Do enkephalins in basal ganglia mediate a physiological motor rest mechanism?
Identifieur interne : 000269 ( Istex/Corpus ); précédent : 000268; suivant : 000270Do enkephalins in basal ganglia mediate a physiological motor rest mechanism?
Auteurs : M. L. De Ceballos ; M. Baker ; S. Rose ; P. Jenner ; MarsdenSource :
- Movement Disorders [ 0885-3185 ] ; 1986.
English descriptors
- KwdEn :
Abstract
Thermal injury (30‐s immersion in water at 62°C) of one hind limb of rats caused a gradual withdrawal of the limb from use, such that after 1 week 50% of the animals walked on three legs. At 24 h following thermal lesion and at a time when the lesioned paw was still used for walking there was a reduction in met‐and leu‐enkephalin content in the periaqueductal grey (PAG) and bilateral reduction in leu‐enkephalin content of the globus pallidus, but no change in enkephalin levels in caudate‐putamen. One week following the lesion, animals exhibiting complete withdrawal of the injured limb, showed bilateral reduction of met‐ and leu‐enkephalin content of PAG. Both met‐ and leu‐enkephalin were bilaterally reduced in globus pallidus as was the met‐enkephalin content in caudate‐putamen. In each case the change was more marked in basal ganglia areas contralateral to the lesion. In animals lesioned 1 week previously and which did not use the injured limb, there was no change in the monoamine (or metabolite) content of caudate‐putamen or in the spontaneous or potassium‐evoked release of 3H‐dopamine from striatal slices. Thermal injury did not cause any general change in pain sensitivity and the time of change in pain threshold in the injured limb did not parallel the withdrawal of the affected limb from walking. The results suggest that after a thermal limb lesion, delayed changes in basal ganglia enkephalin content may be important in withdrawing the injured limb from the normal pattern of locomotion. Basal ganglia enkephalins may be involved in a physiological rest mechanism, which allows healing of the affected part.
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DOI: 10.1002/mds.870010402
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ISTEX:5B639AD929ED9CFA3FC59C428CB09C55E88AEBC0Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Do enkephalins in basal ganglia mediate a physiological motor rest mechanism?</title><author><name sortKey="De Ceballos, M L" sort="De Ceballos, M L" uniqKey="De Ceballos M" first="M. L." last="De Ceballos">M. L. De Ceballos</name><affiliation><mods:affiliation>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</mods:affiliation></affiliation></author><author><name sortKey="Baker, M" sort="Baker, M" uniqKey="Baker M" first="M." last="Baker">M. Baker</name><affiliation><mods:affiliation>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</mods:affiliation></affiliation></author><author><name sortKey="Rose, S" sort="Rose, S" uniqKey="Rose S" first="S." last="Rose">S. Rose</name><affiliation><mods:affiliation>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</mods:affiliation></affiliation></author><author><name sortKey="Jenner, P" sort="Jenner, P" uniqKey="Jenner P" first="P." last="Jenner">P. 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L." last="De Ceballos">M. L. De Ceballos</name><affiliation><mods:affiliation>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</mods:affiliation></affiliation></author><author><name sortKey="Baker, M" sort="Baker, M" uniqKey="Baker M" first="M." last="Baker">M. Baker</name><affiliation><mods:affiliation>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</mods:affiliation></affiliation></author><author><name sortKey="Rose, S" sort="Rose, S" uniqKey="Rose S" first="S." last="Rose">S. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1986">1986</date><biblScope unit="vol">1</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="223">223</biblScope><biblScope unit="page" to="233">233</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5B639AD929ED9CFA3FC59C428CB09C55E88AEBC0</idno><idno type="DOI">10.1002/mds.870010402</idno><idno type="ArticleID">MDS870010402</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal ganglia</term><term>Enkephalins</term><term>Locomotion</term><term>Rest mechanisms</term><term>Thermal injury</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Thermal injury (30‐s immersion in water at 62°C) of one hind limb of rats caused a gradual withdrawal of the limb from use, such that after 1 week 50% of the animals walked on three legs. At 24 h following thermal lesion and at a time when the lesioned paw was still used for walking there was a reduction in met‐and leu‐enkephalin content in the periaqueductal grey (PAG) and bilateral reduction in leu‐enkephalin content of the globus pallidus, but no change in enkephalin levels in caudate‐putamen. One week following the lesion, animals exhibiting complete withdrawal of the injured limb, showed bilateral reduction of met‐ and leu‐enkephalin content of PAG. Both met‐ and leu‐enkephalin were bilaterally reduced in globus pallidus as was the met‐enkephalin content in caudate‐putamen. In each case the change was more marked in basal ganglia areas contralateral to the lesion. In animals lesioned 1 week previously and which did not use the injured limb, there was no change in the monoamine (or metabolite) content of caudate‐putamen or in the spontaneous or potassium‐evoked release of 3H‐dopamine from striatal slices. Thermal injury did not cause any general change in pain sensitivity and the time of change in pain threshold in the injured limb did not parallel the withdrawal of the affected limb from walking. The results suggest that after a thermal limb lesion, delayed changes in basal ganglia enkephalin content may be important in withdrawing the injured limb from the normal pattern of locomotion. Basal ganglia enkephalins may be involved in a physiological rest mechanism, which allows healing of the affected part.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>M. L. de Ceballos</name><affiliations><json:string>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</json:string></affiliations></json:item><json:item><name>M. Baker</name><affiliations><json:string>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</json:string></affiliations></json:item><json:item><name>S. Rose</name><affiliations><json:string>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</json:string></affiliations></json:item><json:item><name>P. Jenner</name><affiliations><json:string>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</json:string></affiliations></json:item><json:item><name>Professor Marsden</name><affiliations><json:string>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Thermal injury</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Basal ganglia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Rest mechanisms</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Enkephalins</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Locomotion</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Thermal injury (30‐s immersion in water at 62°C) of one hind limb of rats caused a gradual withdrawal of the limb from use, such that after 1 week 50% of the animals walked on three legs. At 24 h following thermal lesion and at a time when the lesioned paw was still used for walking there was a reduction in met‐and leu‐enkephalin content in the periaqueductal grey (PAG) and bilateral reduction in leu‐enkephalin content of the globus pallidus, but no change in enkephalin levels in caudate‐putamen. One week following the lesion, animals exhibiting complete withdrawal of the injured limb, showed bilateral reduction of met‐ and leu‐enkephalin content of PAG. Both met‐ and leu‐enkephalin were bilaterally reduced in globus pallidus as was the met‐enkephalin content in caudate‐putamen. In each case the change was more marked in basal ganglia areas contralateral to the lesion. In animals lesioned 1 week previously and which did not use the injured limb, there was no change in the monoamine (or metabolite) content of caudate‐putamen or in the spontaneous or potassium‐evoked release of 3H‐dopamine from striatal slices. Thermal injury did not cause any general change in pain sensitivity and the time of change in pain threshold in the injured limb did not parallel the withdrawal of the affected limb from walking. The results suggest that after a thermal limb lesion, delayed changes in basal ganglia enkephalin content may be important in withdrawing the injured limb from the normal pattern of locomotion. 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L.</forename><surname>de Ceballos</surname></persName><affiliation>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</affiliation></author><author><persName><forename type="first">M.</forename><surname>Baker</surname></persName><affiliation>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</affiliation></author><author><persName><forename type="first">S.</forename><surname>Rose</surname></persName><affiliation>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</affiliation></author><author><persName><forename type="first">P.</forename><surname>Jenner</surname></persName><affiliation>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</affiliation></author><author><persName><surname>Marsden</surname><roleName type="degree">Professor</roleName></persName><note type="correspondence"><p>Correspondence: Department of Neurology, Institute of Psychiatry, De Crespigny Park, London SE5, 8AF U.K.</p></note><affiliation>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1986"></date><biblScope unit="vol">1</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="223">223</biblScope><biblScope unit="page" to="233">233</biblScope></imprint></monogr><idno type="istex">5B639AD929ED9CFA3FC59C428CB09C55E88AEBC0</idno><idno type="DOI">10.1002/mds.870010402</idno><idno type="ArticleID">MDS870010402</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1986</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Thermal injury (30‐s immersion in water at 62°C) of one hind limb of rats caused a gradual withdrawal of the limb from use, such that after 1 week 50% of the animals walked on three legs. At 24 h following thermal lesion and at a time when the lesioned paw was still used for walking there was a reduction in met‐and leu‐enkephalin content in the periaqueductal grey (PAG) and bilateral reduction in leu‐enkephalin content of the globus pallidus, but no change in enkephalin levels in caudate‐putamen. One week following the lesion, animals exhibiting complete withdrawal of the injured limb, showed bilateral reduction of met‐ and leu‐enkephalin content of PAG. Both met‐ and leu‐enkephalin were bilaterally reduced in globus pallidus as was the met‐enkephalin content in caudate‐putamen. In each case the change was more marked in basal ganglia areas contralateral to the lesion. In animals lesioned 1 week previously and which did not use the injured limb, there was no change in the monoamine (or metabolite) content of caudate‐putamen or in the spontaneous or potassium‐evoked release of 3H‐dopamine from striatal slices. Thermal injury did not cause any general change in pain sensitivity and the time of change in pain threshold in the injured limb did not parallel the withdrawal of the affected limb from walking. The results suggest that after a thermal limb lesion, delayed changes in basal ganglia enkephalin content may be important in withdrawing the injured limb from the normal pattern of locomotion. Basal ganglia enkephalins may be involved in a physiological rest mechanism, which allows healing of the affected part.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Thermal injury</term></item><item><term>Basal ganglia</term></item><item><term>Rest mechanisms</term></item><item><term>Enkephalins</term></item><item><term>Locomotion</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Original Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1986">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/5B639AD929ED9CFA3FC59C428CB09C55E88AEBC0/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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L.</givenNames><familyName>de Ceballos</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>M.</givenNames><familyName>Baker</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>S.</givenNames><familyName>Rose</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>P.</givenNames><familyName>Jenner</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><honorifics>Professor</honorifics><givenNames>C. D.</givenNames><familyName>Marsden</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="GB" type="organization"><unparsedAffiliation>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Thermal injury</keyword><keyword xml:id="kwd2">Basal ganglia</keyword><keyword xml:id="kwd3">Rest mechanisms</keyword><keyword xml:id="kwd4">Enkephalins</keyword><keyword xml:id="kwd5">Locomotion</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Thermal injury (30‐s immersion in water at 62°C) of one hind limb of rats caused a gradual withdrawal of the limb from use, such that after 1 week 50% of the animals walked on three legs. At 24 h following thermal lesion and at a time when the lesioned paw was still used for walking there was a reduction in <i>met</i>‐and <i>leu</i>‐enkephalin content in the periaqueductal grey (PAG) and bilateral reduction in <i>leu</i>‐enkephalin content of the globus pallidus, but no change in enkephalin levels in caudate‐putamen. One week following the lesion, animals exhibiting complete withdrawal of the injured limb, showed bilateral reduction of <i>met</i>‐ and <i>leu</i>‐enkephalin content of PAG. Both <i>met</i>‐ and <i>leu</i>‐enkephalin were bilaterally reduced in globus pallidus as was the <i>met</i>‐enkephalin content in caudate‐putamen. In each case the change was more marked in basal ganglia areas contralateral to the lesion. In animals lesioned 1 week previously and which did not use the injured limb, there was no change in the monoamine (or metabolite) content of caudate‐putamen or in the spontaneous or potassium‐evoked release of <sup>3</sup>H‐dopamine from striatal slices. Thermal injury did not cause any general change in pain sensitivity and the time of change in pain threshold in the injured limb did not parallel the withdrawal of the affected limb from walking. The results suggest that after a thermal limb lesion, delayed changes in basal ganglia enkephalin content may be important in withdrawing the injured limb from the normal pattern of locomotion. Basal ganglia enkephalins may be involved in a physiological rest mechanism, which allows healing of the affected part.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Do enkephalins in basal ganglia mediate a physiological motor rest mechanism?</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>ENKEPHALINS IN BASAL GANGLIA</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Do enkephalins in basal ganglia mediate a physiological motor rest mechanism?</title></titleInfo><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">de Ceballos</namePart><affiliation>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Baker</namePart><affiliation>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Rose</namePart><affiliation>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Jenner</namePart><affiliation>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Professor</namePart><namePart type="family">Marsden</namePart><affiliation>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, U.K.</affiliation><description>Correspondence: Department of Neurology, Institute of Psychiatry, De Crespigny Park, London SE5, 8AF U.K.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1986</dateIssued><copyrightDate encoding="w3cdtf">1986</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">4</extent><extent unit="tables">1</extent><extent unit="references">21</extent></physicalDescription><abstract lang="en">Thermal injury (30‐s immersion in water at 62°C) of one hind limb of rats caused a gradual withdrawal of the limb from use, such that after 1 week 50% of the animals walked on three legs. At 24 h following thermal lesion and at a time when the lesioned paw was still used for walking there was a reduction in met‐and leu‐enkephalin content in the periaqueductal grey (PAG) and bilateral reduction in leu‐enkephalin content of the globus pallidus, but no change in enkephalin levels in caudate‐putamen. One week following the lesion, animals exhibiting complete withdrawal of the injured limb, showed bilateral reduction of met‐ and leu‐enkephalin content of PAG. Both met‐ and leu‐enkephalin were bilaterally reduced in globus pallidus as was the met‐enkephalin content in caudate‐putamen. In each case the change was more marked in basal ganglia areas contralateral to the lesion. In animals lesioned 1 week previously and which did not use the injured limb, there was no change in the monoamine (or metabolite) content of caudate‐putamen or in the spontaneous or potassium‐evoked release of 3H‐dopamine from striatal slices. Thermal injury did not cause any general change in pain sensitivity and the time of change in pain threshold in the injured limb did not parallel the withdrawal of the affected limb from walking. The results suggest that after a thermal limb lesion, delayed changes in basal ganglia enkephalin content may be important in withdrawing the injured limb from the normal pattern of locomotion. Basal ganglia enkephalins may be involved in a physiological rest mechanism, which allows healing of the affected part.</abstract><subject lang="en"><genre>Keywords</genre><topic>Thermal injury</topic><topic>Basal ganglia</topic><topic>Rest mechanisms</topic><topic>Enkephalins</topic><topic>Locomotion</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>223</start><end>233</end><total>11</total></extent></part></relatedItem><identifier type="istex">5B639AD929ED9CFA3FC59C428CB09C55E88AEBC0</identifier><identifier type="DOI">10.1002/mds.870010402</identifier><identifier type="ArticleID">MDS870010402</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1986 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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