How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor
Identifieur interne : 000430 ( Istex/Corpus ); précédent : 000429; suivant : 000431How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor
Auteurs : Elan D. Louis ; Joaquim J. FerreiraSource :
- Movement Disorders [ 0885-3185 ] ; 2010-04-15.
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Abstract
Essential tremor (ET) is among the more prevalent neurological disorders, yet prevalence estimates have varied enormously, making it difficult to establish prevalence with precision. We: (1) reviewed the worldwide prevalence of ET in population‐based epidemiological studies, (2) derived as precisely as possible an estimate of disease prevalence, and (3) examined trends and important differences across studies. We identified 28 population‐based prevalence studies (19 countries). In a meta‐analysis, pooled prevalence (all ages) = 0.9%, with statistically significant heterogeneity across studies (I2 = 99%, P < 0.001). In additional descriptive analyses, crude prevalence (all ages) = 0.4%. Prevalence increased markedly with age, and especially with advanced age. In the meta‐analysis, prevalence (age ≥ 65 years) = 4.6%, and in additional descriptive analyses, median crude prevalence (age ≥ 60–65) = 6.3%. In one study of those age ≥ 95 years, crude prevalence = 21.7%. Several studies reported ethnic differences in prevalence, although more studies are needed. Greater than one‐third of studies show a gender difference, with most demonstrating a higher prevalence among men. This possible gender preference is interesting given clinical, epidemiological, and pathological associations between ET and Parkinson's disease. Precise prevalence estimates such as those we provide are important because they form the numerical basis for planned public health initiatives, provide data on the background occurrence of disease for family studies, and offer clues about the existence of environmental or underlying biological factors of possible mechanistic importance. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.22838
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Louis</name><affiliation><mods:affiliation>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Ferreira, Joaquim J" sort="Ferreira, Joaquim J" uniqKey="Ferreira J" first="Joaquim J." last="Ferreira">Joaquim J. 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We: (1) reviewed the worldwide prevalence of ET in population‐based epidemiological studies, (2) derived as precisely as possible an estimate of disease prevalence, and (3) examined trends and important differences across studies. We identified 28 population‐based prevalence studies (19 countries). In a meta‐analysis, pooled prevalence (all ages) = 0.9%, with statistically significant heterogeneity across studies (I2 = 99%, P < 0.001). In additional descriptive analyses, crude prevalence (all ages) = 0.4%. Prevalence increased markedly with age, and especially with advanced age. In the meta‐analysis, prevalence (age ≥ 65 years) = 4.6%, and in additional descriptive analyses, median crude prevalence (age ≥ 60–65) = 6.3%. In one study of those age ≥ 95 years, crude prevalence = 21.7%. Several studies reported ethnic differences in prevalence, although more studies are needed. Greater than one‐third of studies show a gender difference, with most demonstrating a higher prevalence among men. This possible gender preference is interesting given clinical, epidemiological, and pathological associations between ET and Parkinson's disease. Precise prevalence estimates such as those we provide are important because they form the numerical basis for planned public health initiatives, provide data on the background occurrence of disease for family studies, and offer clues about the existence of environmental or underlying biological factors of possible mechanistic importance. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Elan D. 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Greater than one‐third of studies show a gender difference, with most demonstrating a higher prevalence among men. This possible gender preference is interesting given clinical, epidemiological, and pathological associations between ET and Parkinson's disease. 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Greater than one‐third of studies show a gender difference, with most demonstrating a higher prevalence among men. This possible gender preference is interesting given clinical, epidemiological, and pathological associations between ET and Parkinson's disease. 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Update on the worldwide prevalence of essential tremor<link href="#fn1"></link> <link href="#fn2"></link></title><title type="short" xml:lang="en">Prevalence of Essential Tremor</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af3 #af4" corresponding="yes"><personName><givenNames>Elan D.</givenNames><familyName>Louis</familyName><degrees>MD, MSc</degrees></personName><contactDetails><email>EDL2@columbia.edu</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Joaquim J.</givenNames><familyName>Ferreira</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="PT" type="organization"><unparsedAffiliation>Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon, Portugal</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">essential tremor</keyword><keyword xml:id="kwd2">epidemiology</keyword><keyword xml:id="kwd3">prevalence</keyword><keyword xml:id="kwd4">clinical</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Essential tremor (ET) is among the more prevalent neurological disorders, yet prevalence estimates have varied enormously, making it difficult to establish prevalence with precision. We: (1) reviewed the worldwide prevalence of ET in population‐based epidemiological studies, (2) derived as precisely as possible an estimate of disease prevalence, and (3) examined trends and important differences across studies. We identified 28 population‐based prevalence studies (19 countries). In a meta‐analysis, pooled prevalence (all ages) = 0.9%, with statistically significant heterogeneity across studies (I<sup>2</sup> = 99%, <i>P</i> < 0.001). In additional descriptive analyses, crude prevalence (all ages) = 0.4%. Prevalence increased markedly with age, and especially with advanced age. In the meta‐analysis, prevalence (age ≥ 65 years) = 4.6%, and in additional descriptive analyses, median crude prevalence (age ≥ 60–65) = 6.3%. In one study of those age ≥ 95 years, crude prevalence = 21.7%. Several studies reported ethnic differences in prevalence, although more studies are needed. Greater than one‐third of studies show a gender difference, with most demonstrating a higher prevalence among men. This possible gender preference is interesting given clinical, epidemiological, and pathological associations between ET and Parkinson's disease. Precise prevalence estimates such as those we provide are important because they form the numerical basis for planned public health initiatives, provide data on the background occurrence of disease for family studies, and offer clues about the existence of environmental or underlying biological factors of possible mechanistic importance. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Nothing to report.</p></note><note xml:id="fn2"><p>This article is part of the journal's online CME program. The CME activity including form, can be found online at <url href="http://www.movementdisorders.org/education/journalcme/">http://www.movementdisorders.org/education/journalcme/</url></p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Prevalence of Essential Tremor</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor</title></titleInfo><name type="personal"><namePart type="given">Elan D.</namePart><namePart type="family">Louis</namePart><namePart type="termsOfAddress">MD, MSc</namePart><affiliation>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</affiliation><description>Correspondence: Unit 198, Neurological Institute, 710 West 168th Street, New York, NY 10032</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joaquim J.</namePart><namePart type="family">Ferreira</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon, Portugal</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">reviewArticle</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-04-15</dateIssued><dateCaptured encoding="w3cdtf">2009-02-10</dateCaptured><dateValid encoding="w3cdtf">2009-09-18</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">3</extent><extent unit="references">53</extent><extent unit="words">6126</extent></physicalDescription><abstract lang="en">Essential tremor (ET) is among the more prevalent neurological disorders, yet prevalence estimates have varied enormously, making it difficult to establish prevalence with precision. We: (1) reviewed the worldwide prevalence of ET in population‐based epidemiological studies, (2) derived as precisely as possible an estimate of disease prevalence, and (3) examined trends and important differences across studies. We identified 28 population‐based prevalence studies (19 countries). In a meta‐analysis, pooled prevalence (all ages) = 0.9%, with statistically significant heterogeneity across studies (I2 = 99%, P < 0.001). In additional descriptive analyses, crude prevalence (all ages) = 0.4%. Prevalence increased markedly with age, and especially with advanced age. In the meta‐analysis, prevalence (age ≥ 65 years) = 4.6%, and in additional descriptive analyses, median crude prevalence (age ≥ 60–65) = 6.3%. In one study of those age ≥ 95 years, crude prevalence = 21.7%. Several studies reported ethnic differences in prevalence, although more studies are needed. Greater than one‐third of studies show a gender difference, with most demonstrating a higher prevalence among men. This possible gender preference is interesting given clinical, epidemiological, and pathological associations between ET and Parkinson's disease. Precise prevalence estimates such as those we provide are important because they form the numerical basis for planned public health initiatives, provide data on the background occurrence of disease for family studies, and offer clues about the existence of environmental or underlying biological factors of possible mechanistic importance. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><note type="content">*This article is part of the journal's online CME program. The CME activity including form, can be found online at http://www.movementdisorders.org/education/journalcme/</note><subject lang="en"><genre>Keywords</genre><topic>essential tremor</topic><topic>epidemiology</topic><topic>prevalence</topic><topic>clinical</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Review</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>534</start><end>541</end><total>8</total></extent></part></relatedItem><identifier type="istex">2AD397C3053941F1EE13B0F80D52218473F30B6F</identifier><identifier type="DOI">10.1002/mds.22838</identifier><identifier type="ArticleID">MDS22838</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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