Movement Disorders (revue)

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Levodopa responsiveness in disorders with parkinsonism: A review of the literature

Identifieur interne : 000E39 ( Istex/Corpus ); précédent : 000E38; suivant : 000E40

Levodopa responsiveness in disorders with parkinsonism: A review of the literature

Auteurs : Radu Constantinescu ; Irene Richard ; Roger Kurlan

Source :

RBID : ISTEX:2D425B5E315A99C47905E1A12CECFE8F42F7F802

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Abstract

A literature review was conducted to investigate whether or not levodopa (LD) responsiveness (LR) is a useful criterion in the diagnosis of parkinsonian disorders. Although LR does appear to differ among the parkinsonian disorders, there is considerable confusion in the literature. While most patients with Parkinson's disease (PD) have a sustained benefit from LD, a small minority of patients with documented PD do not respond. The literature suggests that the LR rate is higher for multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) than based on published diagnostic criteria. Magnitude and duration of response to LD and tolerability (time course, type and distribution of dyskinesias, mental effects and motor worsening) may be useful features in distinguishing PD, MSA, PSP, and CBD. Efforts should be directed toward better defining LR when used for diagnostic purposes and in scientific publications. © 2007 Movement Disorder Society

Url:
DOI: 10.1002/mds.21578

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ISTEX:2D425B5E315A99C47905E1A12CECFE8F42F7F802

Le document en format XML

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<dateIssued encoding="w3cdtf">2007-11-15</dateIssued>
<dateCaptured encoding="w3cdtf">2006-05-19</dateCaptured>
<dateValid encoding="w3cdtf">2007-04-16</dateValid>
<copyrightDate encoding="w3cdtf">2007</copyrightDate>
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<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
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<abstract lang="en">A literature review was conducted to investigate whether or not levodopa (LD) responsiveness (LR) is a useful criterion in the diagnosis of parkinsonian disorders. Although LR does appear to differ among the parkinsonian disorders, there is considerable confusion in the literature. While most patients with Parkinson's disease (PD) have a sustained benefit from LD, a small minority of patients with documented PD do not respond. The literature suggests that the LR rate is higher for multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) than based on published diagnostic criteria. Magnitude and duration of response to LD and tolerability (time course, type and distribution of dyskinesias, mental effects and motor worsening) may be useful features in distinguishing PD, MSA, PSP, and CBD. Efforts should be directed toward better defining LR when used for diagnostic purposes and in scientific publications. © 2007 Movement Disorder Society</abstract>
<note type="content">*This article is part of the journal's CME program. The CME form can be found on page 2295 and is available online at http://www.movementdisorders.org/education/activities.html</note>
<note type="funding">Parkinson's Disease Data and Organizing Center (PD‐DOC)</note>
<note type="funding">NINDS - No. U01 NS050095; </note>
<note type="funding">National Parkinson Foundation Center of Excellence at the University of Rochester</note>
<note type="funding">NINDS Career Development Award - No. 1 K23NS02184; </note>
<subject lang="en">
<genre>Keywords</genre>
<topic>parkinsonism</topic>
<topic>Parkinson's disease</topic>
<topic>parkinsonian disorders</topic>
<topic>levodopa</topic>
<topic>levodopa response</topic>
</subject>
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<titleInfo>
<title>Movement Disorders</title>
<subTitle>Official Journal of the Movement Disorder Society</subTitle>
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<title>Mov. Disord.</title>
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<genre>article category</genre>
<topic>Review</topic>
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<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part>
<date>2007</date>
<detail type="volume">
<caption>vol.</caption>
<number>22</number>
</detail>
<detail type="issue">
<caption>no.</caption>
<number>15</number>
</detail>
<extent unit="pages">
<start>2141</start>
<end>2148</end>
<total>8</total>
</extent>
</part>
</relatedItem>
<identifier type="istex">2D425B5E315A99C47905E1A12CECFE8F42F7F802</identifier>
<identifier type="DOI">10.1002/mds.21578</identifier>
<identifier type="ArticleID">MDS21578</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition>
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