Sensory perception changes induced by transcranial magnetic stimulation over the primary somatosensory cortex in Parkinson's disease
Identifieur interne : 000B11 ( Istex/Corpus ); précédent : 000B10; suivant : 000B12Sensory perception changes induced by transcranial magnetic stimulation over the primary somatosensory cortex in Parkinson's disease
Auteurs : Francisco J. Palomar ; Francisco Díaz-Corrales ; Fatima Carrillo ; Miguel Fernández-Del-Olmo ; Giacomo Koch ; Pablo MirSource :
- Movement Disorders [ 0885-3185 ] ; 2011-09.
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- KwdEn :
Abstract
Sensory symptoms are common nonmotor manifestations of Parkinson's disease. It has been hypothesized that abnormal central processing of sensory signals occurs in Parkinson's disease and is related to dopaminergic treatment. The objective of this study was to investigate the alterations in sensory perception induced by transcranial magnetic stimulation of the primary somatosensory cortex in patients with Parkinson's disease and the modulatory effects of dopaminergic treatment. Fourteen patients with Parkinson's disease with and without dopaminergic treatment and 13 control subjects were included. Twenty milliseconds after peripheral electrical tactile stimuli in the contralateral thumb, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex was delivered. We evaluated the perception of peripheral electrical tactile stimuli at 2 conditioning stimulus intensities, set at 70% and 90% of the right resting motor threshold, using different interstimulus intervals. At 70% of the resting motor threshold, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex induced an increase in positive responses at short interstimulus intervals (1–7 ms) in controls but not in patients with dopaminergic treatment. At 90% of the resting motor threshold, controls and patients showed similar transcranial magnetic stimulation effects. Changes in peripheral electrical tactile stimuli perception after paired‐pulse transcranial magnetic stimulation over the primary somatosensory cortex are altered in patients with Parkinson's disease with dopaminergic treatment compared with controls. These findings suggest that primary somatosensory cortex excitability could be involved in changes in somatosensory integration in Parkinson's disease with dopaminergic treatment. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23779
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Palomar</name><affiliation><mods:affiliation>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain</mods:affiliation></affiliation></author><author><name sortKey="Diaz Orrales, Francisco" sort="Diaz Orrales, Francisco" uniqKey="Diaz Orrales F" first="Francisco" last="Díaz-Corrales">Francisco Díaz-Corrales</name><affiliation><mods:affiliation>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain</mods:affiliation></affiliation></author><author><name sortKey="Carrillo, Fatima" sort="Carrillo, Fatima" uniqKey="Carrillo F" first="Fatima" last="Carrillo">Fatima Carrillo</name><affiliation><mods:affiliation>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain</mods:affiliation></affiliation></author><author><name sortKey="Fernandez El Lmo, Miguel" sort="Fernandez El Lmo, Miguel" uniqKey="Fernandez El Lmo M" first="Miguel" last="Fernández-Del-Olmo">Miguel Fernández-Del-Olmo</name><affiliation><mods:affiliation>INEF Galicia, Instituto de Educación Física y Deporte, La Coruña, Spain</mods:affiliation></affiliation></author><author><name sortKey="Koch, Giacomo" sort="Koch, Giacomo" uniqKey="Koch G" first="Giacomo" last="Koch">Giacomo Koch</name><affiliation><mods:affiliation>Clinica Neurologica, Dipartamento de Neuroscienze, Università di Roma Tor Vergata, Rome, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratorio di Neurologia Clinica e Comportamentale, Fondazione S. Lucia I.R.C.C.S., Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Mir, Pablo" sort="Mir, Pablo" uniqKey="Mir P" first="Pablo" last="Mir">Pablo Mir</name><affiliation><mods:affiliation>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain</mods:affiliation></affiliation><affiliation><mods:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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It has been hypothesized that abnormal central processing of sensory signals occurs in Parkinson's disease and is related to dopaminergic treatment. The objective of this study was to investigate the alterations in sensory perception induced by transcranial magnetic stimulation of the primary somatosensory cortex in patients with Parkinson's disease and the modulatory effects of dopaminergic treatment. Fourteen patients with Parkinson's disease with and without dopaminergic treatment and 13 control subjects were included. Twenty milliseconds after peripheral electrical tactile stimuli in the contralateral thumb, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex was delivered. We evaluated the perception of peripheral electrical tactile stimuli at 2 conditioning stimulus intensities, set at 70% and 90% of the right resting motor threshold, using different interstimulus intervals. At 70% of the resting motor threshold, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex induced an increase in positive responses at short interstimulus intervals (1–7 ms) in controls but not in patients with dopaminergic treatment. At 90% of the resting motor threshold, controls and patients showed similar transcranial magnetic stimulation effects. Changes in peripheral electrical tactile stimuli perception after paired‐pulse transcranial magnetic stimulation over the primary somatosensory cortex are altered in patients with Parkinson's disease with dopaminergic treatment compared with controls. These findings suggest that primary somatosensory cortex excitability could be involved in changes in somatosensory integration in Parkinson's disease with dopaminergic treatment. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Francisco J. Palomar MD</name><affiliations><json:string>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain</json:string></affiliations></json:item><json:item><name>Francisco Díaz‐Corrales MD, PhD</name><affiliations><json:string>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain</json:string></affiliations></json:item><json:item><name>Fatima Carrillo MD</name><affiliations><json:string>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain</json:string></affiliations></json:item><json:item><name>Miguel Fernández‐del‐Olmo PhD</name><affiliations><json:string>INEF Galicia, Instituto de Educación Física y Deporte, La Coruña, Spain</json:string></affiliations></json:item><json:item><name>Giacomo Koch MD, PhD</name><affiliations><json:string>Clinica Neurologica, Dipartamento de Neuroscienze, Università di Roma Tor Vergata, Rome, Italy</json:string><json:string>Laboratorio di Neurologia Clinica e Comportamentale, Fondazione S. Lucia I.R.C.C.S., Rome, Italy</json:string></affiliations></json:item><json:item><name>Pablo Mir MD, PhD</name><affiliations><json:string>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain</json:string><json:string>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>transcranial magnetic stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>primary somatosensory cortex</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dopaminergic treatment</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Sensory symptoms are common nonmotor manifestations of Parkinson's disease. It has been hypothesized that abnormal central processing of sensory signals occurs in Parkinson's disease and is related to dopaminergic treatment. The objective of this study was to investigate the alterations in sensory perception induced by transcranial magnetic stimulation of the primary somatosensory cortex in patients with Parkinson's disease and the modulatory effects of dopaminergic treatment. Fourteen patients with Parkinson's disease with and without dopaminergic treatment and 13 control subjects were included. Twenty milliseconds after peripheral electrical tactile stimuli in the contralateral thumb, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex was delivered. We evaluated the perception of peripheral electrical tactile stimuli at 2 conditioning stimulus intensities, set at 70% and 90% of the right resting motor threshold, using different interstimulus intervals. At 70% of the resting motor threshold, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex induced an increase in positive responses at short interstimulus intervals (1–7 ms) in controls but not in patients with dopaminergic treatment. At 90% of the resting motor threshold, controls and patients showed similar transcranial magnetic stimulation effects. Changes in peripheral electrical tactile stimuli perception after paired‐pulse transcranial magnetic stimulation over the primary somatosensory cortex are altered in patients with Parkinson's disease with dopaminergic treatment compared with controls. These findings suggest that primary somatosensory cortex excitability could be involved in changes in somatosensory integration in Parkinson's disease with dopaminergic treatment. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>6.984</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1867</abstractCharCount><pdfWordCount>4056</pdfWordCount><pdfCharCount>25359</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>244</abstractWordCount></qualityIndicators><title>Sensory perception changes induced by transcranial magnetic stimulation over the primary somatosensory cortex in Parkinson's disease</title><genre><json:string>Serial article</json:string></genre><host><volume>26</volume><pages><total>7</total><last>2064</last><first>2058</first></pages><issn><json:string>0885-3185</json:string></issn><issue>11</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23779</json:string></doi><id>87CC8850362775ACB3B5E4FC15A41FD4967ACC89</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/87CC8850362775ACB3B5E4FC15A41FD4967ACC89/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/87CC8850362775ACB3B5E4FC15A41FD4967ACC89/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/87CC8850362775ACB3B5E4FC15A41FD4967ACC89/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Sensory perception changes induced by transcranial magnetic stimulation over the primary somatosensory cortex in Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2011</date></publicationStmt><notesStmt><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note><note>Francisco J. Palomar, Fatima Carrillo, and Pablo Mir were supported by grants from the Ministerio de Ciencia e Innovación de España - No. SAF2007‐60700;</note><note>Instituto de Salud Carlos III - No. PI10/01674;</note><note>Consejería de Innovación, Ciencia y Empresa de la Junta de Andalucía - No. CVI‐02526;</note><note>Consejería de Salud de la Junta de Andalucía - No. PI‐0377/2007; No. PI‐0741/2010;</note><note>Sociedad Andaluza de Neurología, and the Jaques and Gloria Gossweiler Foundation</note><note>Francisco Díaz‐Corrales was supported by a fellowship from the Fundación Carolina/BBVA</note><note>Miguel Fernández‐del‐Olmo was supported by the Ministerio de Ciencia e Innovación, Spain - No. PSI2008‐03175;</note><note>Jaques and Gloria Gossweiler Foundation</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Sensory perception changes induced by transcranial magnetic stimulation over the primary somatosensory cortex in Parkinson's disease</title><author><persName><forename type="first">Francisco J.</forename><surname>Palomar</surname><roleName type="degree">MD</roleName></persName><affiliation>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain</affiliation></author><author><persName><forename type="first">Francisco</forename><surname>Díaz‐Corrales</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain</affiliation></author><author><persName><forename type="first">Fatima</forename><surname>Carrillo</surname><roleName type="degree">MD</roleName></persName><affiliation>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain</affiliation></author><author><persName><forename type="first">Miguel</forename><surname>Fernández‐del‐Olmo</surname><roleName type="degree">PhD</roleName></persName><affiliation>INEF Galicia, Instituto de Educación Física y Deporte, La Coruña, Spain</affiliation></author><author><persName><forename type="first">Giacomo</forename><surname>Koch</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Clinica Neurologica, Dipartamento de Neuroscienze, Università di Roma Tor Vergata, Rome, Italy</affiliation><affiliation>Laboratorio di Neurologia Clinica e Comportamentale, Fondazione S. Lucia I.R.C.C.S., Rome, Italy</affiliation></author><author><persName><forename type="first">Pablo</forename><surname>Mir</surname><roleName type="degree">MD, PhD</roleName></persName><note type="correspondence"><p>Correspondence: Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología, Hospital Universitario Virgen del Rocío, Avda. Manuel Siurot sn, 41013 Sevilla, Spain</p></note><affiliation>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain</affiliation><affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-09"></date><biblScope unit="vol">26</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="2058">2058</biblScope><biblScope unit="page" to="2064">2064</biblScope></imprint></monogr><idno type="istex">87CC8850362775ACB3B5E4FC15A41FD4967ACC89</idno><idno type="DOI">10.1002/mds.23779</idno><idno type="ArticleID">MDS23779</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Sensory symptoms are common nonmotor manifestations of Parkinson's disease. It has been hypothesized that abnormal central processing of sensory signals occurs in Parkinson's disease and is related to dopaminergic treatment. The objective of this study was to investigate the alterations in sensory perception induced by transcranial magnetic stimulation of the primary somatosensory cortex in patients with Parkinson's disease and the modulatory effects of dopaminergic treatment. Fourteen patients with Parkinson's disease with and without dopaminergic treatment and 13 control subjects were included. Twenty milliseconds after peripheral electrical tactile stimuli in the contralateral thumb, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex was delivered. We evaluated the perception of peripheral electrical tactile stimuli at 2 conditioning stimulus intensities, set at 70% and 90% of the right resting motor threshold, using different interstimulus intervals. At 70% of the resting motor threshold, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex induced an increase in positive responses at short interstimulus intervals (1–7 ms) in controls but not in patients with dopaminergic treatment. At 90% of the resting motor threshold, controls and patients showed similar transcranial magnetic stimulation effects. Changes in peripheral electrical tactile stimuli perception after paired‐pulse transcranial magnetic stimulation over the primary somatosensory cortex are altered in patients with Parkinson's disease with dopaminergic treatment compared with controls. These findings suggest that primary somatosensory cortex excitability could be involved in changes in somatosensory integration in Parkinson's disease with dopaminergic treatment. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>transcranial magnetic stimulation</term></item><item><term>primary somatosensory cortex</term></item><item><term>dopaminergic treatment</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-03-03">Received</change><change when="2011-04-11">Registration</change><change when="2011-09">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/87CC8850362775ACB3B5E4FC15A41FD4967ACC89/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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Manuel Siurot sn, 41013 Sevilla, Spain</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23779.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="24"></count><count type="wordTotal" number="6057"></count></countGroup><titleGroup><title type="main" xml:lang="en">Sensory perception changes induced by transcranial magnetic stimulation over the primary somatosensory cortex in Parkinson's disease<link href="#fn1"></link><link href="#fn2"></link></title><title type="short" xml:lang="en">TMS of Primary Somatosensory Cortex in PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Francisco J.</givenNames><familyName>Palomar</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Francisco</givenNames><familyName>Díaz‐Corrales</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Fatima</givenNames><familyName>Carrillo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Miguel</givenNames><familyName>Fernández‐del‐Olmo</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3 #af4"><personName><givenNames>Giacomo</givenNames><familyName>Koch</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1 #af5" corresponding="yes"><personName><givenNames>Pablo</givenNames><familyName>Mir</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>pablo.mir.sspa@juntadeandalucia.es</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="ES" type="organization"><unparsedAffiliation>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="ES" type="organization"><unparsedAffiliation>INEF Galicia, Instituto de Educación Física y Deporte, La Coruña, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="IT" type="organization"><unparsedAffiliation>Clinica Neurologica, Dipartamento de Neuroscienze, Università di Roma Tor Vergata, Rome, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="IT" type="organization"><unparsedAffiliation>Laboratorio di Neurologia Clinica e Comportamentale, Fondazione S. Lucia I.R.C.C.S., Rome, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="ES" type="organization"><unparsedAffiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">transcranial magnetic stimulation</keyword><keyword xml:id="kwd3">primary somatosensory cortex</keyword><keyword xml:id="kwd4">dopaminergic treatment</keyword></keywordGroup><fundingInfo><fundingAgency>Francisco J. Palomar, Fatima Carrillo, and Pablo Mir were supported by grants from the Ministerio de Ciencia e Innovación de España</fundingAgency><fundingNumber>SAF2007‐60700</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Instituto de Salud Carlos III</fundingAgency><fundingNumber>PI10/01674</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Consejería de Innovación, Ciencia y Empresa de la Junta de Andalucía</fundingAgency><fundingNumber>CVI‐02526</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Consejería de Salud de la Junta de Andalucía</fundingAgency><fundingNumber>PI‐0377/2007</fundingNumber><fundingNumber>PI‐0741/2010</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Sociedad Andaluza de Neurología, and the Jaques and Gloria Gossweiler Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Francisco Díaz‐Corrales was supported by a fellowship from the Fundación Carolina/BBVA</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Miguel Fernández‐del‐Olmo was supported by the Ministerio de Ciencia e Innovación, Spain</fundingAgency><fundingNumber>PSI2008‐03175</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Jaques and Gloria Gossweiler Foundation</fundingAgency></fundingInfo><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23779:MDS_23779_sm_suppinfo"></mediaResource><caption>Supporting Information</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Sensory symptoms are common nonmotor manifestations of Parkinson's disease. It has been hypothesized that abnormal central processing of sensory signals occurs in Parkinson's disease and is related to dopaminergic treatment. The objective of this study was to investigate the alterations in sensory perception induced by transcranial magnetic stimulation of the primary somatosensory cortex in patients with Parkinson's disease and the modulatory effects of dopaminergic treatment. Fourteen patients with Parkinson's disease with and without dopaminergic treatment and 13 control subjects were included. Twenty milliseconds after peripheral electrical tactile stimuli in the contralateral thumb, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex was delivered. We evaluated the perception of peripheral electrical tactile stimuli at 2 conditioning stimulus intensities, set at 70% and 90% of the right resting motor threshold, using different interstimulus intervals. At 70% of the resting motor threshold, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex induced an increase in positive responses at short interstimulus intervals (1–7 ms) in controls but not in patients with dopaminergic treatment. At 90% of the resting motor threshold, controls and patients showed similar transcranial magnetic stimulation effects. Changes in peripheral electrical tactile stimuli perception after paired‐pulse transcranial magnetic stimulation over the primary somatosensory cortex are altered in patients with Parkinson's disease with dopaminergic treatment compared with controls. These findings suggest that primary somatosensory cortex excitability could be involved in changes in somatosensory integration in Parkinson's disease with dopaminergic treatment. © 2011 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p><b>Relevant conflicts of interest/financial disclosures:</b> Nothing to report.</p></note><note xml:id="fn2"><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Sensory perception changes induced by transcranial magnetic stimulation over the primary somatosensory cortex in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>TMS of Primary Somatosensory Cortex in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Sensory perception changes induced by transcranial magnetic stimulation over the primary somatosensory cortex in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Francisco J.</namePart><namePart type="family">Palomar</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francisco</namePart><namePart type="family">Díaz‐Corrales</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fatima</namePart><namePart type="family">Carrillo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Miguel</namePart><namePart type="family">Fernández‐del‐Olmo</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>INEF Galicia, Instituto de Educación Física y Deporte, La Coruña, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giacomo</namePart><namePart type="family">Koch</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Clinica Neurologica, Dipartamento de Neuroscienze, Università di Roma Tor Vergata, Rome, Italy</affiliation><affiliation>Laboratorio di Neurologia Clinica e Comportamentale, Fondazione S. Lucia I.R.C.C.S., Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pablo</namePart><namePart type="family">Mir</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain</affiliation><affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain</affiliation><description>Correspondence: Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología, Hospital Universitario Virgen del Rocío, Avda. Manuel Siurot sn, 41013 Sevilla, Spain</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-09</dateIssued><dateCaptured encoding="w3cdtf">2009-03-03</dateCaptured><dateValid encoding="w3cdtf">2011-04-11</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">24</extent><extent unit="words">6057</extent></physicalDescription><abstract lang="en">Sensory symptoms are common nonmotor manifestations of Parkinson's disease. It has been hypothesized that abnormal central processing of sensory signals occurs in Parkinson's disease and is related to dopaminergic treatment. The objective of this study was to investigate the alterations in sensory perception induced by transcranial magnetic stimulation of the primary somatosensory cortex in patients with Parkinson's disease and the modulatory effects of dopaminergic treatment. Fourteen patients with Parkinson's disease with and without dopaminergic treatment and 13 control subjects were included. Twenty milliseconds after peripheral electrical tactile stimuli in the contralateral thumb, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex was delivered. We evaluated the perception of peripheral electrical tactile stimuli at 2 conditioning stimulus intensities, set at 70% and 90% of the right resting motor threshold, using different interstimulus intervals. At 70% of the resting motor threshold, paired‐pulse transcranial magnetic stimulation over the right primary somatosensory cortex induced an increase in positive responses at short interstimulus intervals (1–7 ms) in controls but not in patients with dopaminergic treatment. At 90% of the resting motor threshold, controls and patients showed similar transcranial magnetic stimulation effects. Changes in peripheral electrical tactile stimuli perception after paired‐pulse transcranial magnetic stimulation over the primary somatosensory cortex are altered in patients with Parkinson's disease with dopaminergic treatment compared with controls. These findings suggest that primary somatosensory cortex excitability could be involved in changes in somatosensory integration in Parkinson's disease with dopaminergic treatment. © 2011 Movement Disorder Society</abstract><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note><note type="funding">Francisco J. Palomar, Fatima Carrillo, and Pablo Mir were supported by grants from the Ministerio de Ciencia e Innovación de España - No. SAF2007‐60700; </note><note type="funding">Instituto de Salud Carlos III - No. PI10/01674; </note><note type="funding">Consejería de Innovación, Ciencia y Empresa de la Junta de Andalucía - No. CVI‐02526; </note><note type="funding">Consejería de Salud de la Junta de Andalucía - No. PI‐0377/2007; No. PI‐0741/2010; </note><note type="funding">Sociedad Andaluza de Neurología, and the Jaques and Gloria Gossweiler Foundation</note><note type="funding">Francisco Díaz‐Corrales was supported by a fellowship from the Fundación Carolina/BBVA</note><note type="funding">Miguel Fernández‐del‐Olmo was supported by the Ministerio de Ciencia e Innovación, Spain - No. PSI2008‐03175; </note><note type="funding">Jaques and Gloria Gossweiler Foundation</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>transcranial magnetic stimulation</topic><topic>primary somatosensory cortex</topic><topic>dopaminergic treatment</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Supporting Information - </note><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>2058</start><end>2064</end><total>7</total></extent></part></relatedItem><identifier type="istex">87CC8850362775ACB3B5E4FC15A41FD4967ACC89</identifier><identifier type="DOI">10.1002/mds.23779</identifier><identifier type="ArticleID">MDS23779</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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