Movement Disorders (revue)

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Gait variability and basal ganglia disorders: Stride‐to‐stride variations of gait cycle timing in parkinson's disease and Huntington's disease

Identifieur interne : 000543 ( Istex/Corpus ); précédent : 000542; suivant : 000544

Gait variability and basal ganglia disorders: Stride‐to‐stride variations of gait cycle timing in parkinson's disease and Huntington's disease

Auteurs : Jeffrey M. Hausdorff ; Merit E. Cudkowicz ; Renée Firtion ; Jeanne Y. Wei ; Ary L. Goldberger

Source :

RBID : ISTEX:C036604D933032CDCF3827D4405899318977C1C8

English descriptors

Abstract

The basal ganglia are thought to play an important role in regulating motor programs involved in gait and in the fluidity and sequencing of movement. We postulated that the ability to maintain a steady gait, with low stride‐to‐stride variability of gait cycle timing and its subphases, would be diminished with both Parkinson's disease (PD) and Huntington's disease (HD). To test this hypothesis, we obtained quantitative measures of stride‐to‐stride variability of gait cycle timing in subjects with PD (n = 15), HD (n = 20), and disease‐free controls (n = 16). All measures of gait variability were significantly increased in PD and HD. In subjects with PD and HD, gait variability measures were two and three times that observed in control subjects, respectively. The degree of gait variability correlated with disease severity. In contrast, gait speed was significantly lower in PD, but not in HD, and average gait cycle duration and the time spent in many subphases of the gait cycle were similar in control subjects, HD subjects, and PD subjects. These findings are consistent with a differential control of gait variability, speed, and average gait cycle timing that may have implications for understanding the role of the basal ganglia in locomotor control and for quantitatively assessing gait in clinical settings.

Url:
DOI: 10.1002/mds.870130310

Links to Exploration step

ISTEX:C036604D933032CDCF3827D4405899318977C1C8

Le document en format XML

<record>
<TEI wicri:istexFullTextTei="biblStruct">
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Gait variability and basal ganglia disorders: Stride‐to‐stride variations of gait cycle timing in parkinson's disease and Huntington's disease</title>
<author>
<name sortKey="Hausdorff, Jeffrey M" sort="Hausdorff, Jeffrey M" uniqKey="Hausdorff J" first="Jeffrey M." last="Hausdorff">Jeffrey M. Hausdorff</name>
<affiliation>
<mods:affiliation>Gerontology Division, Beth Israel Deaconess Medical Center</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>Department of Medicine, Beth Israel Deaconess Medical Center</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>Harvard Medical School, Boston, Massachusetts, U.S.A.</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Cudkowicz, Merit E" sort="Cudkowicz, Merit E" uniqKey="Cudkowicz M" first="Merit E." last="Cudkowicz">Merit E. Cudkowicz</name>
<affiliation>
<mods:affiliation>Neurology Department, Massachusetts General Hospital, Massachusetts, U.S.A.</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>Harvard Medical School, Boston, Massachusetts, U.S.A.</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Firtion, Renee" sort="Firtion, Renee" uniqKey="Firtion R" first="Renée" last="Firtion">Renée Firtion</name>
<affiliation>
<mods:affiliation>Department of Medicine, Beth Israel Deaconess Medical Center</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>Biomedical Engineering Department, Boston University, Massachusetts, U.S.A.</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Wei, Jeanne Y" sort="Wei, Jeanne Y" uniqKey="Wei J" first="Jeanne Y." last="Wei">Jeanne Y. Wei</name>
<affiliation>
<mods:affiliation>Gerontology Division, Beth Israel Deaconess Medical Center</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>Department of Medicine, Beth Israel Deaconess Medical Center</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>Harvard Medical School, Boston, Massachusetts, U.S.A.</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Goldberger, Ary L" sort="Goldberger, Ary L" uniqKey="Goldberger A" first="Ary L." last="Goldberger">Ary L. Goldberger</name>
<affiliation>
<mods:affiliation>Department of Medicine, Beth Israel Deaconess Medical Center</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>Biomedical Engineering Department, Boston University, Massachusetts, U.S.A.</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>Harvard Medical School, Boston, Massachusetts, U.S.A.</mods:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:C036604D933032CDCF3827D4405899318977C1C8</idno>
<date when="1998" year="1998">1998</date>
<idno type="doi">10.1002/mds.870130310</idno>
<idno type="url">https://api.istex.fr/document/C036604D933032CDCF3827D4405899318977C1C8/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000543</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title level="a" type="main" xml:lang="en">Gait variability and basal ganglia disorders: Stride‐to‐stride variations of gait cycle timing in parkinson's disease and Huntington's disease</title>
<author>
<name sortKey="Hausdorff, Jeffrey M" sort="Hausdorff, Jeffrey M" uniqKey="Hausdorff J" first="Jeffrey M." last="Hausdorff">Jeffrey M. Hausdorff</name>
<affiliation>
<mods:affiliation>Gerontology Division, Beth Israel Deaconess Medical Center</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>Department of Medicine, Beth Israel Deaconess Medical Center</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>Harvard Medical School, Boston, Massachusetts, U.S.A.</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Cudkowicz, Merit E" sort="Cudkowicz, Merit E" uniqKey="Cudkowicz M" first="Merit E." last="Cudkowicz">Merit E. Cudkowicz</name>
<affiliation>
<mods:affiliation>Neurology Department, Massachusetts General Hospital, Massachusetts, U.S.A.</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>Harvard Medical School, Boston, Massachusetts, U.S.A.</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Firtion, Renee" sort="Firtion, Renee" uniqKey="Firtion R" first="Renée" last="Firtion">Renée Firtion</name>
<affiliation>
<mods:affiliation>Department of Medicine, Beth Israel Deaconess Medical Center</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>Biomedical Engineering Department, Boston University, Massachusetts, U.S.A.</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Wei, Jeanne Y" sort="Wei, Jeanne Y" uniqKey="Wei J" first="Jeanne Y." last="Wei">Jeanne Y. Wei</name>
<affiliation>
<mods:affiliation>Gerontology Division, Beth Israel Deaconess Medical Center</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>Department of Medicine, Beth Israel Deaconess Medical Center</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>Harvard Medical School, Boston, Massachusetts, U.S.A.</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Goldberger, Ary L" sort="Goldberger, Ary L" uniqKey="Goldberger A" first="Ary L." last="Goldberger">Ary L. Goldberger</name>
<affiliation>
<mods:affiliation>Department of Medicine, Beth Israel Deaconess Medical Center</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>Biomedical Engineering Department, Boston University, Massachusetts, U.S.A.</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>Harvard Medical School, Boston, Massachusetts, U.S.A.</mods:affiliation>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series>
<title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint>
<publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="1998-05">1998-05</date>
<biblScope unit="vol">13</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="428">428</biblScope>
<biblScope unit="page" to="437">437</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">C036604D933032CDCF3827D4405899318977C1C8</idno>
<idno type="DOI">10.1002/mds.870130310</idno>
<idno type="ArticleID">MDS870130310</idno>
</biblStruct>
</sourceDesc>
<seriesStmt>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Gait analysis</term>
<term>Motor control</term>
<term>Time series analysis</term>
</keywords>
</textClass>
<langUsage>
<language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">The basal ganglia are thought to play an important role in regulating motor programs involved in gait and in the fluidity and sequencing of movement. We postulated that the ability to maintain a steady gait, with low stride‐to‐stride variability of gait cycle timing and its subphases, would be diminished with both Parkinson's disease (PD) and Huntington's disease (HD). To test this hypothesis, we obtained quantitative measures of stride‐to‐stride variability of gait cycle timing in subjects with PD (n = 15), HD (n = 20), and disease‐free controls (n = 16). All measures of gait variability were significantly increased in PD and HD. In subjects with PD and HD, gait variability measures were two and three times that observed in control subjects, respectively. The degree of gait variability correlated with disease severity. In contrast, gait speed was significantly lower in PD, but not in HD, and average gait cycle duration and the time spent in many subphases of the gait cycle were similar in control subjects, HD subjects, and PD subjects. These findings are consistent with a differential control of gait variability, speed, and average gait cycle timing that may have implications for understanding the role of the basal ganglia in locomotor control and for quantitatively assessing gait in clinical settings.</div>
</front>
</TEI>
<istex>
<corpusName>wiley</corpusName>
<author>
<json:item>
<name>Jeffrey M. Hausdorff PhD</name>
<affiliations>
<json:string>Gerontology Division, Beth Israel Deaconess Medical Center</json:string>
<json:string>Department of Medicine, Beth Israel Deaconess Medical Center</json:string>
<json:string>Harvard Medical School, Boston, Massachusetts, U.S.A.</json:string>
</affiliations>
</json:item>
<json:item>
<name>Merit E. Cudkowicz MD</name>
<affiliations>
<json:string>Neurology Department, Massachusetts General Hospital, Massachusetts, U.S.A.</json:string>
<json:string>Harvard Medical School, Boston, Massachusetts, U.S.A.</json:string>
</affiliations>
</json:item>
<json:item>
<name>Renée Firtion BS</name>
<affiliations>
<json:string>Department of Medicine, Beth Israel Deaconess Medical Center</json:string>
<json:string>Biomedical Engineering Department, Boston University, Massachusetts, U.S.A.</json:string>
</affiliations>
</json:item>
<json:item>
<name>Jeanne Y. Wei MD, PhD</name>
<affiliations>
<json:string>Gerontology Division, Beth Israel Deaconess Medical Center</json:string>
<json:string>Department of Medicine, Beth Israel Deaconess Medical Center</json:string>
<json:string>Harvard Medical School, Boston, Massachusetts, U.S.A.</json:string>
</affiliations>
</json:item>
<json:item>
<name>Ary L. Goldberger MD</name>
<affiliations>
<json:string>Department of Medicine, Beth Israel Deaconess Medical Center</json:string>
<json:string>Biomedical Engineering Department, Boston University, Massachusetts, U.S.A.</json:string>
<json:string>Harvard Medical School, Boston, Massachusetts, U.S.A.</json:string>
</affiliations>
</json:item>
</author>
<subject>
<json:item>
<lang>
<json:string>eng</json:string>
</lang>
<value>Gait analysis</value>
</json:item>
<json:item>
<lang>
<json:string>eng</json:string>
</lang>
<value>Time series analysis</value>
</json:item>
<json:item>
<lang>
<json:string>eng</json:string>
</lang>
<value>Motor control</value>
</json:item>
</subject>
<language>
<json:string>eng</json:string>
</language>
<abstract>The basal ganglia are thought to play an important role in regulating motor programs involved in gait and in the fluidity and sequencing of movement. We postulated that the ability to maintain a steady gait, with low stride‐to‐stride variability of gait cycle timing and its subphases, would be diminished with both Parkinson's disease (PD) and Huntington's disease (HD). To test this hypothesis, we obtained quantitative measures of stride‐to‐stride variability of gait cycle timing in subjects with PD (n = 15), HD (n = 20), and disease‐free controls (n = 16). All measures of gait variability were significantly increased in PD and HD. In subjects with PD and HD, gait variability measures were two and three times that observed in control subjects, respectively. The degree of gait variability correlated with disease severity. In contrast, gait speed was significantly lower in PD, but not in HD, and average gait cycle duration and the time spent in many subphases of the gait cycle were similar in control subjects, HD subjects, and PD subjects. These findings are consistent with a differential control of gait variability, speed, and average gait cycle timing that may have implications for understanding the role of the basal ganglia in locomotor control and for quantitatively assessing gait in clinical settings.</abstract>
<qualityIndicators>
<score>7.52</score>
<pdfVersion>1.3</pdfVersion>
<pdfPageSize>612 x 792 pts (letter)</pdfPageSize>
<refBibsNative>true</refBibsNative>
<abstractCharCount>1324</abstractCharCount>
<pdfWordCount>6370</pdfWordCount>
<pdfCharCount>38583</pdfCharCount>
<pdfPageCount>10</pdfPageCount>
<abstractWordCount>210</abstractWordCount>
</qualityIndicators>
<title>Gait variability and basal ganglia disorders: Stride‐to‐stride variations of gait cycle timing in parkinson's disease and Huntington's disease</title>
<genre>
<json:string>Serial article</json:string>
</genre>
<host>
<volume>13</volume>
<pages>
<total>10</total>
<last>437</last>
<first>428</first>
</pages>
<issn>
<json:string>0885-3185</json:string>
</issn>
<issue>3</issue>
<subject>
<json:item>
<value>Article</value>
</json:item>
</subject>
<genre></genre>
<language>
<json:string>unknown</json:string>
</language>
<title>Movement Disorders</title>
<doi>
<json:string>10.1002/(ISSN)1531-8257</json:string>
</doi>
</host>
<publicationDate>1998</publicationDate>
<copyrightDate>1998</copyrightDate>
<doi>
<json:string>10.1002/mds.870130310</json:string>
</doi>
<id>C036604D933032CDCF3827D4405899318977C1C8</id>
<fulltext>
<json:item>
<original>true</original>
<mimetype>application/pdf</mimetype>
<extension>pdf</extension>
<uri>https://api.istex.fr/document/C036604D933032CDCF3827D4405899318977C1C8/fulltext/pdf</uri>
</json:item>
<json:item>
<original>false</original>
<mimetype>application/zip</mimetype>
<extension>zip</extension>
<uri>https://api.istex.fr/document/C036604D933032CDCF3827D4405899318977C1C8/fulltext/zip</uri>
</json:item>
<istex:fulltextTEI uri="https://api.istex.fr/document/C036604D933032CDCF3827D4405899318977C1C8/fulltext/tei">
<teiHeader type="text">
<fileDesc>
<titleStmt>
<title level="a" type="main" xml:lang="en">Gait variability and basal ganglia disorders: Stride‐to‐stride variations of gait cycle timing in parkinson's disease and Huntington's disease</title>
</titleStmt>
<publicationStmt>
<authority>ISTEX</authority>
<publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<availability>
<p>Wiley Subscription Services, Inc., A Wiley Company</p>
</availability>
<date>1998</date>
</publicationStmt>
<sourceDesc>
<biblStruct type="inbook">
<analytic>
<title level="a" type="main" xml:lang="en">Gait variability and basal ganglia disorders: Stride‐to‐stride variations of gait cycle timing in parkinson's disease and Huntington's disease</title>
<author>
<persName>
<forename type="first">Jeffrey M.</forename>
<surname>Hausdorff</surname>
<roleName type="degree">PhD</roleName>
</persName>
<note type="correspondence">
<p>Correspondence: Beth Israel Deaconess Medical Center, 330 Brookline Ave., Room KB‐26, Boston, MA 02215, U.S.A.===</p>
</note>
<affiliation>Gerontology Division, Beth Israel Deaconess Medical Center</affiliation>
<affiliation>Department of Medicine, Beth Israel Deaconess Medical Center</affiliation>
<affiliation>Harvard Medical School, Boston, Massachusetts, U.S.A.</affiliation>
</author>
<author>
<persName>
<forename type="first">Merit E.</forename>
<surname>Cudkowicz</surname>
<roleName type="degree">MD</roleName>
</persName>
<affiliation>Neurology Department, Massachusetts General Hospital, Massachusetts, U.S.A.</affiliation>
<affiliation>Harvard Medical School, Boston, Massachusetts, U.S.A.</affiliation>
</author>
<author>
<persName>
<forename type="first">Renée</forename>
<surname>Firtion</surname>
<roleName type="degree">BS</roleName>
</persName>
<affiliation>Department of Medicine, Beth Israel Deaconess Medical Center</affiliation>
<affiliation>Biomedical Engineering Department, Boston University, Massachusetts, U.S.A.</affiliation>
</author>
<author>
<persName>
<forename type="first">Jeanne Y.</forename>
<surname>Wei</surname>
<roleName type="degree">MD, PhD</roleName>
</persName>
<affiliation>Gerontology Division, Beth Israel Deaconess Medical Center</affiliation>
<affiliation>Department of Medicine, Beth Israel Deaconess Medical Center</affiliation>
<affiliation>Harvard Medical School, Boston, Massachusetts, U.S.A.</affiliation>
</author>
<author>
<persName>
<forename type="first">Ary L.</forename>
<surname>Goldberger</surname>
<roleName type="degree">MD</roleName>
</persName>
<affiliation>Department of Medicine, Beth Israel Deaconess Medical Center</affiliation>
<affiliation>Biomedical Engineering Department, Boston University, Massachusetts, U.S.A.</affiliation>
<affiliation>Harvard Medical School, Boston, Massachusetts, U.S.A.</affiliation>
</author>
</analytic>
<monogr>
<title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="pISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<idno type="DOI">10.1002/(ISSN)1531-8257</idno>
<imprint>
<publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="1998-05"></date>
<biblScope unit="vol">13</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="428">428</biblScope>
<biblScope unit="page" to="437">437</biblScope>
</imprint>
</monogr>
<idno type="istex">C036604D933032CDCF3827D4405899318977C1C8</idno>
<idno type="DOI">10.1002/mds.870130310</idno>
<idno type="ArticleID">MDS870130310</idno>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<creation>
<date>1998</date>
</creation>
<langUsage>
<language ident="en">en</language>
</langUsage>
<abstract xml:lang="en">
<p>The basal ganglia are thought to play an important role in regulating motor programs involved in gait and in the fluidity and sequencing of movement. We postulated that the ability to maintain a steady gait, with low stride‐to‐stride variability of gait cycle timing and its subphases, would be diminished with both Parkinson's disease (PD) and Huntington's disease (HD). To test this hypothesis, we obtained quantitative measures of stride‐to‐stride variability of gait cycle timing in subjects with PD (n = 15), HD (n = 20), and disease‐free controls (n = 16). All measures of gait variability were significantly increased in PD and HD. In subjects with PD and HD, gait variability measures were two and three times that observed in control subjects, respectively. The degree of gait variability correlated with disease severity. In contrast, gait speed was significantly lower in PD, but not in HD, and average gait cycle duration and the time spent in many subphases of the gait cycle were similar in control subjects, HD subjects, and PD subjects. These findings are consistent with a differential control of gait variability, speed, and average gait cycle timing that may have implications for understanding the role of the basal ganglia in locomotor control and for quantitatively assessing gait in clinical settings.</p>
</abstract>
<textClass xml:lang="en">
<keywords scheme="keyword">
<list>
<head>Keywords</head>
<item>
<term>Gait analysis</term>
</item>
<item>
<term>Time series analysis</term>
</item>
<item>
<term>Motor control</term>
</item>
</list>
</keywords>
</textClass>
<textClass>
<keywords scheme="Journal Subject">
<list>
<head>Article category</head>
<item>
<term>Article</term>
</item>
</list>
</keywords>
</textClass>
</profileDesc>
<revisionDesc>
<change when="1997-07-17">Received</change>
<change when="1997-10-31">Registration</change>
<change when="1998-05">Published</change>
</revisionDesc>
</teiHeader>
</istex:fulltextTEI>
<json:item>
<original>false</original>
<mimetype>text/plain</mimetype>
<extension>txt</extension>
<uri>https://api.istex.fr/document/C036604D933032CDCF3827D4405899318977C1C8/fulltext/txt</uri>
</json:item>
</fulltext>
<metadata>
<istex:metadataXml wicri:clean="Wiley, elements deleted: body">
<istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration>
<istex:document>
<component version="2.0" type="serialArticle" xml:lang="en">
<header>
<publicationMeta level="product">
<publisherInfo>
<publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName>
<publisherLoc>Hoboken</publisherLoc>
</publisherInfo>
<doi registered="yes">10.1002/(ISSN)1531-8257</doi>
<issn type="print">0885-3185</issn>
<issn type="electronic">1531-8257</issn>
<idGroup>
<id type="product" value="MDS"></id>
</idGroup>
<titleGroup>
<title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title>
<title type="tocForm">Movement Disorders</title>
<title type="short">Mov. Disord.</title>
</titleGroup>
</publicationMeta>
<publicationMeta level="part" position="30">
<doi origin="wiley" registered="yes">10.1002/mds.v13:3</doi>
<numberingGroup>
<numbering type="journalVolume" number="13">13</numbering>
<numbering type="journalIssue">3</numbering>
</numberingGroup>
<coverDate startDate="1998-05">May 1998</coverDate>
</publicationMeta>
<publicationMeta level="unit" type="article" position="10" status="forIssue">
<doi origin="wiley" registered="yes">10.1002/mds.870130310</doi>
<idGroup>
<id type="unit" value="MDS870130310"></id>
</idGroup>
<countGroup>
<count type="pageTotal" number="10"></count>
</countGroup>
<titleGroup>
<title type="articleCategory">Article</title>
<title type="tocHeading1">Articles</title>
</titleGroup>
<copyright ownership="thirdParty">Copyright © 1998 Movement Disorder Society</copyright>
<eventGroup>
<event type="manuscriptReceived" date="1997-07-17"></event>
<event type="manuscriptRevised" date="1997-10-29"></event>
<event type="manuscriptAccepted" date="1997-10-31"></event>
<event type="firstOnline" date="2004-11-04"></event>
<event type="publishedOnlineFinalForm" date="2004-11-04"></event>
<event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.3.2 mode:FullText" date="2014-06-23"></event>
<event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.2 mode:FullText" date="2014-06-23"></event>
<event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event>
</eventGroup>
<numberingGroup>
<numbering type="pageFirst">428</numbering>
<numbering type="pageLast">437</numbering>
</numberingGroup>
<correspondenceTo>Beth Israel Deaconess Medical Center, 330 Brookline Ave., Room KB‐26, Boston, MA 02215, U.S.A.===</correspondenceTo>
<linkGroup>
<link type="toTypesetVersion" href="file:MDS.MDS870130310.pdf"></link>
</linkGroup>
</publicationMeta>
<contentMeta>
<countGroup>
<count type="figureTotal" number="1"></count>
<count type="tableTotal" number="6"></count>
<count type="referenceTotal" number="46"></count>
</countGroup>
<titleGroup>
<title type="main" xml:lang="en">Gait variability and basal ganglia disorders: Stride‐to‐stride variations of gait cycle timing in parkinson's disease and Huntington's disease</title>
<title type="short" xml:lang="en">GAIT VARIABILITY AND THE BASAL GANGLIA</title>
</titleGroup>
<creators>
<creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af5" corresponding="yes">
<personName>
<givenNames>Jeffrey M.</givenNames>
<familyName>Hausdorff</familyName>
<degrees>PhD</degrees>
</personName>
</creator>
<creator xml:id="au2" creatorRole="author" affiliationRef="#af3 #af5">
<personName>
<givenNames>Merit E.</givenNames>
<familyName>Cudkowicz</familyName>
<degrees>MD</degrees>
</personName>
</creator>
<creator xml:id="au3" creatorRole="author" affiliationRef="#af2 #af4">
<personName>
<givenNames>Renée</givenNames>
<familyName>Firtion</familyName>
<degrees>BS</degrees>
</personName>
</creator>
<creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af2 #af5">
<personName>
<givenNames>Jeanne Y.</givenNames>
<familyName>Wei</familyName>
<degrees>MD, PhD</degrees>
</personName>
</creator>
<creator xml:id="au5" creatorRole="author" affiliationRef="#af2 #af4 #af5">
<personName>
<givenNames>Ary L.</givenNames>
<familyName>Goldberger</familyName>
<degrees>MD</degrees>
</personName>
</creator>
</creators>
<affiliationGroup>
<affiliation xml:id="af1" countryCode="IL" type="organization">
<unparsedAffiliation>Gerontology Division, Beth Israel Deaconess Medical Center</unparsedAffiliation>
</affiliation>
<affiliation xml:id="af2" countryCode="IL" type="organization">
<unparsedAffiliation>Department of Medicine, Beth Israel Deaconess Medical Center</unparsedAffiliation>
</affiliation>
<affiliation xml:id="af3" countryCode="US" type="organization">
<unparsedAffiliation>Neurology Department, Massachusetts General Hospital, Massachusetts, U.S.A.</unparsedAffiliation>
</affiliation>
<affiliation xml:id="af4" countryCode="US" type="organization">
<unparsedAffiliation>Biomedical Engineering Department, Boston University, Massachusetts, U.S.A.</unparsedAffiliation>
</affiliation>
<affiliation xml:id="af5" countryCode="US" type="organization">
<unparsedAffiliation>Harvard Medical School, Boston, Massachusetts, U.S.A.</unparsedAffiliation>
</affiliation>
</affiliationGroup>
<keywordGroup xml:lang="en" type="author">
<keyword xml:id="kwd1">Gait analysis</keyword>
<keyword xml:id="kwd2">Time series analysis</keyword>
<keyword xml:id="kwd3">Motor control</keyword>
</keywordGroup>
<abstractGroup>
<abstract type="main" xml:lang="en">
<title type="main">Abstract</title>
<p>The basal ganglia are thought to play an important role in regulating motor programs involved in gait and in the fluidity and sequencing of movement. We postulated that the ability to maintain a steady gait, with low stride‐to‐stride variability of gait cycle timing and its subphases, would be diminished with both Parkinson's disease (PD) and Huntington's disease (HD). To test this hypothesis, we obtained quantitative measures of stride‐to‐stride variability of gait cycle timing in subjects with PD (n = 15), HD (n = 20), and disease‐free controls (n = 16). All measures of gait variability were significantly increased in PD and HD. In subjects with PD and HD, gait variability measures were two and three times that observed in control subjects, respectively. The degree of gait variability correlated with disease severity. In contrast, gait speed was significantly lower in PD, but not in HD, and average gait cycle duration and the time spent in many subphases of the gait cycle were similar in control subjects, HD subjects, and PD subjects. These findings are consistent with a differential control of gait variability, speed, and average gait cycle timing that may have implications for understanding the role of the basal ganglia in locomotor control and for quantitatively assessing gait in clinical settings.</p>
</abstract>
</abstractGroup>
</contentMeta>
</header>
</component>
</istex:document>
</istex:metadataXml>
<!--Version 0.6 générée le 3-12-2015-->
<mods version="3.6">
<titleInfo lang="en">
<title>Gait variability and basal ganglia disorders: Stride‐to‐stride variations of gait cycle timing in parkinson's disease and Huntington's disease</title>
</titleInfo>
<titleInfo type="abbreviated" lang="en">
<title>GAIT VARIABILITY AND THE BASAL GANGLIA</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA" lang="en">
<title>Gait variability and basal ganglia disorders: Stride‐to‐stride variations of gait cycle timing in parkinson's disease and Huntington's disease</title>
</titleInfo>
<name type="personal">
<namePart type="given">Jeffrey M.</namePart>
<namePart type="family">Hausdorff</namePart>
<namePart type="termsOfAddress">PhD</namePart>
<affiliation>Gerontology Division, Beth Israel Deaconess Medical Center</affiliation>
<affiliation>Department of Medicine, Beth Israel Deaconess Medical Center</affiliation>
<affiliation>Harvard Medical School, Boston, Massachusetts, U.S.A.</affiliation>
<description>Correspondence: Beth Israel Deaconess Medical Center, 330 Brookline Ave., Room KB‐26, Boston, MA 02215, U.S.A.===</description>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Merit E.</namePart>
<namePart type="family">Cudkowicz</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Neurology Department, Massachusetts General Hospital, Massachusetts, U.S.A.</affiliation>
<affiliation>Harvard Medical School, Boston, Massachusetts, U.S.A.</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Renée</namePart>
<namePart type="family">Firtion</namePart>
<namePart type="termsOfAddress">BS</namePart>
<affiliation>Department of Medicine, Beth Israel Deaconess Medical Center</affiliation>
<affiliation>Biomedical Engineering Department, Boston University, Massachusetts, U.S.A.</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Jeanne Y.</namePart>
<namePart type="family">Wei</namePart>
<namePart type="termsOfAddress">MD, PhD</namePart>
<affiliation>Gerontology Division, Beth Israel Deaconess Medical Center</affiliation>
<affiliation>Department of Medicine, Beth Israel Deaconess Medical Center</affiliation>
<affiliation>Harvard Medical School, Boston, Massachusetts, U.S.A.</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Ary L.</namePart>
<namePart type="family">Goldberger</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Medicine, Beth Israel Deaconess Medical Center</affiliation>
<affiliation>Biomedical Engineering Department, Boston University, Massachusetts, U.S.A.</affiliation>
<affiliation>Harvard Medical School, Boston, Massachusetts, U.S.A.</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre authority="originalCategForm">article</genre>
<originInfo>
<publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<place>
<placeTerm type="text">Hoboken</placeTerm>
</place>
<dateIssued encoding="w3cdtf">1998-05</dateIssued>
<dateCaptured encoding="w3cdtf">1997-07-17</dateCaptured>
<dateValid encoding="w3cdtf">1997-10-31</dateValid>
<copyrightDate encoding="w3cdtf">1998</copyrightDate>
</originInfo>
<language>
<languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
<physicalDescription>
<internetMediaType>text/html</internetMediaType>
<extent unit="figures">1</extent>
<extent unit="tables">6</extent>
<extent unit="references">46</extent>
</physicalDescription>
<abstract lang="en">The basal ganglia are thought to play an important role in regulating motor programs involved in gait and in the fluidity and sequencing of movement. We postulated that the ability to maintain a steady gait, with low stride‐to‐stride variability of gait cycle timing and its subphases, would be diminished with both Parkinson's disease (PD) and Huntington's disease (HD). To test this hypothesis, we obtained quantitative measures of stride‐to‐stride variability of gait cycle timing in subjects with PD (n = 15), HD (n = 20), and disease‐free controls (n = 16). All measures of gait variability were significantly increased in PD and HD. In subjects with PD and HD, gait variability measures were two and three times that observed in control subjects, respectively. The degree of gait variability correlated with disease severity. In contrast, gait speed was significantly lower in PD, but not in HD, and average gait cycle duration and the time spent in many subphases of the gait cycle were similar in control subjects, HD subjects, and PD subjects. These findings are consistent with a differential control of gait variability, speed, and average gait cycle timing that may have implications for understanding the role of the basal ganglia in locomotor control and for quantitatively assessing gait in clinical settings.</abstract>
<subject lang="en">
<genre>Keywords</genre>
<topic>Gait analysis</topic>
<topic>Time series analysis</topic>
<topic>Motor control</topic>
</subject>
<relatedItem type="host">
<titleInfo>
<title>Movement Disorders</title>
</titleInfo>
<titleInfo type="abbreviated">
<title>Mov. Disord.</title>
</titleInfo>
<subject>
<genre>article category</genre>
<topic>Article</topic>
</subject>
<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part>
<date>1998</date>
<detail type="volume">
<caption>vol.</caption>
<number>13</number>
</detail>
<detail type="issue">
<caption>no.</caption>
<number>3</number>
</detail>
<extent unit="pages">
<start>428</start>
<end>437</end>
<total>10</total>
</extent>
</part>
</relatedItem>
<identifier type="istex">C036604D933032CDCF3827D4405899318977C1C8</identifier>
<identifier type="DOI">10.1002/mds.870130310</identifier>
<identifier type="ArticleID">MDS870130310</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 1998 Movement Disorder Society</accessCondition>
<recordInfo>
<recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin>
<recordContentSource>WILEY</recordContentSource>
</recordInfo>
</mods>
</metadata>
<serie></serie>
</istex>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000543 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000543 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Istex
   |étape=   Corpus
   |type=    RBID
   |clé=     ISTEX:C036604D933032CDCF3827D4405899318977C1C8
   |texte=   Gait variability and basal ganglia disorders: Stride‐to‐stride variations of gait cycle timing in parkinson's disease and Huntington's disease
}}

Wicri

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024