PINK1 mutations in a Brazilian cohort of early‐onset Parkinson's disease patients
Identifieur interne : 000F65 ( Istex/Corpus ); précédent : 000F64; suivant : 000F66PINK1 mutations in a Brazilian cohort of early‐onset Parkinson's disease patients
Auteurs : Clecio Godeiro-Junior ; Patricia M. De Carvalho-Aguiar ; Andre C. Felício ; Orlando G. P. Barsottini ; Sonia M. A. Silva ; Vanderci Borges ; Luiz Augusto F. Andrade ; Henrique Ballalai FerrazSource :
- Movement Disorders [ 0885-3185 ] ; 2009-08-15.
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Abstract
Data on the frequency of PINK1 mutations in Brazilian patients with early‐onset Parkinson's disease (EOPD) are lacking. The aim of this report was to investigate mutations of the PINK1 gene in a cohort of Brazilian patients with EOPD. Sixty consecutive familial or sporadic EOPD patients were included. All eight PINK1 exons and exon‐intron boundaries were analyzed. We did not find any pathogenic mutation of PINK1 in our cohort. Single Nucleotide Polymorphisms (SNP) were identified in 46.7% of the patients and in 45.9% of controls (P = 0.9). The SNPs identified in our patients had already been described in previous reports. The results of our study support the hypothesis that mutations in PINK1 may not be a relevant cause of EOPD. In Brazil, if we consider only EOPD patients, it seems that parkin and LRRK2 mutations are more common. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22685
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Barsottini</name><affiliation><mods:affiliation>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</mods:affiliation></affiliation><affiliation><mods:affiliation>Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Silva, Sonia M A" sort="Silva, Sonia M A" uniqKey="Silva S" first="Sonia M. A." last="Silva">Sonia M. A. 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The aim of this report was to investigate mutations of the PINK1 gene in a cohort of Brazilian patients with EOPD. Sixty consecutive familial or sporadic EOPD patients were included. All eight PINK1 exons and exon‐intron boundaries were analyzed. We did not find any pathogenic mutation of PINK1 in our cohort. Single Nucleotide Polymorphisms (SNP) were identified in 46.7% of the patients and in 45.9% of controls (P = 0.9). The SNPs identified in our patients had already been described in previous reports. The results of our study support the hypothesis that mutations in PINK1 may not be a relevant cause of EOPD. In Brazil, if we consider only EOPD patients, it seems that parkin and LRRK2 mutations are more common. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Clecio Godeiro‐Junior MD</name><affiliations><json:string>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</json:string><json:string>Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</json:string></affiliations></json:item><json:item><name>Patricia M. de Carvalho‐Aguiar MD, PhD</name><affiliations><json:string>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</json:string><json:string>Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</json:string></affiliations></json:item><json:item><name>Andre C. Felício MD</name><affiliations><json:string>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</json:string><json:string>Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</json:string></affiliations></json:item><json:item><name>Orlando G.P. Barsottini MD, PhD</name><affiliations><json:string>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</json:string><json:string>Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</json:string></affiliations></json:item><json:item><name>Sonia M.A. Silva MD, PhD</name><affiliations><json:string>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</json:string></affiliations></json:item><json:item><name>Vanderci Borges MD, PhD</name><affiliations><json:string>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</json:string></affiliations></json:item><json:item><name>Luiz Augusto F. Andrade MD, PhD</name><affiliations><json:string>Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</json:string></affiliations></json:item><json:item><name>Henrique Ballalai Ferraz MD, PhD</name><affiliations><json:string>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>early‐onset</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PINK1</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Data on the frequency of PINK1 mutations in Brazilian patients with early‐onset Parkinson's disease (EOPD) are lacking. The aim of this report was to investigate mutations of the PINK1 gene in a cohort of Brazilian patients with EOPD. Sixty consecutive familial or sporadic EOPD patients were included. All eight PINK1 exons and exon‐intron boundaries were analyzed. We did not find any pathogenic mutation of PINK1 in our cohort. Single Nucleotide Polymorphisms (SNP) were identified in 46.7% of the patients and in 45.9% of controls (P = 0.9). The SNPs identified in our patients had already been described in previous reports. The results of our study support the hypothesis that mutations in PINK1 may not be a relevant cause of EOPD. In Brazil, if we consider only EOPD patients, it seems that parkin and LRRK2 mutations are more common. © 2009 Movement Disorder Society</abstract><qualityIndicators><score>6.716</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>875</abstractCharCount><pdfWordCount>7729</pdfWordCount><pdfCharCount>51183</pdfCharCount><pdfPageCount>13</pdfPageCount><abstractWordCount>143</abstractWordCount></qualityIndicators><title>PINK1 mutations in a Brazilian cohort of early‐onset Parkinson's disease patients</title><genre><json:string>Serial article</json:string></genre><host><volume>24</volume><pages><total>5</total><last>1696</last><first>1693</first></pages><issn><json:string>0885-3185</json:string></issn><issue>11</issue><subject><json:item><value>Brief Report</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/mds.22685</json:string></doi><id>026B0CAE2BEC027B9F355FF611F68407C3928321</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/026B0CAE2BEC027B9F355FF611F68407C3928321/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/026B0CAE2BEC027B9F355FF611F68407C3928321/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/026B0CAE2BEC027B9F355FF611F68407C3928321/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">PINK1 mutations in a Brazilian cohort of early‐onset Parkinson's disease patients</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Nothing to report.</note><note>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)</note><note>Fondation Philanthropique Edmond J. Safra</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">PINK1 mutations in a Brazilian cohort of early‐onset Parkinson's disease patients</title><author><persName><forename type="first">Clecio</forename><surname>Godeiro‐Junior</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: Rua Napoleão de Barros, 566, ap. 93, São Paulo, São Paulo, Brazil 04024‐002</p></note><affiliation>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</affiliation><affiliation>Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation></author><author><persName><forename type="first">Patricia M.</forename><surname>de Carvalho‐Aguiar</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</affiliation><affiliation>Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation></author><author><persName><forename type="first">Andre C.</forename><surname>Felício</surname><roleName type="degree">MD</roleName></persName><affiliation>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</affiliation><affiliation>Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation></author><author><persName><forename type="first">Orlando G.P.</forename><surname>Barsottini</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</affiliation><affiliation>Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation></author><author><persName><forename type="first">Sonia M.A.</forename><surname>Silva</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</affiliation></author><author><persName><forename type="first">Vanderci</forename><surname>Borges</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</affiliation></author><author><persName><forename type="first">Luiz Augusto F.</forename><surname>Andrade</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation></author><author><persName><forename type="first">Henrique Ballalai</forename><surname>Ferraz</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. 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date="2009-05-27"></event><event type="publishedOnlineEarlyUnpaginated" date="2009-06-26"></event><event type="firstOnline" date="2009-06-26"></event><event type="publishedOnlineFinalForm" date="2009-08-26"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1693</numbering><numbering type="pageLast">1696</numbering></numberingGroup><correspondenceTo>Rua Napoleão de Barros, 566, ap. 93, São Paulo, São Paulo, Brazil 04024‐002</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22685.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="19"></count><count type="wordTotal" number="3172"></count></countGroup><titleGroup><title type="main" xml:lang="en"><i>PINK1</i> mutations in a Brazilian cohort of early‐onset Parkinson's disease patients<link href="#fn2"></link></title><title type="short" xml:lang="en">PINK 1 Mutations in a Brazilian Cohort</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Clecio</givenNames><familyName>Godeiro‐Junior</familyName><degrees>MD</degrees></personName><contactDetails><email>cleciojunior@yahoo.com.br</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Patricia M.</givenNames><familyName>de Carvalho‐Aguiar</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Andre C.</givenNames><familyName>Felício</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Orlando G.P.</givenNames><familyName>Barsottini</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Sonia M.A.</givenNames><familyName>Silva</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Vanderci</givenNames><familyName>Borges</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Luiz Augusto F.</givenNames><familyName>Andrade</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Henrique Ballalai</givenNames><familyName>Ferraz</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="BR" type="organization"><unparsedAffiliation>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="BR" type="organization"><unparsedAffiliation>Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">early‐onset</keyword><keyword xml:id="kwd3"><i>PINK1</i></keyword></keywordGroup><fundingInfo><fundingAgency>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Fondation Philanthropique Edmond J. Safra</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Data on the frequency of <i>PINK1</i> mutations in Brazilian patients with early‐onset Parkinson's disease (EOPD) are lacking. The aim of this report was to investigate mutations of the <i>PINK1</i> gene in a cohort of Brazilian patients with EOPD. Sixty consecutive familial or sporadic EOPD patients were included. All eight <i>PINK1</i> exons and exon‐intron boundaries were analyzed. We did not find any pathogenic mutation of <i>PINK1</i> in our cohort. Single Nucleotide Polymorphisms (SNP) were identified in 46.7% of the patients and in 45.9% of controls (<i>P</i> = 0.9). The SNPs identified in our patients had already been described in previous reports. The results of our study support the hypothesis that mutations in <i>PINK1</i> may not be a relevant cause of EOPD. In Brazil, if we consider only EOPD patients, it seems that parkin and LRRK2 mutations are more common. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn2"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>PINK1 mutations in a Brazilian cohort of early‐onset Parkinson's disease patients</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>PINK 1 Mutations in a Brazilian Cohort</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>mutations in a Brazilian cohort of early‐onset Parkinson's disease patients</title></titleInfo><name type="personal"><namePart type="given">Clecio</namePart><namePart type="family">Godeiro‐Junior</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</affiliation><affiliation>Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation><description>Correspondence: Rua Napoleão de Barros, 566, ap. 93, São Paulo, São Paulo, Brazil 04024‐002</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Patricia M.</namePart><namePart type="family">de Carvalho‐Aguiar</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</affiliation><affiliation>Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andre C.</namePart><namePart type="family">Felício</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</affiliation><affiliation>Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Orlando G.P.</namePart><namePart type="family">Barsottini</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</affiliation><affiliation>Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sonia M.A.</namePart><namePart type="family">Silva</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vanderci</namePart><namePart type="family">Borges</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luiz Augusto F.</namePart><namePart type="family">Andrade</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Henrique Ballalai</namePart><namePart type="family">Ferraz</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo‐SP, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-08-15</dateIssued><dateCaptured encoding="w3cdtf">2008-11-12</dateCaptured><dateValid encoding="w3cdtf">2009-05-27</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">19</extent><extent unit="words">3172</extent></physicalDescription><abstract lang="en">Data on the frequency of PINK1 mutations in Brazilian patients with early‐onset Parkinson's disease (EOPD) are lacking. The aim of this report was to investigate mutations of the PINK1 gene in a cohort of Brazilian patients with EOPD. Sixty consecutive familial or sporadic EOPD patients were included. All eight PINK1 exons and exon‐intron boundaries were analyzed. We did not find any pathogenic mutation of PINK1 in our cohort. Single Nucleotide Polymorphisms (SNP) were identified in 46.7% of the patients and in 45.9% of controls (P = 0.9). The SNPs identified in our patients had already been described in previous reports. The results of our study support the hypothesis that mutations in PINK1 may not be a relevant cause of EOPD. In Brazil, if we consider only EOPD patients, it seems that parkin and LRRK2 mutations are more common. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><note type="funding">Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)</note><note type="funding">Fondation Philanthropique Edmond J. Safra</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>early‐onset</topic><topic>PINK1</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>1693</start><end>1696</end><total>5</total></extent></part></relatedItem><identifier type="istex">026B0CAE2BEC027B9F355FF611F68407C3928321</identifier><identifier type="DOI">10.1002/mds.22685</identifier><identifier type="ArticleID">MDS22685</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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