Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease
Identifieur interne : 000725 ( Istex/Corpus ); précédent : 000724; suivant : 000726Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease
Auteurs : Aurélie Funkiewiez ; Claire Ardouin ; Paul Krack ; Valérie Fraix ; Nadège Van Blercom ; Jing Xie ; Elena Moro ; Alim-Louis Benabid ; Pierre PollakSource :
- Movement Disorders [ 0885-3185 ] ; 2003-05.
English descriptors
Abstract
High‐frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves the motor symptoms of Parkinson's disease (PD). Opposite changes in mood, such as mania or depression, have been reported after surgery, but it is not known whether these side effects are specifically related to STN DBS. To learn whether STN DBS also influences the limbic loop, we investigated acute subjective psychotropic effects related to levodopa or bilateral STN DBS. After a median postoperative follow‐up of 12 months, 50 PD patients completed the Addiction Research Center Inventory (ARCI), assessing subjective psychotropic effects in four conditions: off‐drug/on‐stimulation; off‐drug/off‐stimulation; on‐drug/off‐stimulation; and on‐drug/on‐stimulation. Both levodopa and STN DBS improved all the ARCI subscales, indicating subjective feelings of well being, euphoria, increase in motivation, and decrease in fatigue, anxiety, and tension. A suprathreshold dose of levodopa was significantly more effective than STN DBS, using the same electrical parameters as for chronic stimulation, on four of the five ARCI subscales. We concluded that 1) both STN DBS and levodopa have synergistic acute beneficial psychotropic effects in PD, 2) the psychotropic effects of both treatments need to be considered in the long‐term management of chronic STN DBS, and 3) the results indicate an involvement of the limbic STN in mood disorders of PD. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10441
Links to Exploration step
ISTEX:A300B348DE718838110366E71FB11E28194C2609Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease</title><author><name sortKey="Funkiewiez, Aurelie" sort="Funkiewiez, Aurelie" uniqKey="Funkiewiez A" first="Aurélie" last="Funkiewiez">Aurélie Funkiewiez</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Ardouin, Claire" sort="Ardouin, Claire" uniqKey="Ardouin C" first="Claire" last="Ardouin">Claire Ardouin</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadège" last="Van Blercom">Nadège Van Blercom</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Benabid, Alim Ouis" sort="Benabid, Alim Ouis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A300B348DE718838110366E71FB11E28194C2609</idno><date when="2003" year="2003">2003</date><idno type="doi">10.1002/mds.10441</idno><idno type="url">https://api.istex.fr/document/A300B348DE718838110366E71FB11E28194C2609/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000725</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease</title><author><name sortKey="Funkiewiez, Aurelie" sort="Funkiewiez, Aurelie" uniqKey="Funkiewiez A" first="Aurélie" last="Funkiewiez">Aurélie Funkiewiez</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Ardouin, Claire" sort="Ardouin, Claire" uniqKey="Ardouin C" first="Claire" last="Ardouin">Claire Ardouin</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadège" last="Van Blercom">Nadège Van Blercom</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Benabid, Alim Ouis" sort="Benabid, Alim Ouis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2003-05">2003-05</date><biblScope unit="vol">18</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="524">524</biblScope><biblScope unit="page" to="530">530</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A300B348DE718838110366E71FB11E28194C2609</idno><idno type="DOI">10.1002/mds.10441</idno><idno type="ArticleID">MDS10441</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>deep brain stimulation</term><term>euphoria</term><term>levodopa</term><term>mood</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High‐frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves the motor symptoms of Parkinson's disease (PD). Opposite changes in mood, such as mania or depression, have been reported after surgery, but it is not known whether these side effects are specifically related to STN DBS. To learn whether STN DBS also influences the limbic loop, we investigated acute subjective psychotropic effects related to levodopa or bilateral STN DBS. After a median postoperative follow‐up of 12 months, 50 PD patients completed the Addiction Research Center Inventory (ARCI), assessing subjective psychotropic effects in four conditions: off‐drug/on‐stimulation; off‐drug/off‐stimulation; on‐drug/off‐stimulation; and on‐drug/on‐stimulation. Both levodopa and STN DBS improved all the ARCI subscales, indicating subjective feelings of well being, euphoria, increase in motivation, and decrease in fatigue, anxiety, and tension. A suprathreshold dose of levodopa was significantly more effective than STN DBS, using the same electrical parameters as for chronic stimulation, on four of the five ARCI subscales. We concluded that 1) both STN DBS and levodopa have synergistic acute beneficial psychotropic effects in PD, 2) the psychotropic effects of both treatments need to be considered in the long‐term management of chronic STN DBS, and 3) the results indicate an involvement of the limbic STN in mood disorders of PD. © 2003 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Aurélie Funkiewiez MA</name><affiliations><json:string>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</json:string></affiliations></json:item><json:item><name>Claire Ardouin MA</name><affiliations><json:string>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</json:string></affiliations></json:item><json:item><name>Paul Krack MD</name><affiliations><json:string>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</json:string></affiliations></json:item><json:item><name>Valérie Fraix MD</name><affiliations><json:string>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</json:string></affiliations></json:item><json:item><name>Nadège Van Blercom MD</name><affiliations><json:string>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</json:string></affiliations></json:item><json:item><name>Jing Xie MD</name><affiliations><json:string>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</json:string></affiliations></json:item><json:item><name>Elena Moro MD, PhD</name><affiliations><json:string>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</json:string></affiliations></json:item><json:item><name>Alim‐Louis Benabid MD, PhD</name><affiliations><json:string>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</json:string></affiliations></json:item><json:item><name>Pierre Pollak MD</name><affiliations><json:string>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>deep brain stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>subthalamic nucleus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>levodopa</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mood</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>euphoria</value></json:item></subject><language><json:string>eng</json:string></language><abstract>High‐frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves the motor symptoms of Parkinson's disease (PD). Opposite changes in mood, such as mania or depression, have been reported after surgery, but it is not known whether these side effects are specifically related to STN DBS. To learn whether STN DBS also influences the limbic loop, we investigated acute subjective psychotropic effects related to levodopa or bilateral STN DBS. After a median postoperative follow‐up of 12 months, 50 PD patients completed the Addiction Research Center Inventory (ARCI), assessing subjective psychotropic effects in four conditions: off‐drug/on‐stimulation; off‐drug/off‐stimulation; on‐drug/off‐stimulation; and on‐drug/on‐stimulation. Both levodopa and STN DBS improved all the ARCI subscales, indicating subjective feelings of well being, euphoria, increase in motivation, and decrease in fatigue, anxiety, and tension. A suprathreshold dose of levodopa was significantly more effective than STN DBS, using the same electrical parameters as for chronic stimulation, on four of the five ARCI subscales. We concluded that 1) both STN DBS and levodopa have synergistic acute beneficial psychotropic effects in PD, 2) the psychotropic effects of both treatments need to be considered in the long‐term management of chronic STN DBS, and 3) the results indicate an involvement of the limbic STN in mood disorders of PD. © 2003 Movement Disorder Society</abstract><qualityIndicators><score>7.321</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1465</abstractCharCount><pdfWordCount>4777</pdfWordCount><pdfCharCount>31750</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>212</abstractWordCount></qualityIndicators><title>Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease</title><genre><json:string>Serial article</json:string></genre><host><volume>18</volume><pages><total>7</total><last>530</last><first>524</first></pages><issn><json:string>0885-3185</json:string></issn><issue>5</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2003</publicationDate><copyrightDate>2003</copyrightDate><doi><json:string>10.1002/mds.10441</json:string></doi><id>A300B348DE718838110366E71FB11E28194C2609</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/A300B348DE718838110366E71FB11E28194C2609/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/A300B348DE718838110366E71FB11E28194C2609/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/A300B348DE718838110366E71FB11E28194C2609/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2003</date></publicationStmt><notesStmt><note>INSERM</note><note>Rhône Alpes government</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease</title><author><persName><forename type="first">Aurélie</forename><surname>Funkiewiez</surname><roleName type="degree">MA</roleName></persName><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation></author><author><persName><forename type="first">Claire</forename><surname>Ardouin</surname><roleName type="degree">MA</roleName></persName><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation></author><author><persName><forename type="first">Paul</forename><surname>Krack</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, BP 217, 38043 Grenoble Cedex 9, France</p></note><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation></author><author><persName><forename type="first">Valérie</forename><surname>Fraix</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation></author><author><persName><forename type="first">Nadège</forename><surname>Van Blercom</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation></author><author><persName><forename type="first">Jing</forename><surname>Xie</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation></author><author><persName><forename type="first">Elena</forename><surname>Moro</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation></author><author><persName><forename type="first">Alim‐Louis</forename><surname>Benabid</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation></author><author><persName><forename type="first">Pierre</forename><surname>Pollak</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2003-05"></date><biblScope unit="vol">18</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="524">524</biblScope><biblScope unit="page" to="530">530</biblScope></imprint></monogr><idno type="istex">A300B348DE718838110366E71FB11E28194C2609</idno><idno type="DOI">10.1002/mds.10441</idno><idno type="ArticleID">MDS10441</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2003</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>High‐frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves the motor symptoms of Parkinson's disease (PD). Opposite changes in mood, such as mania or depression, have been reported after surgery, but it is not known whether these side effects are specifically related to STN DBS. To learn whether STN DBS also influences the limbic loop, we investigated acute subjective psychotropic effects related to levodopa or bilateral STN DBS. After a median postoperative follow‐up of 12 months, 50 PD patients completed the Addiction Research Center Inventory (ARCI), assessing subjective psychotropic effects in four conditions: off‐drug/on‐stimulation; off‐drug/off‐stimulation; on‐drug/off‐stimulation; and on‐drug/on‐stimulation. Both levodopa and STN DBS improved all the ARCI subscales, indicating subjective feelings of well being, euphoria, increase in motivation, and decrease in fatigue, anxiety, and tension. A suprathreshold dose of levodopa was significantly more effective than STN DBS, using the same electrical parameters as for chronic stimulation, on four of the five ARCI subscales. We concluded that 1) both STN DBS and levodopa have synergistic acute beneficial psychotropic effects in PD, 2) the psychotropic effects of both treatments need to be considered in the long‐term management of chronic STN DBS, and 3) the results indicate an involvement of the limbic STN in mood disorders of PD. © 2003 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>deep brain stimulation</term></item><item><term>subthalamic nucleus</term></item><item><term>Parkinson's disease</term></item><item><term>levodopa</term></item><item><term>mood</term></item><item><term>euphoria</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2002-03-08">Received</change><change when="2002-12-10">Registration</change><change when="2003-05">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/A300B348DE718838110366E71FB11E28194C2609/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi origin="wiley" registered="yes">10.1002/mds.v18:5</doi><numberingGroup><numbering type="journalVolume" number="18">18</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="2003-05">May 2003</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="70" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.10441</doi><idGroup><id type="unit" value="MDS10441"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2003 Movement Disorders Society</copyright><eventGroup><event type="manuscriptReceived" date="2002-03-08"></event><event type="manuscriptRevised" date="2002-11-18"></event><event type="manuscriptAccepted" date="2002-12-10"></event><event type="firstOnline" date="2003-03-20"></event><event type="publishedOnlineFinalForm" date="2003-04-23"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2003-03-20"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.27 mode:FullText source:FullText result:FullText" date="2010-11-22"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">524</numbering><numbering type="pageLast">530</numbering></numberingGroup><correspondenceTo>Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, BP 217, 38043 Grenoble Cedex 9, France</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS10441.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="73"></count><count type="wordTotal" number="5410"></count></countGroup><titleGroup><title type="main" xml:lang="en">Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease</title><title type="short" xml:lang="en">Psychotropic Effects of STN DBS</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Aurélie</givenNames><familyName>Funkiewiez</familyName><degrees>MA</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Claire</givenNames><familyName>Ardouin</familyName><degrees>MA</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Paul</givenNames><familyName>Krack</familyName><degrees>MD</degrees></personName><contactDetails><email normalForm="paul.krack@ujf-grenoble.fr">paul.krack@ujf‐grenoble.fr</email></contactDetails></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Valérie</givenNames><familyName>Fraix</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Nadège</givenNames><familyName>Van Blercom</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Jing</givenNames><familyName>Xie</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Elena</givenNames><familyName>Moro</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Alim‐Louis</givenNames><familyName>Benabid</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Pierre</givenNames><familyName>Pollak</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">deep brain stimulation</keyword><keyword xml:id="kwd2">subthalamic nucleus</keyword><keyword xml:id="kwd3">Parkinson's disease</keyword><keyword xml:id="kwd4">levodopa</keyword><keyword xml:id="kwd5">mood</keyword><keyword xml:id="kwd6">euphoria</keyword></keywordGroup><fundingInfo><fundingAgency>INSERM</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Rhône Alpes government</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>High‐frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves the motor symptoms of Parkinson's disease (PD). Opposite changes in mood, such as mania or depression, have been reported after surgery, but it is not known whether these side effects are specifically related to STN DBS. To learn whether STN DBS also influences the limbic loop, we investigated acute subjective psychotropic effects related to levodopa or bilateral STN DBS. After a median postoperative follow‐up of 12 months, 50 PD patients completed the Addiction Research Center Inventory (ARCI), assessing subjective psychotropic effects in four conditions: <i>off</i>‐drug/on‐stimulation; <i>off</i>‐drug/off‐stimulation; <i>on</i>‐drug/off‐stimulation; and <i>on</i>‐drug/on‐stimulation. Both levodopa and STN DBS improved all the ARCI subscales, indicating subjective feelings of well being, euphoria, increase in motivation, and decrease in fatigue, anxiety, and tension. A suprathreshold dose of levodopa was significantly more effective than STN DBS, using the same electrical parameters as for chronic stimulation, on four of the five ARCI subscales. We concluded that 1) both STN DBS and levodopa have synergistic acute beneficial psychotropic effects in PD, 2) the psychotropic effects of both treatments need to be considered in the long‐term management of chronic STN DBS, and 3) the results indicate an involvement of the limbic STN in mood disorders of PD. © 2003 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Psychotropic Effects of STN DBS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Aurélie</namePart><namePart type="family">Funkiewiez</namePart><namePart type="termsOfAddress">MA</namePart><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claire</namePart><namePart type="family">Ardouin</namePart><namePart type="termsOfAddress">MA</namePart><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul</namePart><namePart type="family">Krack</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation><description>Correspondence: Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, BP 217, 38043 Grenoble Cedex 9, France</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Valérie</namePart><namePart type="family">Fraix</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nadège</namePart><namePart type="family">Van Blercom</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jing</namePart><namePart type="family">Xie</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elena</namePart><namePart type="family">Moro</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alim‐Louis</namePart><namePart type="family">Benabid</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pierre</namePart><namePart type="family">Pollak</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2003-05</dateIssued><dateCaptured encoding="w3cdtf">2002-03-08</dateCaptured><dateValid encoding="w3cdtf">2002-12-10</dateValid><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">73</extent><extent unit="words">5410</extent></physicalDescription><abstract lang="en">High‐frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves the motor symptoms of Parkinson's disease (PD). Opposite changes in mood, such as mania or depression, have been reported after surgery, but it is not known whether these side effects are specifically related to STN DBS. To learn whether STN DBS also influences the limbic loop, we investigated acute subjective psychotropic effects related to levodopa or bilateral STN DBS. After a median postoperative follow‐up of 12 months, 50 PD patients completed the Addiction Research Center Inventory (ARCI), assessing subjective psychotropic effects in four conditions: off‐drug/on‐stimulation; off‐drug/off‐stimulation; on‐drug/off‐stimulation; and on‐drug/on‐stimulation. Both levodopa and STN DBS improved all the ARCI subscales, indicating subjective feelings of well being, euphoria, increase in motivation, and decrease in fatigue, anxiety, and tension. A suprathreshold dose of levodopa was significantly more effective than STN DBS, using the same electrical parameters as for chronic stimulation, on four of the five ARCI subscales. We concluded that 1) both STN DBS and levodopa have synergistic acute beneficial psychotropic effects in PD, 2) the psychotropic effects of both treatments need to be considered in the long‐term management of chronic STN DBS, and 3) the results indicate an involvement of the limbic STN in mood disorders of PD. © 2003 Movement Disorder Society</abstract><note type="funding">INSERM</note><note type="funding">Rhône Alpes government</note><subject lang="en"><genre>Keywords</genre><topic>deep brain stimulation</topic><topic>subthalamic nucleus</topic><topic>Parkinson's disease</topic><topic>levodopa</topic><topic>mood</topic><topic>euphoria</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>524</start><end>530</end><total>7</total></extent></part></relatedItem><identifier type="istex">A300B348DE718838110366E71FB11E28194C2609</identifier><identifier type="DOI">10.1002/mds.10441</identifier><identifier type="ArticleID">MDS10441</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2003 Movement Disorders Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000725 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000725 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:A300B348DE718838110366E71FB11E28194C2609
|texte= Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |