Decision making in restless legs syndrome
Identifieur interne : 000845 ( Istex/Corpus ); précédent : 000844; suivant : 000846Decision making in restless legs syndrome
Auteurs : Sophie Bayard ; Huan Yu ; Muriel Croisier Langenier ; Bertrand Carlander ; Yves DauvilliersSource :
- Movement Disorders [ 0885-3185 ] ; 2010-11-15.
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- KwdEn :
Abstract
The dopamine system is implicated in reward‐based decision making with explicit information (decision making under risk) and implicit probabilities (decision making under ambiguity). Although the pathophysiology of restless legs syndrome (RLS) is not yet fully understood, the genetic factors, iron status, and dopaminergic system are thought to play a role. RLS provides an opportunity to test the dopaminergic hypothesis in a drug‐free population and to characterize reward processing using decision‐making paradigms. We investigated impulsivity, impulse control disorders, and decision making in 50 untreated patients with primary RLS compared with 60 sex‐ and age‐matched normal controls using one night of polysomnography recording, a structured psychiatric interview, and questionnaires (RLS Severity Scale, Beck Depression Inventory, and Urgency Premeditation Perseverance Impulsive Behavior Scale). Subjects performed the Iowa Gambling Task to assess decision making under ambiguity and the Game of Dice Task to assess decision making under risk. Patients with RLS showed selective changes in decision making on the Iowa Gambling Task and normal decision making on the Game of Dice Task compared with controls. Patients with RLS had greater depressive symptoms than controls, but no difference was found in impulsivity, impulse control disorders, or addictive behaviors. Clinical and polysomnographic variables were unrelated to decision‐making performance. Results indicate reduced decision‐making performance under ambiguity in drug‐free patients with RLS. From a clinical perspective, when using dopaminergic medication to treat RLS, patients with abnormal baseline behaviors should be closely monitored. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23326
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ISTEX:3EDB3439C9CFCED46011873E18780EE694638E7BLe document en format XML
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France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM U888, Montpellier, France</mods:affiliation></affiliation><affiliation><mods:affiliation>National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-11-15">2010-11-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">15</biblScope><biblScope unit="page" from="2634">2634</biblScope><biblScope unit="page" to="2640">2640</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3EDB3439C9CFCED46011873E18780EE694638E7B</idno><idno type="DOI">10.1002/mds.23326</idno><idno type="ArticleID">MDS23326</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Game of Dice Task</term><term>Iowa Gambling Task</term><term>decision making</term><term>dopamine</term><term>impulsivity</term><term>restless legs syndrome</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The dopamine system is implicated in reward‐based decision making with explicit information (decision making under risk) and implicit probabilities (decision making under ambiguity). Although the pathophysiology of restless legs syndrome (RLS) is not yet fully understood, the genetic factors, iron status, and dopaminergic system are thought to play a role. RLS provides an opportunity to test the dopaminergic hypothesis in a drug‐free population and to characterize reward processing using decision‐making paradigms. We investigated impulsivity, impulse control disorders, and decision making in 50 untreated patients with primary RLS compared with 60 sex‐ and age‐matched normal controls using one night of polysomnography recording, a structured psychiatric interview, and questionnaires (RLS Severity Scale, Beck Depression Inventory, and Urgency Premeditation Perseverance Impulsive Behavior Scale). Subjects performed the Iowa Gambling Task to assess decision making under ambiguity and the Game of Dice Task to assess decision making under risk. Patients with RLS showed selective changes in decision making on the Iowa Gambling Task and normal decision making on the Game of Dice Task compared with controls. Patients with RLS had greater depressive symptoms than controls, but no difference was found in impulsivity, impulse control disorders, or addictive behaviors. Clinical and polysomnographic variables were unrelated to decision‐making performance. Results indicate reduced decision‐making performance under ambiguity in drug‐free patients with RLS. From a clinical perspective, when using dopaminergic medication to treat RLS, patients with abnormal baseline behaviors should be closely monitored. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Sophie Bayard PhD</name><affiliations><json:string>Department of Neurology, Gui de Chauliac Hospital, Montpellier 34295, France</json:string><json:string>INSERM U888, Montpellier, France</json:string><json:string>National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), France</json:string></affiliations></json:item><json:item><name>Huan Yu MD</name><affiliations><json:string>Department of Neurology, Gui de Chauliac Hospital, Montpellier 34295, France</json:string><json:string>Department of Neurology, Shanghai Huashan Hospital, Shangai Fudan University, Shangai, China</json:string></affiliations></json:item><json:item><name>Muriel Croisier Langenier</name><affiliations><json:string>Department of Neurology, Gui de Chauliac Hospital, Montpellier 34295, France</json:string></affiliations></json:item><json:item><name>Bertrand Carlander MD</name><affiliations><json:string>Department of Neurology, Gui de Chauliac Hospital, Montpellier 34295, France</json:string><json:string>National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), France</json:string></affiliations></json:item><json:item><name>Yves Dauvilliers MD, PhD</name><affiliations><json:string>Department of Neurology, Gui de Chauliac Hospital, Montpellier 34295, France</json:string><json:string>INSERM U888, Montpellier, France</json:string><json:string>National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>restless legs syndrome</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dopamine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>impulsivity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>decision making</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Iowa Gambling Task</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Game of Dice Task</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The dopamine system is implicated in reward‐based decision making with explicit information (decision making under risk) and implicit probabilities (decision making under ambiguity). Although the pathophysiology of restless legs syndrome (RLS) is not yet fully understood, the genetic factors, iron status, and dopaminergic system are thought to play a role. RLS provides an opportunity to test the dopaminergic hypothesis in a drug‐free population and to characterize reward processing using decision‐making paradigms. We investigated impulsivity, impulse control disorders, and decision making in 50 untreated patients with primary RLS compared with 60 sex‐ and age‐matched normal controls using one night of polysomnography recording, a structured psychiatric interview, and questionnaires (RLS Severity Scale, Beck Depression Inventory, and Urgency Premeditation Perseverance Impulsive Behavior Scale). Subjects performed the Iowa Gambling Task to assess decision making under ambiguity and the Game of Dice Task to assess decision making under risk. Patients with RLS showed selective changes in decision making on the Iowa Gambling Task and normal decision making on the Game of Dice Task compared with controls. Patients with RLS had greater depressive symptoms than controls, but no difference was found in impulsivity, impulse control disorders, or addictive behaviors. Clinical and polysomnographic variables were unrelated to decision‐making performance. Results indicate reduced decision‐making performance under ambiguity in drug‐free patients with RLS. From a clinical perspective, when using dopaminergic medication to treat RLS, patients with abnormal baseline behaviors should be closely monitored. © 2010 Movement Disorder Society</abstract><qualityIndicators><score>7.187</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1748</abstractCharCount><pdfWordCount>4319</pdfWordCount><pdfCharCount>28627</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>239</abstractWordCount></qualityIndicators><title>Decision making in restless legs syndrome</title><genre><json:string>Serial article</json:string></genre><host><volume>25</volume><pages><total>7</total><last>2640</last><first>2634</first></pages><issn><json:string>0885-3185</json:string></issn><issue>15</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1002/mds.23326</json:string></doi><id>3EDB3439C9CFCED46011873E18780EE694638E7B</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/3EDB3439C9CFCED46011873E18780EE694638E7B/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/3EDB3439C9CFCED46011873E18780EE694638E7B/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/3EDB3439C9CFCED46011873E18780EE694638E7B/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Decision making in restless legs syndrome</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: This was not an industry‐supported study. The authors declare no conflict of interest. Prof. Dauvilliers has consulted for UCB Pharma, Sanofi‐Aventis, Cephalon, Bioprojet, GlaxoSmithKline, and Boehringer Ingelheim. Ms. Bayard and Croisier Langenier and Drs. Yu and Carlander report no financial conflicts of interest.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Decision making in restless legs syndrome</title><author><persName><forename type="first">Sophie</forename><surname>Bayard</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Neurology, Gui de Chauliac Hospital, Montpellier 34295, France</affiliation><affiliation>INSERM U888, Montpellier, France</affiliation><affiliation>National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), France</affiliation></author><author><persName><forename type="first">Huan</forename><surname>Yu</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Gui de Chauliac Hospital, Montpellier 34295, France</affiliation><affiliation>Department of Neurology, Shanghai Huashan Hospital, Shangai Fudan University, Shangai, China</affiliation></author><author><persName><forename type="first">Muriel Croisier</forename><surname>Langenier</surname></persName><affiliation>Department of Neurology, Gui de Chauliac Hospital, Montpellier 34295, France</affiliation></author><author><persName><forename type="first">Bertrand</forename><surname>Carlander</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Gui de Chauliac Hospital, Montpellier 34295, France</affiliation><affiliation>National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), France</affiliation></author><author><persName><forename type="first">Yves</forename><surname>Dauvilliers</surname><roleName type="degree">MD, PhD</roleName></persName><note type="correspondence"><p>Correspondence: Service de Neurologie, Hôpital Gui‐de‐Chauliac, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France</p></note><affiliation>Department of Neurology, Gui de Chauliac Hospital, Montpellier 34295, France</affiliation><affiliation>INSERM U888, Montpellier, France</affiliation><affiliation>National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), France</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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Although the pathophysiology of restless legs syndrome (RLS) is not yet fully understood, the genetic factors, iron status, and dopaminergic system are thought to play a role. RLS provides an opportunity to test the dopaminergic hypothesis in a drug‐free population and to characterize reward processing using decision‐making paradigms. We investigated impulsivity, impulse control disorders, and decision making in 50 untreated patients with primary RLS compared with 60 sex‐ and age‐matched normal controls using one night of polysomnography recording, a structured psychiatric interview, and questionnaires (RLS Severity Scale, Beck Depression Inventory, and Urgency Premeditation Perseverance Impulsive Behavior Scale). Subjects performed the Iowa Gambling Task to assess decision making under ambiguity and the Game of Dice Task to assess decision making under risk. Patients with RLS showed selective changes in decision making on the Iowa Gambling Task and normal decision making on the Game of Dice Task compared with controls. Patients with RLS had greater depressive symptoms than controls, but no difference was found in impulsivity, impulse control disorders, or addictive behaviors. Clinical and polysomnographic variables were unrelated to decision‐making performance. Results indicate reduced decision‐making performance under ambiguity in drug‐free patients with RLS. 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Although the pathophysiology of restless legs syndrome (RLS) is not yet fully understood, the genetic factors, iron status, and dopaminergic system are thought to play a role. RLS provides an opportunity to test the dopaminergic hypothesis in a drug‐free population and to characterize reward processing using decision‐making paradigms. We investigated impulsivity, impulse control disorders, and decision making in 50 untreated patients with primary RLS compared with 60 sex‐ and age‐matched normal controls using one night of polysomnography recording, a structured psychiatric interview, and questionnaires (RLS Severity Scale, Beck Depression Inventory, and Urgency Premeditation Perseverance Impulsive Behavior Scale). Subjects performed the Iowa Gambling Task to assess decision making under ambiguity and the Game of Dice Task to assess decision making under risk. Patients with RLS showed selective changes in decision making on the Iowa Gambling Task and normal decision making on the Game of Dice Task compared with controls. Patients with RLS had greater depressive symptoms than controls, but no difference was found in impulsivity, impulse control disorders, or addictive behaviors. Clinical and polysomnographic variables were unrelated to decision‐making performance. Results indicate reduced decision‐making performance under ambiguity in drug‐free patients with RLS. From a clinical perspective, when using dopaminergic medication to treat RLS, patients with abnormal baseline behaviors should be closely monitored. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn3"><p>Potential conflict of interest: This was not an industry‐supported study. The authors declare no conflict of interest. Prof. Dauvilliers has consulted for UCB Pharma, Sanofi‐Aventis, Cephalon, Bioprojet, GlaxoSmithKline, and Boehringer Ingelheim. Ms. Bayard and Croisier Langenier and Drs. Yu and Carlander report no financial conflicts of interest.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Decision making in restless legs syndrome</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Decision Making in Restless Legs Syndrome</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Decision making in restless legs syndrome</title></titleInfo><name type="personal"><namePart type="given">Sophie</namePart><namePart type="family">Bayard</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Gui de Chauliac Hospital, Montpellier 34295, France</affiliation><affiliation>INSERM U888, Montpellier, France</affiliation><affiliation>National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Huan</namePart><namePart type="family">Yu</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Gui de Chauliac Hospital, Montpellier 34295, France</affiliation><affiliation>Department of Neurology, Shanghai Huashan Hospital, Shangai Fudan University, Shangai, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Muriel Croisier</namePart><namePart type="family">Langenier</namePart><affiliation>Department of Neurology, Gui de Chauliac Hospital, Montpellier 34295, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bertrand</namePart><namePart type="family">Carlander</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Gui de Chauliac Hospital, Montpellier 34295, France</affiliation><affiliation>National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yves</namePart><namePart type="family">Dauvilliers</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Gui de Chauliac Hospital, Montpellier 34295, France</affiliation><affiliation>INSERM U888, Montpellier, France</affiliation><affiliation>National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), France</affiliation><description>Correspondence: Service de Neurologie, Hôpital Gui‐de‐Chauliac, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-11-15</dateIssued><dateCaptured encoding="w3cdtf">2010-02-16</dateCaptured><dateValid encoding="w3cdtf">2010-06-02</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">2</extent><extent unit="references">45</extent><extent unit="words">5218</extent></physicalDescription><abstract lang="en">The dopamine system is implicated in reward‐based decision making with explicit information (decision making under risk) and implicit probabilities (decision making under ambiguity). Although the pathophysiology of restless legs syndrome (RLS) is not yet fully understood, the genetic factors, iron status, and dopaminergic system are thought to play a role. RLS provides an opportunity to test the dopaminergic hypothesis in a drug‐free population and to characterize reward processing using decision‐making paradigms. We investigated impulsivity, impulse control disorders, and decision making in 50 untreated patients with primary RLS compared with 60 sex‐ and age‐matched normal controls using one night of polysomnography recording, a structured psychiatric interview, and questionnaires (RLS Severity Scale, Beck Depression Inventory, and Urgency Premeditation Perseverance Impulsive Behavior Scale). Subjects performed the Iowa Gambling Task to assess decision making under ambiguity and the Game of Dice Task to assess decision making under risk. Patients with RLS showed selective changes in decision making on the Iowa Gambling Task and normal decision making on the Game of Dice Task compared with controls. Patients with RLS had greater depressive symptoms than controls, but no difference was found in impulsivity, impulse control disorders, or addictive behaviors. Clinical and polysomnographic variables were unrelated to decision‐making performance. Results indicate reduced decision‐making performance under ambiguity in drug‐free patients with RLS. From a clinical perspective, when using dopaminergic medication to treat RLS, patients with abnormal baseline behaviors should be closely monitored. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: This was not an industry‐supported study. The authors declare no conflict of interest. Prof. Dauvilliers has consulted for UCB Pharma, Sanofi‐Aventis, Cephalon, Bioprojet, GlaxoSmithKline, and Boehringer Ingelheim. Ms. Bayard and Croisier Langenier and Drs. Yu and Carlander report no financial conflicts of interest.</note><subject lang="en"><genre>Keywords</genre><topic>restless legs syndrome</topic><topic>dopamine</topic><topic>impulsivity</topic><topic>decision making</topic><topic>Iowa Gambling Task</topic><topic>Game of Dice Task</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>15</number></detail><extent unit="pages"><start>2634</start><end>2640</end><total>7</total></extent></part></relatedItem><identifier type="istex">3EDB3439C9CFCED46011873E18780EE694638E7B</identifier><identifier type="DOI">10.1002/mds.23326</identifier><identifier type="ArticleID">MDS23326</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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