Multiple sclerosis tremor and the Stewart‐Holmes manoeuvre
Identifieur interne : 000388 ( Istex/Corpus ); précédent : 000387; suivant : 000389Multiple sclerosis tremor and the Stewart‐Holmes manoeuvre
Auteurs : Emmanuelle Waubant ; Sophie Tezenas Du Montcel ; Charles Jedynak ; Michael Obadia ; Hassan Hosseini ; Philippe Damier ; Catherine Lubetzki ; Yves Agid ; Jean-Denis DegosSource :
- Movement Disorders [ 0885-3185 ] ; 2003-08.
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- KwdEn :
Abstract
The objective of this study is to define tremor and cerebellar dysfunction and determine whether kinetic and postural tremor correlate with cerebellar dysfunction in patients with multiple sclerosis (MS). Cerebellar symptoms such as dysmetria often interfere with tremor evaluation in MS. The Stewart‐Holmes (SH) manoeuvre, which has been recently quantified, may offer a selective evaluation of cerebellar dysfunction in such patients. Thirty‐two patients with definite MS and arm tremor were evaluated (simplified Fahn tremor scale for kinetic and postural tremor, finger‐to‐nose test, clinical SH manoeuvre, quantitative study of the SH manoeuvre). Median severity of kinetic and postural tremor on the most disabled side was, respectively, 2 (range 0–4) and 1.5 (range 0–4). Clinical SH scores were moderately correlated to quantified SH measures (r = 0.36, P < 0.05). Kinetic and postural tremors were strongly correlated (r = 0.73, P < 0.0001) but did not correlate with clinical or quantified SH scores. Patients with bilateral tremor had higher scores for quantified SH, and a trend to higher clinical SH and finger‐to‐nose scores than patients with unilateral tremor. Although clinically associated, cerebellar dysfunction and tremor may be partly independent symptoms, suggesting they may relate to dysfunction of different neuronal systems. The SH manoeuvre should be part of the evaluation of MS patients considered for surgery of tremor. © 2003 Movement Disorder Society
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DOI: 10.1002/mds.10454
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uniqKey="Jedynak C" first="Charles" last="Jedynak">Charles Jedynak</name><affiliation><mods:affiliation>Federation de Neurologie, CHU Pitié Salpêtrière, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Obadia, Michael" sort="Obadia, Michael" uniqKey="Obadia M" first="Michael" last="Obadia">Michael Obadia</name><affiliation><mods:affiliation>Federation de Neurologie, CHU Pitié Salpêtrière, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Hosseini, Hassan" sort="Hosseini, Hassan" uniqKey="Hosseini H" first="Hassan" last="Hosseini">Hassan Hosseini</name><affiliation><mods:affiliation>Service de Neurologie, Hôpital Henri Mondor, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Damier, Philippe" sort="Damier, Philippe" uniqKey="Damier P" first="Philippe" last="Damier">Philippe Damier</name><affiliation><mods:affiliation>Federation de Neurologie, CHU Pitié Salpêtrière, Paris, 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-08">2003-08</date><biblScope unit="vol">18</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="948">948</biblScope><biblScope unit="page" to="952">952</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3FDBF354FC85EDE1240F6C114E545BFB4C5AF720</idno><idno type="DOI">10.1002/mds.10454</idno><idno type="ArticleID">MDS10454</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>cerebellar syndrome</term><term>multiple sclerosis</term><term>rebound</term><term>tremor</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study is to define tremor and cerebellar dysfunction and determine whether kinetic and postural tremor correlate with cerebellar dysfunction in patients with multiple sclerosis (MS). Cerebellar symptoms such as dysmetria often interfere with tremor evaluation in MS. The Stewart‐Holmes (SH) manoeuvre, which has been recently quantified, may offer a selective evaluation of cerebellar dysfunction in such patients. Thirty‐two patients with definite MS and arm tremor were evaluated (simplified Fahn tremor scale for kinetic and postural tremor, finger‐to‐nose test, clinical SH manoeuvre, quantitative study of the SH manoeuvre). Median severity of kinetic and postural tremor on the most disabled side was, respectively, 2 (range 0–4) and 1.5 (range 0–4). Clinical SH scores were moderately correlated to quantified SH measures (r = 0.36, P < 0.05). Kinetic and postural tremors were strongly correlated (r = 0.73, P < 0.0001) but did not correlate with clinical or quantified SH scores. Patients with bilateral tremor had higher scores for quantified SH, and a trend to higher clinical SH and finger‐to‐nose scores than patients with unilateral tremor. Although clinically associated, cerebellar dysfunction and tremor may be partly independent symptoms, suggesting they may relate to dysfunction of different neuronal systems. The SH manoeuvre should be part of the evaluation of MS patients considered for surgery of tremor. © 2003 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Emmanuelle Waubant MD</name><affiliations><json:string>Federation de Neurologie, CHU Pitié Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Sophie Tezenas du Montcel MD, PhD</name><affiliations><json:string>Service d'Informatique Médicale, CHU Pitié Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Charles Jedynak MD</name><affiliations><json:string>Federation de Neurologie, CHU Pitié Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Michael Obadia MD</name><affiliations><json:string>Federation de Neurologie, CHU Pitié Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Hassan Hosseini MD</name><affiliations><json:string>Service de Neurologie, Hôpital Henri Mondor, Créteil, France</json:string></affiliations></json:item><json:item><name>Philippe Damier MD, PhD</name><affiliations><json:string>Federation de Neurologie, CHU Pitié Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Catherine Lubetzki MD, PhD</name><affiliations><json:string>Federation de Neurologie, CHU Pitié Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Yves Agid MD, PhD</name><affiliations><json:string>Federation de Neurologie, CHU Pitié Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Jean‐Denis Degos MD</name><affiliations><json:string>Service de Neurologie, Hôpital Henri Mondor, Créteil, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>tremor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cerebellar syndrome</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>rebound</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>multiple sclerosis</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The objective of this study is to define tremor and cerebellar dysfunction and determine whether kinetic and postural tremor correlate with cerebellar dysfunction in patients with multiple sclerosis (MS). Cerebellar symptoms such as dysmetria often interfere with tremor evaluation in MS. The Stewart‐Holmes (SH) manoeuvre, which has been recently quantified, may offer a selective evaluation of cerebellar dysfunction in such patients. Thirty‐two patients with definite MS and arm tremor were evaluated (simplified Fahn tremor scale for kinetic and postural tremor, finger‐to‐nose test, clinical SH manoeuvre, quantitative study of the SH manoeuvre). Median severity of kinetic and postural tremor on the most disabled side was, respectively, 2 (range 0–4) and 1.5 (range 0–4). Clinical SH scores were moderately correlated to quantified SH measures (r = 0.36, P > 0.05). Kinetic and postural tremors were strongly correlated (r = 0.73, P > 0.0001) but did not correlate with clinical or quantified SH scores. Patients with bilateral tremor had higher scores for quantified SH, and a trend to higher clinical SH and finger‐to‐nose scores than patients with unilateral tremor. Although clinically associated, cerebellar dysfunction and tremor may be partly independent symptoms, suggesting they may relate to dysfunction of different neuronal systems. 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Although clinically associated, cerebellar dysfunction and tremor may be partly independent symptoms, suggesting they may relate to dysfunction of different neuronal systems. 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number="1"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="15"></count><count type="wordTotal" number="3623"></count></countGroup><titleGroup><title type="main" xml:lang="en">Multiple sclerosis tremor and the Stewart‐Holmes manoeuvre</title><title type="short" xml:lang="en">Multiple Sclerosis Tremor</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Emmanuelle</givenNames><familyName>Waubant</familyName><degrees>MD</degrees></personName><contactDetails><email>waubant@itsa.ucsf.edu</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Sophie</givenNames><familyName>Tezenas du Montcel</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Charles</givenNames><familyName>Jedynak</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Michael</givenNames><familyName>Obadia</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Hassan</givenNames><familyName>Hosseini</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Philippe</givenNames><familyName>Damier</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Catherine</givenNames><familyName>Lubetzki</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Yves</givenNames><familyName>Agid</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af3" noteRef="#fn1"><personName><givenNames>Jean‐Denis</givenNames><familyName>Degos</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>Federation de Neurologie, CHU Pitié Salpêtrière, Paris, France</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="FR" type="organization"><unparsedAffiliation>Service d'Informatique Médicale, CHU Pitié Salpêtrière, Paris, France</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="FR" type="organization"><unparsedAffiliation>Service de Neurologie, Hôpital Henri Mondor, Créteil, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">tremor</keyword><keyword xml:id="kwd2">cerebellar syndrome</keyword><keyword xml:id="kwd3">rebound</keyword><keyword xml:id="kwd4">multiple sclerosis</keyword></keywordGroup><fundingInfo><fundingAgency>Parisian Directorate of Clinical Research (DRC)</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The objective of this study is to define tremor and cerebellar dysfunction and determine whether kinetic and postural tremor correlate with cerebellar dysfunction in patients with multiple sclerosis (MS). Cerebellar symptoms such as dysmetria often interfere with tremor evaluation in MS. The Stewart‐Holmes (SH) manoeuvre, which has been recently quantified, may offer a selective evaluation of cerebellar dysfunction in such patients. Thirty‐two patients with definite MS and arm tremor were evaluated (simplified Fahn tremor scale for kinetic and postural tremor, finger‐to‐nose test, clinical SH manoeuvre, quantitative study of the SH manoeuvre). Median severity of kinetic and postural tremor on the most disabled side was, respectively, 2 (range 0–4) and 1.5 (range 0–4). Clinical SH scores were moderately correlated to quantified SH measures (r = 0.36, <i>P</i> < 0.05). Kinetic and postural tremors were strongly correlated (r = 0.73, <i>P</i> < 0.0001) but did not correlate with clinical or quantified SH scores. Patients with bilateral tremor had higher scores for quantified SH, and a trend to higher clinical SH and finger‐to‐nose scores than patients with unilateral tremor. Although clinically associated, cerebellar dysfunction and tremor may be partly independent symptoms, suggesting they may relate to dysfunction of different neuronal systems. The SH manoeuvre should be part of the evaluation of MS patients considered for surgery of tremor. © 2003 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Dr. Jean‐Denis Degos is deceased.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Multiple sclerosis tremor and the Stewart‐Holmes manoeuvre</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Multiple Sclerosis Tremor</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Multiple sclerosis tremor and the Stewart‐Holmes manoeuvre</title></titleInfo><name type="personal"><namePart type="given">Emmanuelle</namePart><namePart type="family">Waubant</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Federation de Neurologie, CHU Pitié Salpêtrière, Paris, France</affiliation><description>Correspondence: UCSF MS Center, 350 Parnassus Street, Suite 908, San Francisco, CA 94117</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sophie</namePart><namePart type="family">Tezenas du Montcel</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Service d'Informatique Médicale, CHU Pitié Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Charles</namePart><namePart type="family">Jedynak</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Federation de Neurologie, CHU Pitié Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Obadia</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Federation de Neurologie, CHU Pitié Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hassan</namePart><namePart type="family">Hosseini</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Service de Neurologie, Hôpital Henri Mondor, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Philippe</namePart><namePart type="family">Damier</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Federation de Neurologie, CHU Pitié Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Catherine</namePart><namePart type="family">Lubetzki</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Federation de Neurologie, CHU Pitié Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yves</namePart><namePart type="family">Agid</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Federation de Neurologie, CHU Pitié Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Denis</namePart><namePart type="family">Degos</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Service de Neurologie, Hôpital Henri Mondor, Créteil, France</affiliation><description>Dr. Jean‐Denis Degos is deceased.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2003-08</dateIssued><dateCaptured encoding="w3cdtf">2002-05-14</dateCaptured><dateValid encoding="w3cdtf">2003-01-06</dateValid><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">3</extent><extent unit="references">15</extent><extent unit="words">3623</extent></physicalDescription><abstract lang="en">The objective of this study is to define tremor and cerebellar dysfunction and determine whether kinetic and postural tremor correlate with cerebellar dysfunction in patients with multiple sclerosis (MS). Cerebellar symptoms such as dysmetria often interfere with tremor evaluation in MS. The Stewart‐Holmes (SH) manoeuvre, which has been recently quantified, may offer a selective evaluation of cerebellar dysfunction in such patients. Thirty‐two patients with definite MS and arm tremor were evaluated (simplified Fahn tremor scale for kinetic and postural tremor, finger‐to‐nose test, clinical SH manoeuvre, quantitative study of the SH manoeuvre). Median severity of kinetic and postural tremor on the most disabled side was, respectively, 2 (range 0–4) and 1.5 (range 0–4). Clinical SH scores were moderately correlated to quantified SH measures (r = 0.36, P < 0.05). Kinetic and postural tremors were strongly correlated (r = 0.73, P < 0.0001) but did not correlate with clinical or quantified SH scores. Patients with bilateral tremor had higher scores for quantified SH, and a trend to higher clinical SH and finger‐to‐nose scores than patients with unilateral tremor. Although clinically associated, cerebellar dysfunction and tremor may be partly independent symptoms, suggesting they may relate to dysfunction of different neuronal systems. The SH manoeuvre should be part of the evaluation of MS patients considered for surgery of tremor. © 2003 Movement Disorder Society</abstract><note type="funding">Parisian Directorate of Clinical Research (DRC)</note><subject lang="en"><genre>Keywords</genre><topic>tremor</topic><topic>cerebellar syndrome</topic><topic>rebound</topic><topic>multiple sclerosis</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>948</start><end>952</end><total>5</total></extent></part></relatedItem><identifier type="istex">3FDBF354FC85EDE1240F6C114E545BFB4C5AF720</identifier><identifier type="DOI">10.1002/mds.10454</identifier><identifier type="ArticleID">MDS10454</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2003 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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