Increased 5‐HT2A receptors in the temporal cortex of parkinsonian patients with visual hallucinations
Identifieur interne : 000148 ( Istex/Corpus ); précédent : 000147; suivant : 000149Increased 5‐HT2A receptors in the temporal cortex of parkinsonian patients with visual hallucinations
Auteurs : Philippe Huot ; Tom H. Johnston ; Tayyeba Darr ; Lili-Naz Hazrati ; Naomi P. Visanji ; Donna Pires ; Jonathan M. Brotchie ; Susan H. FoxSource :
- Movement Disorders [ 0885-3185 ] ; 2010-07-30.
English descriptors
Abstract
Well‐formed visual hallucinations (VH) are common in patients with Parkinson's disease (PD). The pathophysiology of VH in PD is unknown but may involve structures mediating visual processing such as the inferior temporal cortex. Serotonergic type 2A (5‐HT2A) receptors have been linked to many psychiatric disorders, including psychosis. We hypothesized that enhanced 5‐HT2A receptor levels may be involved in VH in PD. Autoradiographic binding using [3H]‐ketanserin and spiperone, to define 5‐HT2A receptors, was performed in 6 PD patients with VH, 6 PD patients without VH, and 5 healthy, age‐matched controls. The cerebral regions studied included the orbitofrontal cortex, inferolateral temporal cortex, motor cortex, striatum, and substantia nigra. There was a significant (45.6%) increase in the levels of [3H]‐ketanserin binding in the inferolateral temporal cortex of PD patients with VH when compared with PD patients without VH (54.3 ± 5.2 fmol/mg vs. 37.3 ± 4.3 fmol/mg, P = 0.039). Additionally, there was a significant increase in the levels of 5‐HT2A receptors in the motor cortex of all PD patients taken as a group when compared with controls (57.8 ± 5.7 fmol/mg vs. 41.2 ± 2.6 fmol/mg, P = 0.0297). These results suggest that enhanced 5‐HT2A‐mediated neurotransmission in the inferolateral temporal cortex, a critical structure in visual processing, might be associated with the development of VH in PD. Our results provide new insights into the pathophysiology of VH in PD and provide an anatomical basis to explain why compounds with 5‐HT2A antagonist activity are effective at alleviating this debilitating complication. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23083
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<front><div type="abstract" xml:lang="en">Well‐formed visual hallucinations (VH) are common in patients with Parkinson's disease (PD). The pathophysiology of VH in PD is unknown but may involve structures mediating visual processing such as the inferior temporal cortex. Serotonergic type 2A (5‐HT2A) receptors have been linked to many psychiatric disorders, including psychosis. We hypothesized that enhanced 5‐HT2A receptor levels may be involved in VH in PD. Autoradiographic binding using [3H]‐ketanserin and spiperone, to define 5‐HT2A receptors, was performed in 6 PD patients with VH, 6 PD patients without VH, and 5 healthy, age‐matched controls. The cerebral regions studied included the orbitofrontal cortex, inferolateral temporal cortex, motor cortex, striatum, and substantia nigra. There was a significant (45.6%) increase in the levels of [3H]‐ketanserin binding in the inferolateral temporal cortex of PD patients with VH when compared with PD patients without VH (54.3 ± 5.2 fmol/mg vs. 37.3 ± 4.3 fmol/mg, P = 0.039). Additionally, there was a significant increase in the levels of 5‐HT2A receptors in the motor cortex of all PD patients taken as a group when compared with controls (57.8 ± 5.7 fmol/mg vs. 41.2 ± 2.6 fmol/mg, P = 0.0297). These results suggest that enhanced 5‐HT2A‐mediated neurotransmission in the inferolateral temporal cortex, a critical structure in visual processing, might be associated with the development of VH in PD. Our results provide new insights into the pathophysiology of VH in PD and provide an anatomical basis to explain why compounds with 5‐HT2A antagonist activity are effective at alleviating this debilitating complication. © 2010 Movement Disorder Society</div>
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<abstract>Well‐formed visual hallucinations (VH) are common in patients with Parkinson's disease (PD). The pathophysiology of VH in PD is unknown but may involve structures mediating visual processing such as the inferior temporal cortex. Serotonergic type 2A (5‐HT2A) receptors have been linked to many psychiatric disorders, including psychosis. We hypothesized that enhanced 5‐HT2A receptor levels may be involved in VH in PD. Autoradiographic binding using [3H]‐ketanserin and spiperone, to define 5‐HT2A receptors, was performed in 6 PD patients with VH, 6 PD patients without VH, and 5 healthy, age‐matched controls. The cerebral regions studied included the orbitofrontal cortex, inferolateral temporal cortex, motor cortex, striatum, and substantia nigra. There was a significant (45.6%) increase in the levels of [3H]‐ketanserin binding in the inferolateral temporal cortex of PD patients with VH when compared with PD patients without VH (54.3 ± 5.2 fmol/mg vs. 37.3 ± 4.3 fmol/mg, P = 0.039). Additionally, there was a significant increase in the levels of 5‐HT2A receptors in the motor cortex of all PD patients taken as a group when compared with controls (57.8 ± 5.7 fmol/mg vs. 41.2 ± 2.6 fmol/mg, P = 0.0297). These results suggest that enhanced 5‐HT2A‐mediated neurotransmission in the inferolateral temporal cortex, a critical structure in visual processing, might be associated with the development of VH in PD. Our results provide new insights into the pathophysiology of VH in PD and provide an anatomical basis to explain why compounds with 5‐HT2A antagonist activity are effective at alleviating this debilitating complication. © 2010 Movement Disorder Society</abstract>
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<notesStmt><note type="content">*Potential conflict of interest: None reported.</note>
<note>Dean's New Staff Award (SHF)</note>
<note>Cure Parkinson's Trust</note>
<note>Krembil Foundation (JMB)</note>
<note>Edmond J. Safra Philanthropic Foundation</note>
<note>Parkinson Society Canada</note>
<note>United Kingdom Parkinson's Disease Society Tissue Bank at Imperial College</note>
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<note type="correspondence"><p>Correspondence: Movement Disorder Clinic, MCL7.421, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8</p>
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<abstract xml:lang="en"><p>Well‐formed visual hallucinations (VH) are common in patients with Parkinson's disease (PD). The pathophysiology of VH in PD is unknown but may involve structures mediating visual processing such as the inferior temporal cortex. Serotonergic type 2A (5‐HT2A) receptors have been linked to many psychiatric disorders, including psychosis. We hypothesized that enhanced 5‐HT2A receptor levels may be involved in VH in PD. Autoradiographic binding using [3H]‐ketanserin and spiperone, to define 5‐HT2A receptors, was performed in 6 PD patients with VH, 6 PD patients without VH, and 5 healthy, age‐matched controls. The cerebral regions studied included the orbitofrontal cortex, inferolateral temporal cortex, motor cortex, striatum, and substantia nigra. There was a significant (45.6%) increase in the levels of [3H]‐ketanserin binding in the inferolateral temporal cortex of PD patients with VH when compared with PD patients without VH (54.3 ± 5.2 fmol/mg vs. 37.3 ± 4.3 fmol/mg, P = 0.039). Additionally, there was a significant increase in the levels of 5‐HT2A receptors in the motor cortex of all PD patients taken as a group when compared with controls (57.8 ± 5.7 fmol/mg vs. 41.2 ± 2.6 fmol/mg, P = 0.0297). These results suggest that enhanced 5‐HT2A‐mediated neurotransmission in the inferolateral temporal cortex, a critical structure in visual processing, might be associated with the development of VH in PD. Our results provide new insights into the pathophysiology of VH in PD and provide an anatomical basis to explain why compounds with 5‐HT2A antagonist activity are effective at alleviating this debilitating complication. © 2010 Movement Disorder Society</p>
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<titleGroup><title type="main" xml:lang="en">Increased 5‐HT<sub>2A</sub>
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<p>Well‐formed visual hallucinations (VH) are common in patients with Parkinson's disease (PD). The pathophysiology of VH in PD is unknown but may involve structures mediating visual processing such as the inferior temporal cortex. Serotonergic type 2A (5‐HT<sub>2A</sub>
) receptors have been linked to many psychiatric disorders, including psychosis. We hypothesized that enhanced 5‐HT<sub>2A</sub>
receptor levels may be involved in VH in PD. Autoradiographic binding using [<sup>3</sup>
H]‐ketanserin and spiperone, to define 5‐HT<sub>2A</sub>
receptors, was performed in 6 PD patients with VH, 6 PD patients without VH, and 5 healthy, age‐matched controls. The cerebral regions studied included the orbitofrontal cortex, inferolateral temporal cortex, motor cortex, striatum, and substantia nigra. There was a significant (45.6%) increase in the levels of [<sup>3</sup>
H]‐ketanserin binding in the inferolateral temporal cortex of PD patients with VH when compared with PD patients without VH (54.3 ± 5.2 fmol/mg vs. 37.3 ± 4.3 fmol/mg, <i>P</i>
= 0.039). Additionally, there was a significant increase in the levels of 5‐HT<sub>2A</sub>
receptors in the motor cortex of all PD patients taken as a group when compared with controls (57.8 ± 5.7 fmol/mg vs. 41.2 ± 2.6 fmol/mg, <i>P</i>
= 0.0297). These results suggest that enhanced 5‐HT<sub>2A</sub>
‐mediated neurotransmission in the inferolateral temporal cortex, a critical structure in visual processing, might be associated with the development of VH in PD. Our results provide new insights into the pathophysiology of VH in PD and provide an anatomical basis to explain why compounds with 5‐HT<sub>2A</sub>
antagonist activity are effective at alleviating this debilitating complication. © 2010 Movement Disorder Society</p>
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<abstract lang="en">Well‐formed visual hallucinations (VH) are common in patients with Parkinson's disease (PD). The pathophysiology of VH in PD is unknown but may involve structures mediating visual processing such as the inferior temporal cortex. Serotonergic type 2A (5‐HT2A) receptors have been linked to many psychiatric disorders, including psychosis. We hypothesized that enhanced 5‐HT2A receptor levels may be involved in VH in PD. Autoradiographic binding using [3H]‐ketanserin and spiperone, to define 5‐HT2A receptors, was performed in 6 PD patients with VH, 6 PD patients without VH, and 5 healthy, age‐matched controls. The cerebral regions studied included the orbitofrontal cortex, inferolateral temporal cortex, motor cortex, striatum, and substantia nigra. There was a significant (45.6%) increase in the levels of [3H]‐ketanserin binding in the inferolateral temporal cortex of PD patients with VH when compared with PD patients without VH (54.3 ± 5.2 fmol/mg vs. 37.3 ± 4.3 fmol/mg, P = 0.039). Additionally, there was a significant increase in the levels of 5‐HT2A receptors in the motor cortex of all PD patients taken as a group when compared with controls (57.8 ± 5.7 fmol/mg vs. 41.2 ± 2.6 fmol/mg, P = 0.0297). These results suggest that enhanced 5‐HT2A‐mediated neurotransmission in the inferolateral temporal cortex, a critical structure in visual processing, might be associated with the development of VH in PD. Our results provide new insights into the pathophysiology of VH in PD and provide an anatomical basis to explain why compounds with 5‐HT2A antagonist activity are effective at alleviating this debilitating complication. © 2010 Movement Disorder Society</abstract>
<note type="content">*Potential conflict of interest: None reported.</note>
<note type="funding">Dean's New Staff Award (SHF)</note>
<note type="funding">Cure Parkinson's Trust</note>
<note type="funding">Krembil Foundation (JMB)</note>
<note type="funding">Edmond J. Safra Philanthropic Foundation</note>
<note type="funding">Parkinson Society Canada</note>
<note type="funding">United Kingdom Parkinson's Disease Society Tissue Bank at Imperial College</note>
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<topic>autoradiography</topic>
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