Long‐term follow‐up of botulinum toxin therapy for focal hand dystonia: Outcome at 10 years or more
Identifieur interne : 000B35 ( Istex/Corpus ); précédent : 000B34; suivant : 000B36Long‐term follow‐up of botulinum toxin therapy for focal hand dystonia: Outcome at 10 years or more
Auteurs : Codrin Lungu ; Barbara I. Karp ; Katharine Alter ; Regina Zolbrod ; Mark HallettSource :
- Movement Disorders [ 0885-3185 ] ; 2011-03.
English descriptors
- KwdEn :
Abstract
Background:: Previous studies have explored the efficacy and safety of botulinum neurotoxin (BoNT) treatment for Focal hand dystonia (FHD), but none have followed a large number of patients for 10 years or more. Methods:: Retrospective study, with benefit and weakness assessed on a 0 to 4 subjective scale. Demographic, clinical and treatment characteristics were analyzed using t tests and Pearson correlations. Results:: Twenty FHD patients had 10 years or longer treatment. Interinjection intervals were variable. Musicians were more likely to wait longer between injections and had less complex dystonia. There was a trend for larger benefit in women and with shorter intervals. The dose increased over time. Dystonia characteristics did not predict response or side‐effects, but benefit magnitude predicted longer compliance. No serious side‐effects or antibody‐mediated resistance occurred. Conclusion:: This is the longest reported period of BoNT treatment in the largest FHD cohort. BoNT therapy for FHD remains safe and effective after more than a decade of treatment. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23504
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<front><div type="abstract" xml:lang="en">Background:: Previous studies have explored the efficacy and safety of botulinum neurotoxin (BoNT) treatment for Focal hand dystonia (FHD), but none have followed a large number of patients for 10 years or more. Methods:: Retrospective study, with benefit and weakness assessed on a 0 to 4 subjective scale. Demographic, clinical and treatment characteristics were analyzed using t tests and Pearson correlations. Results:: Twenty FHD patients had 10 years or longer treatment. Interinjection intervals were variable. Musicians were more likely to wait longer between injections and had less complex dystonia. There was a trend for larger benefit in women and with shorter intervals. The dose increased over time. Dystonia characteristics did not predict response or side‐effects, but benefit magnitude predicted longer compliance. No serious side‐effects or antibody‐mediated resistance occurred. Conclusion:: This is the longest reported period of BoNT treatment in the largest FHD cohort. BoNT therapy for FHD remains safe and effective after more than a decade of treatment. © 2011 Movement Disorder Society</div>
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<section xml:id="abs1-4"><title type="main">Conclusion:</title>
<p>This is the longest reported period of BoNT treatment in the largest FHD cohort. BoNT therapy for FHD remains safe and effective after more than a decade of treatment. © 2011 Movement Disorder Society</p>
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<noteGroup><note xml:id="fn1"><p>Relevant conflicts of interest/financial disclosures: Nothing to report Full financial disclosures and author roles can be found in the online version of this article.</p>
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<!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Long‐term follow‐up of botulinum toxin therapy for focal hand dystonia: Outcome at 10 years or more</title>
</titleInfo>
<titleInfo type="abbreviated" lang="en"><title>Long‐Term Botulinum in Focal Hand Dystonia</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Long‐term follow‐up of botulinum toxin therapy for focal hand dystonia: Outcome at 10 years or more</title>
</titleInfo>
<name type="personal"><namePart type="given">Codrin</namePart>
<namePart type="family">Lungu</namePart>
<namePart type="termsOfAddress">MD,</namePart>
<affiliation>Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Barbara I.</namePart>
<namePart type="family">Karp</namePart>
<namePart type="termsOfAddress">MD,</namePart>
<affiliation>Combined Neuroscience IRB, National Institutes of Health, Bethesda, Maryland, USA</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Katharine</namePart>
<namePart type="family">Alter</namePart>
<namePart type="termsOfAddress">MD,</namePart>
<affiliation>Physical Disabilities Section, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Regina</namePart>
<namePart type="family">Zolbrod,</namePart>
<affiliation>Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Mark</namePart>
<namePart type="family">Hallett</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA</affiliation>
<description>Correspondence: NIH Medical Neurology, Bldg 10, Rm 7D37, MSC 1428, 10 Center Dr, Bethesda, MD 20892, USA</description>
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<originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<place><placeTerm type="text">Hoboken</placeTerm>
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<dateIssued encoding="w3cdtf">2011-03</dateIssued>
<dateCaptured encoding="w3cdtf">2010-04-29</dateCaptured>
<dateValid encoding="w3cdtf">2010-10-03</dateValid>
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<abstract lang="en">Background:: Previous studies have explored the efficacy and safety of botulinum neurotoxin (BoNT) treatment for Focal hand dystonia (FHD), but none have followed a large number of patients for 10 years or more. Methods:: Retrospective study, with benefit and weakness assessed on a 0 to 4 subjective scale. Demographic, clinical and treatment characteristics were analyzed using t tests and Pearson correlations. Results:: Twenty FHD patients had 10 years or longer treatment. Interinjection intervals were variable. Musicians were more likely to wait longer between injections and had less complex dystonia. There was a trend for larger benefit in women and with shorter intervals. The dose increased over time. Dystonia characteristics did not predict response or side‐effects, but benefit magnitude predicted longer compliance. No serious side‐effects or antibody‐mediated resistance occurred. Conclusion:: This is the longest reported period of BoNT treatment in the largest FHD cohort. BoNT therapy for FHD remains safe and effective after more than a decade of treatment. © 2011 Movement Disorder Society</abstract>
<note type="additional physical form">Author Roles and Disclosures</note>
<note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report Full financial disclosures and author roles can be found in the online version of this article.</note>
<subject lang="en"><genre>Keywords</genre>
<topic>botulinum</topic>
<topic>dystonia</topic>
<topic>focal hand dystonia</topic>
<topic>safety</topic>
<topic>efficacy</topic>
</subject>
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<titleInfo type="abbreviated"><title>Mov. Disord.</title>
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<subject><genre>article category</genre>
<topic>Brief Report</topic>
</subject>
<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part><date>2011</date>
<detail type="volume"><caption>vol.</caption>
<number>26</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>4</number>
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<extent unit="pages"><start>750</start>
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<identifier type="DOI">10.1002/mds.23504</identifier>
<identifier type="ArticleID">MDS23504</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition>
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