Sensory perception changes induced by transcranial magnetic stimulation over the primary somatosensory cortex in Parkinson's disease
Identifieur interne : 000B11 ( Istex/Corpus ); précédent : 000B10; suivant : 000B12Sensory perception changes induced by transcranial magnetic stimulation over the primary somatosensory cortex in Parkinson's disease
Auteurs : Francisco J. Palomar ; Francisco Díaz-Corrales ; Fatima Carrillo ; Miguel Fernández-Del-Olmo ; Giacomo Koch ; Pablo MirSource :
- Movement Disorders [ 0885-3185 ] ; 2011-09.
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- KwdEn :
Abstract
Sensory symptoms are common nonmotor manifestations of Parkinson's disease. It has been hypothesized that abnormal central processing of sensory signals occurs in Parkinson's disease and is related to dopaminergic treatment. The objective of this study was to investigate the alterations in sensory perception induced by transcranial magnetic stimulation of the primary somatosensory cortex in patients with Parkinson's disease and the modulatory effects of dopaminergic treatment. Fourteen patients with Parkinson's disease with and without dopaminergic treatment and 13 control subjects were included. Twenty milliseconds after peripheral electrical tactile stimuli in the contralateral thumb, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex was delivered. We evaluated the perception of peripheral electrical tactile stimuli at 2 conditioning stimulus intensities, set at 70% and 90% of the right resting motor threshold, using different interstimulus intervals. At 70% of the resting motor threshold, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex induced an increase in positive responses at short interstimulus intervals (1–7 ms) in controls but not in patients with dopaminergic treatment. At 90% of the resting motor threshold, controls and patients showed similar transcranial magnetic stimulation effects. Changes in peripheral electrical tactile stimuli perception after paired‐pulse transcranial magnetic stimulation over the primary somatosensory cortex are altered in patients with Parkinson's disease with dopaminergic treatment compared with controls. These findings suggest that primary somatosensory cortex excitability could be involved in changes in somatosensory integration in Parkinson's disease with dopaminergic treatment. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23779
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<notesStmt><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note>
<note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note>
<note>Francisco J. Palomar, Fatima Carrillo, and Pablo Mir were supported by grants from the Ministerio de Ciencia e Innovación de España - No. SAF2007‐60700;</note>
<note>Instituto de Salud Carlos III - No. PI10/01674;</note>
<note>Consejería de Innovación, Ciencia y Empresa de la Junta de Andalucía - No. CVI‐02526;</note>
<note>Consejería de Salud de la Junta de Andalucía - No. PI‐0377/2007; No. PI‐0741/2010;</note>
<note>Sociedad Andaluza de Neurología, and the Jaques and Gloria Gossweiler Foundation</note>
<note>Francisco Díaz‐Corrales was supported by a fellowship from the Fundación Carolina/BBVA</note>
<note>Miguel Fernández‐del‐Olmo was supported by the Ministerio de Ciencia e Innovación, Spain - No. PSI2008‐03175;</note>
<note>Jaques and Gloria Gossweiler Foundation</note>
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<note type="correspondence"><p>Correspondence: Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología, Hospital Universitario Virgen del Rocío, Avda. Manuel Siurot sn, 41013 Sevilla, Spain</p>
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<titleGroup><title type="main" xml:lang="en">Sensory perception changes induced by transcranial magnetic stimulation over the primary somatosensory cortex in Parkinson's disease<link href="#fn1"></link>
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<fundingInfo><fundingAgency>Francisco J. Palomar, Fatima Carrillo, and Pablo Mir were supported by grants from the Ministerio de Ciencia e Innovación de España</fundingAgency>
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<p>Sensory symptoms are common nonmotor manifestations of Parkinson's disease. It has been hypothesized that abnormal central processing of sensory signals occurs in Parkinson's disease and is related to dopaminergic treatment. The objective of this study was to investigate the alterations in sensory perception induced by transcranial magnetic stimulation of the primary somatosensory cortex in patients with Parkinson's disease and the modulatory effects of dopaminergic treatment. Fourteen patients with Parkinson's disease with and without dopaminergic treatment and 13 control subjects were included. Twenty milliseconds after peripheral electrical tactile stimuli in the contralateral thumb, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex was delivered. We evaluated the perception of peripheral electrical tactile stimuli at 2 conditioning stimulus intensities, set at 70% and 90% of the right resting motor threshold, using different interstimulus intervals. At 70% of the resting motor threshold, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex induced an increase in positive responses at short interstimulus intervals (1–7 ms) in controls but not in patients with dopaminergic treatment. At 90% of the resting motor threshold, controls and patients showed similar transcranial magnetic stimulation effects. Changes in peripheral electrical tactile stimuli perception after paired‐pulse transcranial magnetic stimulation over the primary somatosensory cortex are altered in patients with Parkinson's disease with dopaminergic treatment compared with controls. These findings suggest that primary somatosensory cortex excitability could be involved in changes in somatosensory integration in Parkinson's disease with dopaminergic treatment. © 2011 Movement Disorder Society</p>
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<noteGroup><note xml:id="fn1"><p><b>Relevant conflicts of interest/financial disclosures:</b>
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<abstract lang="en">Sensory symptoms are common nonmotor manifestations of Parkinson's disease. It has been hypothesized that abnormal central processing of sensory signals occurs in Parkinson's disease and is related to dopaminergic treatment. The objective of this study was to investigate the alterations in sensory perception induced by transcranial magnetic stimulation of the primary somatosensory cortex in patients with Parkinson's disease and the modulatory effects of dopaminergic treatment. Fourteen patients with Parkinson's disease with and without dopaminergic treatment and 13 control subjects were included. Twenty milliseconds after peripheral electrical tactile stimuli in the contralateral thumb, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex was delivered. We evaluated the perception of peripheral electrical tactile stimuli at 2 conditioning stimulus intensities, set at 70% and 90% of the right resting motor threshold, using different interstimulus intervals. At 70% of the resting motor threshold, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex induced an increase in positive responses at short interstimulus intervals (1–7 ms) in controls but not in patients with dopaminergic treatment. At 90% of the resting motor threshold, controls and patients showed similar transcranial magnetic stimulation effects. Changes in peripheral electrical tactile stimuli perception after paired‐pulse transcranial magnetic stimulation over the primary somatosensory cortex are altered in patients with Parkinson's disease with dopaminergic treatment compared with controls. These findings suggest that primary somatosensory cortex excitability could be involved in changes in somatosensory integration in Parkinson's disease with dopaminergic treatment. © 2011 Movement Disorder Society</abstract>
<note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note>
<note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note>
<note type="funding">Francisco J. Palomar, Fatima Carrillo, and Pablo Mir were supported by grants from the Ministerio de Ciencia e Innovación de España - No. SAF2007‐60700; </note>
<note type="funding">Instituto de Salud Carlos III - No. PI10/01674; </note>
<note type="funding">Consejería de Innovación, Ciencia y Empresa de la Junta de Andalucía - No. CVI‐02526; </note>
<note type="funding">Consejería de Salud de la Junta de Andalucía - No. PI‐0377/2007; No. PI‐0741/2010; </note>
<note type="funding">Sociedad Andaluza de Neurología, and the Jaques and Gloria Gossweiler Foundation</note>
<note type="funding">Francisco Díaz‐Corrales was supported by a fellowship from the Fundación Carolina/BBVA</note>
<note type="funding">Miguel Fernández‐del‐Olmo was supported by the Ministerio de Ciencia e Innovación, Spain - No. PSI2008‐03175; </note>
<note type="funding">Jaques and Gloria Gossweiler Foundation</note>
<subject lang="en"><genre>Keywords</genre>
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