Voluntary, spontaneous, and reflex blinking in Parkinson's disease
Identifieur interne : 000E62 ( Istex/Corpus ); précédent : 000E61; suivant : 000E63Voluntary, spontaneous, and reflex blinking in Parkinson's disease
Auteurs : Rocco Agostino ; Matteo Bologna ; Loredana Dinapoli ; Bruno Gregori ; Giovanni Fabbrini ; Neri Accornero ; Alfredo BerardelliSource :
- Movement Disorders [ 0885-3185 ] ; 2008-04-15.
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Abstract
Blinking, a motor act consisting of a closing and an opening eyelid movement, can be performed voluntarily, spontaneously, and reflexly. In this study we investigated the kinematic features of voluntary, spontaneous, and reflex blinking in patients with Parkinson's disease (PD), OFF and ON dopaminergic treatment. Patients were asked to blink voluntarily as fast as possible. Spontaneous blinking was recorded for a minute during which the subjects just relaxed. Reflex blinking was evoked by electrical stimulation on the supraorbital nerve. Eyelid movements were recorded with the SMART analyzer motion system. Patients OFF therapy paused longer than controls during voluntary blinking but not during spontaneous and reflex blinking. The blink rate tended to be lower in patients OFF therapy than in controls and the spontaneous blinking had abnormally low amplitude and peak velocity. Finally, in patients OFF therapy the excitability of the neural circuit mediating the closing phase of the reflex blinking was enhanced. Dopaminergic treatment shortened the pause during voluntary blinking and increased the blink rate. In PD patients the longer pauses between the closing and opening phase in comparison to normal subjects, suggest bradykinesia of voluntary blinking. PD patients also display kinematic abnormalities of spontaneous blinking and changes in the excitability of the closing phase of reflex blinking. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21887
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In this study we investigated the kinematic features of voluntary, spontaneous, and reflex blinking in patients with Parkinson's disease (PD), OFF and ON dopaminergic treatment. Patients were asked to blink voluntarily as fast as possible. Spontaneous blinking was recorded for a minute during which the subjects just relaxed. Reflex blinking was evoked by electrical stimulation on the supraorbital nerve. Eyelid movements were recorded with the SMART analyzer motion system. Patients OFF therapy paused longer than controls during voluntary blinking but not during spontaneous and reflex blinking. The blink rate tended to be lower in patients OFF therapy than in controls and the spontaneous blinking had abnormally low amplitude and peak velocity. Finally, in patients OFF therapy the excitability of the neural circuit mediating the closing phase of the reflex blinking was enhanced. Dopaminergic treatment shortened the pause during voluntary blinking and increased the blink rate. In PD patients the longer pauses between the closing and opening phase in comparison to normal subjects, suggest bradykinesia of voluntary blinking. PD patients also display kinematic abnormalities of spontaneous blinking and changes in the excitability of the closing phase of reflex blinking. © 2007 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Rocco Agostino MD</name><affiliations><json:string>Department of Neurological Sciences, “Sapienza” University of Rome, Rome, Italy</json:string><json:string>Neuromed Institute (IRCCS), “Sapienza” University of Rome, Rome, Italy</json:string></affiliations></json:item><json:item><name>Matteo Bologna MD</name><affiliations><json:string>Department of Neurological Sciences, “Sapienza” University of Rome, Rome, Italy</json:string></affiliations></json:item><json:item><name>Loredana Dinapoli PhD</name><affiliations><json:string>Neuromed Institute (IRCCS), “Sapienza” University of Rome, Rome, Italy</json:string></affiliations></json:item><json:item><name>Bruno Gregori MD</name><affiliations><json:string>Department of Neurological Sciences, “Sapienza” University of Rome, Rome, Italy</json:string></affiliations></json:item><json:item><name>Giovanni Fabbrini MD</name><affiliations><json:string>Department of Neurological Sciences, “Sapienza” University of Rome, Rome, Italy</json:string></affiliations></json:item><json:item><name>Neri Accornero MD</name><affiliations><json:string>Department of Neurological Sciences, “Sapienza” University of Rome, Rome, Italy</json:string></affiliations></json:item><json:item><name>Alfredo Berardelli MD</name><affiliations><json:string>Department of Neurological Sciences, “Sapienza” University of Rome, Rome, Italy</json:string><json:string>Neuromed Institute (IRCCS), “Sapienza” University of Rome, Rome, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>blink</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>movement control</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Blinking, a motor act consisting of a closing and an opening eyelid movement, can be performed voluntarily, spontaneously, and reflexly. 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In PD patients the longer pauses between the closing and opening phase in comparison to normal subjects, suggest bradykinesia of voluntary blinking. 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In this study we investigated the kinematic features of voluntary, spontaneous, and reflex blinking in patients with Parkinson's disease (PD), OFF and ON dopaminergic treatment. Patients were asked to blink voluntarily as fast as possible. Spontaneous blinking was recorded for a minute during which the subjects just relaxed. Reflex blinking was evoked by electrical stimulation on the supraorbital nerve. Eyelid movements were recorded with the SMART analyzer motion system. Patients OFF therapy paused longer than controls during voluntary blinking but not during spontaneous and reflex blinking. The blink rate tended to be lower in patients OFF therapy than in controls and the spontaneous blinking had abnormally low amplitude and peak velocity. Finally, in patients OFF therapy the excitability of the neural circuit mediating the closing phase of the reflex blinking was enhanced. Dopaminergic treatment shortened the pause during voluntary blinking and increased the blink rate. In PD patients the longer pauses between the closing and opening phase in comparison to normal subjects, suggest bradykinesia of voluntary blinking. PD patients also display kinematic abnormalities of spontaneous blinking and changes in the excitability of the closing phase of reflex blinking. © 2007 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>blink</term></item><item><term>movement control</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-07-23">Received</change><change when="2007-11-06">Registration</change><change when="2008-04-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/E5C3677194727BBF4FF4F5998FB646D955FA1FAD/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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In this study we investigated the kinematic features of voluntary, spontaneous, and reflex blinking in patients with Parkinson's disease (PD), OFF and ON dopaminergic treatment. Patients were asked to blink voluntarily as fast as possible. Spontaneous blinking was recorded for a minute during which the subjects just relaxed. Reflex blinking was evoked by electrical stimulation on the supraorbital nerve. Eyelid movements were recorded with the SMART analyzer motion system. Patients OFF therapy paused longer than controls during voluntary blinking but not during spontaneous and reflex blinking. The blink rate tended to be lower in patients OFF therapy than in controls and the spontaneous blinking had abnormally low amplitude and peak velocity. Finally, in patients OFF therapy the excitability of the neural circuit mediating the closing phase of the reflex blinking was enhanced. Dopaminergic treatment shortened the pause during voluntary blinking and increased the blink rate. In PD patients the longer pauses between the closing and opening phase in comparison to normal subjects, suggest bradykinesia of voluntary blinking. PD patients also display kinematic abnormalities of spontaneous blinking and changes in the excitability of the closing phase of reflex blinking. © 2007 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Voluntary, spontaneous, and reflex blinking in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Voluntary, Spontaneous, and Reflex Blinking in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Voluntary, spontaneous, and reflex blinking in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Rocco</namePart><namePart type="family">Agostino</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, “Sapienza” University of Rome, Rome, Italy</affiliation><affiliation>Neuromed Institute (IRCCS), “Sapienza” University of Rome, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matteo</namePart><namePart type="family">Bologna</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, “Sapienza” University of Rome, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Loredana</namePart><namePart type="family">Dinapoli</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Neuromed Institute (IRCCS), “Sapienza” University of Rome, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bruno</namePart><namePart type="family">Gregori</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, “Sapienza” University of Rome, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giovanni</namePart><namePart type="family">Fabbrini</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, “Sapienza” University of Rome, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Neri</namePart><namePart type="family">Accornero</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, “Sapienza” University of Rome, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alfredo</namePart><namePart type="family">Berardelli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, “Sapienza” University of Rome, Rome, Italy</affiliation><affiliation>Neuromed Institute (IRCCS), “Sapienza” University of Rome, Rome, Italy</affiliation><description>Correspondence: Department of Neurological Sciences, Sapienza, University of Rome, Viale dell'Università, 30, 00185 Rome, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-04-15</dateIssued><dateCaptured encoding="w3cdtf">2007-07-23</dateCaptured><dateValid encoding="w3cdtf">2007-11-06</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">3</extent><extent unit="references">37</extent><extent unit="words">4922</extent></physicalDescription><abstract lang="en">Blinking, a motor act consisting of a closing and an opening eyelid movement, can be performed voluntarily, spontaneously, and reflexly. In this study we investigated the kinematic features of voluntary, spontaneous, and reflex blinking in patients with Parkinson's disease (PD), OFF and ON dopaminergic treatment. Patients were asked to blink voluntarily as fast as possible. Spontaneous blinking was recorded for a minute during which the subjects just relaxed. Reflex blinking was evoked by electrical stimulation on the supraorbital nerve. Eyelid movements were recorded with the SMART analyzer motion system. Patients OFF therapy paused longer than controls during voluntary blinking but not during spontaneous and reflex blinking. The blink rate tended to be lower in patients OFF therapy than in controls and the spontaneous blinking had abnormally low amplitude and peak velocity. Finally, in patients OFF therapy the excitability of the neural circuit mediating the closing phase of the reflex blinking was enhanced. Dopaminergic treatment shortened the pause during voluntary blinking and increased the blink rate. In PD patients the longer pauses between the closing and opening phase in comparison to normal subjects, suggest bradykinesia of voluntary blinking. PD patients also display kinematic abnormalities of spontaneous blinking and changes in the excitability of the closing phase of reflex blinking. © 2007 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>blink</topic><topic>movement control</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>669</start><end>675</end><total>7</total></extent></part></relatedItem><identifier type="istex">E5C3677194727BBF4FF4F5998FB646D955FA1FAD</identifier><identifier type="DOI">10.1002/mds.21887</identifier><identifier type="ArticleID">MDS21887</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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