Influence of target size on vertical gaze palsy in a pathologically proven case of progressive supranuclear palsy
Identifieur interne : 000919 ( Istex/Corpus ); précédent : 000918; suivant : 000920Influence of target size on vertical gaze palsy in a pathologically proven case of progressive supranuclear palsy
Auteurs : Barry M. Seemungal ; Mary Faldon ; Tamas Revesz ; Andrew J. Lees ; David S. Zee ; Adolfo M. BronsteinSource :
- Movement Disorders [ 0885-3185 ] ; 2003-07.
English descriptors
Abstract
We document a new oculomotor phenomenon in a patient with pathologically proven progressive supranuclear gaze palsy (PSP), namely that vertical gaze excursion improves with larger pursuit targets. We used computerised video‐oculography during vertical smooth pursuit eye movements (SPEM) of circular targets of diameter 0.16 degrees and 16 degrees, sinusoidally oscillating at 0.08 Hz (peak‐to‐peak amplitude 49 degrees). Increasing target size improved vertical gaze excursion from 10 degrees to 25 degrees. There was no concomitant increase in slow phase eye velocity. The findings could be explained by a potentiation of the position control mechanism of pursuit by target size due to increased activation of brainstem pursuit‐optokinetic pathways and to higher order attentional mechanisms. This observation may be useful in the clinical assessment of PSP patients with severe neck rigidity in whom the doll's head–eye manoeuvre cannot be performed by comparing the degree of vertical gaze palsy during smooth pursuit testing between at least two differently sized targets and observing whether there is a larger excursion in response to a large target such as a newspaper. © 2003 Movement Disorder Society
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DOI: 10.1002/mds.10434
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ISTEX:2077898C64B307CDB30611269FB1498B484CD0AELe document en format XML
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This observation may be useful in the clinical assessment of PSP patients with severe neck rigidity in whom the doll's head–eye manoeuvre cannot be performed by comparing the degree of vertical gaze palsy during smooth pursuit testing between at least two differently sized targets and observing whether there is a larger excursion in response to a large target such as a newspaper. © 2003 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Barry M. 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This observation may be useful in the clinical assessment of PSP patients with severe neck rigidity in whom the doll's head–eye manoeuvre cannot be performed by comparing the degree of vertical gaze palsy during smooth pursuit testing between at least two differently sized targets and observing whether there is a larger excursion in response to a large target such as a newspaper. © 2003 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>progressive supranuclear palsy</term></item><item><term>improved vertical gaze palsy</term></item><item><term>target size</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2002-01-17">Received</change><change when="2002-11-24">Registration</change><change when="2003-07">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/2077898C64B307CDB30611269FB1498B484CD0AE/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="70"><doi origin="wiley" registered="yes">10.1002/mds.v18:7</doi><numberingGroup><numbering type="journalVolume" number="18">18</numbering><numbering type="journalIssue">7</numbering></numberingGroup><coverDate startDate="2003-07">July 2003</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="120" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.10434</doi><idGroup><id type="unit" value="MDS10434"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">Copyright © 2003 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2002-01-17"></event><event type="manuscriptRevised" date="2002-08-09"></event><event type="manuscriptAccepted" date="2002-11-24"></event><event type="firstOnline" date="2003-04-11"></event><event type="publishedOnlineFinalForm" date="2003-06-12"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2003-04-11"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.4.7 mode:FullText source:FullText result:FullText" date="2011-02-24"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">818</numbering><numbering type="pageLast">822</numbering></numberingGroup><correspondenceTo>The Academic Department of Neuro‐Otology, Division of Neurosciences and Psychological Medicine, Imperial College School Of Medicine, Charing Cross Hospital Campus, St. Dunstan's Road, London W6 8RF, United Kindgom</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS10434.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="26"></count><count type="wordTotal" number="3574"></count></countGroup><titleGroup><title type="main" xml:lang="en">Influence of target size on vertical gaze palsy in a pathologically proven case of progressive supranuclear palsy<link href="#fn1"></link></title><title type="short" xml:lang="en">Target Size and Vertical Gaze Palsy</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Barry M.</givenNames><familyName>Seemungal</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Mary</givenNames><familyName>Faldon</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Tamas</givenNames><familyName>Revesz</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Andrew J.</givenNames><familyName>Lees</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3"><personName><givenNames>David S.</givenNames><familyName>Zee</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Adolfo M.</givenNames><familyName>Bronstein</familyName><degrees>MD</degrees></personName><contactDetails><email>a.bronstein@ic.ac.uk</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="GB" type="organization"><unparsedAffiliation>The Academic Department of Neuro‐Otology, Division of Neurosciences and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, London, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="GB" type="organization"><unparsedAffiliation>Institute of Neurology, London, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>The Johns Hopkins School of Medicine, Baltimore, Maryland, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">progressive supranuclear palsy</keyword><keyword xml:id="kwd2">improved vertical gaze palsy</keyword><keyword xml:id="kwd3">target size</keyword></keywordGroup><fundingInfo><fundingAgency>Medical Research Council UK</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Dix Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Robert M. and Annetta J. Coffelt endowment</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We document a new oculomotor phenomenon in a patient with pathologically proven progressive supranuclear gaze palsy (PSP), namely that vertical gaze excursion improves with larger pursuit targets. We used computerised video‐oculography during vertical smooth pursuit eye movements (SPEM) of circular targets of diameter 0.16 degrees and 16 degrees, sinusoidally oscillating at 0.08 Hz (peak‐to‐peak amplitude 49 degrees). Increasing target size improved vertical gaze excursion from 10 degrees to 25 degrees. There was no concomitant increase in slow phase eye velocity. The findings could be explained by a potentiation of the position control mechanism of pursuit by target size due to increased activation of brainstem pursuit‐optokinetic pathways and to higher order attentional mechanisms. This observation may be useful in the clinical assessment of PSP patients with severe neck rigidity in whom the doll's head–eye manoeuvre cannot be performed by comparing the degree of vertical gaze palsy during smooth pursuit testing between at least two differently sized targets and observing whether there is a larger excursion in response to a large target such as a newspaper. © 2003 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>A videotape accompanies this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Influence of target size on vertical gaze palsy in a pathologically proven case of progressive supranuclear palsy</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Target Size and Vertical Gaze Palsy</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Influence of target size on vertical gaze palsy in a pathologically proven case of progressive supranuclear palsy</title></titleInfo><name type="personal"><namePart type="given">Barry M.</namePart><namePart type="family">Seemungal</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>The Academic Department of Neuro‐Otology, Division of Neurosciences and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mary</namePart><namePart type="family">Faldon</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>The Academic Department of Neuro‐Otology, Division of Neurosciences and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tamas</namePart><namePart type="family">Revesz</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute of Neurology, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andrew J.</namePart><namePart type="family">Lees</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute of Neurology, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David S.</namePart><namePart type="family">Zee</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>The Johns Hopkins School of Medicine, Baltimore, Maryland, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Adolfo M.</namePart><namePart type="family">Bronstein</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>The Academic Department of Neuro‐Otology, Division of Neurosciences and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, London, United Kingdom</affiliation><description>Correspondence: The Academic Department of Neuro‐Otology, Division of Neurosciences and Psychological Medicine, Imperial College School Of Medicine, Charing Cross Hospital Campus, St. Dunstan's Road, London W6 8RF, United Kindgom</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2003-07</dateIssued><dateCaptured encoding="w3cdtf">2002-01-17</dateCaptured><dateValid encoding="w3cdtf">2002-11-24</dateValid><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">1</extent><extent unit="references">26</extent><extent unit="words">3574</extent></physicalDescription><abstract lang="en">We document a new oculomotor phenomenon in a patient with pathologically proven progressive supranuclear gaze palsy (PSP), namely that vertical gaze excursion improves with larger pursuit targets. We used computerised video‐oculography during vertical smooth pursuit eye movements (SPEM) of circular targets of diameter 0.16 degrees and 16 degrees, sinusoidally oscillating at 0.08 Hz (peak‐to‐peak amplitude 49 degrees). Increasing target size improved vertical gaze excursion from 10 degrees to 25 degrees. There was no concomitant increase in slow phase eye velocity. The findings could be explained by a potentiation of the position control mechanism of pursuit by target size due to increased activation of brainstem pursuit‐optokinetic pathways and to higher order attentional mechanisms. This observation may be useful in the clinical assessment of PSP patients with severe neck rigidity in whom the doll's head–eye manoeuvre cannot be performed by comparing the degree of vertical gaze palsy during smooth pursuit testing between at least two differently sized targets and observing whether there is a larger excursion in response to a large target such as a newspaper. © 2003 Movement Disorder Society</abstract><note type="content">*A videotape accompanies this article.</note><note type="funding">Medical Research Council UK</note><note type="funding">Dix Foundation</note><note type="funding">Robert M. and Annetta J. Coffelt endowment</note><subject lang="en"><genre>Keywords</genre><topic>progressive supranuclear palsy</topic><topic>improved vertical gaze palsy</topic><topic>target size</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. 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