Parsing brain activity associated with acupuncture treatment in Parkinson's diseases
Identifieur interne : 000952 ( Istex/Corpus ); précédent : 000951; suivant : 000953Parsing brain activity associated with acupuncture treatment in Parkinson's diseases
Auteurs : Younbyoung Chae ; Hyejung Lee ; Hackjin Kim ; Chang-Hwan Kim ; Dae-Il Chang ; Kyung-Mi Kim ; Hi-Joon ParkSource :
- Movement Disorders [ 0885-3185 ] ; 2009-09-15.
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Abstract
Acupuncture, a common treatment modality within complementary and alternative medicine, has been widely used for Parkinson's disease (PD). Using functional magnetic resonance imaging (fMRI), we explored the neural mechanisms underlying the effect of specific and genuine acupuncture treatment on the motor function in patients with PD. Three fMRI scans were performed in random order in a block design, one for verum acupuncture (VA) treatment, another one for a covert placebo (CP), and the third one for an overt placebo (OP) at the motor function implicated acupoint GB34 on the left foot of 10 patients with PD. We calculated the contrast that subtracts the blood‐oxygen‐level dependent (BOLD) response for the acupuncture effect (VA vs. CP) and the placebo effect (CP vs. OP). We found a significant improvement in the motor function of the affected hand after acupuncture treatment. The putamen and the primary motor cortex were activated when patients with PD received the acupuncture treatment (VA vs. CP) and these activations correlated with individual enhanced motor function. Expectation towards acupuncture modality (CP vs. OP) elicited activation over the anterior cingulate gyrus, the superior frontal gyrus, and the superior temporal gyrus. These findings suggest that acupuncture treatment might facilitate improvement in the motor functioning of patients with PD via the basal ganglia‐thalamocortical circuit. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22673
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Chang Wan" uniqKey="Kim C" first="Chang-Hwan" last="Kim">Chang-Hwan Kim</name><affiliation><mods:affiliation>Department of Acupuncture and Moxibustion, Kyung Hee University Hospital, Dongdaemun‐gu, Seoul, Republic of Korea</mods:affiliation></affiliation></author><author><name sortKey="Chang, Dae L" sort="Chang, Dae L" uniqKey="Chang D" first="Dae-Il" last="Chang">Dae-Il Chang</name><affiliation><mods:affiliation>Department of Neurology, College of Medicine, Kyung Hee University, Dongdaemun‐gu, Seoul, Republic of Korea</mods:affiliation></affiliation></author><author><name sortKey="Kim, Kyung I" sort="Kim, Kyung I" uniqKey="Kim K" first="Kyung-Mi" last="Kim">Kyung-Mi Kim</name><affiliation><mods:affiliation>Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun‐gu, Seoul, Republic of Korea</mods:affiliation></affiliation></author><author><name sortKey="Park, Hi Oon" sort="Park, Hi Oon" uniqKey="Park H" first="Hi-Joon" last="Park">Hi-Joon 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Using functional magnetic resonance imaging (fMRI), we explored the neural mechanisms underlying the effect of specific and genuine acupuncture treatment on the motor function in patients with PD. Three fMRI scans were performed in random order in a block design, one for verum acupuncture (VA) treatment, another one for a covert placebo (CP), and the third one for an overt placebo (OP) at the motor function implicated acupoint GB34 on the left foot of 10 patients with PD. We calculated the contrast that subtracts the blood‐oxygen‐level dependent (BOLD) response for the acupuncture effect (VA vs. CP) and the placebo effect (CP vs. OP). We found a significant improvement in the motor function of the affected hand after acupuncture treatment. The putamen and the primary motor cortex were activated when patients with PD received the acupuncture treatment (VA vs. CP) and these activations correlated with individual enhanced motor function. Expectation towards acupuncture modality (CP vs. OP) elicited activation over the anterior cingulate gyrus, the superior frontal gyrus, and the superior temporal gyrus. These findings suggest that acupuncture treatment might facilitate improvement in the motor functioning of patients with PD via the basal ganglia‐thalamocortical circuit. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Younbyoung Chae KMD, PhD</name><affiliations><json:string>Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun‐gu, Seoul, Republic of Korea</json:string></affiliations></json:item><json:item><name>Hyejung Lee KMD, PhD</name><affiliations><json:string>Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun‐gu, Seoul, Republic of Korea</json:string></affiliations></json:item><json:item><name>Hackjin Kim PhD</name><affiliations><json:string>Department of Psychology, Korea University, Anam‐dong Seongbuk‐Gu, Seoul, Republic of Korea</json:string></affiliations></json:item><json:item><name>Chang‐Hwan Kim KMD, PhD</name><affiliations><json:string>Department of Acupuncture and Moxibustion, Kyung Hee University Hospital, Dongdaemun‐gu, Seoul, Republic of Korea</json:string></affiliations></json:item><json:item><name>Dae‐Il Chang MD, PhD</name><affiliations><json:string>Department of Neurology, College of Medicine, Kyung Hee University, Dongdaemun‐gu, Seoul, Republic of Korea</json:string></affiliations></json:item><json:item><name>Kyung‐Mi Kim KMD, MS</name><affiliations><json:string>Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun‐gu, Seoul, Republic of Korea</json:string></affiliations></json:item><json:item><name>Hi‐Joon Park KMD, PhD</name><affiliations><json:string>Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun‐gu, Seoul, Republic of Korea</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>acupuncture</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>fMRI</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>placebo</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>putamen</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Acupuncture, a common treatment modality within complementary and alternative medicine, has been widely used for Parkinson's disease (PD). Using functional magnetic resonance imaging (fMRI), we explored the neural mechanisms underlying the effect of specific and genuine acupuncture treatment on the motor function in patients with PD. Three fMRI scans were performed in random order in a block design, one for verum acupuncture (VA) treatment, another one for a covert placebo (CP), and the third one for an overt placebo (OP) at the motor function implicated acupoint GB34 on the left foot of 10 patients with PD. We calculated the contrast that subtracts the blood‐oxygen‐level dependent (BOLD) response for the acupuncture effect (VA vs. CP) and the placebo effect (CP vs. OP). We found a significant improvement in the motor function of the affected hand after acupuncture treatment. The putamen and the primary motor cortex were activated when patients with PD received the acupuncture treatment (VA vs. CP) and these activations correlated with individual enhanced motor function. Expectation towards acupuncture modality (CP vs. OP) elicited activation over the anterior cingulate gyrus, the superior frontal gyrus, and the superior temporal gyrus. These findings suggest that acupuncture treatment might facilitate improvement in the motor functioning of patients with PD via the basal ganglia‐thalamocortical circuit. © 2009 Movement Disorder Society</abstract><qualityIndicators><score>7.113</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1460</abstractCharCount><pdfWordCount>4521</pdfWordCount><pdfCharCount>28493</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>216</abstractWordCount></qualityIndicators><title>Parsing brain activity associated with acupuncture treatment in Parkinson's diseases</title><genre><json:string>Serial article</json:string></genre><host><volume>24</volume><pages><total>9</total><last>1802</last><first>1794</first></pages><issn><json:string>0885-3185</json:string></issn><issue>12</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/mds.22673</json:string></doi><id>9592D1982D9B6CD7CDC90682D4640B91D46006D3</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/9592D1982D9B6CD7CDC90682D4640B91D46006D3/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/9592D1982D9B6CD7CDC90682D4640B91D46006D3/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/9592D1982D9B6CD7CDC90682D4640B91D46006D3/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Parsing brain activity associated with acupuncture treatment in Parkinson's diseases</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: None.</note><note>Health, Welfare, and Family Affairs - No. 02‐PJ9‐PG1‐CO03‐0005;</note><note>Korea Science and Engineering Foundation - No. R11‐2005‐014;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Parsing brain activity associated with acupuncture treatment in Parkinson's diseases</title><author><persName><forename type="first">Younbyoung</forename><surname>Chae</surname><roleName type="degree">KMD, PhD</roleName></persName><affiliation>Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun‐gu, Seoul, Republic of Korea</affiliation></author><author><persName><forename type="first">Hyejung</forename><surname>Lee</surname><roleName type="degree">KMD, PhD</roleName></persName><affiliation>Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun‐gu, Seoul, Republic of Korea</affiliation></author><author><persName><forename type="first">Hackjin</forename><surname>Kim</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Psychology, Korea University, Anam‐dong Seongbuk‐Gu, Seoul, Republic of Korea</affiliation></author><author><persName><forename type="first">Chang‐Hwan</forename><surname>Kim</surname><roleName type="degree">KMD, PhD</roleName></persName><affiliation>Department of Acupuncture and Moxibustion, Kyung Hee University Hospital, Dongdaemun‐gu, Seoul, Republic of Korea</affiliation></author><author><persName><forename type="first">Dae‐Il</forename><surname>Chang</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Neurology, College of Medicine, Kyung Hee University, Dongdaemun‐gu, Seoul, Republic of Korea</affiliation></author><author><persName><forename type="first">Kyung‐Mi</forename><surname>Kim</surname><roleName type="degree">KMD, MS</roleName></persName><affiliation>Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun‐gu, Seoul, Republic of Korea</affiliation></author><author><persName><forename type="first">Hi‐Joon</forename><surname>Park</surname><roleName type="degree">KMD, PhD</roleName></persName><note type="correspondence"><p>Correspondence: Room 205, Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, 1 Hoegi‐dong, Dongdaemun‐gu, Seoul 130‐701, Republic of Korea</p></note><affiliation>Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun‐gu, Seoul, Republic of Korea</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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Using functional magnetic resonance imaging (fMRI), we explored the neural mechanisms underlying the effect of specific and genuine acupuncture treatment on the motor function in patients with PD. Three fMRI scans were performed in random order in a block design, one for verum acupuncture (VA) treatment, another one for a covert placebo (CP), and the third one for an overt placebo (OP) at the motor function implicated acupoint GB34 on the left foot of 10 patients with PD. We calculated the contrast that subtracts the blood‐oxygen‐level dependent (BOLD) response for the acupuncture effect (VA vs. CP) and the placebo effect (CP vs. OP). We found a significant improvement in the motor function of the affected hand after acupuncture treatment. The putamen and the primary motor cortex were activated when patients with PD received the acupuncture treatment (VA vs. CP) and these activations correlated with individual enhanced motor function. Expectation towards acupuncture modality (CP vs. OP) elicited activation over the anterior cingulate gyrus, the superior frontal gyrus, and the superior temporal gyrus. 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Republic of Korea</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">acupuncture</keyword><keyword xml:id="kwd2">Parkinson's disease</keyword><keyword xml:id="kwd3">fMRI</keyword><keyword xml:id="kwd4">placebo</keyword><keyword xml:id="kwd5">putamen</keyword></keywordGroup><fundingInfo><fundingAgency>Health, Welfare, and Family Affairs</fundingAgency><fundingNumber>02‐PJ9‐PG1‐CO03‐0005</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Korea Science and Engineering Foundation</fundingAgency><fundingNumber>R11‐2005‐014</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Acupuncture, a common treatment modality within complementary and alternative medicine, has been widely used for Parkinson's disease (PD). Using functional magnetic resonance imaging (fMRI), we explored the neural mechanisms underlying the effect of specific and genuine acupuncture treatment on the motor function in patients with PD. Three fMRI scans were performed in random order in a block design, one for verum acupuncture (VA) treatment, another one for a covert placebo (CP), and the third one for an overt placebo (OP) at the motor function implicated acupoint GB34 on the left foot of 10 patients with PD. We calculated the contrast that subtracts the blood‐oxygen‐level dependent (BOLD) response for the acupuncture effect (VA vs. CP) and the placebo effect (CP vs. OP). We found a significant improvement in the motor function of the affected hand after acupuncture treatment. The putamen and the primary motor cortex were activated when patients with PD received the acupuncture treatment (VA vs. CP) and these activations correlated with individual enhanced motor function. Expectation towards acupuncture modality (CP vs. OP) elicited activation over the anterior cingulate gyrus, the superior frontal gyrus, and the superior temporal gyrus. These findings suggest that acupuncture treatment might facilitate improvement in the motor functioning of patients with PD via the basal ganglia‐thalamocortical circuit. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: None.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Parsing brain activity associated with acupuncture treatment in Parkinson's diseases</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Dissociation Between Acupuncture and Placebo Effect in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Parsing brain activity associated with acupuncture treatment in Parkinson's diseases</title></titleInfo><name type="personal"><namePart type="given">Younbyoung</namePart><namePart type="family">Chae</namePart><namePart type="termsOfAddress">KMD, PhD</namePart><affiliation>Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun‐gu, Seoul, Republic of Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hyejung</namePart><namePart type="family">Lee</namePart><namePart type="termsOfAddress">KMD, PhD</namePart><affiliation>Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun‐gu, Seoul, Republic of Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hackjin</namePart><namePart type="family">Kim</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Psychology, Korea University, Anam‐dong Seongbuk‐Gu, Seoul, Republic of Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chang‐Hwan</namePart><namePart type="family">Kim</namePart><namePart type="termsOfAddress">KMD, PhD</namePart><affiliation>Department of Acupuncture and Moxibustion, Kyung Hee University Hospital, Dongdaemun‐gu, Seoul, Republic of Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dae‐Il</namePart><namePart type="family">Chang</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, College of Medicine, Kyung Hee University, Dongdaemun‐gu, Seoul, Republic of Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kyung‐Mi</namePart><namePart type="family">Kim</namePart><namePart type="termsOfAddress">KMD, MS</namePart><affiliation>Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun‐gu, Seoul, Republic of Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hi‐Joon</namePart><namePart type="family">Park</namePart><namePart type="termsOfAddress">KMD, PhD</namePart><affiliation>Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun‐gu, Seoul, Republic of Korea</affiliation><description>Correspondence: Room 205, Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, 1 Hoegi‐dong, Dongdaemun‐gu, Seoul 130‐701, Republic of Korea</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-09-15</dateIssued><dateCaptured encoding="w3cdtf">2009-02-04</dateCaptured><dateValid encoding="w3cdtf">2009-05-11</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">2</extent><extent unit="references">30</extent><extent unit="words">5658</extent></physicalDescription><abstract lang="en">Acupuncture, a common treatment modality within complementary and alternative medicine, has been widely used for Parkinson's disease (PD). Using functional magnetic resonance imaging (fMRI), we explored the neural mechanisms underlying the effect of specific and genuine acupuncture treatment on the motor function in patients with PD. Three fMRI scans were performed in random order in a block design, one for verum acupuncture (VA) treatment, another one for a covert placebo (CP), and the third one for an overt placebo (OP) at the motor function implicated acupoint GB34 on the left foot of 10 patients with PD. We calculated the contrast that subtracts the blood‐oxygen‐level dependent (BOLD) response for the acupuncture effect (VA vs. CP) and the placebo effect (CP vs. OP). We found a significant improvement in the motor function of the affected hand after acupuncture treatment. The putamen and the primary motor cortex were activated when patients with PD received the acupuncture treatment (VA vs. CP) and these activations correlated with individual enhanced motor function. Expectation towards acupuncture modality (CP vs. OP) elicited activation over the anterior cingulate gyrus, the superior frontal gyrus, and the superior temporal gyrus. These findings suggest that acupuncture treatment might facilitate improvement in the motor functioning of patients with PD via the basal ganglia‐thalamocortical circuit. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None.</note><note type="funding">Health, Welfare, and Family Affairs - No. 02‐PJ9‐PG1‐CO03‐0005; </note><note type="funding">Korea Science and Engineering Foundation - No. R11‐2005‐014; </note><subject lang="en"><genre>Keywords</genre><topic>acupuncture</topic><topic>Parkinson's disease</topic><topic>fMRI</topic><topic>placebo</topic><topic>putamen</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>1794</start><end>1802</end><total>9</total></extent></part></relatedItem><identifier type="istex">9592D1982D9B6CD7CDC90682D4640B91D46006D3</identifier><identifier type="DOI">10.1002/mds.22673</identifier><identifier type="ArticleID">MDS22673</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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