Further studies on periodic limb movement disorder and restless legs syndrome in children with attention‐deficit hyperactivity disorder
Identifieur interne : 000160 ( Istex/Corpus ); précédent : 000159; suivant : 000161Further studies on periodic limb movement disorder and restless legs syndrome in children with attention‐deficit hyperactivity disorder
Auteurs : Daniel L. Picchietti ; Donna J. Underwood ; William A. Farris ; Arthur S. Walters ; Mona M. Shah ; Ronald E. Dahl ; Laura J. Trubnick ; Michele A. Bertocci ; Mary Wagner ; Wayne A. HeningSource :
- Movement Disorders [ 0885-3185 ] ; 1999-11.
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- KwdEn :
Abstract
Fourteen consecutive children who were newly diagnosed with attention‐deficit hyperactivity disorder (ADHD) and who had never been exposed to stimulants and 10 control children without ADHD underwent polysomnographic studies to quantify Periodic Limb Movements in Sleep (PLMS) and arousals. Parents commonly gave both false‐negative and false‐positive reports of PLMS in their children, and a sleep study was necessary to confirm their presence or absence. The prevalence of PLMS on polysomnography was higher in the children with ADHD than in the control subjects. Nine of 14 (64%) children with ADHD had PLMS at a rate of >5 per hour of sleep compared with none of the control children (p <0.0015). Three of 14 children with ADHD (21%) had PLMS at a rate of >20 per hour of sleep. Many of the PLMS in the children with ADHD were associated with arousals. Historical sleep times were less for children with ADHD. The children with ADHD who had PLMS chronically got 43 minutes less sleep at home than the control subjects (p = 0.0091). All nine children with ADHD who had a PLMS index of >5 per hour of sleep had a long‐standing clinical history of sleep onset problems (>30 minutes) and/or maintenance problems (more than two full awakenings nightly) thus meeting the criteria for Periodic Limb Movement Disorder (PLMD). None of the control children had a clinical history of sleep onset or maintenance problems. The parents of the children with ADHD were more likely to have restless legs syndrome (RLS) than the parents of the control children. Twenty‐five of 28 biologic parents of the children with ADHD and all of the biologic parents of the control children were reached for interview. Eight of twenty‐five parents of the children with ADHD (32%) had symptoms of RLS as opposed to none of the control parents (p = 0.011). PLMS may directly lead to symptoms of ADHD through the mechanism of sleep disruption. Alternative explanations for the association between ADHD and RLS/PLMS are that they are genetically linked, they share a common dopaminergic deficit, or both.
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DOI: 10.1002/1531-8257(199911)14:6<1000::AID-MDS1014>3.0.CO;2-P
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Picchietti</name><affiliation><mods:affiliation>Pediatric Neurology, Carle Clinic, Urbana, Illinois</mods:affiliation></affiliation><affiliation><mods:affiliation>University of Illinois College of Medicine at Urbana‐Champaign</mods:affiliation></affiliation></author><author><name sortKey="Underwood, Donna J" sort="Underwood, Donna J" uniqKey="Underwood D" first="Donna J." last="Underwood">Donna J. Underwood</name><affiliation><mods:affiliation>University of Illinois College of Medicine at Urbana‐Champaign</mods:affiliation></affiliation><affiliation><mods:affiliation>Medical Research, Carle Foundation, Urbana, Illinois</mods:affiliation></affiliation></author><author><name sortKey="Farris, William A" sort="Farris, William A" uniqKey="Farris W" first="William A." last="Farris">William A. Farris</name><affiliation><mods:affiliation>Pediatric Neurology, Carle Clinic, Urbana, Illinois</mods:affiliation></affiliation><affiliation><mods:affiliation>University of Illinois College of Medicine at Urbana‐Champaign</mods:affiliation></affiliation></author><author><name sortKey="Walters, Arthur S" sort="Walters, Arthur S" uniqKey="Walters A" first="Arthur S." last="Walters">Arthur S. Walters</name><affiliation><mods:affiliation>Movement Disorder Group, Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey, and the Neurology Service, VA Medical Center, Lyons, New Jersey</mods:affiliation></affiliation></author><author><name sortKey="Shah, Mona M" sort="Shah, Mona M" uniqKey="Shah M" first="Mona M." last="Shah">Mona M. Shah</name><affiliation><mods:affiliation>Rutgers University College of Pharmacy, Piscataway, New Jersey, U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Dahl, Ronald E" sort="Dahl, Ronald E" uniqKey="Dahl R" first="Ronald E." last="Dahl">Ronald E. Dahl</name><affiliation><mods:affiliation>Child and Adolescent Sleep Laboratory and Departments of Psychiatry and Pediatrics, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania</mods:affiliation></affiliation></author><author><name sortKey="Trubnick, Laura J" sort="Trubnick, Laura J" uniqKey="Trubnick L" first="Laura J." last="Trubnick">Laura J. Trubnick</name><affiliation><mods:affiliation>Child and Adolescent Sleep Laboratory and Departments of Psychiatry and Pediatrics, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania</mods:affiliation></affiliation></author><author><name sortKey="Bertocci, Michele A" sort="Bertocci, Michele A" uniqKey="Bertocci M" first="Michele A." last="Bertocci">Michele A. Bertocci</name><affiliation><mods:affiliation>Child and Adolescent Sleep Laboratory and Departments of Psychiatry and Pediatrics, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania</mods:affiliation></affiliation></author><author><name sortKey="Wagner, Mary" sort="Wagner, Mary" uniqKey="Wagner M" first="Mary" last="Wagner">Mary Wagner</name><affiliation><mods:affiliation>Rutgers University College of Pharmacy, Piscataway, New Jersey, U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Hening, Wayne A" sort="Hening, Wayne A" uniqKey="Hening W" first="Wayne A." last="Hening">Wayne A. Hening</name><affiliation><mods:affiliation>Movement Disorder Group, Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey, and the Neurology Service, VA Medical Center, Lyons, New Jersey</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="1999-11">1999-11</date><biblScope unit="vol">14</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1000">1000</biblScope><biblScope unit="page" to="1007">1007</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">9939D5E54B7E12139A7BB54B764A30EB57EC3F0B</idno><idno type="DOI">10.1002/1531-8257(199911)14:6<1000::AID-MDS1014>3.0.CO;2-P</idno><idno type="ArticleID">MDS1014</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Attention‐deficit hyperactivity disorder (ADHD)</term><term>Periodic Limb Movement Disorder (PLMD)</term><term>Periodic Limb Movements in Sleep (PLMS)</term><term>Polysomnography</term><term>Restless legs syndrome(RLS)</term><term>Sleep disorders</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fourteen consecutive children who were newly diagnosed with attention‐deficit hyperactivity disorder (ADHD) and who had never been exposed to stimulants and 10 control children without ADHD underwent polysomnographic studies to quantify Periodic Limb Movements in Sleep (PLMS) and arousals. Parents commonly gave both false‐negative and false‐positive reports of PLMS in their children, and a sleep study was necessary to confirm their presence or absence. The prevalence of PLMS on polysomnography was higher in the children with ADHD than in the control subjects. Nine of 14 (64%) children with ADHD had PLMS at a rate of >5 per hour of sleep compared with none of the control children (p <0.0015). Three of 14 children with ADHD (21%) had PLMS at a rate of >20 per hour of sleep. Many of the PLMS in the children with ADHD were associated with arousals. Historical sleep times were less for children with ADHD. The children with ADHD who had PLMS chronically got 43 minutes less sleep at home than the control subjects (p = 0.0091). All nine children with ADHD who had a PLMS index of >5 per hour of sleep had a long‐standing clinical history of sleep onset problems (>30 minutes) and/or maintenance problems (more than two full awakenings nightly) thus meeting the criteria for Periodic Limb Movement Disorder (PLMD). None of the control children had a clinical history of sleep onset or maintenance problems. The parents of the children with ADHD were more likely to have restless legs syndrome (RLS) than the parents of the control children. Twenty‐five of 28 biologic parents of the children with ADHD and all of the biologic parents of the control children were reached for interview. Eight of twenty‐five parents of the children with ADHD (32%) had symptoms of RLS as opposed to none of the control parents (p = 0.011). PLMS may directly lead to symptoms of ADHD through the mechanism of sleep disruption. Alternative explanations for the association between ADHD and RLS/PLMS are that they are genetically linked, they share a common dopaminergic deficit, or both.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Daniel L. Picchietti MD</name><affiliations><json:string>Pediatric Neurology, Carle Clinic, Urbana, Illinois</json:string><json:string>University of Illinois College of Medicine at Urbana‐Champaign</json:string></affiliations></json:item><json:item><name>Donna J. Underwood MS</name><affiliations><json:string>University of Illinois College of Medicine at Urbana‐Champaign</json:string><json:string>Medical Research, Carle Foundation, Urbana, Illinois</json:string></affiliations></json:item><json:item><name>William A. Farris MD</name><affiliations><json:string>Pediatric Neurology, Carle Clinic, Urbana, Illinois</json:string><json:string>University of Illinois College of Medicine at Urbana‐Champaign</json:string></affiliations></json:item><json:item><name>Arthur S. Walters MD</name><affiliations><json:string>Movement Disorder Group, Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey, and the Neurology Service, VA Medical Center, Lyons, New Jersey</json:string></affiliations></json:item><json:item><name>Mona M. Shah</name><affiliations><json:string>Rutgers University College of Pharmacy, Piscataway, New Jersey, U.S.A.</json:string></affiliations></json:item><json:item><name>Ronald E. Dahl MD</name><affiliations><json:string>Child and Adolescent Sleep Laboratory and Departments of Psychiatry and Pediatrics, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania</json:string></affiliations></json:item><json:item><name>Laura J. Trubnick BS, RPsgT</name><affiliations><json:string>Child and Adolescent Sleep Laboratory and Departments of Psychiatry and Pediatrics, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania</json:string></affiliations></json:item><json:item><name>Michele A. Bertocci MA, RPsgT</name><affiliations><json:string>Child and Adolescent Sleep Laboratory and Departments of Psychiatry and Pediatrics, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania</json:string></affiliations></json:item><json:item><name>Mary Wagner PharmD</name><affiliations><json:string>Rutgers University College of Pharmacy, Piscataway, New Jersey, U.S.A.</json:string></affiliations></json:item><json:item><name>Wayne A. Hening MD, PhD</name><affiliations><json:string>Movement Disorder Group, Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey, and the Neurology Service, VA Medical Center, Lyons, New Jersey</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Restless legs syndrome(RLS)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Periodic Limb Movements in Sleep (PLMS)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Periodic Limb Movement Disorder (PLMD)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Attention‐deficit hyperactivity disorder (ADHD)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Sleep disorders</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Polysomnography</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Fourteen consecutive children who were newly diagnosed with attention‐deficit hyperactivity disorder (ADHD) and who had never been exposed to stimulants and 10 control children without ADHD underwent polysomnographic studies to quantify Periodic Limb Movements in Sleep (PLMS) and arousals. Parents commonly gave both false‐negative and false‐positive reports of PLMS in their children, and a sleep study was necessary to confirm their presence or absence. The prevalence of PLMS on polysomnography was higher in the children with ADHD than in the control subjects. Nine of 14 (64%) children with ADHD had PLMS at a rate of >5 per hour of sleep compared with none of the control children (p >0.0015). Three of 14 children with ADHD (21%) had PLMS at a rate of >20 per hour of sleep. Many of the PLMS in the children with ADHD were associated with arousals. Historical sleep times were less for children with ADHD. The children with ADHD who had PLMS chronically got 43 minutes less sleep at home than the control subjects (p = 0.0091). All nine children with ADHD who had a PLMS index of >5 per hour of sleep had a long‐standing clinical history of sleep onset problems (>30 minutes) and/or maintenance problems (more than two full awakenings nightly) thus meeting the criteria for Periodic Limb Movement Disorder (PLMD). None of the control children had a clinical history of sleep onset or maintenance problems. The parents of the children with ADHD were more likely to have restless legs syndrome (RLS) than the parents of the control children. Twenty‐five of 28 biologic parents of the children with ADHD and all of the biologic parents of the control children were reached for interview. Eight of twenty‐five parents of the children with ADHD (32%) had symptoms of RLS as opposed to none of the control parents (p = 0.011). PLMS may directly lead to symptoms of ADHD through the mechanism of sleep disruption. Alternative explanations for the association between ADHD and RLS/PLMS are that they are genetically linked, they share a common dopaminergic deficit, or both.</abstract><qualityIndicators><score>8</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>2074</abstractCharCount><pdfWordCount>5414</pdfWordCount><pdfCharCount>33620</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>341</abstractWordCount></qualityIndicators><title>Further studies on periodic limb movement disorder and restless legs syndrome in children with attention‐deficit hyperactivity disorder</title><genre><json:string>Serial article</json:string></genre><host><volume>14</volume><pages><total>8</total><last>1007</last><first>1000</first></pages><issn><json:string>0885-3185</json:string></issn><issue>6</issue><subject><json:item><value>Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>1999</publicationDate><copyrightDate>1999</copyrightDate><doi><json:string>10.1002/1531-8257(199911)14:6>1000::AID-MDS1014>3.0.CO;2-P</json:string></doi><id>9939D5E54B7E12139A7BB54B764A30EB57EC3F0B</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/9939D5E54B7E12139A7BB54B764A30EB57EC3F0B/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/9939D5E54B7E12139A7BB54B764A30EB57EC3F0B/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/9939D5E54B7E12139A7BB54B764A30EB57EC3F0B/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Further studies on periodic limb movement disorder and restless legs syndrome in children with attention‐deficit hyperactivity disorder</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><availability><p>John Wiley & Sons, Inc.</p></availability><date>1999</date></publicationStmt><notesStmt><note>American Academy of Pediatric Research in Pediatric Practice Fund</note><note>VA Merit Review</note><note>University of Illinois College of Medicine at Urbana‐Champaign</note><note>MH - No. 41712;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Further studies on periodic limb movement disorder and restless legs syndrome in children with attention‐deficit hyperactivity disorder</title><author><persName><forename type="first">Daniel L.</forename><surname>Picchietti</surname><roleName type="degree">MD</roleName></persName><affiliation>Pediatric Neurology, Carle Clinic, Urbana, Illinois</affiliation><affiliation>University of Illinois College of Medicine at Urbana‐Champaign</affiliation></author><author><persName><forename type="first">Donna J.</forename><surname>Underwood</surname><roleName type="degree">MS</roleName></persName><affiliation>University of Illinois College of Medicine at Urbana‐Champaign</affiliation><affiliation>Medical Research, Carle Foundation, Urbana, Illinois</affiliation></author><author><persName><forename type="first">William A.</forename><surname>Farris</surname><roleName type="degree">MD</roleName></persName><affiliation>Pediatric Neurology, Carle Clinic, Urbana, Illinois</affiliation><affiliation>University of Illinois College of Medicine at Urbana‐Champaign</affiliation></author><author><persName><forename type="first">Arthur S.</forename><surname>Walters</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: New Jersey Neuroscience Institute, JFK Medical Center, 65 James Street, Edison, NJ 08818, U.S.A.</p></note><affiliation>Movement Disorder Group, Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey, and the Neurology Service, VA Medical Center, Lyons, New Jersey</affiliation></author><author><persName><forename type="first">Mona M.</forename><surname>Shah</surname></persName><affiliation>Rutgers University College of Pharmacy, Piscataway, New Jersey, U.S.A.</affiliation></author><author><persName><forename type="first">Ronald E.</forename><surname>Dahl</surname><roleName type="degree">MD</roleName></persName><affiliation>Child and Adolescent Sleep Laboratory and Departments of Psychiatry and Pediatrics, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania</affiliation></author><author><persName><forename type="first">Laura J.</forename><surname>Trubnick</surname><roleName type="degree">BS, RPsgT</roleName></persName><affiliation>Child and Adolescent Sleep Laboratory and Departments of Psychiatry and Pediatrics, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania</affiliation></author><author><persName><forename type="first">Michele A.</forename><surname>Bertocci</surname><roleName type="degree">MA, RPsgT</roleName></persName><affiliation>Child and Adolescent Sleep Laboratory and Departments of Psychiatry and Pediatrics, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania</affiliation></author><author><persName><forename type="first">Mary</forename><surname>Wagner</surname><roleName type="degree">PharmD</roleName></persName><affiliation>Rutgers University College of Pharmacy, Piscataway, New Jersey, U.S.A.</affiliation></author><author><persName><forename type="first">Wayne A.</forename><surname>Hening</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Movement Disorder Group, Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey, and the Neurology Service, VA Medical Center, Lyons, New Jersey</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="1999-11"></date><biblScope unit="vol">14</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1000">1000</biblScope><biblScope unit="page" to="1007">1007</biblScope></imprint></monogr><idno type="istex">9939D5E54B7E12139A7BB54B764A30EB57EC3F0B</idno><idno type="DOI">10.1002/1531-8257(199911)14:6<1000::AID-MDS1014>3.0.CO;2-P</idno><idno type="ArticleID">MDS1014</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1999</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Fourteen consecutive children who were newly diagnosed with attention‐deficit hyperactivity disorder (ADHD) and who had never been exposed to stimulants and 10 control children without ADHD underwent polysomnographic studies to quantify Periodic Limb Movements in Sleep (PLMS) and arousals. Parents commonly gave both false‐negative and false‐positive reports of PLMS in their children, and a sleep study was necessary to confirm their presence or absence. The prevalence of PLMS on polysomnography was higher in the children with ADHD than in the control subjects. Nine of 14 (64%) children with ADHD had PLMS at a rate of >5 per hour of sleep compared with none of the control children (p <0.0015). Three of 14 children with ADHD (21%) had PLMS at a rate of >20 per hour of sleep. Many of the PLMS in the children with ADHD were associated with arousals. Historical sleep times were less for children with ADHD. The children with ADHD who had PLMS chronically got 43 minutes less sleep at home than the control subjects (p = 0.0091). All nine children with ADHD who had a PLMS index of >5 per hour of sleep had a long‐standing clinical history of sleep onset problems (>30 minutes) and/or maintenance problems (more than two full awakenings nightly) thus meeting the criteria for Periodic Limb Movement Disorder (PLMD). None of the control children had a clinical history of sleep onset or maintenance problems. The parents of the children with ADHD were more likely to have restless legs syndrome (RLS) than the parents of the control children. Twenty‐five of 28 biologic parents of the children with ADHD and all of the biologic parents of the control children were reached for interview. Eight of twenty‐five parents of the children with ADHD (32%) had symptoms of RLS as opposed to none of the control parents (p = 0.011). PLMS may directly lead to symptoms of ADHD through the mechanism of sleep disruption. Alternative explanations for the association between ADHD and RLS/PLMS are that they are genetically linked, they share a common dopaminergic deficit, or both.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Restless legs syndrome(RLS)</term></item><item><term>Periodic Limb Movements in Sleep (PLMS)</term></item><item><term>Periodic Limb Movement Disorder (PLMD)</term></item><item><term>Attention‐deficit hyperactivity disorder (ADHD)</term></item><item><term>Sleep disorders</term></item><item><term>Polysomnography</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999-01-11">Received</change><change when="1999-07-22">Registration</change><change when="1999-11">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/9939D5E54B7E12139A7BB54B764A30EB57EC3F0B/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Inc.</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="60"><doi origin="wiley" registered="yes">10.1002/1531-8257(199911)14:6<>1.0.CO;2-Q</doi><numberingGroup><numbering type="journalVolume" number="14">14</numbering><numbering type="journalIssue">6</numbering></numberingGroup><coverDate startDate="1999-11">November 1999</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="14" status="forIssue"><doi origin="wiley" registered="yes">10.1002/1531-8257(199911)14:6<1000::AID-MDS1014>3.0.CO;2-P</doi><idGroup><id type="unit" value="MDS1014"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Article</title><title type="tocHeading1">Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 1999 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="1999-01-11"></event><event type="manuscriptRevised" date="1999-06-02"></event><event type="manuscriptAccepted" date="1999-07-22"></event><event type="firstOnline" date="2001-01-25"></event><event type="publishedOnlineFinalForm" date="2001-01-25"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1000</numbering><numbering type="pageLast">1007</numbering></numberingGroup><correspondenceTo>New Jersey Neuroscience Institute, JFK Medical Center, 65 James Street, Edison, NJ 08818, U.S.A.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS1014.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="63"></count><count type="wordTotal" number="5259"></count></countGroup><titleGroup><title type="main" xml:lang="en">Further studies on periodic limb movement disorder and restless legs syndrome in children with attention‐deficit hyperactivity disorder</title><title type="short" xml:lang="en">Movement Disorders and Restless Legs Syndrome in Children</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Daniel L.</givenNames><familyName>Picchietti</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2 #af3"><personName><givenNames>Donna J.</givenNames><familyName>Underwood</familyName><degrees>MS</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>William A.</givenNames><familyName>Farris</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4" corresponding="yes"><personName><givenNames>Arthur S.</givenNames><familyName>Walters</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Mona M.</givenNames><familyName>Shah</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Ronald E.</givenNames><familyName>Dahl</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Laura J.</givenNames><familyName>Trubnick</familyName><degrees>BS, RPsgT</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Michele A.</givenNames><familyName>Bertocci</familyName><degrees>MA, RPsgT</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Mary</givenNames><familyName>Wagner</familyName><degrees>PharmD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Wayne A.</givenNames><familyName>Hening</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Pediatric Neurology, Carle Clinic, Urbana, Illinois</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>University of Illinois College of Medicine at Urbana‐Champaign</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Medical Research, Carle Foundation, Urbana, Illinois</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Movement Disorder Group, Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey, and the Neurology Service, VA Medical Center, Lyons, New Jersey</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="US" type="organization"><unparsedAffiliation>Child and Adolescent Sleep Laboratory and Departments of Psychiatry and Pediatrics, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="US" type="organization"><unparsedAffiliation>Rutgers University College of Pharmacy, Piscataway, New Jersey, U.S.A.</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Restless legs syndrome(RLS)</keyword><keyword xml:id="kwd2">Periodic Limb Movements in Sleep (PLMS)</keyword><keyword xml:id="kwd3">Periodic Limb Movement Disorder (PLMD)</keyword><keyword xml:id="kwd4">Attention‐deficit hyperactivity disorder (ADHD)</keyword><keyword xml:id="kwd5">Sleep disorders</keyword><keyword xml:id="kwd6">Polysomnography</keyword></keywordGroup><fundingInfo><fundingAgency>American Academy of Pediatric Research in Pediatric Practice Fund</fundingAgency></fundingInfo><fundingInfo><fundingAgency>VA Merit Review</fundingAgency></fundingInfo><fundingInfo><fundingAgency>University of Illinois College of Medicine at Urbana‐Champaign</fundingAgency></fundingInfo><fundingInfo><fundingAgency>MH</fundingAgency><fundingNumber>41712</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Fourteen consecutive children who were newly diagnosed with attention‐deficit hyperactivity disorder (ADHD) and who had never been exposed to stimulants and 10 control children without ADHD underwent polysomnographic studies to quantify Periodic Limb Movements in Sleep (PLMS) and arousals. Parents commonly gave both false‐negative and false‐positive reports of PLMS in their children, and a sleep study was necessary to confirm their presence or absence. The prevalence of PLMS on polysomnography was higher in the children with ADHD than in the control subjects. Nine of 14 (64%) children with ADHD had PLMS at a rate of >5 per hour of sleep compared with none of the control children (p <0.0015). Three of 14 children with ADHD (21%) had PLMS at a rate of >20 per hour of sleep. Many of the PLMS in the children with ADHD were associated with arousals. Historical sleep times were less for children with ADHD. The children with ADHD who had PLMS chronically got 43 minutes less sleep at home than the control subjects (p = 0.0091). All nine children with ADHD who had a PLMS index of >5 per hour of sleep had a long‐standing clinical history of sleep onset problems (>30 minutes) and/or maintenance problems (more than two full awakenings nightly) thus meeting the criteria for Periodic Limb Movement Disorder (PLMD). None of the control children had a clinical history of sleep onset or maintenance problems. The parents of the children with ADHD were more likely to have restless legs syndrome (RLS) than the parents of the control children. Twenty‐five of 28 biologic parents of the children with ADHD and all of the biologic parents of the control children were reached for interview. Eight of twenty‐five parents of the children with ADHD (32%) had symptoms of RLS as opposed to none of the control parents (p = 0.011). PLMS may directly lead to symptoms of ADHD through the mechanism of sleep disruption. Alternative explanations for the association between ADHD and RLS/PLMS are that they are genetically linked, they share a common dopaminergic deficit, or both.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Further studies on periodic limb movement disorder and restless legs syndrome in children with attention‐deficit hyperactivity disorder</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Movement Disorders and Restless Legs Syndrome in Children</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Further studies on periodic limb movement disorder and restless legs syndrome in children with attention‐deficit hyperactivity disorder</title></titleInfo><name type="personal"><namePart type="given">Daniel L.</namePart><namePart type="family">Picchietti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Pediatric Neurology, Carle Clinic, Urbana, Illinois</affiliation><affiliation>University of Illinois College of Medicine at Urbana‐Champaign</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Donna J.</namePart><namePart type="family">Underwood</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>University of Illinois College of Medicine at Urbana‐Champaign</affiliation><affiliation>Medical Research, Carle Foundation, Urbana, Illinois</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">William A.</namePart><namePart type="family">Farris</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Pediatric Neurology, Carle Clinic, Urbana, Illinois</affiliation><affiliation>University of Illinois College of Medicine at Urbana‐Champaign</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Arthur S.</namePart><namePart type="family">Walters</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorder Group, Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey, and the Neurology Service, VA Medical Center, Lyons, New Jersey</affiliation><description>Correspondence: New Jersey Neuroscience Institute, JFK Medical Center, 65 James Street, Edison, NJ 08818, U.S.A.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mona M.</namePart><namePart type="family">Shah</namePart><affiliation>Rutgers University College of Pharmacy, Piscataway, New Jersey, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ronald E.</namePart><namePart type="family">Dahl</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Child and Adolescent Sleep Laboratory and Departments of Psychiatry and Pediatrics, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laura J.</namePart><namePart type="family">Trubnick</namePart><namePart type="termsOfAddress">BS, RPsgT</namePart><affiliation>Child and Adolescent Sleep Laboratory and Departments of Psychiatry and Pediatrics, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michele A.</namePart><namePart type="family">Bertocci</namePart><namePart type="termsOfAddress">MA, RPsgT</namePart><affiliation>Child and Adolescent Sleep Laboratory and Departments of Psychiatry and Pediatrics, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mary</namePart><namePart type="family">Wagner</namePart><namePart type="termsOfAddress">PharmD</namePart><affiliation>Rutgers University College of Pharmacy, Piscataway, New Jersey, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wayne A.</namePart><namePart type="family">Hening</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Movement Disorder Group, Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey, and the Neurology Service, VA Medical Center, Lyons, New Jersey</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">1999-11</dateIssued><dateCaptured encoding="w3cdtf">1999-01-11</dateCaptured><dateValid encoding="w3cdtf">1999-07-22</dateValid><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">63</extent><extent unit="words">5259</extent></physicalDescription><abstract lang="en">Fourteen consecutive children who were newly diagnosed with attention‐deficit hyperactivity disorder (ADHD) and who had never been exposed to stimulants and 10 control children without ADHD underwent polysomnographic studies to quantify Periodic Limb Movements in Sleep (PLMS) and arousals. Parents commonly gave both false‐negative and false‐positive reports of PLMS in their children, and a sleep study was necessary to confirm their presence or absence. The prevalence of PLMS on polysomnography was higher in the children with ADHD than in the control subjects. Nine of 14 (64%) children with ADHD had PLMS at a rate of >5 per hour of sleep compared with none of the control children (p <0.0015). Three of 14 children with ADHD (21%) had PLMS at a rate of >20 per hour of sleep. Many of the PLMS in the children with ADHD were associated with arousals. Historical sleep times were less for children with ADHD. The children with ADHD who had PLMS chronically got 43 minutes less sleep at home than the control subjects (p = 0.0091). All nine children with ADHD who had a PLMS index of >5 per hour of sleep had a long‐standing clinical history of sleep onset problems (>30 minutes) and/or maintenance problems (more than two full awakenings nightly) thus meeting the criteria for Periodic Limb Movement Disorder (PLMD). None of the control children had a clinical history of sleep onset or maintenance problems. The parents of the children with ADHD were more likely to have restless legs syndrome (RLS) than the parents of the control children. Twenty‐five of 28 biologic parents of the children with ADHD and all of the biologic parents of the control children were reached for interview. Eight of twenty‐five parents of the children with ADHD (32%) had symptoms of RLS as opposed to none of the control parents (p = 0.011). PLMS may directly lead to symptoms of ADHD through the mechanism of sleep disruption. Alternative explanations for the association between ADHD and RLS/PLMS are that they are genetically linked, they share a common dopaminergic deficit, or both.</abstract><note type="funding">American Academy of Pediatric Research in Pediatric Practice Fund</note><note type="funding">VA Merit Review</note><note type="funding">University of Illinois College of Medicine at Urbana‐Champaign</note><note type="funding">MH - No. 41712; </note><subject lang="en"><genre>Keywords</genre><topic>Restless legs syndrome(RLS)</topic><topic>Periodic Limb Movements in Sleep (PLMS)</topic><topic>Periodic Limb Movement Disorder (PLMD)</topic><topic>Attention‐deficit hyperactivity disorder (ADHD)</topic><topic>Sleep disorders</topic><topic>Polysomnography</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>1000</start><end>1007</end><total>8</total></extent></part></relatedItem><identifier type="istex">9939D5E54B7E12139A7BB54B764A30EB57EC3F0B</identifier><identifier type="DOI">10.1002/1531-8257(199911)14:6<1000::AID-MDS1014>3.0.CO;2-P</identifier><identifier type="ArticleID">MDS1014</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1999 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>John Wiley & Sons, Inc.</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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