The pharmacological treatment for uremic restless legs syndrome: Evidence‐based review
Identifieur interne : 000E75 ( Istex/Corpus ); précédent : 000E74; suivant : 000E76The pharmacological treatment for uremic restless legs syndrome: Evidence‐based review
Auteurs : Márcio Moysés De Oliveira ; Cristiane Fiquene Conti ; Juliana Spelta Valbuza ; Luciane Bizari Coin De Carvalho ; Gilmar Fernandes Do PradoSource :
- Movement Disorders [ 0885-3185 ] ; 2010-07-30.
English descriptors
Abstract
Restless legs syndrome (RLS) is a common and often misdiagnosed entity among the general population and it may be more common among dialysis patients, with an estimated prevalence of 6.6 to 21.5%. The treatment for uremic RLS has been controversial and therefore a systematic synthesis of the evidence is needed in order to evaluate the effectiveness and safety of treatments for uremic RLS. This was a systematic review of randomized or quasi‐randomized double‐blind trials on treatments for uremic RLS. The outcomes considered were relief of RLS symptoms marked on a validated scale, subjective sleep quality, sleep quality measured using night polysomnography and actigraphy, quality of life measured subjectively, and adverse events associated with these treatments. Six eligible clinical trials were included. The results from subjective analyses in these studies were divergent, although objective analyses in one trial showed that there was a statistically significant improvement in periodic leg movement while asleep in the treatment group. No combined analysis (meta‐analysis) was performed. The most common adverse event seen was gastrointestinal symptoms. Only a few therapeutic trials on patients with uremia with RLS have been published, and there is insufficient scientific evidence to favor any specific therapeutic regimen for uremic‐associated RLS. Therapy using levodopa, dopaminergic agonists, anticonvulsants, and clonidine tend to be effective, but further studies are needed. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.22955
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ISTEX:04824B1548A65B83C660098381805668157E900DLe document en format XML
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Brazil</mods:affiliation></affiliation></author><author><name sortKey="De Carvalho, Luciane Bizari Coin" sort="De Carvalho, Luciane Bizari Coin" uniqKey="De Carvalho L" first="Luciane Bizari Coin" last="De Carvalho">Luciane Bizari Coin De Carvalho</name><affiliation><mods:affiliation>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</mods:affiliation></affiliation><affiliation><mods:affiliation>Sao Paulo Hospital Sleep Laboratory (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Do Prado, Gilmar Fernandes" sort="Do Prado, Gilmar Fernandes" uniqKey="Do Prado G" first="Gilmar Fernandes" last="Do Prado">Gilmar Fernandes Do Prado</name><affiliation><mods:affiliation>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-07-30">2010-07-30</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1335">1335</biblScope><biblScope unit="page" to="1342">1342</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">04824B1548A65B83C660098381805668157E900D</idno><idno type="DOI">10.1002/mds.22955</idno><idno type="ArticleID">MDS22955</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>end‐stage renal disease</term><term>restless legs syndrome</term><term>systematic review</term><term>uremic</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Restless legs syndrome (RLS) is a common and often misdiagnosed entity among the general population and it may be more common among dialysis patients, with an estimated prevalence of 6.6 to 21.5%. The treatment for uremic RLS has been controversial and therefore a systematic synthesis of the evidence is needed in order to evaluate the effectiveness and safety of treatments for uremic RLS. This was a systematic review of randomized or quasi‐randomized double‐blind trials on treatments for uremic RLS. The outcomes considered were relief of RLS symptoms marked on a validated scale, subjective sleep quality, sleep quality measured using night polysomnography and actigraphy, quality of life measured subjectively, and adverse events associated with these treatments. Six eligible clinical trials were included. The results from subjective analyses in these studies were divergent, although objective analyses in one trial showed that there was a statistically significant improvement in periodic leg movement while asleep in the treatment group. No combined analysis (meta‐analysis) was performed. The most common adverse event seen was gastrointestinal symptoms. Only a few therapeutic trials on patients with uremia with RLS have been published, and there is insufficient scientific evidence to favor any specific therapeutic regimen for uremic‐associated RLS. Therapy using levodopa, dopaminergic agonists, anticonvulsants, and clonidine tend to be effective, but further studies are needed. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Márcio Moysés de Oliveira MD, PhD</name><affiliations><json:string>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</json:string><json:string>Brazilian Cochrane Center (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</json:string><json:string>Sao Paulo Hospital Sleep Laboratory (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Cristiane Fiquene Conti MD, PhD</name><affiliations><json:string>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</json:string><json:string>Brazilian Cochrane Center (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</json:string><json:string>Sao Paulo Hospital Sleep Laboratory (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Juliana Spelta Valbuza PhD</name><affiliations><json:string>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</json:string><json:string>Brazilian Cochrane Center (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</json:string><json:string>Sao Paulo Hospital Sleep Laboratory (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Luciane Bizari Coin de Carvalho PhD</name><affiliations><json:string>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</json:string><json:string>Sao Paulo Hospital Sleep Laboratory (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Gilmar Fernandes do Prado MD, PhD</name><affiliations><json:string>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</json:string><json:string>Sao Paulo Hospital Sleep Laboratory (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>systematic review</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>restless legs syndrome</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>uremic</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>end‐stage renal disease</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Restless legs syndrome (RLS) is a common and often misdiagnosed entity among the general population and it may be more common among dialysis patients, with an estimated prevalence of 6.6 to 21.5%. The treatment for uremic RLS has been controversial and therefore a systematic synthesis of the evidence is needed in order to evaluate the effectiveness and safety of treatments for uremic RLS. This was a systematic review of randomized or quasi‐randomized double‐blind trials on treatments for uremic RLS. The outcomes considered were relief of RLS symptoms marked on a validated scale, subjective sleep quality, sleep quality measured using night polysomnography and actigraphy, quality of life measured subjectively, and adverse events associated with these treatments. Six eligible clinical trials were included. The results from subjective analyses in these studies were divergent, although objective analyses in one trial showed that there was a statistically significant improvement in periodic leg movement while asleep in the treatment group. No combined analysis (meta‐analysis) was performed. The most common adverse event seen was gastrointestinal symptoms. Only a few therapeutic trials on patients with uremia with RLS have been published, and there is insufficient scientific evidence to favor any specific therapeutic regimen for uremic‐associated RLS. Therapy using levodopa, dopaminergic agonists, anticonvulsants, and clonidine tend to be effective, but further studies are needed. © 2010 Movement Disorder Society</abstract><qualityIndicators><score>6.784</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1531</abstractCharCount><pdfWordCount>4132</pdfWordCount><pdfCharCount>27697</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>221</abstractWordCount></qualityIndicators><title>The pharmacological treatment for uremic restless legs syndrome: Evidence‐based review</title><genre><json:string>Serial article</json:string></genre><host><volume>25</volume><pages><total>8</total><last>1342</last><first>1335</first></pages><issn><json:string>0885-3185</json:string></issn><issue>10</issue><subject><json:item><value>Review</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement 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review</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Nothing to report.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">The pharmacological treatment for uremic restless legs syndrome: Evidence‐based review</title><author><persName><forename type="first">Márcio Moysés</forename><surname>de Oliveira</surname><roleName type="degree">MD, PhD</roleName></persName><note type="biography">The first two authors contributed equally to this work.</note><affiliation>The first two authors contributed equally to this work.</affiliation><affiliation>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><affiliation>Brazilian Cochrane Center (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><affiliation>Sao Paulo Hospital Sleep Laboratory (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation></author><author><persName><forename type="first">Cristiane Fiquene</forename><surname>Conti</surname><roleName type="degree">MD, PhD</roleName></persName><note type="biography">The first two authors contributed equally to this work.</note><affiliation>The first two authors contributed equally to this work.</affiliation><affiliation>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><affiliation>Brazilian Cochrane Center (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><affiliation>Sao Paulo Hospital Sleep Laboratory (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation></author><author><persName><forename type="first">Juliana Spelta</forename><surname>Valbuza</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><affiliation>Brazilian Cochrane Center (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><affiliation>Sao Paulo Hospital Sleep Laboratory (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation></author><author><persName><forename type="first">Luciane Bizari Coin</forename><surname>de Carvalho</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><affiliation>Sao Paulo Hospital Sleep Laboratory (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation></author><author><persName><forename type="first">Gilmar Fernandes</forename><surname>do Prado</surname><roleName type="degree">MD, PhD</roleName></persName><note type="correspondence"><p>Correspondence: Rua Claudio Rossi, 394 Sao Paulo – SP, CEP 01547‐000, Brazil</p></note><affiliation>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><affiliation>Sao Paulo Hospital Sleep Laboratory (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-07-30"></date><biblScope unit="vol">25</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1335">1335</biblScope><biblScope unit="page" to="1342">1342</biblScope></imprint></monogr><idno type="istex">04824B1548A65B83C660098381805668157E900D</idno><idno type="DOI">10.1002/mds.22955</idno><idno type="ArticleID">MDS22955</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Restless legs syndrome (RLS) is a common and often misdiagnosed entity among the general population and it may be more common among dialysis patients, with an estimated prevalence of 6.6 to 21.5%. The treatment for uremic RLS has been controversial and therefore a systematic synthesis of the evidence is needed in order to evaluate the effectiveness and safety of treatments for uremic RLS. This was a systematic review of randomized or quasi‐randomized double‐blind trials on treatments for uremic RLS. The outcomes considered were relief of RLS symptoms marked on a validated scale, subjective sleep quality, sleep quality measured using night polysomnography and actigraphy, quality of life measured subjectively, and adverse events associated with these treatments. Six eligible clinical trials were included. The results from subjective analyses in these studies were divergent, although objective analyses in one trial showed that there was a statistically significant improvement in periodic leg movement while asleep in the treatment group. No combined analysis (meta‐analysis) was performed. The most common adverse event seen was gastrointestinal symptoms. Only a few therapeutic trials on patients with uremia with RLS have been published, and there is insufficient scientific evidence to favor any specific therapeutic regimen for uremic‐associated RLS. Therapy using levodopa, dopaminergic agonists, anticonvulsants, and clonidine tend to be effective, but further studies are needed. © 2010 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>systematic review</term></item><item><term>restless legs syndrome</term></item><item><term>uremic</term></item><item><term>end‐stage renal disease</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Review</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-02-19">Received</change><change when="2009-11-13">Registration</change><change when="2010-07-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/04824B1548A65B83C660098381805668157E900D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="100"><doi origin="wiley" registered="yes">10.1002/mds.v25:10</doi><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">10</numbering></numberingGroup><coverDate startDate="2010-07-30">30 July 2010</coverDate></publicationMeta><publicationMeta level="unit" type="reviewArticle" position="20" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22955</doi><idGroup><id type="unit" value="MDS22955"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Review</title><title type="tocHeading1">Reviews</title></titleGroup><copyright ownership="thirdParty">Copyright © 2010 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2009-02-19"></event><event type="manuscriptRevised" date="2009-08-15"></event><event type="manuscriptAccepted" date="2009-11-13"></event><event type="firstOnline" date="2010-06-11"></event><event type="publishedOnlineFinalForm" date="2010-07-23"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2010-06-11"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.5.2 mode:FullText source:FullText result:FullText" date="2011-06-21"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1335</numbering><numbering type="pageLast">1342</numbering></numberingGroup><correspondenceTo>Rua Claudio Rossi, 394 Sao Paulo – SP, CEP 01547‐000, Brazil</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22955.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="42"></count><count type="wordTotal" number="5125"></count></countGroup><titleGroup><title type="main" xml:lang="en">The pharmacological treatment for uremic restless legs syndrome: Evidence‐based review<link href="#fn2"></link></title><title type="short" xml:lang="en">Treatment for Uremic Restless Legs Syndrome</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af3" noteRef="#fn4"><personName><givenNames>Márcio Moysés</givenNames><familyName>de Oliveira</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af2 #af3" noteRef="#fn4"><personName><givenNames>Cristiane Fiquene</givenNames><familyName>Conti</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af2 #af3"><personName><givenNames>Juliana Spelta</givenNames><familyName>Valbuza</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Luciane Bizari Coin</givenNames><familyName>de Carvalho</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af3" corresponding="yes"><personName><givenNames>Gilmar Fernandes</givenNames><familyName>do Prado</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>gilmarunifesp@yahoo.com.br</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="BR" type="organization"><unparsedAffiliation>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="BR" type="organization"><unparsedAffiliation>Brazilian Cochrane Center (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="BR" type="organization"><unparsedAffiliation>Sao Paulo Hospital Sleep Laboratory (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">systematic review</keyword><keyword xml:id="kwd2">restless legs syndrome</keyword><keyword xml:id="kwd3">uremic</keyword><keyword xml:id="kwd4">end‐stage renal disease</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Restless legs syndrome (RLS) is a common and often misdiagnosed entity among the general population and it may be more common among dialysis patients, with an estimated prevalence of 6.6 to 21.5%. The treatment for uremic RLS has been controversial and therefore a systematic synthesis of the evidence is needed in order to evaluate the effectiveness and safety of treatments for uremic RLS. This was a systematic review of randomized or quasi‐randomized double‐blind trials on treatments for uremic RLS. The outcomes considered were relief of RLS symptoms marked on a validated scale, subjective sleep quality, sleep quality measured using night polysomnography and actigraphy, quality of life measured subjectively, and adverse events associated with these treatments. Six eligible clinical trials were included. The results from subjective analyses in these studies were divergent, although objective analyses in one trial showed that there was a statistically significant improvement in periodic leg movement while asleep in the treatment group. No combined analysis (meta‐analysis) was performed. The most common adverse event seen was gastrointestinal symptoms. Only a few therapeutic trials on patients with uremia with RLS have been published, and there is insufficient scientific evidence to favor any specific therapeutic regimen for uremic‐associated RLS. Therapy using levodopa, dopaminergic agonists, anticonvulsants, and clonidine tend to be effective, but further studies are needed. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn2"><p>Potential conflict of interest: Nothing to report.</p></note><note xml:id="fn4"><p>The first two authors contributed equally to this work.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>The pharmacological treatment for uremic restless legs syndrome: Evidence‐based review</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Treatment for Uremic Restless Legs Syndrome</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The pharmacological treatment for uremic restless legs syndrome: Evidence‐based review</title></titleInfo><name type="personal"><namePart type="given">Márcio Moysés</namePart><namePart type="family">de Oliveira</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><affiliation>Brazilian Cochrane Center (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><affiliation>Sao Paulo Hospital Sleep Laboratory (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><description>The first two authors contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Cristiane Fiquene</namePart><namePart type="family">Conti</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><affiliation>Brazilian Cochrane Center (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><affiliation>Sao Paulo Hospital Sleep Laboratory (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><description>The first two authors contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Juliana Spelta</namePart><namePart type="family">Valbuza</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><affiliation>Brazilian Cochrane Center (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><affiliation>Sao Paulo Hospital Sleep Laboratory (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luciane Bizari Coin</namePart><namePart type="family">de Carvalho</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><affiliation>Sao Paulo Hospital Sleep Laboratory (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gilmar Fernandes</namePart><namePart type="family">do Prado</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Emergency Medicine and Evidence Based Medicine (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><affiliation>Sao Paulo Hospital Sleep Laboratory (UNIFESP), Universidade Federal de São Paulo, São Paulo, Brazil</affiliation><description>Correspondence: Rua Claudio Rossi, 394 Sao Paulo – SP, CEP 01547‐000, Brazil</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">reviewArticle</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-07-30</dateIssued><dateCaptured encoding="w3cdtf">2009-02-19</dateCaptured><dateValid encoding="w3cdtf">2009-11-13</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">42</extent><extent unit="words">5125</extent></physicalDescription><abstract lang="en">Restless legs syndrome (RLS) is a common and often misdiagnosed entity among the general population and it may be more common among dialysis patients, with an estimated prevalence of 6.6 to 21.5%. The treatment for uremic RLS has been controversial and therefore a systematic synthesis of the evidence is needed in order to evaluate the effectiveness and safety of treatments for uremic RLS. This was a systematic review of randomized or quasi‐randomized double‐blind trials on treatments for uremic RLS. The outcomes considered were relief of RLS symptoms marked on a validated scale, subjective sleep quality, sleep quality measured using night polysomnography and actigraphy, quality of life measured subjectively, and adverse events associated with these treatments. Six eligible clinical trials were included. The results from subjective analyses in these studies were divergent, although objective analyses in one trial showed that there was a statistically significant improvement in periodic leg movement while asleep in the treatment group. No combined analysis (meta‐analysis) was performed. The most common adverse event seen was gastrointestinal symptoms. Only a few therapeutic trials on patients with uremia with RLS have been published, and there is insufficient scientific evidence to favor any specific therapeutic regimen for uremic‐associated RLS. Therapy using levodopa, dopaminergic agonists, anticonvulsants, and clonidine tend to be effective, but further studies are needed. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><subject lang="en"><genre>Keywords</genre><topic>systematic review</topic><topic>restless legs syndrome</topic><topic>uremic</topic><topic>end‐stage renal disease</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. 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