Effects of bilateral pallidal or subthalamic stimulation on gait in advanced Parkinson's disease
Identifieur interne : 000909 ( Istex/Corpus ); précédent : 000908; suivant : 000910Effects of bilateral pallidal or subthalamic stimulation on gait in advanced Parkinson's disease
Auteurs : N. Allert ; J. Volkmann ; S. Dotse ; H. Hefter ; V. Sturm ; H. FreundSource :
- Movement Disorders [ 0885-3185 ] ; 2001-11.
English descriptors
Abstract
Bilateral high‐frequency stimulation of the internal globus pallidus (GPi) and the subthalamic nucleus (STN) both alleviate akinesia, rigidity, and tremor in idiopathic Parkinson's disease. To test the specific effect of these procedures on gait, we used quantitative gait analysis in addition to relevant subscores of the Unified Parkinson's Disease Rating Scale in a group of 10 patients with advanced Parkinson's disease treated by GPi stimulation and eight patients treated by STN stimulation. Patients were assessed before and 3 months after surgery. Thirty age‐matched healthy subjects served as controls. The non‐random selection allowed a descriptive but no direct statistical comparison of the respective procedure. Gait analysis showed significant stimulation‐induced improvements of spatiotemporal gait and step parameters in both patient groups. Moreover, the effects on step length and cadence suggested a differential effect of both basal ganglia targets. Hence, the increase in gait velocity in the STN group was almost exclusively due to a significant increase in step length, while in the GPi group statistically non‐significant increases in both step length and cadence contributed. © 2001 Movement Disorder Society.
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DOI: 10.1002/mds.1222
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ISTEX:4AEDB1B95623A8ABAF437FF93565CDAD536156E4Le document en format XML
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To test the specific effect of these procedures on gait, we used quantitative gait analysis in addition to relevant subscores of the Unified Parkinson's Disease Rating Scale in a group of 10 patients with advanced Parkinson's disease treated by GPi stimulation and eight patients treated by STN stimulation. Patients were assessed before and 3 months after surgery. Thirty age‐matched healthy subjects served as controls. The non‐random selection allowed a descriptive but no direct statistical comparison of the respective procedure. Gait analysis showed significant stimulation‐induced improvements of spatiotemporal gait and step parameters in both patient groups. Moreover, the effects on step length and cadence suggested a differential effect of both basal ganglia targets. Hence, the increase in gait velocity in the STN group was almost exclusively due to a significant increase in step length, while in the GPi group statistically non‐significant increases in both step length and cadence contributed. © 2001 Movement Disorder Society.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Effects of bilateral pallidal or subthalamic stimulation on gait in advanced Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Effects of GPi or STN Stimulation on Gait</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Effects of bilateral pallidal or subthalamic stimulation on gait in advanced Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Allert</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Heinrich‐Heine University Düsseldorf, Germany</affiliation><description>Correspondence: Department of Neurology, Heinrich‐Heine‐University, Moorenstrasse 5, D‐40225 Düsseldorf, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Volkmann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Heinrich‐Heine University Düsseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Dotse</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Heinrich‐Heine University Düsseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Hefter</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Heinrich‐Heine University Düsseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Sturm</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Stereotaxy and Functional Neurosurgery, University of Cologne, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.‐J.</namePart><namePart type="family">Freund</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Heinrich‐Heine University Düsseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2001-11</dateIssued><dateCaptured encoding="w3cdtf">2000-07-06</dateCaptured><dateValid encoding="w3cdtf">2001-02-26</dateValid><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">4</extent><extent unit="tables">3</extent><extent unit="references">19</extent><extent unit="words">5315</extent></physicalDescription><abstract lang="en">Bilateral high‐frequency stimulation of the internal globus pallidus (GPi) and the subthalamic nucleus (STN) both alleviate akinesia, rigidity, and tremor in idiopathic Parkinson's disease. To test the specific effect of these procedures on gait, we used quantitative gait analysis in addition to relevant subscores of the Unified Parkinson's Disease Rating Scale in a group of 10 patients with advanced Parkinson's disease treated by GPi stimulation and eight patients treated by STN stimulation. Patients were assessed before and 3 months after surgery. Thirty age‐matched healthy subjects served as controls. The non‐random selection allowed a descriptive but no direct statistical comparison of the respective procedure. Gait analysis showed significant stimulation‐induced improvements of spatiotemporal gait and step parameters in both patient groups. Moreover, the effects on step length and cadence suggested a differential effect of both basal ganglia targets. Hence, the increase in gait velocity in the STN group was almost exclusively due to a significant increase in step length, while in the GPi group statistically non‐significant increases in both step length and cadence contributed. © 2001 Movement Disorder Society.</abstract><subject lang="en"><genre>Keywords</genre><topic>Gait</topic><topic>Parkinson's disease</topic><topic>deep brain stimulation</topic><topic>globus pallidus</topic><topic>subthalamic nucleus</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>1076</start><end>1085</end><total>10</total></extent></part></relatedItem><identifier type="istex">4AEDB1B95623A8ABAF437FF93565CDAD536156E4</identifier><identifier type="DOI">10.1002/mds.1222</identifier><identifier type="ArticleID">MDS1222</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2001 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>John Wiley & Sons, Inc.</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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