinson's disease mortality and the industrial use of heavy metals in Michigan
Auteurs : Benjamin A. Rybicki ; Christine Cole Johnson ; Jane Uman ; Jay M. GorellSource :
- Movement Disorders [ 0885-3185 ] ; 1993.
English descriptors
Abstract
Parkinson's disease (PD) mortality rates in Michigan counties for 1986–1988 were calculated with respect to potential heavey metal exposure (iron, zinc, copper, mercury, magnesium, and manganese) from industry based on recent census data. Individuals were counted as a PD death if the diagnosis was listed as an “underlying” or “related” cause of death on the death certificate. Counties with an industry in the paper, chemical, iron, or copper related‐industrial categories (ICs) had statiscally significantly (p < 0.05) higher PD death rates than counties without these industries. Significant correlations of chemical (rs =0.22;p = 0.05), paper (rs =0.22;p = 0.05) and iron (rs =0.29;p = 0.008) industry densities with PD death rates were also present. Counties were divided into high (>15/100,000 individuals 45 years old and over) and low (< = 15/100.000) PD death rate counties by cluster analysis. Geographically, counties with high PD mortality were located mainly in the southern half of the lower peninsula and eastern half of the upper peninsula; low PD death rate counties formed two distinct clusters in the western edge of the upper peninsula and the north‐central portion of the lower peninsula. Other possible risk factors that may explain the varied distribution of PD death rates in Michigan were examined. Those significantly correlated with PD mortality included population density (rs =0.31;p= 0.005), farming density (rs= 0.25;p =0.02), and well water use (rs =−0.24;p =0.03). These ecologic findings suggest a geographic association between PD mortality and the industrial use of heavy metals.
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DOI: 10.1002/mds.870080116
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ISTEX:09E2C962343D570D8AC61E1224539E04C92D637DLe document en format XML
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Gossett Parkinson's Disease Center, Division of Movement Disorders, Henry Ford Hospital, Detroit, Michigan, U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Johnson, Christine Cole" sort="Johnson, Christine Cole" uniqKey="Johnson C" first="Christine Cole" last="Johnson">Christine Cole Johnson</name><affiliation><mods:affiliation>Department of Neurology, Henry Ford Hospital, Detroit, Michigan, U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Uman, Jane" sort="Uman, Jane" uniqKey="Uman J" first="Jane" last="Uman">Jane Uman</name><affiliation><mods:affiliation>Department of Neurology, Henry Ford Hospital, Detroit, Michigan, U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Gorell, Jay M" sort="Gorell, Jay M" uniqKey="Gorell J" first="Jay M." last="Gorell">Jay M. Gorell</name><affiliation><mods:affiliation>Department of Biostatistics and Research Epidemiology and William T. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1993">1993</date><biblScope unit="vol">8</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="87">87</biblScope><biblScope unit="page" to="92">92</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">09E2C962343D570D8AC61E1224539E04C92D637D</idno><idno type="DOI">10.1002/mds.870080116</idno><idno type="ArticleID">MDS870080116</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Heavy metals</term><term>Industrial category</term><term>Parkinson's disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) mortality rates in Michigan counties for 1986–1988 were calculated with respect to potential heavey metal exposure (iron, zinc, copper, mercury, magnesium, and manganese) from industry based on recent census data. Individuals were counted as a PD death if the diagnosis was listed as an “underlying” or “related” cause of death on the death certificate. Counties with an industry in the paper, chemical, iron, or copper related‐industrial categories (ICs) had statiscally significantly (p < 0.05) higher PD death rates than counties without these industries. Significant correlations of chemical (rs =0.22;p = 0.05), paper (rs =0.22;p = 0.05) and iron (rs =0.29;p = 0.008) industry densities with PD death rates were also present. Counties were divided into high (>15/100,000 individuals 45 years old and over) and low (< = 15/100.000) PD death rate counties by cluster analysis. Geographically, counties with high PD mortality were located mainly in the southern half of the lower peninsula and eastern half of the upper peninsula; low PD death rate counties formed two distinct clusters in the western edge of the upper peninsula and the north‐central portion of the lower peninsula. Other possible risk factors that may explain the varied distribution of PD death rates in Michigan were examined. Those significantly correlated with PD mortality included population density (rs =0.31;p= 0.005), farming density (rs= 0.25;p =0.02), and well water use (rs =−0.24;p =0.03). These ecologic findings suggest a geographic association between PD mortality and the industrial use of heavy metals.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Benjamin A. Rybicki M.H.S.</name><affiliations><json:string>Department of Biostatistics and Research Epidemiology and William T. Gossett Parkinson's Disease Center, Division of Movement Disorders, Henry Ford Hospital, Detroit, Michigan, U.S.A.</json:string></affiliations></json:item><json:item><name>Christine Cole Johnson</name><affiliations><json:string>Department of Neurology, Henry Ford Hospital, Detroit, Michigan, U.S.A.</json:string></affiliations></json:item><json:item><name>Jane Uman</name><affiliations><json:string>Department of Neurology, Henry Ford Hospital, Detroit, Michigan, U.S.A.</json:string></affiliations></json:item><json:item><name>Jay M. Gorell</name><affiliations><json:string>Department of Biostatistics and Research Epidemiology and William T. Gossett Parkinson's Disease Center, Division of Movement Disorders, Henry Ford Hospital, Detroit, Michigan, U.S.A.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Industrial category</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Heavy metals</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Parkinson's disease (PD) mortality rates in Michigan counties for 1986–1988 were calculated with respect to potential heavey metal exposure (iron, zinc, copper, mercury, magnesium, and manganese) from industry based on recent census data. Individuals were counted as a PD death if the diagnosis was listed as an “underlying” or “related” cause of death on the death certificate. Counties with an industry in the paper, chemical, iron, or copper related‐industrial categories (ICs) had statiscally significantly (p > 0.05) higher PD death rates than counties without these industries. Significant correlations of chemical (rs =0.22;p = 0.05), paper (rs =0.22;p = 0.05) and iron (rs =0.29;p = 0.008) industry densities with PD death rates were also present. Counties were divided into high (>15/100,000 individuals 45 years old and over) and low (> = 15/100.000) PD death rate counties by cluster analysis. Geographically, counties with high PD mortality were located mainly in the southern half of the lower peninsula and eastern half of the upper peninsula; low PD death rate counties formed two distinct clusters in the western edge of the upper peninsula and the north‐central portion of the lower peninsula. Other possible risk factors that may explain the varied distribution of PD death rates in Michigan were examined. Those significantly correlated with PD mortality included population density (rs =0.31;p= 0.005), farming density (rs= 0.25;p =0.02), and well water use (rs =−0.24;p =0.03). 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Gossett Parkinson's Disease Center, Division of Movement Disorders, Henry Ford Hospital, Detroit, Michigan, U.S.A.</affiliation></author><author><persName><forename type="first">Christine Cole</forename><surname>Johnson</surname></persName><affiliation>Department of Neurology, Henry Ford Hospital, Detroit, Michigan, U.S.A.</affiliation></author><author><persName><forename type="first">Jane</forename><surname>Uman</surname></persName><affiliation>Department of Neurology, Henry Ford Hospital, Detroit, Michigan, U.S.A.</affiliation></author><author><persName><forename type="first">Jay M.</forename><surname>Gorell</surname></persName><affiliation>Department of Biostatistics and Research Epidemiology and William T. 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Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1993"></date><biblScope unit="vol">8</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="87">87</biblScope><biblScope unit="page" to="92">92</biblScope></imprint></monogr><idno type="istex">09E2C962343D570D8AC61E1224539E04C92D637D</idno><idno type="DOI">10.1002/mds.870080116</idno><idno type="ArticleID">MDS870080116</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1993</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Parkinson's disease (PD) mortality rates in Michigan counties for 1986–1988 were calculated with respect to potential heavey metal exposure (iron, zinc, copper, mercury, magnesium, and manganese) from industry based on recent census data. Individuals were counted as a PD death if the diagnosis was listed as an “underlying” or “related” cause of death on the death certificate. Counties with an industry in the paper, chemical, iron, or copper related‐industrial categories (ICs) had statiscally significantly (p < 0.05) higher PD death rates than counties without these industries. Significant correlations of chemical (rs =0.22;p = 0.05), paper (rs =0.22;p = 0.05) and iron (rs =0.29;p = 0.008) industry densities with PD death rates were also present. Counties were divided into high (>15/100,000 individuals 45 years old and over) and low (< = 15/100.000) PD death rate counties by cluster analysis. Geographically, counties with high PD mortality were located mainly in the southern half of the lower peninsula and eastern half of the upper peninsula; low PD death rate counties formed two distinct clusters in the western edge of the upper peninsula and the north‐central portion of the lower peninsula. Other possible risk factors that may explain the varied distribution of PD death rates in Michigan were examined. Those significantly correlated with PD mortality included population density (rs =0.31;p= 0.005), farming density (rs= 0.25;p =0.02), and well water use (rs =−0.24;p =0.03). These ecologic findings suggest a geographic association between PD mortality and the industrial use of heavy metals.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>Industrial category</term></item><item><term>Heavy metals</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Review</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1993">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/09E2C962343D570D8AC61E1224539E04C92D637D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="tocForm">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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Gossett Parkinson's Disease Center, Division of Movement Disorders, Henry Ford Hospital, Detroit, Michigan, U.S.A.</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Henry Ford Hospital, Detroit, Michigan, U.S.A.</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">Industrial category</keyword><keyword xml:id="kwd3">Heavy metals</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Parkinson's disease (PD) mortality rates in Michigan counties for 1986–1988 were calculated with respect to potential heavey metal exposure (iron, zinc, copper, mercury, magnesium, and manganese) from industry based on recent census data. Individuals were counted as a PD death if the diagnosis was listed as an “underlying” or “related” cause of death on the death certificate. Counties with an industry in the paper, chemical, iron, or copper related‐industrial categories (ICs) had statiscally significantly (p < 0.05) higher PD death rates than counties without these industries. Significant correlations of chemical (r<sub>s</sub> =0.22;p = 0.05), paper (r<sub>s</sub> =0.22;p = 0.05) and iron (r<sub>s</sub> =0.29;p = 0.008) industry densities with PD death rates were also present. Counties were divided into high (>15/100,000 individuals 45 years old and over) and low (< = 15/100.000) PD death rate counties by cluster analysis. Geographically, counties with high PD mortality were located mainly in the southern half of the lower peninsula and eastern half of the upper peninsula; low PD death rate counties formed two distinct clusters in the western edge of the upper peninsula and the north‐central portion of the lower peninsula. Other possible risk factors that may explain the varied distribution of PD death rates in Michigan were examined. Those significantly correlated with PD mortality included population density (r<sub>s</sub> =0.31;p= 0.005), farming density (r<sub>s</sub>= 0.25;p =0.02), and well water use (r<sub>s</sub> =−0.24;p =0.03). These ecologic findings suggest a geographic association between PD mortality and the industrial use of heavy metals.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Parkinson's disease mortality and the industrial use of heavy metals in Michigan</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>PD MORTALITY AND HEAVY METALS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Parkinson's disease mortality and the industrial use of heavy metals in Michigan</title></titleInfo><name type="personal"><namePart type="given">Benjamin A.</namePart><namePart type="family">Rybicki</namePart><namePart type="termsOfAddress">M.H.S.</namePart><affiliation>Department of Biostatistics and Research Epidemiology and William T. Gossett Parkinson's Disease Center, Division of Movement Disorders, Henry Ford Hospital, Detroit, Michigan, U.S.A.</affiliation><description>Correspondence: Division of Biostatistics and Research Epidemiology, Henry Ford Health System, 23725 Northwestern Highway, Southfield, MI 48075</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christine Cole</namePart><namePart type="family">Johnson</namePart><affiliation>Department of Neurology, Henry Ford Hospital, Detroit, Michigan, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jane</namePart><namePart type="family">Uman</namePart><affiliation>Department of Neurology, Henry Ford Hospital, Detroit, Michigan, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jay M.</namePart><namePart type="family">Gorell</namePart><affiliation>Department of Biostatistics and Research Epidemiology and William T. Gossett Parkinson's Disease Center, Division of Movement Disorders, Henry Ford Hospital, Detroit, Michigan, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">reviewArticle</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1993</dateIssued><copyrightDate encoding="w3cdtf">1993</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">3</extent><extent unit="references">40</extent></physicalDescription><abstract lang="en">Parkinson's disease (PD) mortality rates in Michigan counties for 1986–1988 were calculated with respect to potential heavey metal exposure (iron, zinc, copper, mercury, magnesium, and manganese) from industry based on recent census data. Individuals were counted as a PD death if the diagnosis was listed as an “underlying” or “related” cause of death on the death certificate. Counties with an industry in the paper, chemical, iron, or copper related‐industrial categories (ICs) had statiscally significantly (p < 0.05) higher PD death rates than counties without these industries. Significant correlations of chemical (rs =0.22;p = 0.05), paper (rs =0.22;p = 0.05) and iron (rs =0.29;p = 0.008) industry densities with PD death rates were also present. Counties were divided into high (>15/100,000 individuals 45 years old and over) and low (< = 15/100.000) PD death rate counties by cluster analysis. Geographically, counties with high PD mortality were located mainly in the southern half of the lower peninsula and eastern half of the upper peninsula; low PD death rate counties formed two distinct clusters in the western edge of the upper peninsula and the north‐central portion of the lower peninsula. Other possible risk factors that may explain the varied distribution of PD death rates in Michigan were examined. Those significantly correlated with PD mortality included population density (rs =0.31;p= 0.005), farming density (rs= 0.25;p =0.02), and well water use (rs =−0.24;p =0.03). These ecologic findings suggest a geographic association between PD mortality and the industrial use of heavy metals.</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>Industrial category</topic><topic>Heavy metals</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Review</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>87</start><end>92</end><total>6</total></extent></part></relatedItem><identifier type="istex">09E2C962343D570D8AC61E1224539E04C92D637D</identifier><identifier type="DOI">10.1002/mds.870080116</identifier><identifier type="ArticleID">MDS870080116</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1993 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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