Transcranial brain sonography findings in clinical subgroups of idiopathic Parkinson's disease
Identifieur interne : 000B09 ( Istex/Corpus ); précédent : 000B08; suivant : 000B10Transcranial brain sonography findings in clinical subgroups of idiopathic Parkinson's disease
Auteurs : Uwe Walter ; Dirk Dressler ; Alexander Wolters ; Matthias Wittstock ; Reiner BeneckeSource :
- Movement Disorders [ 0885-3185 ] ; 2007-01.
English descriptors
Abstract
To investigate whether transcranial brain sonography (TCS) discriminates different courses of idiopathic Parkinson's disease (PD), 101 patients with clinically definite PD were studied. In four patients, TCS was not possible due to insufficient acoustic temporal bone windows. Substantia nigra (SN) hyperechogenicity was found in 96% of assessable patients. Larger SN echogenic size correlated with younger age at PD onset (Spearman correlation, r = −0.383; P < 0.001), but not with age, PD duration, or severity. Marked bilateral SN hyperechogenicity indicated early‐onset rather than late‐onset PD, and akinetic–rigid (AR) or mixed‐type (MX) PD rather than tremor‐dominant PD. SN echogenic sizes were larger contralateral to the clinically more affected side in AR PD and MX PD patients. Reduced echogenicity of brainstem raphe was associated with depression (RR = 1.61; 95% CI = 1.05–2.46; P = 0.044) but not with other clinical features. Caudate nucleus hyperechogenicity was, independently from PD duration, related to drug‐induced psychosis (RR = 2.40; CI = 1.36–4.22; P = 0.001), but not to motor fluctuations. Lenticular nucleus hyperechogenicity indicated AR PD rather than tremor‐dominant PD (RR = 1.44; CI = 1.11–1.86; P = 0.040). Frontal horn dilatation > 15.4 mm (mean of bilateral measurements) indicated increased risk of dementia (RR = 4.11; CI = 1.51–11.2; P = 0.001). We conclude that TCS displays characteristic changes of deep brain structures in different clinical manifestations of PD. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21197
Links to Exploration step
ISTEX:ADA24C386F7D169077DACC645E9E7DAFEAFFD535Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Transcranial brain sonography findings in clinical subgroups of idiopathic Parkinson's disease</title><author><name sortKey="Walter, Uwe" sort="Walter, Uwe" uniqKey="Walter U" first="Uwe" last="Walter">Uwe Walter</name><affiliation><mods:affiliation>Department of Neurology, University of Rostock, Rostock, Germany</mods:affiliation></affiliation></author><author><name sortKey="Dressler, Dirk" sort="Dressler, Dirk" uniqKey="Dressler D" first="Dirk" last="Dressler">Dirk Dressler</name><affiliation><mods:affiliation>Department of Neurology, University of Rostock, Rostock, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wolters, Alexander" sort="Wolters, Alexander" uniqKey="Wolters A" first="Alexander" last="Wolters">Alexander Wolters</name><affiliation><mods:affiliation>Department of Neurology, University of Rostock, Rostock, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wittstock, Matthias" sort="Wittstock, Matthias" uniqKey="Wittstock M" first="Matthias" last="Wittstock">Matthias Wittstock</name><affiliation><mods:affiliation>Department of Neurology, University of Rostock, Rostock, Germany</mods:affiliation></affiliation></author><author><name sortKey="Benecke, Reiner" sort="Benecke, Reiner" uniqKey="Benecke R" first="Reiner" last="Benecke">Reiner Benecke</name><affiliation><mods:affiliation>Department of Neurology, University of Rostock, Rostock, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:ADA24C386F7D169077DACC645E9E7DAFEAFFD535</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mds.21197</idno><idno type="url">https://api.istex.fr/document/ADA24C386F7D169077DACC645E9E7DAFEAFFD535/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000B09</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Transcranial brain sonography findings in clinical subgroups of idiopathic Parkinson's disease</title><author><name sortKey="Walter, Uwe" sort="Walter, Uwe" uniqKey="Walter U" first="Uwe" last="Walter">Uwe Walter</name><affiliation><mods:affiliation>Department of Neurology, University of Rostock, Rostock, Germany</mods:affiliation></affiliation></author><author><name sortKey="Dressler, Dirk" sort="Dressler, Dirk" uniqKey="Dressler D" first="Dirk" last="Dressler">Dirk Dressler</name><affiliation><mods:affiliation>Department of Neurology, University of Rostock, Rostock, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wolters, Alexander" sort="Wolters, Alexander" uniqKey="Wolters A" first="Alexander" last="Wolters">Alexander Wolters</name><affiliation><mods:affiliation>Department of Neurology, University of Rostock, Rostock, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wittstock, Matthias" sort="Wittstock, Matthias" uniqKey="Wittstock M" first="Matthias" last="Wittstock">Matthias Wittstock</name><affiliation><mods:affiliation>Department of Neurology, University of Rostock, Rostock, Germany</mods:affiliation></affiliation></author><author><name sortKey="Benecke, Reiner" sort="Benecke, Reiner" uniqKey="Benecke R" first="Reiner" last="Benecke">Reiner Benecke</name><affiliation><mods:affiliation>Department of Neurology, University of Rostock, Rostock, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-01">2007-01</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="48">48</biblScope><biblScope unit="page" to="54">54</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">ADA24C386F7D169077DACC645E9E7DAFEAFFD535</idno><idno type="DOI">10.1002/mds.21197</idno><idno type="ArticleID">MDS21197</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>brain parenchyma sonography</term><term>substantia nigra</term><term>transcranial sonography</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate whether transcranial brain sonography (TCS) discriminates different courses of idiopathic Parkinson's disease (PD), 101 patients with clinically definite PD were studied. In four patients, TCS was not possible due to insufficient acoustic temporal bone windows. Substantia nigra (SN) hyperechogenicity was found in 96% of assessable patients. Larger SN echogenic size correlated with younger age at PD onset (Spearman correlation, r = −0.383; P < 0.001), but not with age, PD duration, or severity. Marked bilateral SN hyperechogenicity indicated early‐onset rather than late‐onset PD, and akinetic–rigid (AR) or mixed‐type (MX) PD rather than tremor‐dominant PD. SN echogenic sizes were larger contralateral to the clinically more affected side in AR PD and MX PD patients. Reduced echogenicity of brainstem raphe was associated with depression (RR = 1.61; 95% CI = 1.05–2.46; P = 0.044) but not with other clinical features. Caudate nucleus hyperechogenicity was, independently from PD duration, related to drug‐induced psychosis (RR = 2.40; CI = 1.36–4.22; P = 0.001), but not to motor fluctuations. Lenticular nucleus hyperechogenicity indicated AR PD rather than tremor‐dominant PD (RR = 1.44; CI = 1.11–1.86; P = 0.040). Frontal horn dilatation > 15.4 mm (mean of bilateral measurements) indicated increased risk of dementia (RR = 4.11; CI = 1.51–11.2; P = 0.001). We conclude that TCS displays characteristic changes of deep brain structures in different clinical manifestations of PD. © 2006 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Uwe Walter MD</name><affiliations><json:string>Department of Neurology, University of Rostock, Rostock, Germany</json:string></affiliations></json:item><json:item><name>Dirk Dressler MD</name><affiliations><json:string>Department of Neurology, University of Rostock, Rostock, Germany</json:string></affiliations></json:item><json:item><name>Alexander Wolters MD</name><affiliations><json:string>Department of Neurology, University of Rostock, Rostock, Germany</json:string></affiliations></json:item><json:item><name>Matthias Wittstock MD</name><affiliations><json:string>Department of Neurology, University of Rostock, Rostock, Germany</json:string></affiliations></json:item><json:item><name>Reiner Benecke MD</name><affiliations><json:string>Department of Neurology, University of Rostock, Rostock, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>brain parenchyma sonography</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>transcranial sonography</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>substantia nigra</value></json:item></subject><language><json:string>eng</json:string></language><abstract>To investigate whether transcranial brain sonography (TCS) discriminates different courses of idiopathic Parkinson's disease (PD), 101 patients with clinically definite PD were studied. In four patients, TCS was not possible due to insufficient acoustic temporal bone windows. Substantia nigra (SN) hyperechogenicity was found in 96% of assessable patients. Larger SN echogenic size correlated with younger age at PD onset (Spearman correlation, r = −0.383; P > 0.001), but not with age, PD duration, or severity. Marked bilateral SN hyperechogenicity indicated early‐onset rather than late‐onset PD, and akinetic–rigid (AR) or mixed‐type (MX) PD rather than tremor‐dominant PD. SN echogenic sizes were larger contralateral to the clinically more affected side in AR PD and MX PD patients. Reduced echogenicity of brainstem raphe was associated with depression (RR = 1.61; 95% CI = 1.05–2.46; P = 0.044) but not with other clinical features. Caudate nucleus hyperechogenicity was, independently from PD duration, related to drug‐induced psychosis (RR = 2.40; CI = 1.36–4.22; P = 0.001), but not to motor fluctuations. Lenticular nucleus hyperechogenicity indicated AR PD rather than tremor‐dominant PD (RR = 1.44; CI = 1.11–1.86; P = 0.040). Frontal horn dilatation > 15.4 mm (mean of bilateral measurements) indicated increased risk of dementia (RR = 4.11; CI = 1.51–11.2; P = 0.001). We conclude that TCS displays characteristic changes of deep brain structures in different clinical manifestations of PD. © 2006 Movement Disorder Society</abstract><qualityIndicators><score>7.02</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1540</abstractCharCount><pdfWordCount>4248</pdfWordCount><pdfCharCount>26869</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>231</abstractWordCount></qualityIndicators><title>Transcranial brain sonography findings in clinical subgroups of idiopathic Parkinson's disease</title><genre><json:string>Serial article</json:string></genre><host><volume>22</volume><pages><total>7</total><last>54</last><first>48</first></pages><issn><json:string>0885-3185</json:string></issn><issue>1</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2007</publicationDate><copyrightDate>2007</copyrightDate><doi><json:string>10.1002/mds.21197</json:string></doi><id>ADA24C386F7D169077DACC645E9E7DAFEAFFD535</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/ADA24C386F7D169077DACC645E9E7DAFEAFFD535/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/ADA24C386F7D169077DACC645E9E7DAFEAFFD535/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/ADA24C386F7D169077DACC645E9E7DAFEAFFD535/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Transcranial brain sonography findings in clinical subgroups of idiopathic Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2007</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Transcranial brain sonography findings in clinical subgroups of idiopathic Parkinson's disease</title><author><persName><forename type="first">Uwe</forename><surname>Walter</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, D‐18147 Rostock, Germany</p></note><affiliation>Department of Neurology, University of Rostock, Rostock, Germany</affiliation></author><author><persName><forename type="first">Dirk</forename><surname>Dressler</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University of Rostock, Rostock, Germany</affiliation></author><author><persName><forename type="first">Alexander</forename><surname>Wolters</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University of Rostock, Rostock, Germany</affiliation></author><author><persName><forename type="first">Matthias</forename><surname>Wittstock</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University of Rostock, Rostock, Germany</affiliation></author><author><persName><forename type="first">Reiner</forename><surname>Benecke</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University of Rostock, Rostock, Germany</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-01"></date><biblScope unit="vol">22</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="48">48</biblScope><biblScope unit="page" to="54">54</biblScope></imprint></monogr><idno type="istex">ADA24C386F7D169077DACC645E9E7DAFEAFFD535</idno><idno type="DOI">10.1002/mds.21197</idno><idno type="ArticleID">MDS21197</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2007</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>To investigate whether transcranial brain sonography (TCS) discriminates different courses of idiopathic Parkinson's disease (PD), 101 patients with clinically definite PD were studied. In four patients, TCS was not possible due to insufficient acoustic temporal bone windows. Substantia nigra (SN) hyperechogenicity was found in 96% of assessable patients. Larger SN echogenic size correlated with younger age at PD onset (Spearman correlation, r = −0.383; P < 0.001), but not with age, PD duration, or severity. Marked bilateral SN hyperechogenicity indicated early‐onset rather than late‐onset PD, and akinetic–rigid (AR) or mixed‐type (MX) PD rather than tremor‐dominant PD. SN echogenic sizes were larger contralateral to the clinically more affected side in AR PD and MX PD patients. Reduced echogenicity of brainstem raphe was associated with depression (RR = 1.61; 95% CI = 1.05–2.46; P = 0.044) but not with other clinical features. Caudate nucleus hyperechogenicity was, independently from PD duration, related to drug‐induced psychosis (RR = 2.40; CI = 1.36–4.22; P = 0.001), but not to motor fluctuations. Lenticular nucleus hyperechogenicity indicated AR PD rather than tremor‐dominant PD (RR = 1.44; CI = 1.11–1.86; P = 0.040). Frontal horn dilatation > 15.4 mm (mean of bilateral measurements) indicated increased risk of dementia (RR = 4.11; CI = 1.51–11.2; P = 0.001). We conclude that TCS displays characteristic changes of deep brain structures in different clinical manifestations of PD. © 2006 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>brain parenchyma sonography</term></item><item><term>transcranial sonography</term></item><item><term>substantia nigra</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2005-11-17">Received</change><change when="2006-07-15">Registration</change><change when="2007-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/ADA24C386F7D169077DACC645E9E7DAFEAFFD535/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="120"><doi origin="wiley" registered="yes">10.1002/mds.v22:1</doi><numberingGroup><numbering type="journalVolume" number="22">22</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2007-01">January 2007</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="70" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.21197</doi><idGroup><id type="unit" value="MDS21197"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2006 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2005-11-17"></event><event type="manuscriptRevised" date="2006-07-11"></event><event type="manuscriptAccepted" date="2006-07-15"></event><event type="firstOnline" date="2006-11-02"></event><event type="publishedOnlineFinalForm" date="2007-01-22"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2006-11-02"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.4.7 mode:FullText source:FullText result:FullText" date="2011-02-24"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">48</numbering><numbering type="pageLast">54</numbering></numberingGroup><correspondenceTo>Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, D‐18147 Rostock, Germany</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS21197.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="35"></count><count type="wordTotal" number="4848"></count></countGroup><titleGroup><title type="main" xml:lang="en">Transcranial brain sonography findings in clinical subgroups of idiopathic Parkinson's disease</title><title type="short" xml:lang="en">Transcranial Brain Sonography Findings</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Uwe</givenNames><familyName>Walter</familyName><degrees>MD</degrees></personName><contactDetails><email normalForm="uwe.walter@med.uni-rostock.de">uwe.walter@med.uni‐rostock.de</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Dirk</givenNames><familyName>Dressler</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Alexander</givenNames><familyName>Wolters</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Matthias</givenNames><familyName>Wittstock</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Reiner</givenNames><familyName>Benecke</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, University of Rostock, Rostock, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">brain parenchyma sonography</keyword><keyword xml:id="kwd2">transcranial sonography</keyword><keyword xml:id="kwd3">substantia nigra</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>To investigate whether transcranial brain sonography (TCS) discriminates different courses of idiopathic Parkinson's disease (PD), 101 patients with clinically definite PD were studied. In four patients, TCS was not possible due to insufficient acoustic temporal bone windows. Substantia nigra (SN) hyperechogenicity was found in 96% of assessable patients. Larger SN echogenic size correlated with younger age at PD onset (Spearman correlation, r = −0.383; <i>P</i> < 0.001), but not with age, PD duration, or severity. Marked bilateral SN hyperechogenicity indicated early‐onset rather than late‐onset PD, and akinetic–rigid (AR) or mixed‐type (MX) PD rather than tremor‐dominant PD. SN echogenic sizes were larger contralateral to the clinically more affected side in AR PD and MX PD patients. Reduced echogenicity of brainstem raphe was associated with depression (RR = 1.61; 95% CI = 1.05–2.46; <i>P</i> = 0.044) but not with other clinical features. Caudate nucleus hyperechogenicity was, independently from PD duration, related to drug‐induced psychosis (RR = 2.40; CI = 1.36–4.22; <i>P</i> = 0.001), but not to motor fluctuations. Lenticular nucleus hyperechogenicity indicated AR PD rather than tremor‐dominant PD (RR = 1.44; CI = 1.11–1.86; <i>P</i> = 0.040). Frontal horn dilatation > 15.4 mm (mean of bilateral measurements) indicated increased risk of dementia (RR = 4.11; CI = 1.51–11.2; <i>P</i> = 0.001). We conclude that TCS displays characteristic changes of deep brain structures in different clinical manifestations of PD. © 2006 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Transcranial brain sonography findings in clinical subgroups of idiopathic Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Transcranial Brain Sonography Findings</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Transcranial brain sonography findings in clinical subgroups of idiopathic Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Uwe</namePart><namePart type="family">Walter</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Rostock, Rostock, Germany</affiliation><description>Correspondence: Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, D‐18147 Rostock, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dirk</namePart><namePart type="family">Dressler</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Rostock, Rostock, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexander</namePart><namePart type="family">Wolters</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Rostock, Rostock, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matthias</namePart><namePart type="family">Wittstock</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Rostock, Rostock, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Reiner</namePart><namePart type="family">Benecke</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Rostock, Rostock, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-01</dateIssued><dateCaptured encoding="w3cdtf">2005-11-17</dateCaptured><dateValid encoding="w3cdtf">2006-07-15</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">2</extent><extent unit="references">35</extent><extent unit="words">4848</extent></physicalDescription><abstract lang="en">To investigate whether transcranial brain sonography (TCS) discriminates different courses of idiopathic Parkinson's disease (PD), 101 patients with clinically definite PD were studied. In four patients, TCS was not possible due to insufficient acoustic temporal bone windows. Substantia nigra (SN) hyperechogenicity was found in 96% of assessable patients. Larger SN echogenic size correlated with younger age at PD onset (Spearman correlation, r = −0.383; P < 0.001), but not with age, PD duration, or severity. Marked bilateral SN hyperechogenicity indicated early‐onset rather than late‐onset PD, and akinetic–rigid (AR) or mixed‐type (MX) PD rather than tremor‐dominant PD. SN echogenic sizes were larger contralateral to the clinically more affected side in AR PD and MX PD patients. Reduced echogenicity of brainstem raphe was associated with depression (RR = 1.61; 95% CI = 1.05–2.46; P = 0.044) but not with other clinical features. Caudate nucleus hyperechogenicity was, independently from PD duration, related to drug‐induced psychosis (RR = 2.40; CI = 1.36–4.22; P = 0.001), but not to motor fluctuations. Lenticular nucleus hyperechogenicity indicated AR PD rather than tremor‐dominant PD (RR = 1.44; CI = 1.11–1.86; P = 0.040). Frontal horn dilatation > 15.4 mm (mean of bilateral measurements) indicated increased risk of dementia (RR = 4.11; CI = 1.51–11.2; P = 0.001). We conclude that TCS displays characteristic changes of deep brain structures in different clinical manifestations of PD. © 2006 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>brain parenchyma sonography</topic><topic>transcranial sonography</topic><topic>substantia nigra</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>48</start><end>54</end><total>7</total></extent></part></relatedItem><identifier type="istex">ADA24C386F7D169077DACC645E9E7DAFEAFFD535</identifier><identifier type="DOI">10.1002/mds.21197</identifier><identifier type="ArticleID">MDS21197</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B09 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000B09 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:ADA24C386F7D169077DACC645E9E7DAFEAFFD535
|texte= Transcranial brain sonography findings in clinical subgroups of idiopathic Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |