Health‐related quality of life in patients with Gilles de la Tourette's syndrome
Identifieur interne : 001042 ( Istex/Corpus ); précédent : 001041; suivant : 001043Health‐related quality of life in patients with Gilles de la Tourette's syndrome
Auteurs : Kirsten Müller-Vahl ; Ines Dodel ; Norbert Müller ; Alexander Münchau ; Jens Peter Reese ; Monika Balzer-Geldsetzer ; Richard Dodel ; Wolfgang H. OertelSource :
- Movement Disorders [ 0885-3185 ] ; 2010-02-15.
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Abstract
To investigate the health‐related quality of life (HrQoL) of adult patients with Gilles de la Tourette's syndrome (GTS) in Germany. HrQoL was evaluated in 200 adult patients with GTS (Mean age: 34.9 ± 11.8 years). Patients were recruited from three outpatient departments in Germany and completed a semi‐structured, self‐rating interview. HrQoL was measured using the EQ‐5D. Depression was assessed using the Beck's depression inventory (BDI) and clinical symptoms using the Yale Tourette syndrome symptom list (TSSL) and the Shapiro Tourette‐syndrome severity scale (STSSS). Multivariate regression analyses were performed to identify independent predictors of HrQoL. Patients with GTS proved to have a worse HrQoL than a sample from the general German population. The domains most affected were anxiety/depression (57.1%), followed by pain/discomfort (47.5%), usual activities (38.4%), mobility (14%), and self‐care (6.6%). The mean EQ‐5D visual analog scale (EQ‐VAS) was 65.4 ± 21.9. The patients had a mean BDI score of 12.3 ± 9.9, which was considerably worse compared to a healthy group who had a score of 6.45 ± 5.2. The mean STSSS value was 3.2 ± 1.1. In multivariate analyses, depressive symptoms contributed considerably, whereas the severity of symptoms as well as age only contributed minimally to HrQoL in the model (R2 = 0.54). HrQoL is considerably reduced in adult patients with GTS. The main independent factors for determining HrQoL were depression, severity of symptoms, and age. Although, treatment of tics is important, co‐morbidities such as depression should be diagnosed and treated vigorously. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22900
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HrQoL was evaluated in 200 adult patients with GTS (Mean age: 34.9 ± 11.8 years). Patients were recruited from three outpatient departments in Germany and completed a semi‐structured, self‐rating interview. HrQoL was measured using the EQ‐5D. Depression was assessed using the Beck's depression inventory (BDI) and clinical symptoms using the Yale Tourette syndrome symptom list (TSSL) and the Shapiro Tourette‐syndrome severity scale (STSSS). Multivariate regression analyses were performed to identify independent predictors of HrQoL. Patients with GTS proved to have a worse HrQoL than a sample from the general German population. The domains most affected were anxiety/depression (57.1%), followed by pain/discomfort (47.5%), usual activities (38.4%), mobility (14%), and self‐care (6.6%). The mean EQ‐5D visual analog scale (EQ‐VAS) was 65.4 ± 21.9. The patients had a mean BDI score of 12.3 ± 9.9, which was considerably worse compared to a healthy group who had a score of 6.45 ± 5.2. The mean STSSS value was 3.2 ± 1.1. In multivariate analyses, depressive symptoms contributed considerably, whereas the severity of symptoms as well as age only contributed minimally to HrQoL in the model (R2 = 0.54). HrQoL is considerably reduced in adult patients with GTS. The main independent factors for determining HrQoL were depression, severity of symptoms, and age. Although, treatment of tics is important, co‐morbidities such as depression should be diagnosed and treated vigorously. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Kirsten Müller‐Vahl MD</name><affiliations><json:string>Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Germany</json:string></affiliations></json:item><json:item><name>Ines Dodel MD</name><affiliations><json:string>Department of Neurology, Philipps‐University Marburg, Germany</json:string></affiliations></json:item><json:item><name>Norbert Müller MD</name><affiliations><json:string>Department of Psychiatry, Ludwig‐Maximilians‐University Munich, Germany</json:string></affiliations></json:item><json:item><name>Alexander Münchau MD</name><affiliations><json:string>Department of Neurology, University Hamburg Eppendorf, Germany</json:string></affiliations></json:item><json:item><name>Jens Peter Reese PhD, MPH</name><affiliations><json:string>Department of Neurology, Philipps‐University Marburg, Germany</json:string></affiliations></json:item><json:item><name>Monika Balzer‐Geldsetzer PhD</name><affiliations><json:string>Department of Neurology, Philipps‐University Marburg, Germany</json:string></affiliations></json:item><json:item><name>Richard Dodel MD, MPH</name><affiliations><json:string>Department of Neurology, Philipps‐University Marburg, Germany</json:string></affiliations></json:item><json:item><name>Wolfgang H. Oertel MD</name><affiliations><json:string>Department of Neurology, Philipps‐University Marburg, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>movement disorders</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>outcome research</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>quality of life</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Gilles de la Tourette's syndrome</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Euroqol</value></json:item></subject><language><json:string>eng</json:string></language><abstract>To investigate the health‐related quality of life (HrQoL) of adult patients with Gilles de la Tourette's syndrome (GTS) in Germany. HrQoL was evaluated in 200 adult patients with GTS (Mean age: 34.9 ± 11.8 years). Patients were recruited from three outpatient departments in Germany and completed a semi‐structured, self‐rating interview. HrQoL was measured using the EQ‐5D. Depression was assessed using the Beck's depression inventory (BDI) and clinical symptoms using the Yale Tourette syndrome symptom list (TSSL) and the Shapiro Tourette‐syndrome severity scale (STSSS). Multivariate regression analyses were performed to identify independent predictors of HrQoL. Patients with GTS proved to have a worse HrQoL than a sample from the general German population. The domains most affected were anxiety/depression (57.1%), followed by pain/discomfort (47.5%), usual activities (38.4%), mobility (14%), and self‐care (6.6%). The mean EQ‐5D visual analog scale (EQ‐VAS) was 65.4 ± 21.9. The patients had a mean BDI score of 12.3 ± 9.9, which was considerably worse compared to a healthy group who had a score of 6.45 ± 5.2. The mean STSSS value was 3.2 ± 1.1. In multivariate analyses, depressive symptoms contributed considerably, whereas the severity of symptoms as well as age only contributed minimally to HrQoL in the model (R2 = 0.54). HrQoL is considerably reduced in adult patients with GTS. The main independent factors for determining HrQoL were depression, severity of symptoms, and age. Although, treatment of tics is important, co‐morbidities such as depression should be diagnosed and treated vigorously. © 2009 Movement Disorder Society</abstract><qualityIndicators><score>6.621</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1651</abstractCharCount><pdfWordCount>3645</pdfWordCount><pdfCharCount>23797</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>248</abstractWordCount></qualityIndicators><title>Health‐related quality of life in patients with Gilles de la Tourette's syndrome</title><genre><json:string>Serial article</json:string></genre><host><volume>25</volume><pages><total>6</total><last>314</last><first>309</first></pages><issn><json:string>0885-3185</json:string></issn><issue>3</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1002/mds.22900</json:string></doi><id>1747E8870C94850C3E4902D7B5045C831835ADCE</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/1747E8870C94850C3E4902D7B5045C831835ADCE/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/1747E8870C94850C3E4902D7B5045C831835ADCE/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/1747E8870C94850C3E4902D7B5045C831835ADCE/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Health‐related quality of life in patients with Gilles de la Tourette's syndrome</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Nothing to report.</note><note>German Ministry of Education and Research - No. BMBF Nr. 01GI9901/1;</note><note>Competence Network Parkinson's disease</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Health‐related quality of life in patients with Gilles de la Tourette's syndrome</title><author><persName><forename type="first">Kirsten</forename><surname>Müller‐Vahl</surname><roleName type="degree">MD</roleName></persName><note type="biography">Kirsten Müller‐Vahl and Ines Dodel contributed equally to this work.</note><affiliation>Kirsten Müller‐Vahl and Ines Dodel contributed equally to this work.</affiliation><affiliation>Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Germany</affiliation></author><author><persName><forename type="first">Ines</forename><surname>Dodel</surname><roleName type="degree">MD</roleName></persName><note type="biography">Kirsten Müller‐Vahl and Ines Dodel contributed equally to this work.</note><affiliation>Kirsten Müller‐Vahl and Ines Dodel contributed equally to this work.</affiliation><affiliation>Department of Neurology, Philipps‐University Marburg, Germany</affiliation></author><author><persName><forename type="first">Norbert</forename><surname>Müller</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Psychiatry, Ludwig‐Maximilians‐University Munich, Germany</affiliation></author><author><persName><forename type="first">Alexander</forename><surname>Münchau</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University Hamburg Eppendorf, Germany</affiliation></author><author><persName><forename type="first">Jens Peter</forename><surname>Reese</surname><roleName type="degree">PhD, MPH</roleName></persName><affiliation>Department of Neurology, Philipps‐University Marburg, Germany</affiliation></author><author><persName><forename type="first">Monika</forename><surname>Balzer‐Geldsetzer</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Neurology, Philipps‐University Marburg, Germany</affiliation></author><author><persName><forename type="first">Richard</forename><surname>Dodel</surname><roleName type="degree">MD, MPH</roleName></persName><note type="correspondence"><p>Correspondence: Department of Neurology, Philipps‐University Marburg, Rudolf‐Bultmannstr. 8, Marburg 35039, Germany===</p></note><affiliation>Department of Neurology, Philipps‐University Marburg, Germany</affiliation></author><author><persName><forename type="first">Wolfgang H.</forename><surname>Oertel</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Philipps‐University Marburg, Germany</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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HrQoL was evaluated in 200 adult patients with GTS (Mean age: 34.9 ± 11.8 years). Patients were recruited from three outpatient departments in Germany and completed a semi‐structured, self‐rating interview. HrQoL was measured using the EQ‐5D. Depression was assessed using the Beck's depression inventory (BDI) and clinical symptoms using the Yale Tourette syndrome symptom list (TSSL) and the Shapiro Tourette‐syndrome severity scale (STSSS). Multivariate regression analyses were performed to identify independent predictors of HrQoL. Patients with GTS proved to have a worse HrQoL than a sample from the general German population. The domains most affected were anxiety/depression (57.1%), followed by pain/discomfort (47.5%), usual activities (38.4%), mobility (14%), and self‐care (6.6%). The mean EQ‐5D visual analog scale (EQ‐VAS) was 65.4 ± 21.9. The patients had a mean BDI score of 12.3 ± 9.9, which was considerably worse compared to a healthy group who had a score of 6.45 ± 5.2. The mean STSSS value was 3.2 ± 1.1. In multivariate analyses, depressive symptoms contributed considerably, whereas the severity of symptoms as well as age only contributed minimally to HrQoL in the model (R2 = 0.54). HrQoL is considerably reduced in adult patients with GTS. The main independent factors for determining HrQoL were depression, severity of symptoms, and age. 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href="file:MDS.MDS22900.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="25"></count><count type="wordTotal" number="4487"></count></countGroup><titleGroup><title type="main" xml:lang="en">Health‐related quality of life in patients with Gilles de la Tourette's syndrome<link href="#fn1"></link></title><title type="short" xml:lang="en">HrQoL in Patients with Tourette's Syndrome</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" noteRef="#fn2"><personName><givenNames>Kirsten</givenNames><familyName>Müller‐Vahl</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2" noteRef="#fn2"><personName><givenNames>Ines</givenNames><familyName>Dodel</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Norbert</givenNames><familyName>Müller</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Alexander</givenNames><familyName>Münchau</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Jens Peter</givenNames><familyName>Reese</familyName><degrees>PhD, MPH</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Monika</givenNames><familyName>Balzer‐Geldsetzer</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af2" corresponding="yes"><personName><givenNames>Richard</givenNames><familyName>Dodel</familyName><degrees>MD, MPH</degrees></personName><contactDetails><email normalForm="dodel@med.uni-marburg.de">dodel@med.uni‐marburg.de</email></contactDetails></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Wolfgang H.</givenNames><familyName>Oertel</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="DE" type="organization"><unparsedAffiliation>Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, Philipps‐University Marburg, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="DE" type="organization"><unparsedAffiliation>Department of Psychiatry, Ludwig‐Maximilians‐University Munich, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, University Hamburg Eppendorf, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">movement disorders</keyword><keyword xml:id="kwd2">outcome research</keyword><keyword xml:id="kwd3">quality of life</keyword><keyword xml:id="kwd4">Gilles de la Tourette's syndrome</keyword><keyword xml:id="kwd5">Euroqol</keyword></keywordGroup><fundingInfo><fundingAgency>German Ministry of Education and Research</fundingAgency><fundingNumber>BMBF Nr. 01GI9901/1</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Competence Network Parkinson's disease</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>To investigate the health‐related quality of life (HrQoL) of adult patients with Gilles de la Tourette's syndrome (GTS) in Germany. HrQoL was evaluated in 200 adult patients with GTS (Mean age: 34.9 ± 11.8 years). Patients were recruited from three outpatient departments in Germany and completed a semi‐structured, self‐rating interview. HrQoL was measured using the EQ‐5D. Depression was assessed using the Beck's depression inventory (BDI) and clinical symptoms using the Yale Tourette syndrome symptom list (TSSL) and the Shapiro Tourette‐syndrome severity scale (STSSS). Multivariate regression analyses were performed to identify independent predictors of HrQoL. Patients with GTS proved to have a worse HrQoL than a sample from the general German population. The domains most affected were anxiety/depression (57.1%), followed by pain/discomfort (47.5%), usual activities (38.4%), mobility (14%), and self‐care (6.6%). The mean EQ‐5D visual analog scale (EQ‐VAS) was 65.4 ± 21.9. The patients had a mean BDI score of 12.3 ± 9.9, which was considerably worse compared to a healthy group who had a score of 6.45 ± 5.2. The mean STSSS value was 3.2 ± 1.1. In multivariate analyses, depressive symptoms contributed considerably, whereas the severity of symptoms as well as age only contributed minimally to HrQoL in the model (R<sup>2</sup> = 0.54). HrQoL is considerably reduced in adult patients with GTS. The main independent factors for determining HrQoL were depression, severity of symptoms, and age. Although, treatment of tics is important, co‐morbidities such as depression should be diagnosed and treated vigorously. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Nothing to report.</p></note><note xml:id="fn2"><p>Kirsten Müller‐Vahl and Ines Dodel contributed equally to this work.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Health‐related quality of life in patients with Gilles de la Tourette's syndrome</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>HrQoL in Patients with Tourette's Syndrome</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Health‐related quality of life in patients with Gilles de la Tourette's syndrome</title></titleInfo><name type="personal"><namePart type="given">Kirsten</namePart><namePart type="family">Müller‐Vahl</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Germany</affiliation><description>Kirsten Müller‐Vahl and Ines Dodel contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ines</namePart><namePart type="family">Dodel</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Philipps‐University Marburg, Germany</affiliation><description>Kirsten Müller‐Vahl and Ines Dodel contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Norbert</namePart><namePart type="family">Müller</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Psychiatry, Ludwig‐Maximilians‐University Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexander</namePart><namePart type="family">Münchau</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University Hamburg Eppendorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jens Peter</namePart><namePart type="family">Reese</namePart><namePart type="termsOfAddress">PhD, MPH</namePart><affiliation>Department of Neurology, Philipps‐University Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Monika</namePart><namePart type="family">Balzer‐Geldsetzer</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Philipps‐University Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Richard</namePart><namePart type="family">Dodel</namePart><namePart type="termsOfAddress">MD, MPH</namePart><affiliation>Department of Neurology, Philipps‐University Marburg, Germany</affiliation><description>Correspondence: Department of Neurology, Philipps‐University Marburg, Rudolf‐Bultmannstr. 8, Marburg 35039, Germany===</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wolfgang H.</namePart><namePart type="family">Oertel</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Philipps‐University Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-02-15</dateIssued><dateCaptured encoding="w3cdtf">2009-02-13</dateCaptured><dateValid encoding="w3cdtf">2009-10-27</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">2</extent><extent unit="references">25</extent><extent unit="words">4487</extent></physicalDescription><abstract lang="en">To investigate the health‐related quality of life (HrQoL) of adult patients with Gilles de la Tourette's syndrome (GTS) in Germany. HrQoL was evaluated in 200 adult patients with GTS (Mean age: 34.9 ± 11.8 years). Patients were recruited from three outpatient departments in Germany and completed a semi‐structured, self‐rating interview. HrQoL was measured using the EQ‐5D. Depression was assessed using the Beck's depression inventory (BDI) and clinical symptoms using the Yale Tourette syndrome symptom list (TSSL) and the Shapiro Tourette‐syndrome severity scale (STSSS). Multivariate regression analyses were performed to identify independent predictors of HrQoL. Patients with GTS proved to have a worse HrQoL than a sample from the general German population. The domains most affected were anxiety/depression (57.1%), followed by pain/discomfort (47.5%), usual activities (38.4%), mobility (14%), and self‐care (6.6%). The mean EQ‐5D visual analog scale (EQ‐VAS) was 65.4 ± 21.9. The patients had a mean BDI score of 12.3 ± 9.9, which was considerably worse compared to a healthy group who had a score of 6.45 ± 5.2. The mean STSSS value was 3.2 ± 1.1. In multivariate analyses, depressive symptoms contributed considerably, whereas the severity of symptoms as well as age only contributed minimally to HrQoL in the model (R2 = 0.54). HrQoL is considerably reduced in adult patients with GTS. The main independent factors for determining HrQoL were depression, severity of symptoms, and age. Although, treatment of tics is important, co‐morbidities such as depression should be diagnosed and treated vigorously. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><note type="funding">German Ministry of Education and Research - No. BMBF Nr. 01GI9901/1; </note><note type="funding">Competence Network Parkinson's disease</note><subject lang="en"><genre>Keywords</genre><topic>movement disorders</topic><topic>outcome research</topic><topic>quality of life</topic><topic>Gilles de la Tourette's syndrome</topic><topic>Euroqol</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>309</start><end>314</end><total>6</total></extent></part></relatedItem><identifier type="istex">1747E8870C94850C3E4902D7B5045C831835ADCE</identifier><identifier type="DOI">10.1002/mds.22900</identifier><identifier type="ArticleID">MDS22900</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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