Cognitive and behavioral changes after unilateral posteroventral pallidotomy: Relationship with lesional data from MRI
Identifieur interne : 001019 ( Istex/Corpus ); précédent : 001018; suivant : 001020Cognitive and behavioral changes after unilateral posteroventral pallidotomy: Relationship with lesional data from MRI
Auteurs : Carme Junqué ; Montse Alegret ; Frederich A. Nobbe ; Francesc Valldeoriola ; Roser Pueyo ; Pere Vendrell ; Eduardo Tolosa ; Jordi Rumià ; Josep Maria MercaderSource :
- Movement Disorders [ 0885-3185 ] ; 1999-09.
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Abstract
We investigated cognitive and behavioral changes after unilateral posteroventral pallidotomy, and their relationship with lesion size and location as identified in magnetic resonance image quantitative analysis. Fifteen consecutive patients with Parkinson's disease were assessed neuropsychologically before and after unilateral posteroventral pallidotomy (five right and 10 left). Immediate postsurgery evaluation (1 week) demonstrated significant worsening of memory, motor learning, motor speed, and verbal fluency. In the 3‐month follow up, learning, memory, and speed returned to the presurgical level, but verbal fluency remained below the baseline. Significant improvements were observed in visuospatial functions and obsessive‐compulsive behavior. Lesional volume did not correlate with neuropsychologic changes. Left lesions produced more impairment in verbal fluency than right‐sided lesions. Regression analysis identified two lesional areas in the pallidum mediale internum. These regions accounted for 68% of the variance in the visuospatial changes.
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DOI: 10.1002/1531-8257(199909)14:5<780::AID-MDS1010>3.0.CO;2-G
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Fifteen consecutive patients with Parkinson's disease were assessed neuropsychologically before and after unilateral posteroventral pallidotomy (five right and 10 left). Immediate postsurgery evaluation (1 week) demonstrated significant worsening of memory, motor learning, motor speed, and verbal fluency. In the 3‐month follow up, learning, memory, and speed returned to the presurgical level, but verbal fluency remained below the baseline. Significant improvements were observed in visuospatial functions and obsessive‐compulsive behavior. Lesional volume did not correlate with neuropsychologic changes. Left lesions produced more impairment in verbal fluency than right‐sided lesions. Regression analysis identified two lesional areas in the pallidum mediale internum. These regions accounted for 68% of the variance in the visuospatial changes.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Carme Junqué PhD</name><affiliations><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)</json:string></affiliations></json:item><json:item><name>Montse Alegret BA</name><affiliations><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)</json:string></affiliations></json:item><json:item><name>Frederich A. Nobbe MD</name><affiliations><json:string>Unit of Parkinson's and Movement Disorders, Service of Neurology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, IDIBAPS</json:string></affiliations></json:item><json:item><name>Francesc Valldeoriola MD</name><affiliations><json:string>Unit of Parkinson's and Movement Disorders, Service of Neurology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, IDIBAPS</json:string></affiliations></json:item><json:item><name>Roser Pueyo BA</name><affiliations><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)</json:string></affiliations></json:item><json:item><name>Pere Vendrell PhD</name><affiliations><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)</json:string></affiliations></json:item><json:item><name>Eduardo Tolosa MD</name><affiliations><json:string>Unit of Parkinson's and Movement Disorders, Service of Neurology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, IDIBAPS</json:string></affiliations></json:item><json:item><name>Jordi Rumià MD</name><affiliations><json:string>Service of Neurosurgery, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona</json:string></affiliations></json:item><json:item><name>Josep Maria Mercader MD</name><affiliations><json:string>Service of Neuroradiology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Pallidotomy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Neuropsychology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Psychiatry</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Frontostriatal circuitry</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Magnetic resonance imaging</value></json:item></subject><language><json:string>eng</json:string></language><abstract>We investigated cognitive and behavioral changes after unilateral posteroventral pallidotomy, and their relationship with lesion size and location as identified in magnetic resonance image quantitative analysis. Fifteen consecutive patients with Parkinson's disease were assessed neuropsychologically before and after unilateral posteroventral pallidotomy (five right and 10 left). Immediate postsurgery evaluation (1 week) demonstrated significant worsening of memory, motor learning, motor speed, and verbal fluency. In the 3‐month follow up, learning, memory, and speed returned to the presurgical level, but verbal fluency remained below the baseline. Significant improvements were observed in visuospatial functions and obsessive‐compulsive behavior. Lesional volume did not correlate with neuropsychologic changes. Left lesions produced more impairment in verbal fluency than right‐sided lesions. Regression analysis identified two lesional areas in the pallidum mediale internum. 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No. 1996 SGR 00064; No. 1997FI00147;</note><note>Alexander Von Humboldt‐Stiftung - No. V‐3‐FLF‐1020243;</note><note>Àrea de Neurociències Fundació Clínic - No. 990262;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Cognitive and behavioral changes after unilateral posteroventral pallidotomy: Relationship with lesional data from MRI</title><author><persName><forename type="first">Carme</forename><surname>Junqué</surname><roleName type="degree">PhD</roleName></persName><note type="correspondence"><p>Correspondence: Departament de Psiquiatria i Psicobiologia Clínica, Universitat de Barcelona, Passeig de la Vall d'Hebron, 171, 08035 Barcelona, Spain</p></note><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)</affiliation></author><author><persName><forename type="first">Montse</forename><surname>Alegret</surname><roleName type="degree">BA</roleName></persName><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)</affiliation></author><author><persName><forename type="first">Frederich A.</forename><surname>Nobbe</surname><roleName type="degree">MD</roleName></persName><affiliation>Unit of Parkinson's and Movement Disorders, Service of Neurology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, IDIBAPS</affiliation></author><author><persName><forename type="first">Francesc</forename><surname>Valldeoriola</surname><roleName type="degree">MD</roleName></persName><affiliation>Unit of Parkinson's and Movement Disorders, Service of Neurology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, IDIBAPS</affiliation></author><author><persName><forename type="first">Roser</forename><surname>Pueyo</surname><roleName type="degree">BA</roleName></persName><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)</affiliation></author><author><persName><forename type="first">Pere</forename><surname>Vendrell</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)</affiliation></author><author><persName><forename type="first">Eduardo</forename><surname>Tolosa</surname><roleName type="degree">MD</roleName></persName><affiliation>Unit of Parkinson's and Movement Disorders, Service of Neurology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, IDIBAPS</affiliation></author><author><persName><forename type="first">Jordi</forename><surname>Rumià</surname><roleName type="degree">MD</roleName></persName><affiliation>Service of Neurosurgery, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona</affiliation></author><author><persName><forename type="first">Josep Maria</forename><surname>Mercader</surname><roleName type="degree">MD</roleName></persName><affiliation>Service of Neuroradiology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. 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Fifteen consecutive patients with Parkinson's disease were assessed neuropsychologically before and after unilateral posteroventral pallidotomy (five right and 10 left). Immediate postsurgery evaluation (1 week) demonstrated significant worsening of memory, motor learning, motor speed, and verbal fluency. In the 3‐month follow up, learning, memory, and speed returned to the presurgical level, but verbal fluency remained below the baseline. Significant improvements were observed in visuospatial functions and obsessive‐compulsive behavior. Lesional volume did not correlate with neuropsychologic changes. Left lesions produced more impairment in verbal fluency than right‐sided lesions. Regression analysis identified two lesional areas in the pallidum mediale internum. 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href="file:MDS.MDS1010.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="57"></count><count type="wordTotal" number="5256"></count></countGroup><titleGroup><title type="main" xml:lang="en">Cognitive and behavioral changes after unilateral posteroventral pallidotomy: Relationship with lesional data from MRI</title><title type="short" xml:lang="en">Pallidotomy: Neuropsychology and Neuroimaging</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Carme</givenNames><familyName>Junqué</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Montse</givenNames><familyName>Alegret</familyName><degrees>BA</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Frederich A.</givenNames><familyName>Nobbe</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Francesc</givenNames><familyName>Valldeoriola</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Roser</givenNames><familyName>Pueyo</familyName><degrees>BA</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Pere</givenNames><familyName>Vendrell</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Eduardo</givenNames><familyName>Tolosa</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Jordi</givenNames><familyName>Rumià</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Josep Maria</givenNames><familyName>Mercader</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="ES" type="organization"><unparsedAffiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="ES" type="organization"><unparsedAffiliation>Unit of Parkinson's and Movement Disorders, Service of Neurology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, IDIBAPS</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="ES" type="organization"><unparsedAffiliation>Service of Neurosurgery, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="ES" type="organization"><unparsedAffiliation>Service of Neuroradiology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">Pallidotomy</keyword><keyword xml:id="kwd3">Neuropsychology</keyword><keyword xml:id="kwd4">Psychiatry</keyword><keyword xml:id="kwd5">Frontostriatal circuitry</keyword><keyword xml:id="kwd6">Magnetic resonance imaging</keyword></keywordGroup><fundingInfo><fundingAgency>Generalitat of Catalonia</fundingAgency><fundingNumber>1997 SGR 00302</fundingNumber><fundingNumber>1996 SGR 00064</fundingNumber><fundingNumber>1997FI00147</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Alexander Von Humboldt‐Stiftung</fundingAgency><fundingNumber>V‐3‐FLF‐1020243</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Àrea de Neurociències Fundació Clínic</fundingAgency><fundingNumber>990262</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We investigated cognitive and behavioral changes after unilateral posteroventral pallidotomy, and their relationship with lesion size and location as identified in magnetic resonance image quantitative analysis. Fifteen consecutive patients with Parkinson's disease were assessed neuropsychologically before and after unilateral posteroventral pallidotomy (five right and 10 left). Immediate postsurgery evaluation (1 week) demonstrated significant worsening of memory, motor learning, motor speed, and verbal fluency. In the 3‐month follow up, learning, memory, and speed returned to the presurgical level, but verbal fluency remained below the baseline. Significant improvements were observed in visuospatial functions and obsessive‐compulsive behavior. Lesional volume did not correlate with neuropsychologic changes. Left lesions produced more impairment in verbal fluency than right‐sided lesions. Regression analysis identified two lesional areas in the pallidum mediale internum. These regions accounted for 68% of the variance in the visuospatial changes.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Cognitive and behavioral changes after unilateral posteroventral pallidotomy: Relationship with lesional data from MRI</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Pallidotomy: Neuropsychology and Neuroimaging</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Cognitive and behavioral changes after unilateral posteroventral pallidotomy: Relationship with lesional data from MRI</title></titleInfo><name type="personal"><namePart type="given">Carme</namePart><namePart type="family">Junqué</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)</affiliation><description>Correspondence: Departament de Psiquiatria i Psicobiologia Clínica, Universitat de Barcelona, Passeig de la Vall d'Hebron, 171, 08035 Barcelona, Spain</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Montse</namePart><namePart type="family">Alegret</namePart><namePart type="termsOfAddress">BA</namePart><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Frederich A.</namePart><namePart type="family">Nobbe</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Unit of Parkinson's and Movement Disorders, Service of Neurology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, IDIBAPS</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francesc</namePart><namePart type="family">Valldeoriola</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Unit of Parkinson's and Movement Disorders, Service of Neurology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, IDIBAPS</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roser</namePart><namePart type="family">Pueyo</namePart><namePart type="termsOfAddress">BA</namePart><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pere</namePart><namePart type="family">Vendrell</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eduardo</namePart><namePart type="family">Tolosa</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Unit of Parkinson's and Movement Disorders, Service of Neurology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, IDIBAPS</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jordi</namePart><namePart type="family">Rumià</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Service of Neurosurgery, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Josep Maria</namePart><namePart type="family">Mercader</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Service of Neuroradiology, Department of Medicine, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">1999-09</dateIssued><dateCaptured encoding="w3cdtf">1998-12-07</dateCaptured><dateValid encoding="w3cdtf">1999-06-03</dateValid><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">3</extent><extent unit="references">57</extent><extent unit="words">5256</extent></physicalDescription><abstract lang="en">We investigated cognitive and behavioral changes after unilateral posteroventral pallidotomy, and their relationship with lesion size and location as identified in magnetic resonance image quantitative analysis. Fifteen consecutive patients with Parkinson's disease were assessed neuropsychologically before and after unilateral posteroventral pallidotomy (five right and 10 left). Immediate postsurgery evaluation (1 week) demonstrated significant worsening of memory, motor learning, motor speed, and verbal fluency. In the 3‐month follow up, learning, memory, and speed returned to the presurgical level, but verbal fluency remained below the baseline. Significant improvements were observed in visuospatial functions and obsessive‐compulsive behavior. Lesional volume did not correlate with neuropsychologic changes. Left lesions produced more impairment in verbal fluency than right‐sided lesions. Regression analysis identified two lesional areas in the pallidum mediale internum. These regions accounted for 68% of the variance in the visuospatial changes.</abstract><note type="funding">Generalitat of Catalonia - No. 1997 SGR 00302; No. 1996 SGR 00064; No. 1997FI00147; </note><note type="funding">Alexander Von Humboldt‐Stiftung - No. V‐3‐FLF‐1020243; </note><note type="funding">Àrea de Neurociències Fundació Clínic - No. 990262; </note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>Pallidotomy</topic><topic>Neuropsychology</topic><topic>Psychiatry</topic><topic>Frontostriatal circuitry</topic><topic>Magnetic resonance imaging</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>780</start><end>789</end><total>10</total></extent></part></relatedItem><identifier type="istex">9D033B4F09C01017DC4E45BAEAAF7503B211DE33</identifier><identifier type="DOI">10.1002/1531-8257(199909)14:5<780::AID-MDS1010>3.0.CO;2-G</identifier><identifier type="ArticleID">MDS1010</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1999 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>John Wiley & Sons, Inc.</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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