Mortality in Parkinson's disease: A 20‐year follow‐up study
Identifieur interne : 001058 ( Istex/Corpus ); précédent : 001057; suivant : 001059Mortality in Parkinson's disease: A 20‐year follow‐up study
Auteurs : Anja Diem-Zangerl ; Klaus Seppi ; Gregor K. Wenning ; Eugen Trinka ; Gerhard Ransmayr ; Wilhelm Oberaigner ; Werner PoeweSource :
- Movement Disorders [ 0885-3185 ] ; 2009-04-30.
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Abstract
We determined mortality rates and predictors of survival in 238 consecutive patients with Parkinson's disease (PD) with symptom onset between 1974 and 1984. All patients were regularly followed at the Movement Disorder Clinic (Department of Neurology at the Innsbruck Medical University) until December 31, 2004, or death. As of December 31, 2004, 189 patients had died. Standardized mortality ratios (SMRs) increased over time. SMRs were 0.6 (95% CI 0.4–1.0) by 5 years, 0.9 (95% CI 0.7–1.2) by 10 years, 1.2 (95% CI 1.0–1.4) by 15 years, and 1.3 (95% CI 1.1–1.5) by 20 to 30 years. SMR for male patients was significantly increased to 1.3 (95% CI 1.1–1.6), whereas SMR increase of 1.2 (0.9–1.4) observed in female patients was not significant. Significantly increased SMRs were detected in patients with younger and older age of onset. Male gender, gait disorder, lack of tremor, and lack of asymmetry as presenting clinical features predicted poor survival in a Cox's proportional hazard analysis. This study demonstrates similar survival of patients with PD to the normal control population up to a disease duration of 10 years, followed by a modest rise of mortality with disease duration beyond 10 years compared with the general population. Under regular specialist care using all currently available therapies life expectancy in PD does not appear seriously compromised, but male gender, gait disorder, and absent rest tremor at presentation are associated with poorer long‐term survival. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22414
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ISTEX:589B00331F840731FD011A4CDC583312D618C256Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-04-30">2009-04-30</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="819">819</biblScope><biblScope unit="page" to="825">825</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">589B00331F840731FD011A4CDC583312D618C256</idno><idno type="DOI">10.1002/mds.22414</idno><idno type="ArticleID">MDS22414</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>SMR</term><term>mortality</term><term>predictors of survival</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We determined mortality rates and predictors of survival in 238 consecutive patients with Parkinson's disease (PD) with symptom onset between 1974 and 1984. All patients were regularly followed at the Movement Disorder Clinic (Department of Neurology at the Innsbruck Medical University) until December 31, 2004, or death. As of December 31, 2004, 189 patients had died. Standardized mortality ratios (SMRs) increased over time. SMRs were 0.6 (95% CI 0.4–1.0) by 5 years, 0.9 (95% CI 0.7–1.2) by 10 years, 1.2 (95% CI 1.0–1.4) by 15 years, and 1.3 (95% CI 1.1–1.5) by 20 to 30 years. SMR for male patients was significantly increased to 1.3 (95% CI 1.1–1.6), whereas SMR increase of 1.2 (0.9–1.4) observed in female patients was not significant. Significantly increased SMRs were detected in patients with younger and older age of onset. Male gender, gait disorder, lack of tremor, and lack of asymmetry as presenting clinical features predicted poor survival in a Cox's proportional hazard analysis. This study demonstrates similar survival of patients with PD to the normal control population up to a disease duration of 10 years, followed by a modest rise of mortality with disease duration beyond 10 years compared with the general population. Under regular specialist care using all currently available therapies life expectancy in PD does not appear seriously compromised, but male gender, gait disorder, and absent rest tremor at presentation are associated with poorer long‐term survival. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Anja Diem‐Zangerl MD</name><affiliations><json:string>Department of Neurology, Innsbruck Medical University, Austria</json:string></affiliations></json:item><json:item><name>Klaus Seppi MD</name><affiliations><json:string>Department of Neurology, Innsbruck Medical University, Austria</json:string></affiliations></json:item><json:item><name>Gregor K. Wenning MD, PhD</name><affiliations><json:string>Department of Neurology, Innsbruck Medical University, Austria</json:string></affiliations></json:item><json:item><name>Eugen Trinka MD</name><affiliations><json:string>Department of Neurology, Innsbruck Medical University, Austria</json:string></affiliations></json:item><json:item><name>Gerhard Ransmayr MD</name><affiliations><json:string>Department of Neurology and Psychiatry, General Hospital of the City of Linz, Austria</json:string></affiliations></json:item><json:item><name>Wilhelm Oberaigner PhD</name><affiliations><json:string>Department of Clinical Epidemiology, Tyrolean State Hospital Ltd., Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Werner Poewe MD</name><affiliations><json:string>Department of Neurology, Innsbruck Medical University, Austria</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mortality</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SMR</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>predictors of survival</value></json:item></subject><language><json:string>eng</json:string></language><abstract>We determined mortality rates and predictors of survival in 238 consecutive patients with Parkinson's disease (PD) with symptom onset between 1974 and 1984. All patients were regularly followed at the Movement Disorder Clinic (Department of Neurology at the Innsbruck Medical University) until December 31, 2004, or death. As of December 31, 2004, 189 patients had died. Standardized mortality ratios (SMRs) increased over time. SMRs were 0.6 (95% CI 0.4–1.0) by 5 years, 0.9 (95% CI 0.7–1.2) by 10 years, 1.2 (95% CI 1.0–1.4) by 15 years, and 1.3 (95% CI 1.1–1.5) by 20 to 30 years. SMR for male patients was significantly increased to 1.3 (95% CI 1.1–1.6), whereas SMR increase of 1.2 (0.9–1.4) observed in female patients was not significant. Significantly increased SMRs were detected in patients with younger and older age of onset. Male gender, gait disorder, lack of tremor, and lack of asymmetry as presenting clinical features predicted poor survival in a Cox's proportional hazard analysis. This study demonstrates similar survival of patients with PD to the normal control population up to a disease duration of 10 years, followed by a modest rise of mortality with disease duration beyond 10 years compared with the general population. Under regular specialist care using all currently available therapies life expectancy in PD does not appear seriously compromised, but male gender, gait disorder, and absent rest tremor at presentation are associated with poorer long‐term survival. © 2009 Movement Disorder Society</abstract><qualityIndicators><score>6.58</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1529</abstractCharCount><pdfWordCount>3712</pdfWordCount><pdfCharCount>23632</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>239</abstractWordCount></qualityIndicators><title>Mortality in Parkinson's disease: A 20‐year follow‐up study</title><genre><json:string>Serial article</json:string></genre><host><volume>24</volume><pages><total>7</total><last>825</last><first>819</first></pages><issn><json:string>0885-3185</json:string></issn><issue>6</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/mds.22414</json:string></doi><id>589B00331F840731FD011A4CDC583312D618C256</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/589B00331F840731FD011A4CDC583312D618C256/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/589B00331F840731FD011A4CDC583312D618C256/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/589B00331F840731FD011A4CDC583312D618C256/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Mortality in Parkinson's disease: A 20‐year follow‐up study</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Nothing to report.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Mortality in Parkinson's disease: A 20‐year follow‐up study</title><author><persName><forename type="first">Anja</forename><surname>Diem‐Zangerl</surname><roleName type="degree">MD</roleName></persName><note type="biography">Anja Diem‐Zangerl and Klaus Seppi contributed equally to this work.</note><affiliation>Anja Diem‐Zangerl and Klaus Seppi contributed equally to this work.</affiliation><note type="correspondence"><p>Correspondence: Department of Neurology; Innsbruck Medical University, Innsbruck, Austria</p></note><affiliation>Department of Neurology, Innsbruck Medical University, Austria</affiliation></author><author><persName><forename type="first">Klaus</forename><surname>Seppi</surname><roleName type="degree">MD</roleName></persName><note type="biography">Anja Diem‐Zangerl and Klaus Seppi contributed equally to this work.</note><affiliation>Anja Diem‐Zangerl and Klaus Seppi contributed equally to this work.</affiliation><affiliation>Department of Neurology, Innsbruck Medical University, Austria</affiliation></author><author><persName><forename type="first">Gregor K.</forename><surname>Wenning</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Neurology, Innsbruck Medical University, Austria</affiliation></author><author><persName><forename type="first">Eugen</forename><surname>Trinka</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Innsbruck Medical University, Austria</affiliation></author><author><persName><forename type="first">Gerhard</forename><surname>Ransmayr</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology and Psychiatry, General Hospital of the City of Linz, Austria</affiliation></author><author><persName><forename type="first">Wilhelm</forename><surname>Oberaigner</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Clinical Epidemiology, Tyrolean State Hospital Ltd., Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Werner</forename><surname>Poewe</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: Department of Neurology; Innsbruck Medical University, Innsbruck, Austria</p></note><affiliation>Department of Neurology, Innsbruck Medical University, Austria</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-04-30"></date><biblScope unit="vol">24</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="819">819</biblScope><biblScope unit="page" to="825">825</biblScope></imprint></monogr><idno type="istex">589B00331F840731FD011A4CDC583312D618C256</idno><idno type="DOI">10.1002/mds.22414</idno><idno type="ArticleID">MDS22414</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We determined mortality rates and predictors of survival in 238 consecutive patients with Parkinson's disease (PD) with symptom onset between 1974 and 1984. All patients were regularly followed at the Movement Disorder Clinic (Department of Neurology at the Innsbruck Medical University) until December 31, 2004, or death. As of December 31, 2004, 189 patients had died. Standardized mortality ratios (SMRs) increased over time. SMRs were 0.6 (95% CI 0.4–1.0) by 5 years, 0.9 (95% CI 0.7–1.2) by 10 years, 1.2 (95% CI 1.0–1.4) by 15 years, and 1.3 (95% CI 1.1–1.5) by 20 to 30 years. SMR for male patients was significantly increased to 1.3 (95% CI 1.1–1.6), whereas SMR increase of 1.2 (0.9–1.4) observed in female patients was not significant. Significantly increased SMRs were detected in patients with younger and older age of onset. Male gender, gait disorder, lack of tremor, and lack of asymmetry as presenting clinical features predicted poor survival in a Cox's proportional hazard analysis. This study demonstrates similar survival of patients with PD to the normal control population up to a disease duration of 10 years, followed by a modest rise of mortality with disease duration beyond 10 years compared with the general population. Under regular specialist care using all currently available therapies life expectancy in PD does not appear seriously compromised, but male gender, gait disorder, and absent rest tremor at presentation are associated with poorer long‐term survival. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>mortality</term></item><item><term>SMR</term></item><item><term>predictors of survival</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-09-09">Received</change><change when="2008-11-12">Registration</change><change when="2009-04-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/589B00331F840731FD011A4CDC583312D618C256/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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All patients were regularly followed at the Movement Disorder Clinic (Department of Neurology at the Innsbruck Medical University) until December 31, 2004, or death. As of December 31, 2004, 189 patients had died. Standardized mortality ratios (SMRs) increased over time. SMRs were 0.6 (95% CI 0.4–1.0) by 5 years, 0.9 (95% CI 0.7–1.2) by 10 years, 1.2 (95% CI 1.0–1.4) by 15 years, and 1.3 (95% CI 1.1–1.5) by 20 to 30 years. SMR for male patients was significantly increased to 1.3 (95% CI 1.1–1.6), whereas SMR increase of 1.2 (0.9–1.4) observed in female patients was not significant. Significantly increased SMRs were detected in patients with younger and older age of onset. Male gender, gait disorder, lack of tremor, and lack of asymmetry as presenting clinical features predicted poor survival in a Cox's proportional hazard analysis. This study demonstrates similar survival of patients with PD to the normal control population up to a disease duration of 10 years, followed by a modest rise of mortality with disease duration beyond 10 years compared with the general population. Under regular specialist care using all currently available therapies life expectancy in PD does not appear seriously compromised, but male gender, gait disorder, and absent rest tremor at presentation are associated with poorer long‐term survival. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn2"><p>Potential conflict of interest: Nothing to report.</p></note><note xml:id="fn1"><label>a</label><p>Anja Diem‐Zangerl and Klaus Seppi contributed equally to this work.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Mortality in Parkinson's disease: A 20‐year follow‐up study</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Mortality in Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Mortality in Parkinson's disease: A 20‐year follow‐up study</title></titleInfo><name type="personal"><namePart type="given">Anja</namePart><namePart type="family">Diem‐Zangerl</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Innsbruck Medical University, Austria</affiliation><description>Anja Diem‐Zangerl and Klaus Seppi contributed equally to this work.</description><description>Correspondence: Department of Neurology; Innsbruck Medical University, Innsbruck, Austria</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Klaus</namePart><namePart type="family">Seppi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Innsbruck Medical University, Austria</affiliation><description>Anja Diem‐Zangerl and Klaus Seppi contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gregor K.</namePart><namePart type="family">Wenning</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Innsbruck Medical University, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eugen</namePart><namePart type="family">Trinka</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Innsbruck Medical University, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gerhard</namePart><namePart type="family">Ransmayr</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology and Psychiatry, General Hospital of the City of Linz, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wilhelm</namePart><namePart type="family">Oberaigner</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Clinical Epidemiology, Tyrolean State Hospital Ltd., Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Werner</namePart><namePart type="family">Poewe</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Innsbruck Medical University, Austria</affiliation><description>Correspondence: Department of Neurology; Innsbruck Medical University, Innsbruck, Austria</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-04-30</dateIssued><dateCaptured encoding="w3cdtf">2008-09-09</dateCaptured><dateValid encoding="w3cdtf">2008-11-12</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">5</extent><extent unit="references">45</extent><extent unit="words">5102</extent></physicalDescription><abstract lang="en">We determined mortality rates and predictors of survival in 238 consecutive patients with Parkinson's disease (PD) with symptom onset between 1974 and 1984. All patients were regularly followed at the Movement Disorder Clinic (Department of Neurology at the Innsbruck Medical University) until December 31, 2004, or death. As of December 31, 2004, 189 patients had died. Standardized mortality ratios (SMRs) increased over time. SMRs were 0.6 (95% CI 0.4–1.0) by 5 years, 0.9 (95% CI 0.7–1.2) by 10 years, 1.2 (95% CI 1.0–1.4) by 15 years, and 1.3 (95% CI 1.1–1.5) by 20 to 30 years. SMR for male patients was significantly increased to 1.3 (95% CI 1.1–1.6), whereas SMR increase of 1.2 (0.9–1.4) observed in female patients was not significant. Significantly increased SMRs were detected in patients with younger and older age of onset. Male gender, gait disorder, lack of tremor, and lack of asymmetry as presenting clinical features predicted poor survival in a Cox's proportional hazard analysis. This study demonstrates similar survival of patients with PD to the normal control population up to a disease duration of 10 years, followed by a modest rise of mortality with disease duration beyond 10 years compared with the general population. Under regular specialist care using all currently available therapies life expectancy in PD does not appear seriously compromised, but male gender, gait disorder, and absent rest tremor at presentation are associated with poorer long‐term survival. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>mortality</topic><topic>SMR</topic><topic>predictors of survival</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>819</start><end>825</end><total>7</total></extent></part></relatedItem><identifier type="istex">589B00331F840731FD011A4CDC583312D618C256</identifier><identifier type="DOI">10.1002/mds.22414</identifier><identifier type="ArticleID">MDS22414</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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