The prevalence and patterns of pharyngoesophageal dysmotility in patients with early stage Parkinson's disease
Identifieur interne : 000735 ( Istex/Corpus ); précédent : 000734; suivant : 000736The prevalence and patterns of pharyngoesophageal dysmotility in patients with early stage Parkinson's disease
Auteurs : Hye Young Sung ; Joong-Seok Kim ; Kwang-Soo Lee ; Yeong-In Kim ; In-Uk Song ; Sung-Woo Chung ; Dong-Won Yang ; Yu Kyung Cho ; Jae Myung Park ; In Seok Lee ; Sang Woo Kim ; In-Sik Chung ; Myung-Gyu ChoiSource :
- Movement Disorders [ 0885-3185 ] ; 2010-10-30.
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Abstract
Dysphagia occurs in the majority of patients with Parkinson's disease (PD) and is known to correlate with abnormalities of oropharyngeal function. The aim of this study was to evaluate pharyngoesophageal activity in patients with early‐stage PD. Newly diagnosed PD patients with a symptom duration not exceeding 3 years were included. All PD patients were questioned about symptoms of dysphagia and underwent combined multichannel intraluminal impedance manometry and multiple rapid swallow tests. Fifty‐four patients (22 men and 32 women, 67.1 ± 10.3 years) were enrolled. The duration of Parkinsonian motor symptoms was 11.5 ± 8.8 months, the Hoehn and Yahr stage was 1.6 ± 0.4, and the total Unified Parkinson's Disease Rating Scale was 25.1 ± 18.6. Esophageal manometry in the liquid swallow and viscous swallow tests was abnormal in 22 (40.7%) and 31 (67.4%) patients, respectively. Although manometric abnormalities were more common in patients with more severe dysphagia symptoms, many patients with no or minimal symptoms also had manometric abnormalities. Repetitive deglutition significantly correlated with failed peristalsis and incomplete bolus transit. Abnormal responses to multiple rapid swallow tests were found in 33 out of 54 patients; 29 with incomplete inhibition (repetitive contraction) and 4 with failed peristalsis. These results suggest that the majority of patients with early‐stage PD showed pharyngeal and esophageal dysfunction even before clinical manifestations of dysphagia, which may reflect selective involvement of either the brain stem or the esophageal myenteric plexus in early‐stage PD. © 2010 Movement Disorder Society.
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DOI: 10.1002/mds.23290
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Promotion, The Catholic University of Korea, Seoul, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Kim, Joong Eok" sort="Kim, Joong Eok" uniqKey="Kim J" first="Joong-Seok" last="Kim">Joong-Seok Kim</name><affiliation><mods:affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</mods:affiliation></affiliation><affiliation><mods:affiliation>Joong‐Seok Kim, Department of Neurology, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, South KoreaMyung‐Gyu Choi, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, 137‐701, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Lee, Kwang Oo" sort="Lee, Kwang Oo" uniqKey="Lee K" first="Kwang-Soo" last="Lee">Kwang-Soo Lee</name><affiliation><mods:affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Kim, Yeong N" sort="Kim, Yeong N" uniqKey="Kim Y" first="Yeong-In" last="Kim">Yeong-In Kim</name><affiliation><mods:affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Song, In K" sort="Song, In K" uniqKey="Song I" first="In-Uk" last="Song">In-Uk Song</name><affiliation><mods:affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Chung, Sung Oo" sort="Chung, Sung Oo" uniqKey="Chung S" first="Sung-Woo" last="Chung">Sung-Woo Chung</name><affiliation><mods:affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Yang, Dong On" sort="Yang, Dong On" uniqKey="Yang D" first="Dong-Won" last="Yang">Dong-Won Yang</name><affiliation><mods:affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Cho, Yu Kyung" sort="Cho, Yu Kyung" uniqKey="Cho Y" first="Yu Kyung" last="Cho">Yu Kyung Cho</name><affiliation><mods:affiliation>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Park, Jae Myung" sort="Park, Jae Myung" uniqKey="Park J" first="Jae Myung" last="Park">Jae Myung Park</name><affiliation><mods:affiliation>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Lee, In Seok" sort="Lee, In Seok" uniqKey="Lee I" first="In Seok" last="Lee">In Seok Lee</name><affiliation><mods:affiliation>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Kim, Sang Woo" sort="Kim, Sang Woo" uniqKey="Kim S" first="Sang Woo" last="Kim">Sang Woo Kim</name><affiliation><mods:affiliation>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Chung, In Ik" sort="Chung, In Ik" uniqKey="Chung I" first="In-Sik" last="Chung">In-Sik Chung</name><affiliation><mods:affiliation>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</mods:affiliation></affiliation></author><author><name sortKey="Choi, Myung Yu" sort="Choi, Myung Yu" uniqKey="Choi M" first="Myung-Gyu" last="Choi">Myung-Gyu Choi</name><affiliation><mods:affiliation>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</mods:affiliation></affiliation><affiliation><mods:affiliation>Joong‐Seok Kim, Department of Neurology, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, South KoreaMyung‐Gyu Choi, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, 137‐701, South Korea</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-10-30">2010-10-30</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2361">2361</biblScope><biblScope unit="page" to="2368">2368</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">2ED9A219D1EBBB988250077BBFBB951199B37167</idno><idno type="DOI">10.1002/mds.23290</idno><idno type="ArticleID">MDS23290</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>dysphagia</term><term>esophageal manometry</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dysphagia occurs in the majority of patients with Parkinson's disease (PD) and is known to correlate with abnormalities of oropharyngeal function. The aim of this study was to evaluate pharyngoesophageal activity in patients with early‐stage PD. Newly diagnosed PD patients with a symptom duration not exceeding 3 years were included. All PD patients were questioned about symptoms of dysphagia and underwent combined multichannel intraluminal impedance manometry and multiple rapid swallow tests. Fifty‐four patients (22 men and 32 women, 67.1 ± 10.3 years) were enrolled. The duration of Parkinsonian motor symptoms was 11.5 ± 8.8 months, the Hoehn and Yahr stage was 1.6 ± 0.4, and the total Unified Parkinson's Disease Rating Scale was 25.1 ± 18.6. Esophageal manometry in the liquid swallow and viscous swallow tests was abnormal in 22 (40.7%) and 31 (67.4%) patients, respectively. Although manometric abnormalities were more common in patients with more severe dysphagia symptoms, many patients with no or minimal symptoms also had manometric abnormalities. Repetitive deglutition significantly correlated with failed peristalsis and incomplete bolus transit. Abnormal responses to multiple rapid swallow tests were found in 33 out of 54 patients; 29 with incomplete inhibition (repetitive contraction) and 4 with failed peristalsis. These results suggest that the majority of patients with early‐stage PD showed pharyngeal and esophageal dysfunction even before clinical manifestations of dysphagia, which may reflect selective involvement of either the brain stem or the esophageal myenteric plexus in early‐stage PD. © 2010 Movement Disorder Society.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Hye Young Sung MD</name><affiliations><json:string>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</json:string><json:string>Center for Health Promotion, The Catholic University of Korea, Seoul, South Korea</json:string></affiliations></json:item><json:item><name>Joong‐Seok Kim MD</name><affiliations><json:string>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</json:string><json:string>Joong‐Seok Kim, Department of Neurology, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, South KoreaMyung‐Gyu Choi, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, 137‐701, South Korea</json:string></affiliations></json:item><json:item><name>Kwang‐Soo Lee MD</name><affiliations><json:string>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</json:string></affiliations></json:item><json:item><name>Yeong‐In Kim MD</name><affiliations><json:string>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</json:string></affiliations></json:item><json:item><name>In‐Uk Song MD</name><affiliations><json:string>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</json:string></affiliations></json:item><json:item><name>Sung‐Woo Chung MD</name><affiliations><json:string>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</json:string></affiliations></json:item><json:item><name>Dong‐Won Yang MD</name><affiliations><json:string>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</json:string></affiliations></json:item><json:item><name>Yu Kyung Cho MD</name><affiliations><json:string>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</json:string></affiliations></json:item><json:item><name>Jae Myung Park MD</name><affiliations><json:string>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</json:string></affiliations></json:item><json:item><name>In Seok Lee MD</name><affiliations><json:string>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</json:string></affiliations></json:item><json:item><name>Sang Woo Kim MD</name><affiliations><json:string>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</json:string></affiliations></json:item><json:item><name>In‐Sik Chung MD</name><affiliations><json:string>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</json:string></affiliations></json:item><json:item><name>Myung‐Gyu Choi MD</name><affiliations><json:string>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</json:string><json:string>Joong‐Seok Kim, Department of Neurology, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, South KoreaMyung‐Gyu Choi, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, 137‐701, South Korea</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>esophageal manometry</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dysphagia</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Dysphagia occurs in the majority of patients with Parkinson's disease (PD) and is known to correlate with abnormalities of oropharyngeal function. The aim of this study was to evaluate pharyngoesophageal activity in patients with early‐stage PD. Newly diagnosed PD patients with a symptom duration not exceeding 3 years were included. All PD patients were questioned about symptoms of dysphagia and underwent combined multichannel intraluminal impedance manometry and multiple rapid swallow tests. Fifty‐four patients (22 men and 32 women, 67.1 ± 10.3 years) were enrolled. The duration of Parkinsonian motor symptoms was 11.5 ± 8.8 months, the Hoehn and Yahr stage was 1.6 ± 0.4, and the total Unified Parkinson's Disease Rating Scale was 25.1 ± 18.6. Esophageal manometry in the liquid swallow and viscous swallow tests was abnormal in 22 (40.7%) and 31 (67.4%) patients, respectively. Although manometric abnormalities were more common in patients with more severe dysphagia symptoms, many patients with no or minimal symptoms also had manometric abnormalities. Repetitive deglutition significantly correlated with failed peristalsis and incomplete bolus transit. Abnormal responses to multiple rapid swallow tests were found in 33 out of 54 patients; 29 with incomplete inhibition (repetitive contraction) and 4 with failed peristalsis. These results suggest that the majority of patients with early‐stage PD showed pharyngeal and esophageal dysfunction even before clinical manifestations of dysphagia, which may reflect selective involvement of either the brain stem or the esophageal myenteric plexus in early‐stage PD. © 2010 Movement Disorder Society.</abstract><qualityIndicators><score>7.31</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1660</abstractCharCount><pdfWordCount>4406</pdfWordCount><pdfCharCount>30064</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>242</abstractWordCount></qualityIndicators><title>The prevalence and patterns of pharyngoesophageal dysmotility in patients with early stage Parkinson's disease</title><genre><json:string>Serial 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South Korea</affiliation></author><author><persName><forename type="first">Joong‐Seok</forename><surname>Kim</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</affiliation><affiliation>Joong‐Seok Kim, Department of Neurology, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, South KoreaMyung‐Gyu Choi, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, 137‐701, South Korea</affiliation></author><author><persName><forename type="first">Kwang‐Soo</forename><surname>Lee</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</affiliation></author><author><persName><forename type="first">Yeong‐In</forename><surname>Kim</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</affiliation></author><author><persName><forename type="first">In‐Uk</forename><surname>Song</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</affiliation></author><author><persName><forename type="first">Sung‐Woo</forename><surname>Chung</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</affiliation></author><author><persName><forename type="first">Dong‐Won</forename><surname>Yang</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</affiliation></author><author><persName><forename type="first">Yu Kyung</forename><surname>Cho</surname><roleName type="degree">MD</roleName></persName><affiliation>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</affiliation></author><author><persName><forename type="first">Jae Myung</forename><surname>Park</surname><roleName type="degree">MD</roleName></persName><affiliation>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</affiliation></author><author><persName><forename type="first">In Seok</forename><surname>Lee</surname><roleName type="degree">MD</roleName></persName><affiliation>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</affiliation></author><author><persName><forename type="first">Sang Woo</forename><surname>Kim</surname><roleName type="degree">MD</roleName></persName><affiliation>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</affiliation></author><author><persName><forename type="first">In‐Sik</forename><surname>Chung</surname><roleName type="degree">MD</roleName></persName><affiliation>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</affiliation></author><author><persName><forename type="first">Myung‐Gyu</forename><surname>Choi</surname><roleName type="degree">MD</roleName></persName><affiliation>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</affiliation><affiliation>Joong‐Seok Kim, Department of Neurology, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, South KoreaMyung‐Gyu Choi, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, 137‐701, South Korea</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-10-30"></date><biblScope unit="vol">25</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2361">2361</biblScope><biblScope unit="page" to="2368">2368</biblScope></imprint></monogr><idno type="istex">2ED9A219D1EBBB988250077BBFBB951199B37167</idno><idno type="DOI">10.1002/mds.23290</idno><idno type="ArticleID">MDS23290</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Dysphagia occurs in the majority of patients with Parkinson's disease (PD) and is known to correlate with abnormalities of oropharyngeal function. The aim of this study was to evaluate pharyngoesophageal activity in patients with early‐stage PD. Newly diagnosed PD patients with a symptom duration not exceeding 3 years were included. All PD patients were questioned about symptoms of dysphagia and underwent combined multichannel intraluminal impedance manometry and multiple rapid swallow tests. Fifty‐four patients (22 men and 32 women, 67.1 ± 10.3 years) were enrolled. The duration of Parkinsonian motor symptoms was 11.5 ± 8.8 months, the Hoehn and Yahr stage was 1.6 ± 0.4, and the total Unified Parkinson's Disease Rating Scale was 25.1 ± 18.6. Esophageal manometry in the liquid swallow and viscous swallow tests was abnormal in 22 (40.7%) and 31 (67.4%) patients, respectively. Although manometric abnormalities were more common in patients with more severe dysphagia symptoms, many patients with no or minimal symptoms also had manometric abnormalities. Repetitive deglutition significantly correlated with failed peristalsis and incomplete bolus transit. Abnormal responses to multiple rapid swallow tests were found in 33 out of 54 patients; 29 with incomplete inhibition (repetitive contraction) and 4 with failed peristalsis. These results suggest that the majority of patients with early‐stage PD showed pharyngeal and esophageal dysfunction even before clinical manifestations of dysphagia, which may reflect selective involvement of either the brain stem or the esophageal myenteric plexus in early‐stage PD. © 2010 Movement Disorder Society.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>esophageal manometry</term></item><item><term>dysphagia</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-03-03">Received</change><change when="2010-05-10">Registration</change><change when="2010-10-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/2ED9A219D1EBBB988250077BBFBB951199B37167/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="140"><doi origin="wiley" registered="yes">10.1002/mds.v25:14</doi><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">14</numbering></numberingGroup><coverDate startDate="2010-10-30">30 October 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="150" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.23290</doi><idGroup><id type="unit" value="MDS23290"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2010 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2010-03-03"></event><event type="manuscriptRevised" date="2010-04-12"></event><event type="manuscriptAccepted" date="2010-05-10"></event><event type="firstOnline" date="2010-07-28"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2010-07-28"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.5.2 mode:FullText source:FullText result:FullText" date="2011-07-06"></event><event type="publishedOnlineFinalForm" date="2010-10-25"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">2361</numbering><numbering type="pageLast">2368</numbering></numberingGroup><correspondenceTo><lineatedText><line>Joong‐Seok Kim, Department of Neurology, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, South Korea</line><line>Myung‐Gyu Choi, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, 137‐701, South Korea</line></lineatedText></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23290.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="5"></count><count type="referenceTotal" number="31"></count><count type="wordTotal" number="6066"></count></countGroup><titleGroup><title type="main" xml:lang="en">The prevalence and patterns of pharyngoesophageal dysmotility in patients with early stage Parkinson's disease<link href="#fn1"></link></title><title type="short" xml:lang="en">Pharyngoesophageal Dysmotility in Early Parkinson's Disease</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Hye Young</givenNames><familyName>Sung</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af3" corresponding="yes"><personName><givenNames>Joong‐Seok</givenNames><familyName>Kim</familyName><degrees>MD</degrees></personName><contactDetails><email>neuronet@catholic.ac.kr</email></contactDetails></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Kwang‐Soo</givenNames><familyName>Lee</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Yeong‐In</givenNames><familyName>Kim</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3"><personName><givenNames>In‐Uk</givenNames><familyName>Song</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Sung‐Woo</givenNames><familyName>Chung</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Dong‐Won</givenNames><familyName>Yang</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Yu Kyung</givenNames><familyName>Cho</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Jae Myung</givenNames><familyName>Park</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af1"><personName><givenNames>In Seok</givenNames><familyName>Lee</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Sang Woo</givenNames><familyName>Kim</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af1"><personName><givenNames>In‐Sik</givenNames><familyName>Chung</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Myung‐Gyu</givenNames><familyName>Choi</familyName><degrees>MD</degrees></personName><contactDetails><email>choim@catholic.ac.kr</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="KR" type="organization"><unparsedAffiliation>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="KR" type="organization"><unparsedAffiliation>Center for Health Promotion, The Catholic University of Korea, Seoul, South Korea</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="KR" type="organization"><unparsedAffiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">esophageal manometry</keyword><keyword xml:id="kwd3">dysphagia</keyword></keywordGroup><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23290:MDS_23290_sm_suppinfo"></mediaResource><caption>Supporting Information.</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Dysphagia occurs in the majority of patients with Parkinson's disease (PD) and is known to correlate with abnormalities of oropharyngeal function. The aim of this study was to evaluate pharyngoesophageal activity in patients with early‐stage PD. Newly diagnosed PD patients with a symptom duration not exceeding 3 years were included. All PD patients were questioned about symptoms of dysphagia and underwent combined multichannel intraluminal impedance manometry and multiple rapid swallow tests. Fifty‐four patients (22 men and 32 women, 67.1 ± 10.3 years) were enrolled. The duration of Parkinsonian motor symptoms was 11.5 ± 8.8 months, the Hoehn and Yahr stage was 1.6 ± 0.4, and the total Unified Parkinson's Disease Rating Scale was 25.1 ± 18.6. Esophageal manometry in the liquid swallow and viscous swallow tests was abnormal in 22 (40.7%) and 31 (67.4%) patients, respectively. Although manometric abnormalities were more common in patients with more severe dysphagia symptoms, many patients with no or minimal symptoms also had manometric abnormalities. Repetitive deglutition significantly correlated with failed peristalsis and incomplete bolus transit. Abnormal responses to multiple rapid swallow tests were found in 33 out of 54 patients; 29 with incomplete inhibition (repetitive contraction) and 4 with failed peristalsis. These results suggest that the majority of patients with early‐stage PD showed pharyngeal and esophageal dysfunction even before clinical manifestations of dysphagia, which may reflect selective involvement of either the brain stem or the esophageal myenteric plexus in early‐stage PD. © 2010 Movement Disorder Society.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Dr. Kim has received research grants from Novartis Korea.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>The prevalence and patterns of pharyngoesophageal dysmotility in patients with early stage Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Pharyngoesophageal Dysmotility in Early Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The prevalence and patterns of pharyngoesophageal dysmotility in patients with early stage Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Hye Young</namePart><namePart type="family">Sung</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea</affiliation><affiliation>Center for Health Promotion, The Catholic University of Korea, Seoul, South Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joong‐Seok</namePart><namePart type="family">Kim</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</affiliation><affiliation>Joong‐Seok Kim, Department of Neurology, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, South KoreaMyung‐Gyu Choi, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, 137‐701, South Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kwang‐Soo</namePart><namePart type="family">Lee</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yeong‐In</namePart><namePart type="family">Kim</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">In‐Uk</namePart><namePart type="family">Song</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sung‐Woo</namePart><namePart type="family">Chung</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dong‐Won</namePart><namePart type="family">Yang</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, The Catholic University of Korea, Seoul, South Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yu Kyung</namePart><namePart type="family">Cho</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Division of 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Banpo‐dong, Seocho‐gu, Seoul, South KoreaMyung‐Gyu Choi, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, 137‐701, South Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-10-30</dateIssued><dateCaptured encoding="w3cdtf">2010-03-03</dateCaptured><dateValid encoding="w3cdtf">2010-05-10</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">5</extent><extent unit="references">31</extent><extent unit="words">6066</extent></physicalDescription><abstract lang="en">Dysphagia occurs in the majority of patients with Parkinson's disease (PD) and is known to correlate with abnormalities of oropharyngeal function. The aim of this study was to evaluate pharyngoesophageal activity in patients with early‐stage PD. Newly diagnosed PD patients with a symptom duration not exceeding 3 years were included. All PD patients were questioned about symptoms of dysphagia and underwent combined multichannel intraluminal impedance manometry and multiple rapid swallow tests. Fifty‐four patients (22 men and 32 women, 67.1 ± 10.3 years) were enrolled. The duration of Parkinsonian motor symptoms was 11.5 ± 8.8 months, the Hoehn and Yahr stage was 1.6 ± 0.4, and the total Unified Parkinson's Disease Rating Scale was 25.1 ± 18.6. Esophageal manometry in the liquid swallow and viscous swallow tests was abnormal in 22 (40.7%) and 31 (67.4%) patients, respectively. Although manometric abnormalities were more common in patients with more severe dysphagia symptoms, many patients with no or minimal symptoms also had manometric abnormalities. Repetitive deglutition significantly correlated with failed peristalsis and incomplete bolus transit. Abnormal responses to multiple rapid swallow tests were found in 33 out of 54 patients; 29 with incomplete inhibition (repetitive contraction) and 4 with failed peristalsis. These results suggest that the majority of patients with early‐stage PD showed pharyngeal and esophageal dysfunction even before clinical manifestations of dysphagia, which may reflect selective involvement of either the brain stem or the esophageal myenteric plexus in early‐stage PD. © 2010 Movement Disorder Society.</abstract><note type="content">*Potential conflict of interest: Dr. Kim has received research grants from Novartis Korea.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>esophageal manometry</topic><topic>dysphagia</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Supporting Information. - </note><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>14</number></detail><extent unit="pages"><start>2361</start><end>2368</end><total>8</total></extent></part></relatedItem><identifier type="istex">2ED9A219D1EBBB988250077BBFBB951199B37167</identifier><identifier type="DOI">10.1002/mds.23290</identifier><identifier type="ArticleID">MDS23290</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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