Population‐based case–control study of cigarette smoking and essential tremor
Identifieur interne : 000886 ( Istex/Corpus ); précédent : 000885; suivant : 000887Population‐based case–control study of cigarette smoking and essential tremor
Auteurs : Julián Benito-Le N ; Elan D. Louis ; Félix Bermejo-ParejaSource :
- Movement Disorders [ 0885-3185 ] ; 2008-01-30.
English descriptors
Abstract
Parkinson's disease (PD) is inversely associated with smoking cigarettes. Despite long‐standing clinical links between PD and essential tremor (ET), there are surprisingly few data on smoking in ET. We studied whether smoking cigarettes is inversely associated with ET. Using a population‐based, case–control design, cigarette smoking habits were assessed in 221 prevalent ET cases (75.5 ± 7.1 years old) and 663 matched controls (74.6 ± 7.0 years old). In logistical regression analyses, diagnosis (ET vs. control) was the dependent variable, and cigarette smoking status, the independent variable. Ever smokers were marginally less likely to have ET than were never smokers (22.0% vs. 27.0%, odds ratio [OR] 0.76, 95% confidence interval [CI] 0.55–1.04, P = 0.09). In an analysis that adjusted for confounding factors (drink‐years and depressive symptoms), ever smokers were nearly half less likely to have ET than the never smokers (OR 0.58, 95% CI 0.40–0.84, P = 0.004). There was a strong inverse association between pack‐years and odds of ET (adjusted OR 0.991, 95% CI 0.984–0.997, P = 0.005, i.e., with every 10 pack‐year increase, odds of ET were lowered 10%). Ever smokers in the highest pack‐year tertile were one‐third as likely to have ET than the never smokers (adjusted OR 0.39, 95% CI 0.22–0.69, P = 0.001). We demonstrated an inverse association between ever smoking and ET. Additional studies are needed to reproduce these findings and assess whether this association is due to a biologically protective effect. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21810
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ISTEX:76B5298048EA33E13E12C0766277644A40ED79FCLe document en format XML
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Louis</name><affiliation><mods:affiliation>GH Sergievsky Center, Columbia University, New York, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Columbia University, New York, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Bermejo Areja, Felix" sort="Bermejo Areja, Felix" uniqKey="Bermejo Areja F" first="Félix" last="Bermejo-Pareja">Félix Bermejo-Pareja</name><affiliation><mods:affiliation>Department of Neurology, University Hospital “12 de Octubre,” Madrid, Spain</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:76B5298048EA33E13E12C0766277644A40ED79FC</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/mds.21810</idno><idno type="url">https://api.istex.fr/document/76B5298048EA33E13E12C0766277644A40ED79FC/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000886</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Population‐based case–control study of cigarette smoking and essential tremor</title><author><name sortKey="Benito E N, Julian" sort="Benito E N, Julian" uniqKey="Benito E N J" first="Julián" last="Benito-Le N">Julián Benito-Le N</name><affiliation><mods:affiliation>Department of Neurology, University Hospital “12 de Octubre,” Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><affiliation><mods:affiliation>GH Sergievsky Center, Columbia University, New York, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Columbia University, New York, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Bermejo Areja, Felix" sort="Bermejo Areja, Felix" uniqKey="Bermejo Areja F" first="Félix" last="Bermejo-Pareja">Félix Bermejo-Pareja</name><affiliation><mods:affiliation>Department of Neurology, University Hospital “12 de Octubre,” Madrid, Spain</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-01-30">2008-01-30</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="246">246</biblScope><biblScope unit="page" to="252">252</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">76B5298048EA33E13E12C0766277644A40ED79FC</idno><idno type="DOI">10.1002/mds.21810</idno><idno type="ArticleID">MDS21810</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>case–control studies.</term><term>cigarette smoking</term><term>epidemiology</term><term>essential tremor</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">Parkinson's disease (PD) is inversely associated with smoking cigarettes. Despite long‐standing clinical links between PD and essential tremor (ET), there are surprisingly few data on smoking in ET. We studied whether smoking cigarettes is inversely associated with ET. Using a population‐based, case–control design, cigarette smoking habits were assessed in 221 prevalent ET cases (75.5 ± 7.1 years old) and 663 matched controls (74.6 ± 7.0 years old). In logistical regression analyses, diagnosis (ET vs. control) was the dependent variable, and cigarette smoking status, the independent variable. Ever smokers were marginally less likely to have ET than were never smokers (22.0% vs. 27.0%, odds ratio [OR] 0.76, 95% confidence interval [CI] 0.55–1.04, P = 0.09). In an analysis that adjusted for confounding factors (drink‐years and depressive symptoms), ever smokers were nearly half less likely to have ET than the never smokers (OR 0.58, 95% CI 0.40–0.84, P = 0.004). There was a strong inverse association between pack‐years and odds of ET (adjusted OR 0.991, 95% CI 0.984–0.997, P = 0.005, i.e., with every 10 pack‐year increase, odds of ET were lowered 10%). Ever smokers in the highest pack‐year tertile were one‐third as likely to have ET than the never smokers (adjusted OR 0.39, 95% CI 0.22–0.69, P = 0.001). We demonstrated an inverse association between ever smoking and ET. Additional studies are needed to reproduce these findings and assess whether this association is due to a biologically protective effect. © 2007 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Julián Benito‐León MD, PhD</name><affiliations><json:string>Department of Neurology, University Hospital “12 de Octubre,” Madrid, Spain</json:string></affiliations></json:item><json:item><name>Elan D. Louis MD, MSc</name><affiliations><json:string>GH Sergievsky Center, Columbia University, New York, New York, USA</json:string><json:string>Department of Neurology, Columbia University, New York, New York, USA</json:string><json:string>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</json:string><json:string>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</json:string></affiliations></json:item><json:item><name>Félix Bermejo‐Pareja MD, PhD</name><affiliations><json:string>Department of Neurology, University Hospital “12 de Octubre,” Madrid, Spain</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>essential tremor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cigarette smoking</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>epidemiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>case–control studies.</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Parkinson's disease (PD) is inversely associated with smoking cigarettes. Despite long‐standing clinical links between PD and essential tremor (ET), there are surprisingly few data on smoking in ET. We studied whether smoking cigarettes is inversely associated with ET. Using a population‐based, case–control design, cigarette smoking habits were assessed in 221 prevalent ET cases (75.5 ± 7.1 years old) and 663 matched controls (74.6 ± 7.0 years old). In logistical regression analyses, diagnosis (ET vs. control) was the dependent variable, and cigarette smoking status, the independent variable. Ever smokers were marginally less likely to have ET than were never smokers (22.0% vs. 27.0%, odds ratio [OR] 0.76, 95% confidence interval [CI] 0.55–1.04, P = 0.09). In an analysis that adjusted for confounding factors (drink‐years and depressive symptoms), ever smokers were nearly half less likely to have ET than the never smokers (OR 0.58, 95% CI 0.40–0.84, P = 0.004). There was a strong inverse association between pack‐years and odds of ET (adjusted OR 0.991, 95% CI 0.984–0.997, P = 0.005, i.e., with every 10 pack‐year increase, odds of ET were lowered 10%). Ever smokers in the highest pack‐year tertile were one‐third as likely to have ET than the never smokers (adjusted OR 0.39, 95% CI 0.22–0.69, P = 0.001). We demonstrated an inverse association between ever smoking and ET. 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No. 96/1993;</note><note>Spanish Office of Science and Technology</note><note>National Institutes of Health, Bethesda, MD - No. NIH R01 NS042859; No. R01 NS039422;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Population‐based case–control study of cigarette smoking and essential tremor</title><author><orgName>Neurological Disorders in Central Spain (NEDICES) Study Group</orgName><affiliation>Department of Neurology, University Hospital “12 de Octubre,” Madrid, Spain</affiliation><affiliation>GH Sergievsky Center, Columbia University, New York, New York, USA</affiliation><affiliation>Department of Neurology, Columbia University, New York, New York, USA</affiliation><affiliation>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</affiliation></author><author><persName><forename type="first">Julián</forename><surname>Benito‐León</surname><roleName type="degree">MD, PhD</roleName></persName><note type="correspondence"><p>Correspondence: Avda. de la Constitución 73, Portal 3, 7 Izquierda, E‐28821 Coslada, Madrid, Spain</p></note><affiliation>Department of Neurology, University Hospital “12 de Octubre,” Madrid, Spain</affiliation></author><author><persName><forename type="first">Elan D.</forename><surname>Louis</surname><roleName type="degree">MD, MSc</roleName></persName><affiliation>GH Sergievsky Center, Columbia University, New York, New York, USA</affiliation><affiliation>Department of Neurology, Columbia University, New York, New York, USA</affiliation><affiliation>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</affiliation></author><author><persName><forename type="first">Félix</forename><surname>Bermejo‐Pareja</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Neurology, University Hospital “12 de Octubre,” Madrid, Spain</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-01-30"></date><biblScope unit="vol">23</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="246">246</biblScope><biblScope unit="page" to="252">252</biblScope></imprint></monogr><idno type="istex">76B5298048EA33E13E12C0766277644A40ED79FC</idno><idno type="DOI">10.1002/mds.21810</idno><idno type="ArticleID">MDS21810</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="fr"><p>Parkinson's disease (PD) is inversely associated with smoking cigarettes. Despite long‐standing clinical links between PD and essential tremor (ET), there are surprisingly few data on smoking in ET. We studied whether smoking cigarettes is inversely associated with ET. Using a population‐based, case–control design, cigarette smoking habits were assessed in 221 prevalent ET cases (75.5 ± 7.1 years old) and 663 matched controls (74.6 ± 7.0 years old). In logistical regression analyses, diagnosis (ET vs. control) was the dependent variable, and cigarette smoking status, the independent variable. Ever smokers were marginally less likely to have ET than were never smokers (22.0% vs. 27.0%, odds ratio [OR] 0.76, 95% confidence interval [CI] 0.55–1.04, P = 0.09). In an analysis that adjusted for confounding factors (drink‐years and depressive symptoms), ever smokers were nearly half less likely to have ET than the never smokers (OR 0.58, 95% CI 0.40–0.84, P = 0.004). There was a strong inverse association between pack‐years and odds of ET (adjusted OR 0.991, 95% CI 0.984–0.997, P = 0.005, i.e., with every 10 pack‐year increase, odds of ET were lowered 10%). Ever smokers in the highest pack‐year tertile were one‐third as likely to have ET than the never smokers (adjusted OR 0.39, 95% CI 0.22–0.69, P = 0.001). We demonstrated an inverse association between ever smoking and ET. Additional studies are needed to reproduce these findings and assess whether this association is due to a biologically protective effect. © 2007 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>essential tremor</term></item><item><term>cigarette smoking</term></item><item><term>epidemiology</term></item><item><term>case–control studies.</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-09-05">Received</change><change when="2007-10-07">Registration</change><change when="2008-01-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/76B5298048EA33E13E12C0766277644A40ED79FC/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body" wicri:toSee="Element #text; element #text"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"> <header> <publicationMeta level="product"> <publisherInfo> <publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName> <publisherLoc>Hoboken</publisherLoc> </publisherInfo> <doi registered="yes">10.1002/(ISSN)1531-8257</doi> <issn type="print">0885-3185</issn> <issn type="electronic">1531-8257</issn> <idGroup> <id type="product" value="MDS"></id> </idGroup> <titleGroup> <title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title> <title type="short">Mov. 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</objectNameGroup> <linkGroup> <link type="toTypesetVersion" href="file:MDS.MDS21810.pdf"></link> </linkGroup> </publicationMeta> <contentMeta> <countGroup> <count type="figureTotal" number="1"></count> <count type="tableTotal" number="3"></count> <count type="referenceTotal" number="42"></count> <count type="wordTotal" number="4847"></count> </countGroup> <titleGroup> <title type="main" xml:lang="en">Population‐based case–control study of cigarette smoking and essential tremor</title> <title type="short" xml:lang="en">Population‐based Case–Control Study</title> </titleGroup> <creators> <creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"> <personName> <givenNames>Julián</givenNames> <familyName>Benito‐León</familyName> <degrees>MD, PhD</degrees> </personName> <contactDetails> <email>jbenitol@meditex.es</email> </contactDetails> </creator> <creator xml:id="au2" creatorRole="author" affiliationRef="#af2 #af3 #af4 #af5"> <personName> <givenNames>Elan D.</givenNames> <familyName>Louis</familyName> <degrees>MD, MSc</degrees> </personName> </creator> <creator xml:id="au3" creatorRole="author" affiliationRef="#af1"> <personName> <givenNames>Félix</givenNames> <familyName>Bermejo‐Pareja</familyName> <degrees>MD, PhD</degrees> </personName> </creator> <creator xml:id="au4" creatorRole="author" noteRef="#fn1"> <groupName>Neurological Disorders in Central Spain (NEDICES) Study Group</groupName> </creator> </creators> <affiliationGroup> <affiliation xml:id="af1" countryCode="ES" type="organization"> <unparsedAffiliation>Department of Neurology, University Hospital “12 de Octubre,” Madrid, Spain</unparsedAffiliation> </affiliation> <affiliation xml:id="af2" countryCode="US" type="organization"> <unparsedAffiliation>GH Sergievsky Center, Columbia University, New York, New York, USA</unparsedAffiliation> </affiliation> <affiliation xml:id="af3" countryCode="US" type="organization"> <unparsedAffiliation>Department of Neurology, Columbia University, New York, New York, USA</unparsedAffiliation> </affiliation> <affiliation xml:id="af4" countryCode="US" type="organization"> <unparsedAffiliation>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</unparsedAffiliation> </affiliation> <affiliation xml:id="af5" countryCode="US" type="organization"> <unparsedAffiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</unparsedAffiliation> </affiliation> </affiliationGroup> <keywordGroup xml:lang="en" type="author"> <keyword xml:id="kwd1">essential tremor</keyword> <keyword xml:id="kwd2">cigarette smoking</keyword> <keyword xml:id="kwd3">epidemiology</keyword> <keyword xml:id="kwd4">case–control studies.</keyword> </keywordGroup> <fundingInfo> <fundingAgency>Spanish Health Research Agency</fundingAgency> <fundingNumber>FIS 93/0773</fundingNumber> <fundingNumber>96/1993</fundingNumber> </fundingInfo> <fundingInfo> <fundingAgency>Spanish Office of Science and Technology</fundingAgency> </fundingInfo> <fundingInfo> <fundingAgency>National Institutes of Health, Bethesda, MD</fundingAgency> <fundingNumber>NIH R01 NS042859</fundingNumber> <fundingNumber>R01 NS039422</fundingNumber> </fundingInfo> <abstractGroup> <abstract type="main" xml:lang="fr"> <title type="main">Abstract</title> <p>Parkinson's disease (PD) is inversely associated with smoking cigarettes. Despite long‐standing clinical links between PD and essential tremor (ET), there are surprisingly few data on smoking in ET. We studied whether smoking cigarettes is inversely associated with ET. Using a population‐based, case–control design, cigarette smoking habits were assessed in 221 prevalent ET cases (75.5 ± 7.1 years old) and 663 matched controls (74.6 ± 7.0 years old). In logistical regression analyses, diagnosis (ET vs. control) was the dependent variable, and cigarette smoking status, the independent variable. Ever smokers were marginally less likely to have ET than were never smokers (22.0% vs. 27.0%, odds ratio [OR] 0.76, 95% confidence interval [CI] 0.55–1.04, <i>P</i> = 0.09). In an analysis that adjusted for confounding factors (drink‐years and depressive symptoms), ever smokers were nearly half less likely to have ET than the never smokers (OR 0.58, 95% CI 0.40–0.84, <i>P</i> = 0.004). There was a strong inverse association between pack‐years and odds of ET (adjusted OR 0.991, 95% CI 0.984–0.997, <i>P</i> = 0.005, i.e., with every 10 pack‐year increase, odds of ET were lowered 10%). Ever smokers in the highest pack‐year tertile were one‐third as likely to have ET than the never smokers (adjusted OR 0.39, 95% CI 0.22–0.69, <i>P</i> = 0.001). We demonstrated an inverse association between ever smoking and ET. Additional studies are needed to reproduce these findings and assess whether this association is due to a biologically protective effect. © 2007 Movement Disorder Society</p> </abstract> </abstractGroup> </contentMeta> <noteGroup> <note xml:id="fn1"> <p>The other members of the Neurological Disorders in Central Spain (NEDICES) Study Group are listed in Appendix.</p> </note> </noteGroup> </header> </component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Population‐based case–control study of cigarette smoking and essential tremor</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Population‐based Case–Control Study</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Population‐based case–control study of cigarette smoking and essential tremor</title></titleInfo><name type="personal"><namePart type="given">Julián</namePart><namePart type="family">Benito‐León</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, University Hospital “12 de Octubre,” Madrid, Spain</affiliation><description>Correspondence: Avda. de la Constitución 73, Portal 3, 7 Izquierda, E‐28821 Coslada, Madrid, Spain</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elan D.</namePart><namePart type="family">Louis</namePart><namePart type="termsOfAddress">MD, MSc</namePart><affiliation>GH Sergievsky Center, Columbia University, New York, New York, USA</affiliation><affiliation>Department of Neurology, Columbia University, New York, New York, USA</affiliation><affiliation>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Félix</namePart><namePart type="family">Bermejo‐Pareja</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, University Hospital “12 de Octubre,” Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="corporate"><namePart>Neurological Disorders in Central Spain (NEDICES) Study Group</namePart><affiliation>Department of Neurology, University Hospital “12 de Octubre,” Madrid, Spain</affiliation><affiliation>GH Sergievsky Center, Columbia University, New York, New York, USA</affiliation><affiliation>Department of Neurology, Columbia University, New York, New York, USA</affiliation><affiliation>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</affiliation><description>Department of Neurology, University Hospital “12 de Octubre,” Madrid, SpainGH Sergievsky Center, Columbia University, New York, New York, USADepartment of Neurology, Columbia University, New York, New York, USATaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USADepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</description></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-01-30</dateIssued><dateCaptured encoding="w3cdtf">2007-09-05</dateCaptured><dateValid encoding="w3cdtf">2007-10-07</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">3</extent><extent unit="references">42</extent><extent unit="words">4847</extent></physicalDescription><abstract lang="fr">Parkinson's disease (PD) is inversely associated with smoking cigarettes. Despite long‐standing clinical links between PD and essential tremor (ET), there are surprisingly few data on smoking in ET. We studied whether smoking cigarettes is inversely associated with ET. Using a population‐based, case–control design, cigarette smoking habits were assessed in 221 prevalent ET cases (75.5 ± 7.1 years old) and 663 matched controls (74.6 ± 7.0 years old). In logistical regression analyses, diagnosis (ET vs. control) was the dependent variable, and cigarette smoking status, the independent variable. Ever smokers were marginally less likely to have ET than were never smokers (22.0% vs. 27.0%, odds ratio [OR] 0.76, 95% confidence interval [CI] 0.55–1.04, P = 0.09). In an analysis that adjusted for confounding factors (drink‐years and depressive symptoms), ever smokers were nearly half less likely to have ET than the never smokers (OR 0.58, 95% CI 0.40–0.84, P = 0.004). There was a strong inverse association between pack‐years and odds of ET (adjusted OR 0.991, 95% CI 0.984–0.997, P = 0.005, i.e., with every 10 pack‐year increase, odds of ET were lowered 10%). Ever smokers in the highest pack‐year tertile were one‐third as likely to have ET than the never smokers (adjusted OR 0.39, 95% CI 0.22–0.69, P = 0.001). We demonstrated an inverse association between ever smoking and ET. Additional studies are needed to reproduce these findings and assess whether this association is due to a biologically protective effect. © 2007 Movement Disorder Society</abstract><note type="funding">Spanish Health Research Agency - No. FIS 93/0773; No. 96/1993; </note><note type="funding">Spanish Office of Science and Technology</note><note type="funding">National Institutes of Health, Bethesda, MD - No. NIH R01 NS042859; No. R01 NS039422; </note><subject lang="en"><genre>Keywords</genre><topic>essential tremor</topic><topic>cigarette smoking</topic><topic>epidemiology</topic><topic>case–control studies.</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>246</start><end>252</end><total>7</total></extent></part></relatedItem><identifier type="istex">76B5298048EA33E13E12C0766277644A40ED79FC</identifier><identifier type="DOI">10.1002/mds.21810</identifier><identifier type="ArticleID">MDS21810</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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