Striatal microinfusion of Tourette syndrome and PANDAS sera: Failure to induce behavioral changes
Identifieur interne : 000941 ( Istex/Corpus ); précédent : 000940; suivant : 000942Striatal microinfusion of Tourette syndrome and PANDAS sera: Failure to induce behavioral changes
Auteurs : Christopher R. Loiselle ; Olivia Lee ; Timothy H. Moran ; Harvey S. SingerSource :
- Movement Disorders [ 0885-3185 ] ; 2004-04.
English descriptors
- KwdEn :
Abstract
Rodent striatal microinfusions have been suggested as a model for assessing the behavioral effects induced by antineuronal antibodies. We used this approach to evaluate the proposed autoimmune etiology for Tourette syndrome (TS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). Sera were assessed from patients with TS (n = 9) preselected based on the presence of elevated enzyme‐linked immunosorbent assay optical densities against putamen homogenate and sera from patients with PANDAS (n = 8), selected from a larger group assayed for antibodies against a putamen synaptosomal preparation. The effect of antibodies against the streptococcal M5 protein were also studied. A total of 44 Fischer rats received bilateral infusion of sera: 23 ventral striatum (5 PANDAS, 5 TS, 5 anti‐M5 protein, and 8 control); 21 ventrolateral striatum (5 PANDAS, 5 TS, 5 anti‐M5 protein, and 6 controls). Cannulas were placed bilaterally and symmetrically by stereotactic techniques. After animals were allowed to recover for 1 week, sera were microinfused for 3 days. Animal behavior was then simultaneously quantified by daily observation and monitoring using automated activity boxes for 10 days after infusion. No significant alterations in stereotypic behavior or movement were observed between the PANDAS, TS, or anti‐M5 protein and control groups. Our findings are in contrast to previous reports, and suggest the need for further investigations to determine the validity of the model and of autoimmune‐mediated hypotheses for pediatric movement disorders. © 2003 Movement Disorder Society
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DOI: 10.1002/mds.10522
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We used this approach to evaluate the proposed autoimmune etiology for Tourette syndrome (TS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). Sera were assessed from patients with TS (n = 9) preselected based on the presence of elevated enzyme‐linked immunosorbent assay optical densities against putamen homogenate and sera from patients with PANDAS (n = 8), selected from a larger group assayed for antibodies against a putamen synaptosomal preparation. The effect of antibodies against the streptococcal M5 protein were also studied. A total of 44 Fischer rats received bilateral infusion of sera: 23 ventral striatum (5 PANDAS, 5 TS, 5 anti‐M5 protein, and 8 control); 21 ventrolateral striatum (5 PANDAS, 5 TS, 5 anti‐M5 protein, and 6 controls). Cannulas were placed bilaterally and symmetrically by stereotactic techniques. After animals were allowed to recover for 1 week, sera were microinfused for 3 days. Animal behavior was then simultaneously quantified by daily observation and monitoring using automated activity boxes for 10 days after infusion. No significant alterations in stereotypic behavior or movement were observed between the PANDAS, TS, or anti‐M5 protein and control groups. Our findings are in contrast to previous reports, and suggest the need for further investigations to determine the validity of the model and of autoimmune‐mediated hypotheses for pediatric movement disorders. © 2003 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Christopher R. 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Animal behavior was then simultaneously quantified by daily observation and monitoring using automated activity boxes for 10 days after infusion. No significant alterations in stereotypic behavior or movement were observed between the PANDAS, TS, or anti‐M5 protein and control groups. 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We used this approach to evaluate the proposed autoimmune etiology for Tourette syndrome (TS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). Sera were assessed from patients with TS (n = 9) preselected based on the presence of elevated enzyme‐linked immunosorbent assay optical densities against putamen homogenate and sera from patients with PANDAS (n = 8), selected from a larger group assayed for antibodies against a putamen synaptosomal preparation. The effect of antibodies against the streptococcal M5 protein were also studied. A total of 44 Fischer rats received bilateral infusion of sera: 23 ventral striatum (5 PANDAS, 5 TS, 5 anti‐M5 protein, and 8 control); 21 ventrolateral striatum (5 PANDAS, 5 TS, 5 anti‐M5 protein, and 6 controls). Cannulas were placed bilaterally and symmetrically by stereotactic techniques. After animals were allowed to recover for 1 week, sera were microinfused for 3 days. Animal behavior was then simultaneously quantified by daily observation and monitoring using automated activity boxes for 10 days after infusion. No significant alterations in stereotypic behavior or movement were observed between the PANDAS, TS, or anti‐M5 protein and control groups. Our findings are in contrast to previous reports, and suggest the need for further investigations to determine the validity of the model and of autoimmune‐mediated hypotheses for pediatric movement disorders. © 2003 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>striatal microinfusion</term></item><item><term>PANDAS</term></item><item><term>Tourette syndrome</term></item><item><term>antineuronal antibodies</term></item><item><term>M5 protein</term></item><item><term>stereotypies</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2002-10-15">Received</change><change when="2003-04-24">Registration</change><change when="2004-04">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/656D4D0EB68361D6568647FBDD94A84B472365B4/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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Wolfe Street, Baltimore, MD 21287</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS10522.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="36"></count><count type="wordTotal" number="4692"></count></countGroup><titleGroup><title type="main" xml:lang="en">Striatal microinfusion of Tourette syndrome and PANDAS sera: Failure to induce behavioral changes</title><title type="short" xml:lang="en">Rodent Striatal Microinfusions in TS & PANDAS</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Christopher R.</givenNames><familyName>Loiselle</familyName><degrees>BS</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Olivia</givenNames><familyName>Lee</familyName><degrees>BA</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Timothy H.</givenNames><familyName>Moran</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af3" corresponding="yes"><personName><givenNames>Harvey S.</givenNames><familyName>Singer</familyName><degrees>MD</degrees></personName><contactDetails><email>hsinger@jhmi.edu</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Department Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">striatal microinfusion</keyword><keyword xml:id="kwd2">PANDAS</keyword><keyword xml:id="kwd3">Tourette syndrome</keyword><keyword xml:id="kwd4">antineuronal antibodies</keyword><keyword xml:id="kwd5">M5 protein</keyword><keyword xml:id="kwd6">stereotypies</keyword></keywordGroup><fundingInfo><fundingAgency>NIH</fundingAgency><fundingNumber>R01NS37706</fundingNumber></fundingInfo><fundingInfo><fundingAgency>National Tourette Syndrome Association</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Rodent striatal microinfusions have been suggested as a model for assessing the behavioral effects induced by antineuronal antibodies. We used this approach to evaluate the proposed autoimmune etiology for Tourette syndrome (TS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). Sera were assessed from patients with TS (n = 9) preselected based on the presence of elevated enzyme‐linked immunosorbent assay optical densities against putamen homogenate and sera from patients with PANDAS (n = 8), selected from a larger group assayed for antibodies against a putamen synaptosomal preparation. The effect of antibodies against the streptococcal M5 protein were also studied. A total of 44 Fischer rats received bilateral infusion of sera: 23 ventral striatum (5 PANDAS, 5 TS, 5 anti‐M5 protein, and 8 control); 21 ventrolateral striatum (5 PANDAS, 5 TS, 5 anti‐M5 protein, and 6 controls). Cannulas were placed bilaterally and symmetrically by stereotactic techniques. After animals were allowed to recover for 1 week, sera were microinfused for 3 days. Animal behavior was then simultaneously quantified by daily observation and monitoring using automated activity boxes for 10 days after infusion. No significant alterations in stereotypic behavior or movement were observed between the PANDAS, TS, or anti‐M5 protein and control groups. Our findings are in contrast to previous reports, and suggest the need for further investigations to determine the validity of the model and of autoimmune‐mediated hypotheses for pediatric movement disorders. © 2003 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Striatal microinfusion of Tourette syndrome and PANDAS sera: Failure to induce behavioral changes</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Rodent Striatal Microinfusions in TS & PANDAS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Striatal microinfusion of Tourette syndrome and PANDAS sera: Failure to induce behavioral changes</title></titleInfo><name type="personal"><namePart type="given">Christopher R.</namePart><namePart type="family">Loiselle</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Olivia</namePart><namePart type="family">Lee</namePart><namePart type="termsOfAddress">BA</namePart><affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Timothy H.</namePart><namePart type="family">Moran</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Harvey S.</namePart><namePart type="family">Singer</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</affiliation><affiliation>Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</affiliation><description>Correspondence: Johns Hopkins Hospital, Jefferson 124, 600 N. Wolfe Street, Baltimore, MD 21287</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2004-04</dateIssued><dateCaptured encoding="w3cdtf">2002-10-15</dateCaptured><dateValid encoding="w3cdtf">2003-04-24</dateValid><copyrightDate encoding="w3cdtf">2004</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">1</extent><extent unit="references">36</extent><extent unit="words">4692</extent></physicalDescription><abstract lang="en">Rodent striatal microinfusions have been suggested as a model for assessing the behavioral effects induced by antineuronal antibodies. We used this approach to evaluate the proposed autoimmune etiology for Tourette syndrome (TS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). Sera were assessed from patients with TS (n = 9) preselected based on the presence of elevated enzyme‐linked immunosorbent assay optical densities against putamen homogenate and sera from patients with PANDAS (n = 8), selected from a larger group assayed for antibodies against a putamen synaptosomal preparation. The effect of antibodies against the streptococcal M5 protein were also studied. A total of 44 Fischer rats received bilateral infusion of sera: 23 ventral striatum (5 PANDAS, 5 TS, 5 anti‐M5 protein, and 8 control); 21 ventrolateral striatum (5 PANDAS, 5 TS, 5 anti‐M5 protein, and 6 controls). Cannulas were placed bilaterally and symmetrically by stereotactic techniques. After animals were allowed to recover for 1 week, sera were microinfused for 3 days. Animal behavior was then simultaneously quantified by daily observation and monitoring using automated activity boxes for 10 days after infusion. No significant alterations in stereotypic behavior or movement were observed between the PANDAS, TS, or anti‐M5 protein and control groups. Our findings are in contrast to previous reports, and suggest the need for further investigations to determine the validity of the model and of autoimmune‐mediated hypotheses for pediatric movement disorders. © 2003 Movement Disorder Society</abstract><note type="funding">NIH - No. R01NS37706; </note><note type="funding">National Tourette Syndrome Association</note><subject lang="en"><genre>Keywords</genre><topic>striatal microinfusion</topic><topic>PANDAS</topic><topic>Tourette syndrome</topic><topic>antineuronal antibodies</topic><topic>M5 protein</topic><topic>stereotypies</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>390</start><end>396</end><total>7</total></extent></part></relatedItem><identifier type="istex">656D4D0EB68361D6568647FBDD94A84B472365B4</identifier><identifier type="DOI">10.1002/mds.10522</identifier><identifier type="ArticleID">MDS10522</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2003 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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