Corticobasal degeneration and Parkinson's disease assessed by HmPaO SPECT: The utility of factorial discriminant analysis
Identifieur interne : 000A64 ( Istex/Corpus ); précédent : 000A63; suivant : 000A65Corticobasal degeneration and Parkinson's disease assessed by HmPaO SPECT: The utility of factorial discriminant analysis
Auteurs : Alexandre Kreisler ; Luc Defebvre ; Pascal Lecouffe ; Alain Duhamel ; Pierre Charpentier ; Marc Steinling ; Alain DestéeSource :
- Movement Disorders [ 0885-3185 ] ; 2005-11.
English descriptors
Abstract
The diagnosis of corticobasal degeneration (CBD) is difficult despite the existence of some typical clinical features. Single photon emission computerized tomography (SPECT) in CBD presents an original pattern (with asymmetric hypoperfusion in pre‐ and retrorolandic regions) that could facilitate the differential diagnosis of CBD relative to the other degenerative parkinsonian syndromes. The objective of our study was to compare the regional cerebral blood flow measurements studied by SPECT in both CBD and Parkinson's disease (PD) using a multivariate procedure. Twenty‐one patients with probable CBD and 20 patients with probable PD underwent brain 99mTc HmPaO SPECT. We used factorial discriminant analysis (FDA) to study the relative fixation of 26 regions of interest (ROIs) drawn on two transverse slices, together with the asymmetry indexes of 13 pairs of ROIs. FDA performed using the full set of parameters classified all the patients correctly. In order to classify the patients more easily, a predictive score using a selection of parameters was established. The most discriminating ROIs were the temporoinsular, temporoparietal, and frontal medial regions. We believe that this semiautomatic classification may be a precious tool for reinforcing the current clinical differential diagnosis of CBD and PD. © 2005 Movement Disorder Society
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DOI: 10.1002/mds.20611
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ISTEX:CF3979682BB8421145FEB331BF3B511903409B07Le document en format XML
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Regional and University Hospital, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name><affiliation><mods:affiliation>Department of Biostatistics, Regional and University Hospital, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Charpentier, Pierre" sort="Charpentier, Pierre" uniqKey="Charpentier P" first="Pierre" last="Charpentier">Pierre Charpentier</name><affiliation><mods:affiliation>Department of Neurology, Regional and University Hospital, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Steinling, Marc" sort="Steinling, Marc" uniqKey="Steinling M" first="Marc" last="Steinling">Marc Steinling</name><affiliation><mods:affiliation>Department of Nuclear Medicine, Regional and University Hospital, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation><mods:affiliation>Department of Neurology, Regional and University Hospital, Lille, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:CF3979682BB8421145FEB331BF3B511903409B07</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1002/mds.20611</idno><idno type="url">https://api.istex.fr/document/CF3979682BB8421145FEB331BF3B511903409B07/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000A64</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Corticobasal degeneration and Parkinson's disease assessed by HmPaO SPECT: The utility of factorial discriminant analysis</title><author><name sortKey="Kreisler, Alexandre" sort="Kreisler, Alexandre" uniqKey="Kreisler A" first="Alexandre" last="Kreisler">Alexandre 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France</mods:affiliation></affiliation></author><author><name sortKey="Charpentier, Pierre" sort="Charpentier, Pierre" uniqKey="Charpentier P" first="Pierre" last="Charpentier">Pierre Charpentier</name><affiliation><mods:affiliation>Department of Neurology, Regional and University Hospital, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Steinling, Marc" sort="Steinling, Marc" uniqKey="Steinling M" first="Marc" last="Steinling">Marc Steinling</name><affiliation><mods:affiliation>Department of Nuclear Medicine, Regional and University Hospital, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation><mods:affiliation>Department of Neurology, Regional and University Hospital, Lille, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" 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Single photon emission computerized tomography (SPECT) in CBD presents an original pattern (with asymmetric hypoperfusion in pre‐ and retrorolandic regions) that could facilitate the differential diagnosis of CBD relative to the other degenerative parkinsonian syndromes. The objective of our study was to compare the regional cerebral blood flow measurements studied by SPECT in both CBD and Parkinson's disease (PD) using a multivariate procedure. Twenty‐one patients with probable CBD and 20 patients with probable PD underwent brain 99mTc HmPaO SPECT. We used factorial discriminant analysis (FDA) to study the relative fixation of 26 regions of interest (ROIs) drawn on two transverse slices, together with the asymmetry indexes of 13 pairs of ROIs. FDA performed using the full set of parameters classified all the patients correctly. In order to classify the patients more easily, a predictive score using a selection of parameters was established. The most discriminating ROIs were the temporoinsular, temporoparietal, and frontal medial regions. We believe that this semiautomatic classification may be a precious tool for reinforcing the current clinical differential diagnosis of CBD and PD. © 2005 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Alexandre Kreisler MD</name><affiliations><json:string>Department of Neurology, Regional and University Hospital, Lille, France</json:string></affiliations></json:item><json:item><name>Luc Defebvre MD, PhD</name><affiliations><json:string>Department of Neurology, Regional and University Hospital, Lille, France</json:string></affiliations></json:item><json:item><name>Pascal Lecouffe MD</name><affiliations><json:string>Department of Nuclear Medicine, Regional and University Hospital, Lille, France</json:string></affiliations></json:item><json:item><name>Alain Duhamel PhD</name><affiliations><json:string>Department of Biostatistics, Regional and University Hospital, Lille, France</json:string></affiliations></json:item><json:item><name>Pierre Charpentier MD</name><affiliations><json:string>Department of Neurology, Regional and University Hospital, Lille, France</json:string></affiliations></json:item><json:item><name>Marc Steinling MD, PhD</name><affiliations><json:string>Department of Nuclear Medicine, Regional and University Hospital, Lille, France</json:string></affiliations></json:item><json:item><name>Alain Destée MD</name><affiliations><json:string>Department of Neurology, Regional and University Hospital, Lille, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>corticobasal degeneration</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>functional imaging</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>discriminant analysis</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The diagnosis of corticobasal degeneration (CBD) is difficult despite the existence of some typical clinical features. Single photon emission computerized tomography (SPECT) in CBD presents an original pattern (with asymmetric hypoperfusion in pre‐ and retrorolandic regions) that could facilitate the differential diagnosis of CBD relative to the other degenerative parkinsonian syndromes. The objective of our study was to compare the regional cerebral blood flow measurements studied by SPECT in both CBD and Parkinson's disease (PD) using a multivariate procedure. Twenty‐one patients with probable CBD and 20 patients with probable PD underwent brain 99mTc HmPaO SPECT. We used factorial discriminant analysis (FDA) to study the relative fixation of 26 regions of interest (ROIs) drawn on two transverse slices, together with the asymmetry indexes of 13 pairs of ROIs. FDA performed using the full set of parameters classified all the patients correctly. In order to classify the patients more easily, a predictive score using a selection of parameters was established. The most discriminating ROIs were the temporoinsular, temporoparietal, and frontal medial regions. 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Single photon emission computerized tomography (SPECT) in CBD presents an original pattern (with asymmetric hypoperfusion in pre‐ and retrorolandic regions) that could facilitate the differential diagnosis of CBD relative to the other degenerative parkinsonian syndromes. The objective of our study was to compare the regional cerebral blood flow measurements studied by SPECT in both CBD and Parkinson's disease (PD) using a multivariate procedure. Twenty‐one patients with probable CBD and 20 patients with probable PD underwent brain 99mTc HmPaO SPECT. We used factorial discriminant analysis (FDA) to study the relative fixation of 26 regions of interest (ROIs) drawn on two transverse slices, together with the asymmetry indexes of 13 pairs of ROIs. FDA performed using the full set of parameters classified all the patients correctly. In order to classify the patients more easily, a predictive score using a selection of parameters was established. The most discriminating ROIs were the temporoinsular, temporoparietal, and frontal medial regions. We believe that this semiautomatic classification may be a precious tool for reinforcing the current clinical differential diagnosis of CBD and PD. © 2005 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>corticobasal degeneration</term></item><item><term>Parkinson's disease</term></item><item><term>functional imaging</term></item><item><term>discriminant analysis</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2005-01-07">Received</change><change when="2005-02-04">Registration</change><change when="2005-11">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/CF3979682BB8421145FEB331BF3B511903409B07/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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xml:id="kwd4">discriminant analysis</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The diagnosis of corticobasal degeneration (CBD) is difficult despite the existence of some typical clinical features. Single photon emission computerized tomography (SPECT) in CBD presents an original pattern (with asymmetric hypoperfusion in pre‐ and retrorolandic regions) that could facilitate the differential diagnosis of CBD relative to the other degenerative parkinsonian syndromes. The objective of our study was to compare the regional cerebral blood flow measurements studied by SPECT in both CBD and Parkinson's disease (PD) using a multivariate procedure. Twenty‐one patients with probable CBD and 20 patients with probable PD underwent brain <sup>99m</sup>Tc HmPaO SPECT. We used factorial discriminant analysis (FDA) to study the relative fixation of 26 regions of interest (ROIs) drawn on two transverse slices, together with the asymmetry indexes of 13 pairs of ROIs. FDA performed using the full set of parameters classified all the patients correctly. In order to classify the patients more easily, a predictive score using a selection of parameters was established. The most discriminating ROIs were the temporoinsular, temporoparietal, and frontal medial regions. We believe that this semiautomatic classification may be a precious tool for reinforcing the current clinical differential diagnosis of CBD and PD. © 2005 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Corticobasal degeneration and Parkinson's disease assessed by HmPaO SPECT: The utility of factorial discriminant analysis</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Corticobasal Degeneration and PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Corticobasal degeneration and Parkinson's disease assessed by HmPaO SPECT: The utility of factorial discriminant analysis</title></titleInfo><name type="personal"><namePart type="given">Alexandre</namePart><namePart type="family">Kreisler</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Regional and University Hospital, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luc</namePart><namePart type="family">Defebvre</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Regional and University Hospital, Lille, France</affiliation><description>Correspondence: Neurologie A et Pathologie du Mouvement, Hôpital Roger Salengro, F‐59037 Lille Cedex, France</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pascal</namePart><namePart type="family">Lecouffe</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Nuclear Medicine, Regional and University Hospital, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alain</namePart><namePart type="family">Duhamel</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Biostatistics, Regional and University Hospital, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pierre</namePart><namePart type="family">Charpentier</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Regional and University Hospital, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marc</namePart><namePart type="family">Steinling</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Nuclear Medicine, Regional and University Hospital, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alain</namePart><namePart type="family">Destée</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Regional and University Hospital, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2005-11</dateIssued><dateCaptured encoding="w3cdtf">2005-01-07</dateCaptured><dateValid encoding="w3cdtf">2005-02-04</dateValid><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">36</extent><extent unit="words">5840</extent></physicalDescription><abstract lang="en">The diagnosis of corticobasal degeneration (CBD) is difficult despite the existence of some typical clinical features. Single photon emission computerized tomography (SPECT) in CBD presents an original pattern (with asymmetric hypoperfusion in pre‐ and retrorolandic regions) that could facilitate the differential diagnosis of CBD relative to the other degenerative parkinsonian syndromes. The objective of our study was to compare the regional cerebral blood flow measurements studied by SPECT in both CBD and Parkinson's disease (PD) using a multivariate procedure. Twenty‐one patients with probable CBD and 20 patients with probable PD underwent brain 99mTc HmPaO SPECT. We used factorial discriminant analysis (FDA) to study the relative fixation of 26 regions of interest (ROIs) drawn on two transverse slices, together with the asymmetry indexes of 13 pairs of ROIs. FDA performed using the full set of parameters classified all the patients correctly. In order to classify the patients more easily, a predictive score using a selection of parameters was established. The most discriminating ROIs were the temporoinsular, temporoparietal, and frontal medial regions. We believe that this semiautomatic classification may be a precious tool for reinforcing the current clinical differential diagnosis of CBD and PD. © 2005 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>corticobasal degeneration</topic><topic>Parkinson's disease</topic><topic>functional imaging</topic><topic>discriminant analysis</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>1431</start><end>1438</end><total>8</total></extent></part></relatedItem><identifier type="istex">CF3979682BB8421145FEB331BF3B511903409B07</identifier><identifier type="DOI">10.1002/mds.20611</identifier><identifier type="ArticleID">MDS20611</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2005 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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